Risks of testosterone-replacement therapy and recommendations for monitoring.

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889

Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men

Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760

Estrogen plus Progestin and the Risk of Coronary Heart Disease

Manson, J. E., Hsia, J., Johnson, K. C., Rossouw, J. E., Assaf, A. R., Lasser, N. L., Trevisan, M., Black, H. R., Heckbert, S. R., Detrano, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030808 · Cited by 2,065

STUDIES ON PROSTATIC CANCER

Huggins, C. (1941) · Archives of Surgery · doi:10.1001/archsurg.1941.01210140043004 · Cited by 1,694

Longitudinal Evaluation of Prostate-Specific Antigen Levels in Men With and Without Prostate Disease

Carter, H. B. (1992) · JAMA · doi:10.1001/jama.1992.03480160073037 · Cited by 1,076

Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial

Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920

Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men

Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830

Prospective Study of Sex Hormone Levels and Risk of Prostate Cancer

Gann, P. H., Hennekens, C. H., Ma, J., Longcope, C., & Stampfer, M. J. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.16.1118 · Cited by 782

The Frequency of Carcinoma and Intraepithelial Neoplasia of the Prostate in Young Male Patients

Sakr, W., Haas, G. P., Cassin, B. F., Pontes, J. E., & Crissman, J. D. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)35487-3 · Cited by 744

Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.

Huggins, C., & Hodges, C. (2002) · Journal of Urology · doi:10.1016/s0022-5347(02)80307-x · Cited by 637

[Patient with late-start hypogonadism and sexual dysfunction].

Álvarez‐Maestro, M., Gómez, F. J. S., Manso, L. S. J., González, E. R., & Martínez‐Piñeiro, L. (2013) · PubMed

PACIENTE CON SÍNDROME DE DÉFICIT DE TESTOSTERONA TRAS PROSTATECTOMÍA RADICAL

Linares, E., Martínez‐Salamanca, J. I., Morgentaler, A., Moncada, I., del Portillo, L., Rodríguez-Izquierdo, M., Areche, J., & Carballido, J. (2013) · Archivos Españoles de Urología

Testosterone Supplementation Effects on Low BMD in Males Ages 19-62: A Six-Month Intervention

Palmer, K. K. (2012) · Aquila Digital Community (University of Southern Mississippi)

The End of Testosterone?

Heidelbaugh, J. J. (2014) · Journal of Men s Health · doi:10.1089/jomh.2014.0077

Terapia de reemplazo con testosterona y cáncer de próstata: ¿la caída de un paradigma?

Castillo, O., Vidal-Mora, I., & López-Fontana, G. (2015) · Medwave · doi:10.5867/medwave.2015.03.6115

Evidencias actuales acerca de la relación entre el tratamiento de reemplazo hormonal en el síndrome del déficit de testosterona y el cáncer de próstata

Pomerol, J. M. (2008) · Revista Internacional de Andrología · doi:10.1016/s1698-031x(08)76155-7

Re: Testosterone Treatment Is a Potent Tumor Promoter for the Rat Prostate

Scovell, J. M., Butler, P. R., Ramasamy, R., & Lamb, D. J. (2015) · European Urology · doi:10.1016/j.eururo.2014.12.049

Endocriene gevolgen van chronisch opioïdgebruik

Żylicz, Z. (2008) · Pallium · doi:10.1007/bf03077436

Coronary Artery Disease in Men: The Role of Sex Hormones

Channer, K. S. (2006) · Future Cardiology · doi:10.2217/14796678.2.3.247

Case Report: Treatment of Androgen Deficiency in the Aging Male

Hernandez, A., & Baum, N. H. (2008) · Postgraduate Medicine · doi:10.3810/pgm.2008.11.1941

The Role of Hypogonadism in the Evolution of Bone Loss before and after Cardiac Transplantation

Stempfle, H. U. (2005) · Elsevier eBooks · doi:10.1016/b978-012183502-6/50011-0

Metastatic Prostate Cancer After Orchiectomy, Radiotherapy, and Testosterone Replacement in a Patient With Bilateral Seminoma

