Major Depressive Disorder

Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988

Protective and Damaging Effects of Stress Mediators

McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177

Physiology and neurobiology of stress and adaptation: central role of the brain

McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162

Stress and the brain: from adaptation to disease

de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321

Deep Brain Stimulation for Treatment-Resistant Depression

Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766

More hippocampal neurons in adult mice living in an enriched environment

Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586

Genetic Epidemiology of Major Depression: Review and Meta-Analysis

Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431

Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior

Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 1×

Subgenual prefrontal cortex abnormalities in mood disorders

Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693

Allelic Variation of Human Serotonin Transporter Gene Expression

Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221

The Corticosteroid Receptor Hypothesis of Depression

Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059

Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders

Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780

An opponent-process theory of motivation. I. Temporal dynamics of affect

Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis

Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression

Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654

Circadian rhythms from multiple oscillators: lessons from diverse organisms

Bell‐Pedersen, D., Cassone, V. M., Earnest, D. J., Golden, S. S., Hardin, P. E., Thomas, T. L., & Zoran, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1633 · Cited by 1,523

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477

Molecular analysis of mammalian circadian rhythms

Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444

Epigenetic regulation in psychiatric disorders

Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400

Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women: An Epidemiological and Cotwin Control Analysis

Kendler, K. S., Bulik, C. M., Silberg, J., Hettema, J. M., Myers, J., & Prescott, C. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.953 · Cited by 1,259

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225

Adult hippocampal neurogenesis in depression

Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206

When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders

Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197

Depression and cortisol responses to psychological stress: A meta-analysis

Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194

The cellular neurobiology of depression

Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182

Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication

Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027

Course of illness, hippocampal function, and hippocampal volume in major depression

MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980

Mammalian circadian biology: elucidating genome-wide levels of temporal organization

Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862

Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies

Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846

Comparison of Treatment Effects between Animal Experiments and Clinical Trials: Systematic Review

Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P., & Khan, K. S. (2007) · BMJ · doi:10.1136/bmj.39048.407928.be · Cited by 827

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822

Social supports and serotonin transporter gene moderate depression in maltreated children

Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D. S., Krystal, J. H., & Gelernter, J. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404376101 · Cited by 819

Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice

Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817

Mania-like behavior induced by disruption of CLOCK

Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects

Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800

Neurogenesis in the Adult Brain

Gage, F. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00612.2002 · Cited by 796

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796

The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine

Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794

A Swedish National Twin Study of Lifetime Major Depression

Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.109 · Cited by 794

Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover proliferation, and survival in the adult dentate gyrus

Sairanen, M., Lucas, G., Ernfors, P., Castrén, M., & Castrén, E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3741-04.2005 · Cited by 763

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762

Antidepressants increase neural progenitor cells in the human hippocampus

Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686

Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories

Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684

Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis

Zhang, X., Beaulieu, J., Sotnikova, T. D., Gainetdinov, R. R., & Caron, M. G. (2004) · Science · doi:10.1126/science.1097540 · Cited by 683

PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672

Hippocampal Neurogenesis: Regulation by Stress and Antidepressants

Dranovsky, A., & Hen, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.082 · Cited by 663

Neuroimaging studies of mood disorder effects on the brain

Sheline, Y. I. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00347-0 · Cited by 660

Effects of Citalopram and Interpersonal Psychotherapy on Depression in Patients With Coronary Artery Disease: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) Trial

Lespérance, F., Frasure-Smith, N., Koszycki, D., Laliberté, M.-A., van Zyl, L. T., Baker, B., Swenson, J. R., Ghatavi, K., Abramson, B. L., Dorian, P., et al. (2007) · JAMA · doi:10.1001/jama.297.4.367 · Cited by 658

Major Depressive Disorder

D, M. F. M., & Kendler, K. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00112-4 · Cited by 654

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653

Genes, Environment, and Personality

Bouchard, T. J. (1994) · Science · doi:10.1126/science.8209250 · Cited by 633

Organization of the human serotonin transporter gene

Lesch, K., Balling, U., Groß, J., Strauss, K. M., Wolozin, B. L., Murphy, D. L., & Riederer, P. F. (1994) · Journal of Neural Transmission · doi:10.1007/bf01276434 · Cited by 628

Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder

Nemets, B., Stahl, Z., & Belmaker, R. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.477 · Cited by 627

Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs

Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600

The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

Neves-Pereira, M., Mundo, E., Muglia, P., King, N. A., Macciardi, F. M., & Kennedy, J. L. (2002) · The American Journal of Human Genetics · doi:10.1086/342288 · Cited by 595

Low Brain-Derived Neurotrophic Factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity

Karege, F., Bondolfi, G., Gervasoni, N., Schwald, M., Aubry, J., & Bertschy, G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.008 · Cited by 594

Elevated Monoamine Oxidase A Levels in the Brain: An Explanation for the Monoamine Imbalance of Major Depression

Meyer, J. H., Ginovart, N., Boovariwala, A., Sagrati, S., Hussey, D., Garcia, A., Young, T., Praschak-Rieder, N., Wilson, A. A., & Houle, S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1209 · Cited by 585

Association of depression with medical illness: Does cortisol play a role?

Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578

Alterations in 5-HT 1B Receptor Function by p11 in Depression-Like States

Svenningsson, P., Chergui, K., Rachleff, I., Flajolet, M., Zhang, X., Yacoubi, M. E., Vaugeois, J.-M., Nomikos, G. G., & Greengard, P. (2006) · Science · doi:10.1126/science.1117571 · Cited by 572

GABAergic dysfunction in mood disorders

Brambilla, P., Pérez, J., Barale, F., Schettini, G., & Soares, J. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001362 · Cited by 567

Is mood chemistry?

Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563

Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock

Yin, L., Wang, J., Klein, P. S., & Lazar, M. A. (2006) · Science · doi:10.1126/science.1121613 · Cited by 563

Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action

Kim, H. J., Rowe, M. K., Ren, M., Hong, J., Chen, P.-S., & Chuang, D. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.120188 · Cited by 560

BDNF in schizophrenia, depression and corresponding animal models

Angelucci, F., Brené, S., & Mathé, A. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001637 · Cited by 557

Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal

Surget, A., Saxe, M., Leman, S., Ibarguen-Vargas, Y., Chalon, S., Griebel, G., Hen, R., & Belzung, C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.022 · Cited by 556

Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse

Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541

Treatment of Depression in Patients With Alcohol or Other Drug Dependence

Nunes, E. V., & LEVIN, F. R. (2004) · JAMA · doi:10.1001/jama.291.15.1887 · Cited by 535

Polymorphism in serotonin transporter gene associated with susceptibility to major depression

Ogilvie, A. D., Battersby, S., Fink, G., Harmar, A. J., Goodwin, G. M., Bubb, V. J., & Smith, C. A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90079-3 · Cited by 534

The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways

Millan, M. J., Gobert, A., Lejeune, F., Dekeyne, A., Newman‐Tancredi, A., Pasteau, V., Rivet, J., & Cussac, D. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051797 · Cited by 516

Effects of Antidepressant Medication on Morbidity and Mortality in Depressed Patients After Myocardial Infarction

Taylor, C. B. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.792 · Cited by 512

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

Jope, R. S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00206-2 · Cited by 511

Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors

Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502

Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography

Malison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., et al. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00272-8 · Cited by 496

3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity

Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 496

Neurogenesis in adult primate neocortex: an evaluation of the evidence

RAKIC, P. T. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn700 · Cited by 494

Regulation of dopaminergic transmission and cocaine reward by the Clock gene

McClung, C. A., Sidiropoulou, K., Vitaterna, M., Takahashi, J. S., White, F. J., Cooper, D. C., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503584102 · Cited by 493

The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

Chen, G., Zeng, W., YUAN, P., Huang, L., Jiang, Y., Zhao, Z., & Manji, H. K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.720879.x · Cited by 490

Initiation and adaptation: a paradigm for understanding psychotropic drug action

(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.2.151 · Cited by 490

Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates

Perera, T. D., Coplan, J. D., Lisanby, S. H., Lipira, C. M., Arif, M., Carpio, C., Spitzer, G., Santarelli, L., Scharf, B., Hen, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0237-07.2007 · Cited by 476

Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression

Zhang, X., Gainetdinov, R. R., Beaulieu, J.-M., Sotnikova, T. D., Burch, L. H., Williams, R. B., Schwartz, D. A., Krishnan, K. R. R., & Caron, M. G. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.014 · Cited by 473

Bipolar Disorder

Belmaker, R. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra035354 · Cited by 473

An Opponent-Process Theory of Motivation

Solomon, R. L., & Corbit, J. D. (2008) · Cited by 461

Quantitative Cerebral Anatomy in Depression

Coffey, C. E. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820130009002 · Cited by 457

Neuroendocrine aspects of hypercortisolism in major depression

Parker, K. J., Schatzberg, A. F., & Lyons, D. M. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00016-8 · Cited by 455

The circadian basis of winter depression

Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602425103 · Cited by 451

Neocortical neurogenesis in humans is restricted to development

Bhardwaj, R. D., Curtis, M. A., Spalding, K. L., Buchholz, B. A., Fink, D., Björk-Eriksson, T., Nordborg, C., Gage, F. H., Druid, H., Eriksson, P. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605177103 · Cited by 448

Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures

Tsankova, N. M., Kumar, A., & Nestler, E. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0589-04.2004 · Cited by 447

The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3

Chen, G., Huang, L., Jiang, Y., & Manji, H. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0721327.x · Cited by 442

VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438

Cortical 5-HT 2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice

Weisstaub, N., Zhou, M., Lira, A., Lambe, E. K., González‐Maeso, J., Hornung, J., Sibille, E. L., Underwood, M. D., Itohara, S., Dauer, W. T., et al. (2006) · Science · doi:10.1126/science.1123432 · Cited by 434

The Medical Management of Depression

Mann, J. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050730 · Cited by 431

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430

Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood

Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 418

Early Onset of Selective Serotonin Reuptake Inhibitor Antidepressant Action: Systematic Review and Meta-analysis

Taylor, M. J., Freemantle, N., Geddes, J. R., & Bhagwagar, Z. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1217 · Cited by 406

Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABAAReceptor Subunits in Frontal Cortical Brain Region

Merali, Z., Du, L., Hrdina, P., Palkovits, M., Faludi, G., Poulter, M. O., & Anisman, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4734-03.2004 · Cited by 400

High-speed imaging reveals neurophysiological links to behavior in an animal model of depression

Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396

Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality

Souêtre, E., Salvati, E., Belugou, J.-L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J.-L., & Darcourt, G. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90207-2 · Cited by 396

Association of the Brain-Derived Neurotrophic Factor Val66Met Polymorphism With Reduced Hippocampal Volumes in Major Depression

Frodl, T., Schüle, C., Schmitt, G., Born, C., Baghai, T., Zill, P., Bottlender, R., Rupprecht, R., Bondy, B., Reiser, M., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.410 · Cited by 394

Mood Disturbances and Regional Cerebral Metabolic Abnormalities inRecently Abstinent Methamphetamine Abusers

London, E. D., Simon, S. L., Berman, S. M., Mandelkern, M. A., Lichtman, A. M., Bramen, J. E., Shinn, A. K., Miotto, K. A., Learn, J. E., Dong, Y., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.73 · Cited by 390

Anterior Cingulate, Gyrus Rectus, and Orbitofrontal Abnormalities in Elderly Depressed Patients: An MRI-Based Parcellation of the Prefrontal Cortex

Ballmaier, M., Toga, A. W., Blanton, R. E., Sowell, E. R., Lavretsky, H., Peterson, J. R., Pham, D. L., & Kumar, A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.99 · Cited by 387

The Flinders Sensitive Line rat: A selectively bred putative animal model of depression

Overstreet, D. H., Friedman, E. M., Mathé, A. A., & Yadid, G. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.015 · Cited by 380

Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression

Hastings, R. S., Parsey, R. V., Oquendo, M. A., Arango, V., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300371 · Cited by 378

Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior

Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378

A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock

Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373

Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain

Bauer, M., Heinz, A., & Whybrow, P. C. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000963 · Cited by 370

