Cited by 5,514Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders ResearchNatural Compounds in Disease Treatment

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

The Pathogenesis of Rheumatoid Arthritis

McInnes, Iain B., Schett, Georg·2011·New England Journal of Medicine

DOI 10.1056/nejmra1004965

Open this paper in CoChat — free account

Abstract

The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.

Integrity signals

Registry

Crossref · 10.1056/nejmra1004965

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis
Schuerwegh, A. J., Ioan‐Facsinay, A., Dorjée, A. L., Roos, J. A. D. M. D., Bajema, I. M., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913054107 · Cited by 94
Retracted
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Evolving concepts of rheumatoid arthritis
Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,653
The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
Gregersen, P. K., Silver, J., & WINCHESTER, R. J. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780301102 · Cited by 2,633
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,576
Self-citation
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
Rantapää‐Dahlqvist, S., Jong, B. A. W. D., Berglin, E. H., Hallmans, G., Wadell, G., Stenlund, H. C., Sundin, U., & VENROOIJ, W. J. V. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,946
A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination
Klareskog, L., Stolt, P., Lundberg, K., Källberg, H., Bengtsson, C., Grünewald, J., Rönnelid, J., Harris, H. E., Ulfgren, A., Rantapää‐Dahlqvist, S., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21575 · Cited by 1,516

Show all 100 references

Research works printed but not linked: 5

Scher JU, 2010, Arthritis Rheum, 62, 1390
Szekanecz Z, 2009, Front Biosci (Elite Ed), 1, 44
Aupperle KR, 1998, Am J Pathol, 152, 1091
Gravallese EM, 1998, Am J Pathol, 152, 943
Jacobsson LT, 2005, J Rheumatol, 32, 1213