Manassero, F., Erba, P. A., Mariani, G., Mogorovich, A., Giannarini, G., & Selli, C. (2006) · Journal of Andrology · doi:10.2164/jandrol.106.000026

Der hypogonadale ältere Mann in der urologischen Praxis

Kratzik, C., Em, D., Lunglmayr, G., & Schatzl, G. (2005) · Journal für Kardiologie (Krause & Pachernegg GmbH)

Testosterone supplementation and the prostate: a review of the safety issue

Marks, L. S., & Nelson, P. S. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000224808.54566.13

Common Sexual Health Issues in Men

Winn, R. J. (2006) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2005.11.012

Therapeutic Potential of Testosterone Gels

Lunenfeld, B., & Oettel, M. (2009) · Aging Health · doi:10.2217/ahe.09.6

Androgen deficiency in males

Farrell, J. A. B., Deshmukh, A., & Baghaie, A. A. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.59

Diagnóstico e Tratamento do Hipogonadismo Masculino Tardio

Alves, M., Neves, C., & Medina, J. L. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Ophthalmic and Neuro-Ophthalmic Complications of Obstructive Sleep Apnoea

Attarian, H. P., Viola-Saltzman, M., & Jay, W. M. (2011) · Neuro-Ophthalmology · doi:10.3109/01658107.2011.618582

Effects of Androgen on the Cardiovascular System in the Aging Male

Kim, J. W., Kim, J. J., & Moon, D. G. (2011) · Korean Journal of Andrology · doi:10.5534/kja.2011.29.1.10

Low-risk prostate cancer and low testosterone: What are the acceptable alternatives?

Soloway, M. S. (2009) · Current Urology Reports · doi:10.1007/s11934-009-0078-8

Male hormonal contraception: a safe option?

Walton, M. J., & Anderson, R. A. (2006) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.1.1.25

Antiaging Medicine: What Should We Tell Our Patients?

Perls, T. T. (2010) · Aging Health · doi:10.2217/ahe.10.11

Raising testosterone levels in men with hypogonadism

Carson, M. N. (2006) · Independent Nurse · doi:10.12968/indn.2006.1.6.73938

Testosterone and frailty in elderly men

Emmelot‐Vonk, M. H. (2009) · Utrecht University Repository (Utrecht University)

Getting Urology involved in the treatment of men with erectile dysfunction, the metabolic syndrome and hypogonadism

Ian Eardley, C. (2008) · Journal of Men s Health · doi:10.1016/j.jomh.2008.03.011

Short term testosterone replacement therapy improves libido and body composition Reposição de testosterona a curto prazo melhora libido e composição corporal

Júnior, A. D. S., Clapauch, R., & Buksman, S. (2009)

Alternate Therapies for Testosterone Replacement

Şerefoğlu, E. C., Gökçe, A., Hellstrom, W. J. G., & Guay, A. T. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-179-0_11

Transrectal ultrasound (TRUS) findings of the prostate gland in late onset hypogonadism with testosterone supplementation in correlation with clinical outcome.

Phongkitkarun, S., Rassameepong, A., Permpongkosol, S., Taphey, M., & Wibulpolprasert, B. (2012) · PubMed

Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas Clomifeno não reverte o hipogonadismo na maioria dos homens com adenomas pituitários não funcionais tratados de forma convencional

Ribeiro, R. S., & Abucham, J. (2011)

Câncer de próstata e testosterona: riscos e controvérsias Prostate carcinoma and testosterone: risks and controversies

Rhoden, E. L., & Averbeck, M. A. (2009)

Ist es „nur“ das Alter oder braucht er Testosteron?

Heufelder, A. E., Wetterauer, U., & Yassin, A. A. (2014) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-014-3642-1

transplantation How I treat late effects in adults after allogeneic stem cell

Savani, B. N., Griffith, M. L., Jagasia, S. M., & Lee, S. J. (2014)

Testosterone in Older Men: Replay of the Estrogen Story?

