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The Pathogenesis of Rheumatoid Arthritis
Abstract
The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
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“Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial inflammation that can result in damage to articular cartilage and bone.205”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [205]
In the citing paper
“Development of rheumatoid arthritis occurs largely through a loss of tolerance for proteins that have undergone citrullination (ie, posttranslational modification of a positively charged arginine into a neutral citrulline group).205”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [205]
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1 retracted
Schuerwegh, A. J., Ioan‐Facsinay, A., Dorjée, A. L., Roos, J. A. D. M. D., Bajema, I. M., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913054107 · Cited by 94
RetractedGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Evolving concepts of rheumatoid arthritis
Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,653
Gregersen, P. K., Silver, J., & WINCHESTER, R. J. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780301102 · Cited by 2,633
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,576
Self-citationRantapää‐Dahlqvist, S., Jong, B. A. W. D., Berglin, E. H., Hallmans, G., Wadell, G., Stenlund, H. C., Sundin, U., & VENROOIJ, W. J. V. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,946
Klareskog, L., Stolt, P., Lundberg, K., Källberg, H., Bengtsson, C., Grünewald, J., Rönnelid, J., Harris, H. E., Ulfgren, A., Rantapää‐Dahlqvist, S., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21575 · Cited by 1,516
Research works printed but not linked: 5
- Scher JU, 2010, Arthritis Rheum, 62, 1390
- Szekanecz Z, 2009, Front Biosci (Elite Ed), 1, 44
- Aupperle KR, 1998, Am J Pathol, 152, 1091
- Gravallese EM, 1998, Am J Pathol, 152, 943
- Jacobsson LT, 2005, J Rheumatol, 32, 1213
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Sorted by citations
Items 901–1,000 of 1,011
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Tanaka, S. (2013) · World Journal of Orthopedics · doi:10.5312/wjo.v4.i1.1 · Cited by 56
Kurgan, Ş., Fentoğlu, Ö., Önder, C., Serdar, M. A., Eser, F., Tatakis, D. N., & Günhan, M. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12337 · Cited by 57
MICL controls inflammation in rheumatoid arthritis
Redelinghuys, P., Whitehead, L., Augello, A., Drummond, R. A., Levesque, J.-M., Vautier, S., Reid, D. M., Kerscher, B., Taylor, J. A., Nigrovic, P. A., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206644 · Cited by 57
Self-citationByström, J., Clanchy, F. I. L., Taher, T. E. I., Mangat, P. K., Jawad, A. S., Williams, R. O., & Mageed, R. A. (2016) · Cytokine · doi:10.1016/j.cyto.2016.09.001 · Cited by 58
Wunderlich, C., Oliviera, I., Figueiredo, C. P., Rech, J., & Schett, G. A. (2016) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2016.09.011 · Cited by 57
Self-citationFan, Z., Zhang, Y., Yi-hong, G., Huang, N., Ma, H., Huang, H., & Yu, H. (2016) · Scientific Reports · doi:10.1038/srep35804 · Cited by 56
Cardiovascular risk in patients with rheumatoid arthritis
Lauper, K., & Gabay, C. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0632-2 · Cited by 62
Gao, C., Dong, H., Li, T., & Gao, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00037 · Cited by 57
Li, X., Lu, C. C., Fan, D., Lu, X., Xia, Y., Zhao, H., Xu, H., Zhu, Y., Li, J., Liu, H., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00131 · Cited by 57
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BackgroundImmunometabolic Pathways and Its Therapeutic Implication in Autoimmune Diseases
Wang, T., Jiao, Y., & Zhang, X. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08821-6 · Cited by 61
The Role of Long Non-coding RNAs in the Pathogenesis of RA, SLE, and SS
Gao, Y., Li, S., Zhang, Z., Yu, X., & Zheng, J. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00193 · Cited by 55
Behl, T., Kaur, I., Sehgal, A., Zengin, G., Brisc, C., Brisc, M. C., Munteanu, M. A., Nistor-Cseppento, C. D., & BUNGAU, S. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249505 · Cited by 61
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BackgroundLaw, Y., Lee, W.-F., Hsu, C., Lin, Y., Tsai, C., Huang, C., Wu, M., Tang, C., & Liu, J. (2021) · Aging · doi:10.18632/aging.203201 · Cited by 57
Hanlon, M. M., McGarry, T., Marzaioli, V., Amaechi, S., Song, Q., Nagpal, S., Veale, D. J., & Fearon, U. (2022) · Rheumatology · doi:10.1093/rheumatology/keac640 · Cited by 58
Giangregorio, F., Mosconi, E., Debellis, M. G., Provini, S., Esposito, C., Garolfi, M., Oraka, S., KALOUDI, O., Mustafazade, G., Marín‐Baselga, R., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195880 · Cited by 67
“The association between obesity and cancer is particularly strong, as excess adipose tissue contributes to a pro-inflammatory state that may facilitate cancer progression.”
