The DOI matches its Crossref record; 246 of the 246 references it cites were found in a registry or an index.
Major Depressive Disorder
Abstract
This review of major depressive disorder is a comprehensive account of the genetic, biochemical, and neurophysiological changes that have been implicated in the disorder. No single mechanism can account for all the clinical variations in this condition. The monoamine oxidase theory can explain many of the actions of antidepressants, but genetic factors, stress, and psychosocial factors also play a part in depression.
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“It is the most widely used pharmacological target for treating depression and anxiety (Belmaker and Agam, 2008; Ravindran and Stein, 2010)”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Belmaker and Agam, 2008
Citations
Cites
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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
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Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×
“resulting in dendritic atrophy, reduction in spinogenesis, apoptosis of neurons, and possibly inhibition of adult neurogenesis [25].”
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
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Wang, W., Xu, W., Chander, A., Nepal, S., Buck, B., Pakhomov, S., Cohen, T., Ben-Zeev, D., & Campbell, A. (2023) · Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies · doi:10.1145/3610890 · Cited by 19
Baek, S.-E., Lee, G.-J., Rhee, C.-K., Rho, D.-Y., Kim, D.-H., Huh, S., & Lee, S.-K. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.2.222 · Cited by 17
Lyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4580 · Cited by 17
Effect of adjunct yoga therapy in depressive disorders: Findings from a randomized controlled study
Sarkar, S., Kumar, S., Subramaniam, E., Bhavanani, A., & Balasundaram, S. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_173_19 · Cited by 16
Towards Personalised Mood Prediction and Explanation for Depression from Biophysical Data
Chatterjee, S., Mishra, J., Sundram, F., & Roop, P. (2023) · Sensors · doi:10.3390/s24010164 · Cited by 15
Collaborative Empiricism: A Cognitive Response to Exposure Reluctance and Low Distress Tolerance
Clark, D. A. (2013) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2012.06.001 · Cited by 14
Metadata
- Authors
- Belmaker, R. H., & Agam, G.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-01-03
- Volume
- 358
- Issue
- 1
- Pages
- 55-68
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2129579709
- Cited by
- 2,166
- References
- 245
- Citations by year
- 2026: 74 · 2025: 83 · 2024: 115 · 2023: 91 · 2022: 105 · 2021: 158 · 2020: 128 · 2019: 130 · 2018: 132 · 2017: 129 · 2016: 130 · 2015: 147 · 2014: 123 · 2013: 126 · 2012: 116
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, depression, genetic factors, biochemical mechanisms, neurophysiology, monoamine oxidase, antidepressants, stress, psychosocial factors
- MeSH terms
- Animals, Antidepressive Agents, Corticotropin-Releasing Hormone, Depressive Disorder, Major, Major Depressive Disorder, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Norepinephrine, Pituitary-Adrenal System, Serotonin, Stress, Psychological, Biogenic Monoamines
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