Brett, A. S. (2004) · Journal watch · doi:10.1056/jg200404270000006

Indicaties en risico’s van testosteronsubstitutie

Vingerhoeds, A. C. M. (2004) · Medisch-Farmaceutische Mededelingen · doi:10.1007/bf03058430

Long-term monitoring of hypogonadal men receiving intramuscular testosterone replacement: a retrospective audit

Ryś, A., Candan, J., Cox, S., & Smith, J. C. (2015) · Endocrine Abstracts · doi:10.1530/endoabs.38.p375

Oral Administration of Enclomiphene Citrate Results in Physiological Total Testosterone Levels in Men with Low or Normal Testosterone: A Pilot Study

Rd, W. (2015) · International Journal of Endocrinology and Metabolic Disorders · doi:10.16966/2380-548x.114

Pharmacovigilance and Principle of Nonmaleficence in Sex Reassignment

Zamarytė-Sakavičienė, K., Stakišaitis, D., Širinskienė, A., Narbekovas, A., & Juškevičius, J. (2012) · Medicina · doi:10.3390/medicina48110088

Androgen Actions on Bone: Clinical Aspects

Goemaere, S., T'Sjoen, G. G., & Kaufman, J. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-459-9_17

Testosterone therapy for hypogonadal men with prostate cancer

Catarinicchia, S. P., & Crawford, E. D. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.118

Sex Hormone Influenced Differences in Skeletal Muscle Responses to Aging and Exercise

Brown, M., & Tiidus, P. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802388-4.00010-0

Screening of the aging male

(2007) · CRC Press eBooks · doi:10.3109/9780203089798-13

Effects of testosterone replacement therapy on the prostate in the aging male

Kirby, M. G., Cunningham, M. E., & Bunn, F. (2009) · CRC Press eBooks · doi:10.3109/9781439808078-23

Implantable Hormone Pellets for Testosterone Deficiency in Adult Men

Haynes, J. H., & Hines, T. S. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-05267-2.00124-2

Hormonal Evaluation and Therapy of Erectile Dysfunction

Hockenberry, M. S., & Masson, P. (2016) · Springer eBooks · doi:10.1007/978-3-319-31587-4_7

Improving the management of testosterone deficiency

Mayor, S. (2016) · Prescriber · doi:10.1002/psb.1506 · Cited by 1

BENEFÍCIOS E RISCOS DA TERAPIA DE REPOSIÇÃO DE TESTOSTERONA EM HOMENS IDOSOS COM HIPOGONADISMO TARDIO: REVISÃO DA LITERATURA

Barros, L. B. (2014)

Hypogonadism in an opioid dependent man

Nkire, N., Doran, M., & O'Connor, J. J. (2011) · Irish Journal of Psychological Medicine · doi:10.1017/s0790966700012209

Causas y consecuencias del hipogonadismo en varones con diabetes mellitus tipo 2

Ruiz, A. H. (2015) · Gredos (University of Salamanca) · doi:10.14201/gredos.128430

Effects of Castration and Testosterone Substitution on the Hippocampus in Adult Male Albino Rats

El-Sawaf, M. (2010) · The Egyptian Journal of Anatomy · doi:10.21608/ejana.2010.3648

Use and Abuse of Anabolic-Androgenic Steroids and Androgen Precursors

Reyes, K. J., & LeMar, H. J. (2009) · Elsevier eBooks · doi:10.1016/b978-0-323-05885-8.00051-9

Case report. Ongebruikelijke presentatie van een Leydig-celtumormetastase tijdens de behandeling van een prostaatcarcinoom

Stokkel, L. E., van der Poel, H. G., Langbein, S., Kerst, J. M., & van Rhijn, B. W. G. (2018) · Tijdschrift voor Urologie · doi:10.1007/s13629-018-00210-1

Hipogonadismo associado à obesidade: efeitos do tratamento com citrato de clomifeno

Soares, A. H. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-13062018-074535

Unusual Cause of Severe Hyponatraemia

Hanafy, A., Holmes, S., & Rajeswaran, C. (2018) · Endocrine Abstracts · doi:10.1530/endoabs.59.ep96

Testosterone for aging men

Philipraj, S. J., Thomas, J. A., Hegde, P. M., Dorairajan, L. N., & Shah, R. S. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006295.pub2

Prevalence of low androgen levels among middle and old age men attending Outpatient Clinics

Abdelnaser, T., Gayar, D. E., Abdelrahman, I. F. S., & Taher, R. (2018) · Human Andrology · doi:10.21608/ha.2018.4072.1028