BackgroundShen, C., Sun, X., Liu, N., MU, Y., HONG, C.-C., Wei, W., & Zheng, F. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2804 · Cited by 55
Kleyer, A., Krieter, M., Oliveira, I., Faustini, F., Simón, D., Kaemmerer, N., Cavalcante, A. R., Tabosa, T. P., Rech, J., Hueber, A. J., et al. (2016) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2016.05.002 · Cited by 56
Self-citationFranchin, M., Colón, D. F., da Cunha, M. G., Castanheira, F. V. S., Saraiva, A. L., Bueno‐Silva, B., de Alencar, S. M., Cunha, T. M., & Rosalen, P. L. (2016) · Scientific Reports · doi:10.1038/srep36401 · Cited by 58
Hu, J., Zhai, C., Hu, J., Zeng, L., Hao, F., Wang, Z., & Fan, W. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.11.031 · Cited by 56
Tang, Q., Cui, J., Tian, Z., Sun, J., Wang, Z., Chang, S., & Zhu, S. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s120902 · Cited by 56
Zhang, L., Zhu, M., Li, M., Du, Y., Duan, S., Huang, Y., Lu, Y., Zhang, J., Wang, T., & Fu, F. (2017) · Oncotarget · doi:10.18632/oncotarget.19526 · Cited by 57
Down‐regulation of miR‐10a‐5p in synoviocytes contributes to TBX5‐controlled joint inflammation
Hussain, N., Zhu, W., Jiang, C., Xu, J., Wu, X., Geng, M., Hussain, S., Cai, Y., Xu, K., Xu, P., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13312 · Cited by 56
Treatment of Chronic Chikungunya Arthritis With Methotrexate: A Systematic Review
Amaral, J. K., Sutaria, R., & Schoen, R. T. (2018) · Arthritis Care & Research · doi:10.1002/acr.23519 · Cited by 55
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Titanji, B. K., Gavegnano, C., Hsue, P. Y., Schinazi, R. F., & Marconi, V. C. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014873 · Cited by 56
Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
Sehnert, B., Burkhardt, H., Dübel, S., & Voll, R. E. (2020) · Cells · doi:10.3390/cells9071627 · Cited by 57
“driven T helper (TH)17 differentiation followed by IL-17 production aggravates disease progression and induces chronic destructive arthritis [32,45,53,54].”
BackgroundDonate, P. B., de Lima, K. A., Peres, R. S., Almeida, F. B. D. R., Fukada, S. Y., Silva, T. A., Nascimento, D. C., Cecílio, N. T., Talbot, J., de Oliveira, R. D. R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017120118 · Cited by 59
Li, G., Qin, Y., & Du, P.-Q. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.06.019 · Cited by 56
Bözec, A., Luo, Y., Engdahl, C., Figueiredo, C. P., Bang, H., & Schett, G. A. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1527-x · Cited by 55
Self-citationInflammation beyond the Joints: Rheumatoid Arthritis and Cardiovascular Disease.