The Role of CREB in Depression and Antidepressant Treatment

Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365

The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons

Yasuda, S., Liang, M.-H., Marinova, Z., Yahyavi, A., & Chuang, D.-M. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002099 · Cited by 358

Effects of physical exercise on depression, neuroendocrine stress hormones and physiological fitness in adolescent females with depressive symptoms

Nabkasorn, C., Miyai, N., Sootmongkol, A., Junprasert, S., Yamamoto, H., Arita, M., & Miyashita, K. (2006) · European Journal of Public Health · doi:10.1093/eurpub/cki159 · Cited by 353

Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls

Deuschle, M., Schweiger, U., Weber, B., Gotthardt, U., Körner, A., Schmider, J., Standhardt, H., Lammers, C.-H., & Heuser, I. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.1.3689 · Cited by 344

Dysregulation of Endogenous Opioid Emotion Regulation Circuitry in Major Depression in Women

Kennedy, S. E., Koeppe, R. A., Young, E. A., & Zubieta, J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1199 · Cited by 344

Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference

Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341

Functional but not structural subgenual prefrontal cortex abnormalities in melancholia

Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001501 · Cited by 334

A BDNF Coding Variant is Associated with the NEO Personality Inventory Domain Neuroticism, a Risk Factor for Depression

Sen, S., Nesse, R. M., Stoltenberg, S. F., Li, S., Gleiberman, L., Chakravarti, A., Weder, A. B., & Burmeister, M. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300053 · Cited by 331

cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs

Conti, A. C., Cryan, J. F., Dalvi, A., Lucki, I., & Blendy, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03262.2002 · Cited by 328

Mood Disorders and Substance Use Disorder: A Complex Comorbidity

Quello, S. B., Brady, K. T., & Sonne, S. C. (2005) · Science & Practice Perspectives · doi:10.1151/spp053113 · Cited by 326

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Holick, K. A., Lee, D. C., Hen, R., & Dulawa, S. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301399 · Cited by 326

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression

Gillespie, N., Whitfield, J., Williams, B. J., Heath, A., & Martin, N. (2005) · Psychological Medicine · doi:10.1017/s0033291704002727 · Cited by 321

Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis

Banasr, M., Soumier, A., Hery, M., Mocaër, E., & Daszuta, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.025 · Cited by 318

Pathophysiology of hypercortisolism in depression

Carroll, B. J., Cassidy, F., Naftolowitz, D., Tatham, N. E., Wilson, W. H., Iranmanesh, A., Liu, P. Y., & Veldhuis, J. D. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.00967.x · Cited by 317

Molecular studies of major depressive disorder: the epigenetic perspective

Mill, J. S., & Petronis, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001992 · Cited by 311

Reduction in Occipital Cortex γ-Aminobutyric Acid Concentrations in Medication-Free Recovered Unipolar Depressed and Bipolar Subjects

Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Ashworth, F., Sule, A., Matthews, P. M., & Cowen, P. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.048 · Cited by 304

Reduced Brain Norepinephrine and Dopamine Release in Treatment-Refractory Depressive Illness: Evidence in Support of the Catecholamine Hypothesis of Mood Disorders

Lambert, G., Johansson, M., Ågren, H., & Friberg, P. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.787 · Cited by 303

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

Spalletta, G., Bossù, P., Ciaramella, A., Bria, P., Caltagirone, C., & Robinson, R. G. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001879 · Cited by 301

Factor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared rats

Sáenz, J. C. B., Rodríguez‐Villagra, O. A., & Trías, J. F. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.12.001 · Cited by 296

5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern

Hedlund, P. B., Huitron-Resendiz, S., Henriksen, S. J., & Sutcliffe, J. G. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.012 · Cited by 281

Nicotinic acetylcholine receptors as targets for antidepressants

Shytle, R. D., Silver, A. A., Lukas, R. J., Newman, M. B., Sheehan, D. V., & Sanberg, P. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001035 · Cited by 279