A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer

van Rhijn, B. W. G., Stokkel, L. E., der Poel, H. V., Langbein, S., Kerst, J., & de Jong, J. (2020) · Urology Annals · doi:10.4103/ua.ua_38_19

Male Hypogonadism

Stocker, D. J., & Vigersky, R. A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-323-05885-8.00044-1

Sexual Health

Johnson, L. E., & Alline, K. M. (2007) · Elsevier eBooks · doi:10.1016/b978-032303930-7.50039-0

Testosterone Deficiency Evaluation, Management, and Treatment Considerations

Mitchell, K. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-45267-4_2

Glucocorticoid-induced osteoporosis and Cushing’s syndrome

Saag, K. G., Adler, R. A., & Weinstein, R. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00045-9

The anti-inflammatory effects of testosterone on atherosclerosis

Bateman, L. (2020) · Sheffield Hallam University · doi:10.7190/shu-thesis-00351 · Cited by 1

남성갱년기 환자의 약물치료와 추적관찰

민권식, & 강동일 (2011)

Monitoring Haematocrit in Paediatric Patients Receiving Testosterone Therapy in Arab Countries

Alsaffar, H., Habeb, A. M., Hamza, R. T., & Deeb, A. (2021) · Cureus · doi:10.7759/cureus.17618

Genitourinary system: An Introduction

(2007) · CRC Press eBooks · doi:10.3109/9780203089798-16

Risks of Testosterone Treatment

Dobs, A. S., & Yalamanchi, S. (2022) · doi:10.1093/med/9780198870197.003.0490

Correct answers to multiple choice questions appearing in the European Urology Update Series 2005

(2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05978.x

NHG-Standaard Erectiele disfunctie

Leusink, P., Boer, L. D., Vliet, V. C., Rambharose, V., Sprengers, A., Mogendorff, S., Rijn-Van, V., & Kortenhof, N. (2011) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-8279-8_79

Testosterone for aging men

Philipraj, S. J., Thomas, J. A., Hegde, P. M., Dorairajan, L. N., & Shah, R. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006295

Sexualité au masculin

Lopès, P., & Poudat, F.-X. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-77438-6.00005-x

Male Hypogonadism

Theodoraki, A., & Bouloux, P.-M. G. (2009) · Springer eBooks · doi:10.1007/978-1-84882-704-2_13

Erectile Dysfunction

Fortney, L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1793-8.00044-3

Section IV: Surgical Interventions

(2007) · CRC Press eBooks · doi:10.3109/9781420015089-41

Andropause

Hijazi, R. A., & Cunningham, G. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50064-3

Faculty Opinions recommendation of Can testosterone therapy be offered to men on active surveillance for prostate cancer? Preliminary results.

Minhas, S., Tharakan, T., & Miah, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727802981.793556568

Current World Literature

(2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000224813.85060.ab

Effects of testosterone replacement therapy on the prostate in the aging male

Cunningham, M. E., & Bunn, F. (2009) · CRC Press eBooks · doi:10.3109/9781439808078-20

Altershypogonadismus

Weidner, W. (2014) · Springer eBooks · doi:10.1007/978-3-642-44942-0_57

Reproductive endocrinology

Wass, J. A. H., Owen, K. R., & Turner, H. E. (2014) · doi:10.1093/med/9780199644438.003.0004

Male Hypogonadism

Faiman, C. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6643-9.00059-x

Testosterone Therapy and Prostate Cancer

Soares, D. D. F. G., Rhoden, E. L., & Morgentaler, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-46086-4_15

STROKE

Sila, C. A. (2009) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000300025.15285.92

Altershypogonadismus

Weidner, W. (2010) · Springer eBooks · doi:10.1007/978-3-642-01626-4_59

Hypogonadism: Treatment

Mulhall, J. P., Stahl, P. J., & Stember, D. S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6693-2_12

Men’s Health

Muñoz, G. E., & Коган, М. И. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190466268.003.0010