Urman, A. R., Taklalsingh, N., Sorrento, C., & McFarlane, I. M. (2018) · Europe PMC (PubMed Central) · Cited by 55
Pollastro, S., Klarenbeek, P. L., Doorenspleet, M. E., van Schaik, B. D. C., Esveldt, R. E., Thurlings, R. M., Boumans, M. J. H., Gerlag, D. M., Tak, P. P., Vos, K., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-214898 · Cited by 55
A20: a master regulator of arthritis
Wu, Y., He, X., Huang, N., Yu, J., & Shao, B. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02281-1 · Cited by 56
Roles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer
Han, C., Wang, Z., Xu, Y., Chen, S., Han, Y., Li, L., Wang, M., & Xun-bo, J. (2020) · BioMed Research International · doi:10.1155/2020/1269624 · Cited by 57
“Mitochondrial electron transport chain (ETC) composed of complex I, III, and IV induces oxidative phosphorylation (OXPHOS) to produce ATP with a by-product ROS generation due to inevitable electron leakage to O2, which is identified as the major endogenous source of ROS [18].”
BackgroundKim, B., Kim, H. Y., Yoon, B. R., Yeo, J., Jung, J. I., Yu, K., Kim, H. C., Yoo, S., Park, J. K., Kang, S. W., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abi7400 · Cited by 57
Vij, R., Stebbings, K. A., Kim, H., Park, H., & Chang, D. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02763-w · Cited by 55
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Benne, N., ter Braake, D., Stoppelenburg, A. J., & Broere, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864403 · Cited by 57
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de Freitas, F. A., Levy, D., Reichert, C. O., Cunha‐Neto, E., Kalil, J. E., & Bydlowski, S. P. (2022) · Cells · doi:10.3390/cells11081251 · Cited by 58
Deng, C., Zhao, X., Chen, Y., Ai, K., Zhang, Y., Gong, T., Zeng, C., & Lei, G. (2022) · ACS Nano · doi:10.1021/acsnano.2c06584 · Cited by 55
Glycolysis, a driving force of rheumatoid arthritis
Gan, P., Wu, H., Zhu, Y., Shu, Y., & Wei, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111913 · Cited by 57
SDF-1 signaling: a promising target in rheumatic diseases
Villalvilla, A., Gómez, R., Roman‐Blas, J. A., Largo, R., & Herrero‐Beaumont, G. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.930440 · Cited by 55
Li, G., Diogo, D., Wu, D., Spoonamore, J., Dančík, V., Franke, L., Kurreeman, F. A. S., Rossin, E. J., Duclos, G. E., Hartland, C. L., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003487 · Cited by 56
CTLA-4 blockade in the treatment of rheumatoid arthritis: an update
Cutolo, M., Sulli, A., Paolino, S., & Pizzorni, C. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2016.1133295 · Cited by 55
Sultana, F., Neog, M. K., & Rasool, M. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.03.009 · Cited by 55
Yokota, K., Wada, T. T., Akiyama, Y., & Mimura, T. (2017) · Modern Rheumatology · doi:10.1080/14397595.2017.1337288 · Cited by 55
Buhrmann, C., Popper, B., Aggarwal, B. B., & Shakibaei, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186993 · Cited by 55
Nikfar, S., Saiyarsarai, P., Tigabu, B. M., & Abdollahi, M. R. (2018) · Rheumatology International · doi:10.1007/s00296-018-4041-1 · Cited by 55
Park, J. K., Jang, Y. J., Oh, B. R., Shin, J., Bae, D., Ha, N., Choi, Y. I., Youn, G. S., Park, J., Lee, E. Y., et al. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02258-0 · Cited by 56
Autoimmunity in Rheumatoid Arthritis
Klareskog, L., Lundberg, K., & Malmström, V. (2013) · Advances in immunology · doi:10.1016/b978-0-12-407708-9.00003-0 · Cited by 56
Recent insights into the role of autophagy in the pathogenesis of rheumatoid arthritis
Dai, Y., & Hu, S. (2015) · Rheumatology · doi:10.1093/rheumatology/kev337 · Cited by 55
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Zhang, W., Chen, Y., Liu, Q., Zhou, M. L., Wang, K., Wang, Y., Nie, J., Gui, S., Peng, D., He, Z., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.04.001 · Cited by 54
NF-κB Signaling Pathway in Rheumatoid Arthritis: Mechanisms and Therapeutic Potential
Liao, H.-Y., Zheng, J., Lu, J., & Shen, H. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04634-2 · Cited by 59
Adaptive immunity in rheumatoid arthritis
Klareskog, L., Amara, K., & Malmström, V. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000016 · Cited by 54
