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Major Depressive Disorder
Abstract
This review of major depressive disorder is a comprehensive account of the genetic, biochemical, and neurophysiological changes that have been implicated in the disorder. No single mechanism can account for all the clinical variations in this condition. The monoamine oxidase theory can explain many of the actions of antidepressants, but genetic factors, stress, and psychosocial factors also play a part in depression.
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“It is the most widely used pharmacological target for treating depression and anxiety (Belmaker and Agam, 2008; Ravindran and Stein, 2010)”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Belmaker and Agam, 2008
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Metadata
- Authors
- Belmaker, R. H., & Agam, G.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-01-03
- Volume
- 358
- Issue
- 1
- Pages
- 55-68
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2129579709
- Cited by
- 2,166
- References
- 245
- Citations by year
- 2026: 74 · 2025: 83 · 2024: 115 · 2023: 91 · 2022: 105 · 2021: 158 · 2020: 128 · 2019: 130 · 2018: 132 · 2017: 129 · 2016: 130 · 2015: 147 · 2014: 123 · 2013: 126 · 2012: 116
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, depression, genetic factors, biochemical mechanisms, neurophysiology, monoamine oxidase, antidepressants, stress, psychosocial factors
- MeSH terms
- Animals, Antidepressive Agents, Corticotropin-Releasing Hormone, Depressive Disorder, Major, Major Depressive Disorder, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Norepinephrine, Pituitary-Adrenal System, Serotonin, Stress, Psychological, Biogenic Monoamines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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