Androgen Supplementation in the Prostate Cancer Patient

Morgentaler, A. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-555-2_15

Testosterone Therapy in Oncologic Patients

Solsrud, E., Louters, M. M., & Pearlman, A. M. (2023) · Current Sexual Health Reports · doi:10.1007/s11930-022-00351-w

ALTERAÇÕES CARDIOVASCULARES EM INDIVÍDUOS QUE ABUSAM DE ESTEROIDES ANABÓLICOS ANDROGÊNICOS

Feitosa, G. M., & Bachur, T. P. R. (2021) · Revista Intertox de Toxicologia Risco Ambiental e Sociedade · doi:10.22280/revintervol14ed2.500

Semen and Testicular Dynamics of Mature Nigerian Indigenous Cocks Administered Exogenous Follicle Stimulating and Luteinizing Hormone (Menotropin)

Amaduruonye, W., Nathaniel, J., Ibrahim, Y., Patrick, J. G., & Herbert, U. (2023) · Asian Journal of Applied Sciences · doi:10.3923/ajaps.2023.8.15

Testosterone Therapy and Prostate Cancer

Rhoden, E. L., Soares, D. D. F. G., & Morgentaler, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-31501-5_18

Low-Value Prostate Cancer Screening Among Young Men With Private Insurance

Lange, S. M., Vehawn, J., Choudry, M. M., Ambrose, J. P., Cluff, C., Haaland, B. A., Paudel, N., Chipman, J., Hanson, H. A., & O’Neil, B. B. (2023) · Urology Practice · doi:10.1097/upj.0000000000000461

Testosterontherapie und Prostatakrebs

Rhoden, E. L., Soares, D. D. F. G., & Morgentaler, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-65245-5_18

Effects of Human Chorionic Gonadotropin Therapy on Gonadal Function in Men Clinically Confirmed with Subfertility: An Interventional Study at a Teaching Hospital, Ghana

Aidoo, S., Afoko, A. A., Adams, Y., Dapare, P. P. M., Bani, S. B., Afoko, V., & Alliah, V. (2025) · Open Journal of Urology · doi:10.4236/oju.2025.153010

Testosterone Therapy and the Prostate

Morgentaler, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-89650-7_21

History of Testosterone Therapy in Men with Testosterone Deficiency: 1939–2024

Traish, A. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-89650-7_14

Unforeseen Consequences of Anabolic-Androgenic Steroid Use: Acute Limb Ischemia and Subsequent Amputation—A Case Report and Literature Review

Alzubi, A. S., Abdelwahed, A. F., Beshr, M. S., Shelig, M., Abozguia, H., Daloub, S., Alagha, Z., & Mader, J. (2025) · Journal of Investigative Medicine High Impact Case Reports · doi:10.1177/23247096251348908

Sex Steroids and Hypertension

Miller, A. P., & Oparil, S. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-987-5_18

Testosterone Deficiency Syndrome

Meryn, S. (2014) · Springer eBooks · doi:10.1007/978-3-662-45018-5_10

Mechanisms and effects of growth hormone deficiency (due to subarachnoid haemorrhage and traumatic brain injury) on quality of life and regional body composition, and the influence of hormone replacement.

Gardner, C. (2015) · University of Liverpool · doi:10.17638/02006206

Low Testosterone Level in Men and Quality of Life

(2012) · SpringerReference · doi:10.1007/springerreference_73481

The management of prostatic diseases according to testosterone replacement therapy

Lee, J. H., Huh, J., Kim, Y.-J., Park, K. K., & Kim, S. D. (2014) · Journal of Medicine and Life Science · doi:10.22730/jmls.2014.11.2.148

Testosterone replacement therapy and the risk of prostate cancer

Daniel, D., Warburton, Christopher, C., Hobaugh, Grace, Wang, Haocheng, Lin, L., & Run (2015)

Testosterone replacement therapy in prostate cancer patients: is it safe?

Umbas, R., & Sugiono, M. (2010) · PubMed · Cited by 3

Testosterone replacement therapy and the risk of prostate cancer: a perspective view

Barqawi, A. B., & Crawford, E. D. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901323 · Cited by 15

Testosterone replacement therapy and the risk of prostate cancer. Is there a link?

Barqawi, A. B., & Crawford, E. D. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901418 · Cited by 27