Kremer, J. M., Kivitz, A., Campos, J. A. S., Nasonov, E. L., Tony, H., Lee, S.-K., Vlahos, B. L., Hammond, C., Bukowski, J. F., Li, H., et al. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0612-7 · Cited by 55
Arnold, M., Bykerk, V. P., Boire, G., Haraoui, B. P., Hitchon, C. A., Thorne, C., Keystone, E. C., Pope, J. E., & on behalf of CATCH Investigators (2014) · Lara D. Veeken · doi:10.1093/rheumatology/ket449 · Cited by 54
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Hanke, T., Merk, D., Steinhilber, D., Geißlinger, G., & Schubert‐Zsilavecz, M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.011 · Cited by 54
Gan, K., Yang, L., Xu, L., Feng, X., Zhang, Q., Wang, F., Tan, W., & Zhang, M. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.03.038 · Cited by 56
He, P., Zhang, Z., Liao, W., Xu, D., Fu, M., & Kang, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5423 · Cited by 54
Arthritic role of Porphyromonas gingivalis in collagen-induced arthritis mice
Jung, H., Jung, S. M., Rim, Y. A., Park, N., Nam, Y., Lee, J. J., Park, S., & Ju, J. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188698 · Cited by 54
Liang, J., Chang, B., Huang, M., Huang, W., Ma, W., Liu, Y., Tai, W., Long, Y., & Lu, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.12.006 · Cited by 54
Cai, P., Jiang, T., Li, B., Qin, X., Lu, Z., Le, Y., Shen, C., Yang, Y., Zheng, L. X., & Zhao, J. (2018) · Cell Biochemistry and Function · doi:10.1002/cbf.3370 · Cited by 56
Mucosa–Environment Interactions in the Pathogenesis of Rheumatoid Arthritis
Lucchino, B., Spinelli, F. R., Iannuccelli, C., Guzzo, M. P., Conti, F., & Franco, M. D. (2019) · Cells · doi:10.3390/cells8070700 · Cited by 56
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BackgroundBurbano, C., Villar-Vesga, J., Vásquez, G. M., Muñoz‐Vahos, C. H., Rojas, M., & Castaño, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02058 · Cited by 54
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Zhang, L., Song, P., Zhang, X., Metea, C., Schleisman, M., Karstens, L., Leung, E. T., Zhang, J., Xu, Q., Liu, Y., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01684 · Cited by 51
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BackgroundApplications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents
Ng, P. Q., Soon, L., Chellian, J., Madheswaran, T., Panneerselvam, J., Kunnath, A. P., Gupta, G., Satija, S., Mehta, M., Hansbro, P. M., et al. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200610111013 · Cited by 54
Guagnano, M. T., D’Angelo, C., Caniglia, D., Giovanni, P. D., Celletti, E., Sabatini, E., Speranza, L., Bucci, M., Cipollone, F., & Paganelli, R. (2021) · Nutrients · doi:10.3390/nu13103535 · Cited by 54
Sun, X., Feng, X., Tan, W., Lin, N., Hua, M., Wei, Y., Wang, F., Li, N., & Zhang, M. (2015) · Scientific Reports · doi:10.1038/srep11296 · Cited by 54
Interleukin-35: a Potential Therapeutic Agent for Autoimmune Diseases
Guan, S., Leng, R., Khan, M. I., Qureshi, H., Li, X.-P., Ye, D., & Pan, H. (2016) · Inflammation · doi:10.1007/s10753-016-0453-9 · Cited by 51
Peng, W., Shen, H., Lin, B., Han, P., Li, C., Zhang, Q., Ye, B., Rahman, K., Xin, H., Qin, L., et al. (2018) · Medicinal Chemistry Research · doi:10.1007/s00044-018-2215-8 · Cited by 53
Kwon, E.-J., & Ju, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910576 · Cited by 59
Wan, R., Fan, Y., Zhao, A., Xing, Y., Huang, X., Zhou, L., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.829409 · Cited by 57
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BackgroundAndreev, D., Kachler, K., Schett, G. A., & Bözec, A. (2022) · Bone · doi:10.1016/j.bone.2022.116468 · Cited by 57
Self-citationCheng, F., Su, T., Liu, Y., Zhou, S., Qi, J., Guo, W., & Zhu, G. (2023) · Advanced Science · doi:10.1002/advs.202302575 · Cited by 53
Mesenchymal Stem Cells‐Involved Strategies for Rheumatoid Arthritis Therapy
Li, C., Sun, Y., Xu, W., Chang, F., Wang, Y., & Ding, J. (2024) · Advanced Science · doi:10.1002/advs.202305116 · Cited by 53
Autoimmunity's next top models
Wekerle, H., Flügel, A., Fugger, L. H., Schett, G. A., & SERREZE, D. V. (2012) · Nature Medicine · doi:10.1038/nm.2635 · Cited by 53
Self-citationNext stage of RA treatment: is TNF inhibitor-free remission a possible treatment goal?
Tanaka, Y. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202350 · Cited by 53
Aryl hydrocarbon receptor antagonism and its role in rheumatoid arthritis
Kishimoto, T., Nguyen, N., Nakahama, T., Nguyen, H. C., Tran, T. T., Le, V. S., & Hà, C. H. (2015) · Journal of Experimental Pharmacology · doi:10.2147/jep.s63549 · Cited by 57
Biologics for the treatment of autoimmune renal diseases
Holdsworth, S. R., Gan, P., & Kitching, A. R. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.18 · Cited by 53
Microbiota and chronic inflammatory arthritis: an interwoven link
Diamanti, A. P., Rosado, M. M., Laganà, B., & D’Amelio, R. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0989-3 · Cited by 54
Anti cytokine therapy in chronic inflammatory arthritis
Thompson, C., Davies, R., & Choy, E. (2016) · Cytokine · doi:10.1016/j.cyto.2016.07.015 · Cited by 54
Sun, H., Gao, W., Pan, W., Zhang, Q., Wang, G., Feng, D., Geng, X., Yan, X., & Li, S. (2017) · Inflammation · doi:10.1007/s10753-017-0577-6 · Cited by 55
LTB 4 and BLT1 in inflammatory arthritis
Miyabe, Y., Miyabe, C., & Luster, A. D. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.009 · Cited by 53
Barroso, L. C., Magalhães, G. S., Galvão, I., Reis, A. C., Souza, D. G., Sousa, L. P., Santos, R. A. S., Campagnole‐Santos, M. J., Pinho, V., & Teixeira, M. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01596 · Cited by 53
Hasan, H. A., Ismail, H. F., El-Orfali, Y., & Khawaja, G. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2408-1 · Cited by 53
“Many cell types such as macrophages, lymphocytes, synovial cells and neutrophils aggregate into the articular cavity, releasing mediators and inflammatory cytokines [37, 38].”
BackgroundCould Polyphenols Help in the Control of Rheumatoid Arthritis?
Sung, S., Kwon, D., Um, E.-S., & Kim, B. (2019) · Molecules · doi:10.3390/molecules24081589 · Cited by 53
“On the basis of micro-environmental changes, severe synovial systematical reorganization and local fibroblast activation trigger synovial inflammation occur in RA [5].”
BackgroundPlant cell-made protein antigens for induction of Oral tolerance
Daniell, H., Kulis, M. D., & Herzog, R. W. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.06.012 · Cited by 53
“Inflammation may also spread more systemically, affecting cardiovascular, pulmonary, psychological, and skeletal functions (McInnes and Schett, 2011).”
BackgroundWang, X., Yamauchi, K., & Mitsunaga, T. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104482 · Cited by 54
Synthesis and biological activities of drugs for the treatment of osteoporosis
Zhou, S., Huang, G., & Chen, G. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112313 · Cited by 53
Intestinal Microbes in Autoimmune and Inflammatory Disease
Wu, W.-J. H., Zegarra-Ruiz, D. F., & Diehl, G. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.597966 · Cited by 54
“org 3 responses against self-proteins with a citrulline residue leading to cartilage degradation and bone erosion (92).”