Reliability and validity of the cocaine selective severity assessment

Kampman, K. M., Volpicelli, J. R., Mcginnis, D. E., Alterman, A. I., Weinrieb, R. M., D’Angelo, L., & Epperson, L. E. (1998) · Addictive Behaviors · doi:10.1016/s0306-4603(98)00011-2 · Cited by 272

The Homocysteine Hypothesis of Depression

Folstein, M. F., Liu, T., Peter, I., Buel, J., Arsenault, L. N., Scott, T. M., & Qiu, W. W. Q. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.861 · Cited by 271

Antidepressant actions of the exercise-regulated gene VGF

Hunsberger, J. G., Newton, S. S., Bennett, A., Duman, C. H., Russell, D., Salton, S. R., & Duman, R. S. (2007) · Nature Medicine · doi:10.1038/nm1669 · Cited by 270

Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression

Bunney, W. E. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00145-1 · Cited by 268

Endophenotypes in bipolar disorder

Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264

Extending the Bereavement Exclusion for Major Depression to Other Losses

Wakefield, J. C., Schmitz, M. F., First, M. B., & Horwitz, A. V. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.433 · Cited by 263

Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders

Morilak, D. A., & Frazer, A. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004080 · Cited by 263

Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models

Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262

Meta-analysis of serotonin transporter polymorphisms and affective disorders

Lotrich, F. E., & Pollock, B. G. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200409000-00001 · Cited by 261

Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression

Schmidt, P. J., Daly, R. C., Bloch, M., SMITH, M. J., Danaceau, M. A., Clair, L. S. S., Murphy, J. H., Haq, N., & Rubinow, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.154 · Cited by 256

Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade

Millan, M. J., Brocco, M., Gobert, A., & Dekeyne, A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1962-z · Cited by 253

The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety

Schramm‐Sapyta, N. L., McDonald, M. P., & Limbird, L. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04875.2001 · Cited by 250

Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders.

Boivin, D. B. (2000) · PubMed Central · Cited by 247

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3

Kim, A. J., Shi, Y., Austin, R. C., & Werstuck, G. H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01562 · Cited by 235

Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain

Desouza, L. A., Ladiwala, U., Daniel, S. M., Agashe, S., Vaidya, R. A., & Vaidya, V. A. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.010 · Cited by 231

Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness

Vollmayr, B., Simonis, C., Weber, S., Gass, P., & Henn, F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00527-4 · Cited by 229

Probing Brain Reward System Function in Major Depressive Disorder: Altered Response to Dextroamphetamine

Tremblay, L. K., Naranjo, C. A., Cardenas, L., Herrmann, N., & Busto, U. E. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.409 · Cited by 229

Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine

Reagan, L. P., Rosell, D. R., Wood, G. E., Spedding, M., Muñoz, C., Rothstein, J. D., & McEwen, B. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307294101 · Cited by 221

Stress increases vulnerability to inflammation in the rat prefrontal cortex

de Pablos, R. M., Villarán, R. F., Argüelles, S., Herrera, A. J., Venero, J. L., Ayala, A., Cano, J., & Machado, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0802-06.2006 · Cited by 215

In Vivo Gene Modification Elucidates Subtype-Specific Functions of α2-Adrenergic Receptors

Kable, J. W., Murrin, L. C., & Bylund, D. B. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39196-7 · Cited by 213

In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.

Kable, J. W., Murrin, L. C., & Bylund, D. B. (2000) · PubMed · Cited by 207

Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression

Flores, B. H., Kenna, H., Keller, J., Solvason, H. B., & Schatzberg, A. F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300884 · Cited by 203

Dehydroepiandrosterone Augmentation in the Management of Negative, Depressive, and Anxiety Symptoms in Schizophrenia

Strous, R. D., Maayan, R., Lapidus, R., Stryjer, R., Lustig, M., Kotler, M., & Weizman, A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.133 · Cited by 201

Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics

Seeman, P., Ko, F., & Tallerico, T. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001682 · Cited by 200

Neurogenesis and depression: etiology or epiphenomenon?

Henn, F. A., & Vollmayr, B. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.011 · Cited by 192

Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder

Milak, M. S., Parsey, R. V., Keilp, J. G., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.397 · Cited by 179

Cytokines and depression: fortuitous or causative association?

Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000572 · Cited by 174

Decreased Prefrontal Myo-Inositol in Major Depressive Disorder

Coupland, N. J., Ogilvie, C. J., Hegadoren, K., Seres, P., Hanstock, C. C., & Allen, P. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.027 · Cited by 174

Striatal dopamine transporter density in major depression

Laasonen-Balk, T., Kuikka, J. T., Viinam�ki, H., Husso, M., Lehtonen, J., & Tiihonen, J. (1999) · Psychopharmacology · doi:10.1007/s002130051005 · Cited by 171

Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons

Abe, M., Herzog, E. D., & Block, G. D. (2000) · Neuroreport · doi:10.1097/00001756-200009280-00042 · Cited by 169

Dopamine D2-Like Receptors and the Antidepressant Response

Gershon, A. A., Vishne, T. H., & Grunhaus, L. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.031 · Cited by 166

Posttranscriptional and Posttranslational Regulation of Clock Genes

Harms, E., Kivimäe, S., Young, M. W., & Sáez, L. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404268111 · Cited by 166

Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response

Kozlovsky, N., Matar, M. A., Kaplan, Z., Kotler, M., Zohar, J., & Cohen, H. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007560 · Cited by 165

Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus

Sleipness, E. P., Sorg, B. A., & Jansen, H. T. (2007) · Brain Research · doi:10.1016/j.brainres.2006.10.063 · Cited by 160

Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder

Shimon, H., Agam, G., Belmaker, R. H., Hyde, T. M., & Kleinman, J. E. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.8.1148 · Cited by 157

A ‘crash’ course on psychostimulant withdrawal as a model of depression

Barr, A. M., Markou, A., & Phillips, A. G. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02086-2 · Cited by 156

Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”

Zörner, B., Wolfer, D. P., Brandis, D., Kretz, O., Zacher, C., Madani, R., Kadow, I. C. G., Lipp, H., Klein, R., Henn, F. A., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00418-9 · Cited by 148

Clinical Characteristics of Major Depression That Predict Risk of Depression in Relatives

Kendler, K. S., Gardner, C. O., & Prescott, C. A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.322 · Cited by 144

Par-4 Links Dopamine Signaling and Depression

Park, S. K., Nguyen, M. D., Fischer, A., Luke, M. P.-S., Affar, E. B., Dieffenbach, P. B., Tseng, H.-C., Shi, Y., & Tsai, L. (2005) · Cell · doi:10.1016/j.cell.2005.05.031 · Cited by 144

Dopamine receptor-mediated regulation of neuronal “clock” gene expression

Imbesi, M., Yildiz, S., Arslan, A. D., Sharma, R., Manev, H., & Uz, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.044 · Cited by 141

Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Lee, K. J., Kim, S.-J., Kim, S.-W., Choi, S.-H., Shin, Y.-C., Park, S.-H., Moon, B., Cho, E., Lee, M.-S., Choi, S.-H., et al. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.6 · Cited by 139

Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice

Tanda, K., Nishi, A., Matsuo, N., Nakanishi, K., Yamasaki, N., Sugimoto, T., Toyama, K., Takao, K., & Miyakawa, T. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-19 · Cited by 136

Elevated agonist binding to α2-adrenoceptors in the locus coeruleus in major depression

Ordway, G. A., Schenck, J. E., Stockmeier, C. A., May, W., & Klimek, V. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01728-6 · Cited by 134

Animal models of craving for ethanol

Koob, G. F. (2000) · Addiction · doi:10.1080/09652140050111663 · Cited by 127

Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone

Scaccianoce, S., Bianco, P. D., Paolone, G., Caprioli, D., Modafferi, A. M. E., Nencini, P., & Badiani, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.024 · Cited by 122

Normal Prefrontal Gamma-Aminobutyric Acid Levels in Remitted Depressed Subjects Determined by Proton Magnetic Resonance Spectroscopy

Hasler, G., Neumeister, A., van der Veen, J. W. C., Tumonis, T., Bain, E., Shen, J., Drevets, W. C., & Charney, D. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.017 · Cited by 122