Sorted by citations

Items 101–200 of 1,011

The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review
Docherty, S., Harley, R., McAuley, J. J., Crowe, L. A. N., Pedret, C., Kirwan, P., Siebert, S., & Millar, N. L. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00397-2 · Cited by 344
T cell migration in rheumatoid arthritis
Mellado, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00384 · Cited by 300
NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
Guo, C., Fu, R., Wang, S., Huang, Y., Li, X., Zhou, M., Zhao, J., & Yang, N. (2018) · Clinical and Experimental Immunology · doi:10.1111/cei.13167 · Cited by 265
Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells
Rauber, S., Luber, M., Weber, S., Maul, L., Soare, A., Wohlfahrt, T., Lin, N., Dietel, K., Bözec, A., i, M. H., et al. (2017) · Nature Medicine · doi:10.1038/nm.4373 · Cited by 288
Self-citation
Selective JAKinibs: Prospects in Inflammatory and Autoimmune Diseases
Virtanen, A. T., Haikarainen, T., Raivola, J., & Silvennoinen, O. (2019) · BioDrugs · doi:10.1007/s40259-019-00333-w · Cited by 284
“Cytokines including tumor necrosis factor (TNF) alpha, interleukin (IL)-1, IL-6, IL-7, IL-15, IL-17, IL-18, IL-21, IL-23, IL-32, IL-33, and granulocyte-macrophage colony-stimulating factor (GM-CSF) have important roles in pathogenesis of RA [14].”
Background
Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations
McInnes, I. B., Byers, N. L., Higgs, R. E., Lee, J. W. J., Macias, W. L., Na, S., Ortmann, R., Rocha, G., Rooney, T. P., Wehrman, T. S., et al. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1964-1 · Cited by 283
Self-citation
Th17 Cells in Immunity and Autoimmunity
Bedoya, S. K., Lam, B. K., Lau, K., & Larkin, J. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/986789 · Cited by 293
Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy
Alam, J., Jantan, I., & Bukhari, S. N. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.055 · Cited by 286
Interleukin-6 in Rheumatoid Arthritis
Pandolfi, F., Franza, L., Carusi, V., Altamura, S., Andriollo, G., & Nucera, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155238 · Cited by 290
“development of RA can be roughly distinguished into environmental and genetic, with the former influencing the second Overall, it is widely accepted that RA occurs in genetically predisposed individuals following the interaction with different environmental factors [19,20].”
Background
The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans
Dowty, M. E., Lin, J., Ryder, T. F., Wang, W., Walker, G. S., Vaz, A. D. N., Chan, G. L., Krishnaswami, S., & Prakash, C. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.054940 · Cited by 279
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models
Wu, J., Feng, Z., Chen, L., Li, Y., Bian, H., Geng, J., Zheng, Z., Fu, X., Pei, Z., Qin, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27948-4 · Cited by 285
B Cells in Rheumatoid Arthritis：Pathogenic Mechanisms and Treatment Prospects
Wu, F., Gao, J., Kang, J., Wang, X., Niu, Q., Liu, J., & Zhang, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.750753 · Cited by 277
“TNF-a can increase the expression of RANKL by B cells in the presence of IL-1b, thereby promoting the formation of osteoclasts (69).”
Background
Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases
Wang, P., Gong, Q., Hu, J., Li, X., & Zhang, X. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01704 · Cited by 279
Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment
Wu, D., Luo, Y., Li, T., Zhao, X., Lv, T., Fang, G., Ou, P., Li, H., Luo, X., Huang, A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1051082 · Cited by 295
“These factors all have a deleterious effect on bone (132).”
Background
Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders
Ahmad, S. B., Ali, A., Bilal, M., Rashid, S. M., Wani, A. B., Bhat, R. R., & Rehman, M. U. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01324-w · Cited by 290
Autophagy regulates TNFα-mediated joint destruction in experimental arthritis
Lin, N., Beyer, C., Gießl, A., Kireva, T., Scholtysek, C., Uderhardt, S., Munoz, L. E., Dees, C., Distler, A., Wirtz, S. J., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201671 · Cited by 268
Self-citation
Current knowledge on psoriasis and autoimmune diseases
McCormick, T. S., Ayala‐Fontanez, N., & Soler, D. C. (2016) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s64950 · Cited by 279
IgA subclasses have different effector functions associated with distinct glycosylation profiles
Steffen, U., Koeleman, C. A. M., Sokolova, M. V., Bang, H., Kleyer, A., Rech, J., Unterweger, H., Schicht, M., Garreis, F., Hahn, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13992-8 · Cited by 257
Self-citation
The Anti-Inflammatory Actions and Mechanisms of Acupuncture from Acupoint to Target Organs via Neuro-Immune Regulation
Li, N., Guo, Y., Gong, Y., Zhang, Y., Fan, W., Yao, K., Chen, Z., Dou, B., Lin, X., Chen, B., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s341581 · Cited by 284
Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome
Li, H., Guan, Y., Liang, B., Ding, P., Hou, X., Wei, W., & Ma, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175091 · Cited by 258
Neutrophil diversity and function in health and disease
Zhang, F., Xia, Y., Su, J., Quan, F., Zhou, H., Li, Q., Feng, Q., Lin, C., Wang, D., & Jiang, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02049-y · Cited by 306
Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions
de Molon, R. S., Rossa, C., Thurlings, R. M., Cirelli, J. A., & Koenders, M. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184541 · Cited by 274
Ectopic lymphoid neogenesis in rheumatic autoimmune diseases
Bombardieri, M., Lewis, M., & Pitzalis, C. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.217 · Cited by 248
HBEGF + macrophages in rheumatoid arthritis induce fibroblast invasiveness
Kuo, D. C., Ding, J., Cohn, I. S., Zhang, F., Wei, K., Rao, D. A., Rozo, C. T., Sokhi, U. K., Shanaj, S., Oliver, D. J., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau8587 · Cited by 251
IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation
Zhang, F., Mears, J., Shakib, L., Beynor, J. I., Shanaj, S., Korsunsky, I., Nathan, A., Donlin, L. T., & Raychaudhuri, S. (2021) · Genome Medicine · doi:10.1186/s13073-021-00881-3 · Cited by 251
Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients with Active Rheumatoid Arthritis: Safety and Efficacy
Wang, L., Wang, L., Cong, X., Liu, G., Zhou, J., Bai, B., Li, Y., Bai, W., Li, M., Ji, H., et al. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0023 · Cited by 251
Head‐to‐head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: Findings of a phase IIIb, multinational, prospective, randomized study
Weinblatt, M. E., Schiff, M. H., Valente, R. M., van der Heijde, D. M. F. M., Citera, G., Zhao, C. Y., Maldonado, M. A., & Fleischmann, R. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37711 · Cited by 250
Fibroblast pathology in inflammatory diseases
Wei, K., Nguyen, H. N., & Brenner, M. B. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149538 · Cited by 249
Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets
Liu, W., Zhang, Y., Zhu, W., Ma, C., Ruan, J., Long, H., & Wang, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02228 · Cited by 253
The many facets of macrophages in rheumatoid arthritis
Siouti, E., & Andreakos, E. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.03.029 · Cited by 255
Function and Role of Regulatory T Cells in Rheumatoid Arthritis
Jiang, Q., Yang, G., Liu, Q., Wang, S., & Cui, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626193 · Cited by 254
“Innate immune cells, including mast cells, dendritic cells (DCs), innate lymphocytes and adaptive immune cells, such as B cells, plasma cells, follicular regulatory T (TFR) cells and helper T (Th) cells mediate the systemic autoimmune inflammatory response (11).”
Background
Smoke and autoimmunity: The fire behind the disease
Perricone, C., Versini, M., Ben-Ami, D., Gertel, S., Watad, ‬., Segel, M., Ceccarelli, F., Conti, F., Cantarini, L., Bogdanos, D. P., et al. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.01.001 · Cited by 248
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
Friščić, J., Böttcher, M., Reinwald, C., Bruns, H., Wirth, B., Popp, S.-J., Walker, K., Ackermann, J. A., Chen, X., Turner, J. D., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.03.003 · Cited by 257
Self-citation
Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts
Zheng, Y., Wei, K., Jiang, P., Zhao, J., Shan, Y., Shi, Y., Zhao, F., Chang, C., Li, Y., Zhou, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1394108 · Cited by 260
Rheumatoid Factor as a Potentiator of Anti–Citrullinated Protein Antibody–Mediated Inflammation in Rheumatoid Arthritis
Sokolove, J. B., Johnson, D. S., Lahey, L. J., Wagner, C. A., Cheng, D., Thiele, G. M., Michaud, K. D., Sayles, H. R., Reimold, A. M., Caplan, L., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38307 · Cited by 239
Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: A Synopsis.
Gibofsky, A. (2014) · PubMed · Cited by 239
Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints
Pianta, A., Arvikar, S. L., Strle, K., Drouin, E. E., Wang, Q., Costello, C. E., & Steere, A. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93450 · Cited by 239
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES
Baru, P. C. R. (2014) · ADVANCED SCIENCES INDEX · Cited by 236
Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis
Fuggle, N. R., Smith, T. O., Kaul, A., & Sofat, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00080 · Cited by 234
Systemic IL-15, IFN-γ and IP-10/CXCL10 Signature Associated With Effective Immune Response in BNT162b2 mRNA Vaccine Recipients
Bergamaschi, C., Terpos, E., Rosati, M., Angel, M., Bear, J., Stellas, D., Karaliota, S., Apostolakou, F., Bagratuni, T., Patseas, D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109504 · Cited by 236
“Additionally, in autoimmune conditions such as rheumatoid arthritis, localized inflammatory responses are characterized by the concerted release of both IL-15 and IL-6 that are maintained by positive feedback loops and result in systemic disorders (McInnes and Schett, 2011).”
