Cited by 2,166Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

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Major Depressive Disorder

Belmaker, R.H., Agam, Galila·2008·New England Journal of Medicine

DOI 10.1056/nejmra073096

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Abstract

This review of major depressive disorder is a comprehensive account of the genetic, biochemical, and neurophysiological changes that have been implicated in the disorder. No single mechanism can account for all the clinical variations in this condition. The monoamine oxidase theory can explain many of the actions of antidepressants, but genetic factors, stress, and psychosocial factors also play a part in depression.

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Authors: Belmaker, R. H., & Agam, G.
Affiliations: Ben-Gurion University of the Negev (IL)
ORCID: Belmaker, R.H.
Agam, Galila
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2008-01-03
Volume: 358
Issue: 1
Pages: 55-68
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra073096
OpenAlex: W2129579709
Cited by: 2,166
References: 245
Citations by year: 2026: 74 · 2025: 83 · 2024: 115 · 2023: 91 · 2022: 105 · 2021: 158 · 2020: 128 · 2019: 130 · 2018: 132 · 2017: 129 · 2016: 130 · 2015: 147 · 2014: 123 · 2013: 126 · 2012: 116
FWCI: 12.69
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, depression, genetic factors, biochemical mechanisms, neurophysiology, monoamine oxidase, antidepressants, stress, psychosocial factors
MeSH terms: Animals, Antidepressive Agents, Corticotropin-Releasing Hormone, Depressive Disorder, Major, Major Depressive Disorder, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Norepinephrine, Pituitary-Adrenal System, Serotonin, Stress, Psychological, Biogenic Monoamines

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