Early Life Stress Alters Adult Serotonin 2C Receptor Pre-mRNA Editing and Expression of the α Subunit of the Heterotrimeric G-Protein Gq

Bhansali, P., Dunning, J., Singer, S. E., David, L., & Schmauss, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4632-06.2007 · Cited by 116

Reductions in cholesterol and synaptic markers in association cortex in mood disorders

Beasley, C. L., Honer, W. G., von Bergmann, K., Falkai, P., Lütjohann, D., & Bayer, T. A. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00239.x · Cited by 111

A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression

West, D. V., Del‐Favero, J., Aulchenko, Y. S., Oswald, P., Souery, D., Forsgren, T., Sluijs, S., Belkacem, S., Adolfsson, R., Mendlewicz, J., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001420 · Cited by 110

Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients

Jacobsen, L. K., Staley, J. K., Malison, R. T., Zoghbi, S. S., Seibyl, J. P., Kosten, T. R., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1134 · Cited by 110

Sand rats see the light: Short photoperiod induces a depression-like response in a diurnal rodent

Einat, H., Kronfeld‐Schor, N., & Eilam, D. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.006 · Cited by 108

Combined Treatment With Sertraline and Liothyronine in Major Depression

Cooper‐Kazaz, R., Apter, J. T., Cohen, R., Karagichev, L., Muhammed-Moussa, S., Grupper, D., Drori, T., Newman, M. E., Sackeïm, H. A., Gläser, B., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.6.679 · Cited by 106

Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression

Chen, F., Madsen, T. M., Wegener, G., & Nyengaard, J. R. (2009) · Hippocampus · doi:10.1002/hipo.20718 · Cited by 105

Basic concepts in the study of diseases with complex genetics

Burmeister, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00316-3 · Cited by 102

Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi

Hattori, S., Hashimoto, R., Miyakawa, T., Yamanaka, H., Maeno, H., Wada, K., & Kunugi, H. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.036 · Cited by 101

Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?

Renard, C. E., Fiocco, A. J., Clénet, F., Hascoët, M., & Bourin, M. (2001) · Psychopharmacology · doi:10.1007/s002130100836 · Cited by 100

Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats

Torregrossa, M. M., Jutkiewicz, E. M., Mosberg, H. I., Balboni, G., Watson, S. J., & Woods, J. H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.11.005 · Cited by 98

The Bidirectional Relationship of Depression and Inflammation: Double Trouble

Beurel, E., Toups, M., & Nemeroff, C. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.002 · Cited by 2,136

A Handbook for the Study of Mental Health Second Edition

Scheid, T. L., & Brown, T. N. (2009) · Cited by 1,320

Oxidative Stress and the Central Nervous System

Salim, S. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,268

Circadian rhythm disruption and mental health

Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030

Assessing salivary cortisol in large-scale, epidemiological research

Adam, E. K., & Kumari, M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.011 · Cited by 936

Guest Editorial / Misafir EditoryalDüşünen Adam The Journal of Psychiatry and Neurological Sciences 2014;27:181-185 DOI: 10.5350/DAJPN20142703001

Gonul, A. S., & Aksoy, B. (2015)

The Biology of Affective Disorders

Sachar, E. J., & Baron, M. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.002445 · Cited by 66

Neurodevelopmental and Neurobiological Aspects of Major Depressive Disorder

Rawdin, B., Lindqvist, D., Bush, N. R., Hamilton, S. P., Boparai, R., Mackin, R. S., Reus, V. I., Mellon, S. H., & Wolkowitz, O. M. (2014) · Oxford University Press eBooks · doi:10.1093/med/9780199937806.003.0004 · Cited by 1

Major depressive disorder: a genetic view

Arango, M. R., Díaz, E. S., Peláez, M. C. V., Marín-Cárdenas, J. S., Sánchez, L. M. M., & González, D. G. (2017) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.15332/s1794-9998.2017.0002.11 · Cited by 2

New insights into the neurobiological mechanisms of major depressive disorders

Fakhoury, M. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.01.005 · Cited by 45