Epstein-Barr Virus in Systemic Autoimmune Diseases
Draborg, A., Duus, K., & Houen, G. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/535738 · Cited by 220
VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases
Shoshan‐Barmatz, V., Shteinfer‐Kuzmine, A., & Verma, A. (2020) · Biomolecules · doi:10.3390/biom10111485 · Cited by 246
“Systemic inﬂammation mediated by cytokines is central to the pathogenesis of RA [336].”
Background
Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis
He, J., Chu, Y., Li, J., Meng, Q., Liu, Y., Jin, J., Wang, Y., Wang, J., Huang, B., Shi, L., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm1511 · Cited by 237
The Interplay Between Monocytes/Macrophages and CD4+ T Cell Subsets in Rheumatoid Arthritis
Roberts, C. A., Dickinson, A. K., & Taams, L. S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00571 · Cited by 238
Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity
Brusca, S. B., Abramson, S. B., & Scher, J. U. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000008 · Cited by 231
Neutrophils in Rheumatoid Arthritis: Breaking Immune Tolerance and Fueling Disease
O’Neil, L. J., & Kaplan, M. J. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.008 · Cited by 237
New learnings on the pathophysiology of RA from synovial biopsies
Pitzalis, C., Kelly, S., & Humby, F. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32835fd8eb · Cited by 224
Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities
Zhao, T., Wei, Y., Zhu, Y., Xie, Z., Hai, Q., Li, Z., & Qin, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1007165 · Cited by 243
“RA affects ~1% of the population worldwide (2), and its pathogenesis may be linked to genetic and environmental factors (3, 4).”
Background
Association Between the Initiation of Anti–Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster
Winthrop, K. L., Baddley, J. W., Chen, L., Liu, L., Grijalva, C. G., Delzell, E., Beukelman, T., Patkar, N. M., Xie, F., Saag, K. G., et al. (2013) · JAMA · doi:10.1001/jama.2013.1099 · Cited by 222
Role of the Gut Microbiome in Modulating Arthritis Progression in Mice
Liu, X., Zeng, B., Zhang, J., Li, W., Mou, F., Wang, H., Zou, Q., Zhong, B., Wu, L., Wei, H., et al. (2016) · Scientific Reports · doi:10.1038/srep30594 · Cited by 252
The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives
Huwiler, A., & Zangemeister‐Wittke, U. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.11.001 · Cited by 227
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission
Tasaki, S., Suzuki, K., Kassai, Y., Takeshita, M., Murota, A., Kondo, Y., Ando, T., Nakayama, Y., Okuzono, Y., Takiguchi, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05044-4 · Cited by 222
The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases
Kobayashi, N., Takahashi, D., Takano, S., Kimura, S., & Hase, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02345 · Cited by 244
An updated advance of autoantibodies in autoimmune diseases
Xiao, Z. X., Miller, J. S., & Zheng, S. G. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102743 · Cited by 229
Hyaluronate–Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis
Lee, H., Lee, M.-Y., Bhang, S. H., Kim, B., Kim, Y. S., Ju, J. H., Kim, K. S., & Hahn, S. K. (2014) · ACS Nano · doi:10.1021/nn500685h · Cited by 218
Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis
Shi, J., van de Stadt, L. A., Levarht, E. W. N., Huizinga, T. W. J., Hamann, D., van Schaardenburg, D., Toes, R. E. M., & Trouw, L. A. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204154 · Cited by 218
The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis
Mercan, R., Bıtık, B., Tufan, A., Bozbulut, U. B., Ataş, N., Öztürk, M. A., Haznedaroğlu, Ş., & Göker, B. (2015) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21908 · Cited by 218
The role and therapeutic targeting of IL-6 in rheumatoid arthritis
Narazaki, M., Tanaka, T., & Kishimoto, T. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1295850 · Cited by 224
Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation
Liang, H., Peng, B., Dong, C., Liu, L., Mao, J., Wei, S., Wang, X., Xu, H., Shen, J., Mao, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06603-5 · Cited by 218
Citrulline‐Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy
James, E. A., Rieck, M., Pieper, J., Gebe, J. A., Yue, B. B., Tatum, M., Peda, M., Sandin, C., Klareskog, L., Malmström, V., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38637 · Cited by 215
The Jak/STAT pathway: A focus on pain in rheumatoid arthritis
Simon, L. S., Taylor, P. C., Choy, E., Sebba, A. I., Quebe, A. K., Knopp, K. L., & Porreca, F. (2020) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.10.008 · Cited by 222
“In contrast, approved biologics indicated for RA target IL-6 receptors directly [35,68].”
Background
Multifunctional compounds: Smart molecules for multifactorial diseases
Bansal, Y., & Silakari, O. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.01.060 · Cited by 215
JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future
Angelini, J., Talotta, R., Roncato, R., Fornasier, G., Barbiero, G., Cin, L. D., Brancati, S. B., & Scaglione, F. (2020) · Biomolecules · doi:10.3390/biom10071002 · Cited by 224
“Persistent inflammation results in profound changes of the joint anatomy and physiology, progressing from synovial hyperplasia and endothelial cell activation in the early phase to cartilage destruction and bone erosion in the late phase [23].”
Background
Decreased expression of micro RNA ‐21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis
Dong, L., Wang, X., Tan, J., Li, H., Qian, W., Chen, J., Chen, Q., Wang, J., Xu, W., Tao, C., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12353 · Cited by 217
Interleukin-12: Functional activities and implications for disease
Zundler, S., & Neurath, M. F. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.003 · Cited by 225
Implications of Angiogenesis Involvement in Arthritis
MacDonald, I. J., Liu, S., Su, C., Wang, Y., Tsai, C., & Tang, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072012 · Cited by 211
“Moreover, few treated RA patients achieve sustained remission, so require ongoing pharmacologic therapy [1].”
Background
B cell epitope spreading: Mechanisms and contribution to autoimmune diseases
Cornaby, C., Gibbons, L., Todd, V. M., Sloan, C. S., Welling, A., & Poole, B. D. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.11.001 · Cited by 208
Targeting monocytes/macrophages in the treatment of rheumatoid arthritis
Davignon, J.-L., Hayder, M., Baron, M., Boyer, J.-F., Constantin, A., Apparailly, F., Poupot, R., & Cantagrel, A. (2013) · Rheumatology · doi:10.1093/rheumatology/kes304 · Cited by 209
The lung microbiota in early rheumatoid arthritis and autoimmunity
Scher, J. U., Joshua, V., Artacho, A., Abdollahi‐Roodsaz, S., Öckinger, J., Kullberg, S., Sköld, M. C., Eklúnd, A., Grünewald, J., Clemente, J. C., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0206-x · Cited by 214
Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF
Kang, K., Park, S. H., Chen, J., Qiao, Y., Giannopoulou, E., Berg, K., Hanidu, A., Li, J., Nabozny, G., Kang, K., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.017 · Cited by 196
Interleukin 6 and Rheumatoid Arthritis
Yoshida, Y., & Tanaka, T. (2014) · BioMed Research International · doi:10.1155/2014/698313 · Cited by 214
Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS
Giera, M. A., Ioan‐Facsinay, A., Toes, R. E. M., Gao, F., Dalli, J., Deelder, A. M., Serhan, C. N., & Mayboroda, O. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.011 · Cited by 210
Does the microbiota play a role in the pathogenesis of autoimmune diseases?
McLean, M. H., Dieguez, D., Miller, L. M., & Young, H. A. (2014) · Gut · doi:10.1136/gutjnl-2014-308514 · Cited by 214
The interplay between inflammation and metabolism in rheumatoid arthritis
Chimenti, M. S., Triggianese, P., Conigliaro, P., Candi, E., Melino, G., & Perricone, R. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.246 · Cited by 220
Genetics of rheumatoid arthritis
Padyukov, L. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00912-0 · Cited by 219
Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis
Son, H.-J., Lee, J., Lee, S.-Y., Kim, E.-K., Park, M.-J., Kim, K.-W., Park, S.-H., & Cho, M.-L. (2014) · Mediators of Inflammation · doi:10.1155/2014/973986 · Cited by 206
Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets
Furst, D. E., & Emery, P. (2014) · Rheumatology · doi:10.1093/rheumatology/ket414 · Cited by 207
Efficacy and Safety of ABT‐494, a Selective JAK‐1 Inhibitor, in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Genovese, M. C., Smolen, J. S., Weinblatt, M. E., Burmester, G. R., Meerwein, S., Camp, H. S., Wang, L., Othman, A. A., Khan, N., Pangan, A. L., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39808 · Cited by 204
Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis
Gioxari, A., Kaliora, A. C., Marantidou, F., & Panagiotakos, D. P. (2017) · Nutrition · doi:10.1016/j.nut.2017.06.023 · Cited by 203
Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study
Haschka, J., Englbrecht, M., Hueber, A. J., Manger, B., Kleyer, A., Reiser, M., Finzel, S., Tony, H.-P., Kleinert, S., Feuchtenberger, M., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206439 · Cited by 202
Self-citation
Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells
Takahashi, D., Hoshina, N., Kabumoto, Y., Maeda, Y., Suzuki, A., Tanabe, H., Isobe, J., Yamada, T., Muroi, K., Yanagisawa, Y., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102913 · Cited by 205
Abatacept: A Review in Rheumatoid Arthritis
Blair, H. A., & Deeks, E. D. (2017) · Drugs · doi:10.1007/s40265-017-0775-4 · Cited by 199
Microbiota in T-cell homeostasis and inflammatory diseases
Lee, N., & Kim, W. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.36 · Cited by 208
Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients
Kelly, S., Humby, F., Filer, A. D., Ng, N., Cicco, M. D., Hands, R., Rocher, V., Bombardieri, M., D’Agostino, M. A., McInnes, I. B., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204603 · Cited by 196