BackgroundFujiwara, S., & Nakamura, H. (2020) · Pathogens · doi:10.3390/pathogens9020116 · Cited by 52
“RA is a systemic autoimmune disease with multi‐articular erosive arthritis characterized by synovial proliferation and bone destruction [90].”
BackgroundKvacskay, P., Yao, N., Schnotz, J.-H., Scarpone, R., Carvalho, R. A., Klika, K. D., Merkt, W., Tretter, T., Lorenz, H., & Tykocinski, L. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02437-7 · Cited by 53
B cell-activating factor and its targeted therapy in autoimmune diseases
Zhang, Y., Tian, J., Xiao, F., Zheng, L., Zhu, X., Wu, L., Zhao, C., Wang, S., Rui, K., Zou, H., et al. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.11.004 · Cited by 52
Eriksson, K., Lundmark, A., Delgado, L. F., Hu, Y. O. O., Fei, G., Lee, L., Fei, C., Catrina, A. I., Jansson, L. E., Andersson, A. F., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.841139 · Cited by 53
Hardt, U., Carlberg, K., af Klint, E., Sahlström, P., Larsson, L., van Vollenhoven, A., Machado, S. H., Israelsson, L., Amara, K., Chemin, K., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-15293-5 · Cited by 50
Rheumatoid arthritis and mitochondrial homeostasis: The crossroads of metabolism and immunity
Liu, C., Jing, W., Su, C.-H., Liu, L., Xinghua, Z., Yuan, B., Xiaozheng, D., & Wang, H. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1017650 · Cited by 55
“Innate immune cells, such as T cells, macrophages, and dendritic cells (DCs), play an important role in mediating the immune inflammatory response in RA (72).”
BackgroundLi, C., Yu, R., & Ding, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1026457 · Cited by 55
“RANK-L was the main regulator of osteoclastogenesis (McInnes and Schett, 2007; McInnes and Schett, 2011).”
BackgroundTao, S., Yu, H., You, T., Kong, X., Wei, X., Zheng, Z., Zheng, L., Feng, Z., Huang, B. H., Zhang, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03828 · Cited by 55
Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats
Wahba, M. G. F., Messiha, B. A. S., & Abo‐Saif, A. A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.026 · Cited by 52
The effects of high intensity interval training in women with rheumatic disease: a pilot study
Sandstad, J., Stensvold, D., Hoff, M., Nes, B., Arbo, I., & Bye, A. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3186-9 · Cited by 50
ACPA and Bone Loss in Rheumatoid Arthritis
Kocijan, R., Steffen, U., & Schett, G. A. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0366-7 · Cited by 52
Self-citationGalectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts
Arad, U., Madar-Balakirski, N., Angel-Korman, A., Amir, S., Tzadok, S., Segal, O., Menachem, A., Gold, A., Elkayam, O., & Caspi, D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.016 · Cited by 53
Ramadan, G., El‐Beih, N. M., Talaat, R. M., & Abdelghffar, E. A. R. (2015) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12666 · Cited by 52
Metadata
- Authors
- McInnes, I. B., & Schett, G.
- Affiliations
- University of Glasgow (GB)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-12-08
- Volume
- 365
- Issue
- 23
- Pages
- 2205-2219
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2110826367
- Cited by
- 5,514
- References
- 100
- Citations by year
- 2026: 313 · 2025: 415 · 2024: 439 · 2023: 443 · 2022: 469 · 2021: 493 · 2020: 465 · 2019: 409 · 2018: 399 · 2017: 394 · 2016: 379 · 2015: 300 · 2014: 276 · 2013: 204 · 2012: 111
- FWCI
- 27.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- rheumatoid arthritis, pathogenesis, immune mechanisms, disease-modifying antirheumatic drugs, mortality reduction
- MeSH terms
- Arthritis, Rheumatoid, Humans, Antirheumatic Agents, Gene-Environment Interaction
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