Self-citation
Toll-like receptors and chronic inflammation in rheumatic diseases: new developments
Joosten, L. A. B., Abdollahi‐Roodsaz, S., Dinarello, C. A., O'Neill, L. A. J., & Netea, M. G. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.61 · Cited by 208
MicroRNAs in rheumatoid arthritis: From pathogenesis to clinical impact
Evangelatos, G., Fragoulis, G., Koulouri, V., & Lambrou, G. Ι. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102391 · Cited by 200
Maresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21
Jin, S., Chen, H., Li, Y., Zhong, H., Sun, W., Wang, J., Zhang, T., Ma, J., Yan, S.-F., Zhang, J., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213511 · Cited by 197
Treatment for Rheumatoid Arthritis and Risk of Alzheimer’s Disease: A Nested Case-Control Analysis
Chou, R. C., Kane, M., Ghimire, S., Gautam, S., & Gui, J. (2016) · CNS Drugs · doi:10.1007/s40263-016-0374-z · Cited by 194
Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis
Arend, W. P., & Firestein, G. S. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.134 · Cited by 197
Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders
Schön, M. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01764 · Cited by 197
The aryl hydrocarbon receptor as a mediator of host-microbiota interplay
Dong, F., & Perdew, G. H. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1859812 · Cited by 202
Biologic therapies and bone loss in rheumatoid arthritis
Zerbini, C., Clark, P., Méndez-Sánchez, L., Pereira, R. M., Messina, O. D., Uña, C., Adachi, J., Lems, W., Cooper, C., & Lane, N. (2017) · Osteoporosis International · doi:10.1007/s00198-016-3769-2 · Cited by 185
Extracellular DNA traps in inflammation, injury and healing
Daniel, C., Leppkes, M., Munoz, L. E., Schley, G., Schett, G. A., & i, M. H. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0163-2 · Cited by 196
Self-citation
Common signalling pathways in macrophage and osteoclast multinucleation
Pereira, M., Petretto, E. G., Gordon, S., Bassett, J. H. D., Williams, G. R., & Behmoaras, J. V. (2018) · Journal of Cell Science · doi:10.1242/jcs.216267 · Cited by 197
“Moreover, both MGCs and osteoclasts have been reported to play a role in the pathogenesis of osteoarthritis and rheumatoid arthritis (Weinberg et al., 1993; McInnes and Schett, 2011).”
Background
Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1
Hasegawa, T., Kikuta, J., Sudo, T., Matsuura, Y., Matsui, T., Simmons, S., Ebina, K., Hirao, M., Okuzaki, D., Yoshida, Y., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0526-7 · Cited by 195
Bispecific T cell engager therapy for refractory rheumatoid arthritis
Bucci, L., Hagen, M., Rothe, T., Raimondo, M. G., Fagni, F., Tur, C., Wirsching, A., Wacker, J., Wilhelm, A., Auger, J.-P., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02964-1 · Cited by 199
Self-citation
Additive effect of anti-citrullinated protein antibodies and rheumatoid factor on bone erosions in patients with RA
Hecht, C., Englbrecht, M., Rech, J., Schmidt, S., Araujo, E. G., Engelke, K., Finzel, S., & Schett, G. A. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-205428 · Cited by 188
Self-citation
Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double‐Blind, Active Comparator– and Placebo‐Controlled Study
Blanco, F. J., Möricke, R., Dokoupilova, E., Codding, C., Neal, J., Andersson, M., Rohrer, S., & Richards, H. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40070 · Cited by 185
Efficacy and safety of the biosimilar ABP 501 compared with adalimumab in patients with moderate to severe rheumatoid arthritis: a randomised, double-blind, phase III equivalence study
Cohen, S. B., Genovese, M. C., Choy, E., Pérez-Ruiz, F., Matsumoto, A. K., Pavelká, K., Pablos, J. L., Rizzo, W., Hrycaj, P., Zhang, N., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210459 · Cited by 185
Podosome organization drives osteoclast-mediated bone resorption
Georgess, D., Machuca‐Gayet, I., Blangy, A., & Jurdic, P. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.27840 · Cited by 181

Authors: McInnes, I. B., & Schett, G.
Affiliations: University of Glasgow (GB)
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID: McInnes, Iain B.
Schett, Georg
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2011-12-08
Volume: 365
Issue: 23
Pages: 2205-2219
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra1004965
OpenAlex: W2110826367
Cited by: 5,514
References: 100
Citations by year: 2026: 313 · 2025: 415 · 2024: 439 · 2023: 443 · 2022: 469 · 2021: 493 · 2020: 465 · 2019: 409 · 2018: 399 · 2017: 394 · 2016: 379 · 2015: 300 · 2014: 276 · 2013: 204 · 2012: 111
FWCI: 27.90
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: rheumatoid arthritis, pathogenesis, immune mechanisms, disease-modifying antirheumatic drugs, mortality reduction
MeSH terms: Arthritis, Rheumatoid, Humans, Antirheumatic Agents, Gene-Environment Interaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Pathogenesis of Rheumatoid Arthritis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks