Cited by 5,514Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders ResearchNatural Compounds in Disease Treatment

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The Pathogenesis of Rheumatoid Arthritis

McInnes, Iain B., Schett, Georg·2011·New England Journal of Medicine

DOI 10.1056/nejmra1004965

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Abstract

The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.

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Crossref · 10.1056/nejmra1004965

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RETRACTED: Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis
Schuerwegh, A. J., Ioan‐Facsinay, A., Dorjée, A. L., Roos, J. A. D. M. D., Bajema, I. M., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913054107 · Cited by 94
Retracted
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Evolving concepts of rheumatoid arthritis
Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,653
The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
Gregersen, P. K., Silver, J., & WINCHESTER, R. J. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780301102 · Cited by 2,633
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,576
Self-citation
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
Rantapää‐Dahlqvist, S., Jong, B. A. W. D., Berglin, E. H., Hallmans, G., Wadell, G., Stenlund, H. C., Sundin, U., & VENROOIJ, W. J. V. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,946
A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination
Klareskog, L., Stolt, P., Lundberg, K., Källberg, H., Bengtsson, C., Grünewald, J., Rönnelid, J., Harris, H. E., Ulfgren, A., Rantapää‐Dahlqvist, S., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21575 · Cited by 1,516

Show all 100 references

Research works printed but not linked: 5

Scher JU, 2010, Arthritis Rheum, 62, 1390
Szekanecz Z, 2009, Front Biosci (Elite Ed), 1, 44
Aupperle KR, 1998, Am J Pathol, 152, 1091
Gravallese EM, 1998, Am J Pathol, 152, 943
Jacobsson LT, 2005, J Rheumatol, 32, 1213

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Self-citation
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Clinical immunity in bone and joints
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The regulatory roles of glycosphingolipid‐enriched lipid rafts in immune systems
Nakayama, H., Nagafuku, M., Suzuki, A., Iwabuchi, K., & Inokuchi, J. (2018) · FEBS Letters · doi:10.1002/1873-3468.13275 · Cited by 74
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Andersen, S. L., Olsen, J., Carlé, A., & Laurberg, P. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3588 · Cited by 74
Risk of hepatitis B virus reactivation in rheumatoid arthritis patients undergoing biologic treatment: Extending perspective from old to newer drugs
Nard, F. D. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i3.344 · Cited by 73
The impact of biological therapy on regulatory T cells in rheumatoid arthritis
Byng-Maddick, R., & Ehrenstein, M. R. (2015) · Lara D. Veeken · doi:10.1093/rheumatology/keu487 · Cited by 73
A gene catalogue of the Sprague-Dawley rat gut metagenome
Pan, H., Guo, R., Zhu, J., Wang, Q., Ju, Y., Xie, Y., Zheng, Y., Wang, Z., Li, T., Liu, Z., et al. (2018) · GigaScience · doi:10.1093/gigascience/giy055 · Cited by 73
Therapeutic Antibodies in Medicine
Sharma, P., Joshi, R. V., Pritchard, R., Xu, K., & Eicher, M. A. (2023) · Molecules · doi:10.3390/molecules28186438 · Cited by 81
Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis
Rosillo, M. Á., Sánchéz‐Hidalgo, M., González‐Benjumea, A., Fernández‐Bolaños, J. G., Lubberts, E., & Alarcón‐de‐la‐Lastra, C. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500304 · Cited by 73
Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis
Ma, J., Zhou, J., Zheng, D.-H., Chen, L., Mo, Y., Wei, X., Yang, L., & Dai, L. (2014) · Mediators of Inflammation · doi:10.1155/2014/179284 · Cited by 73
Abatacept Reduces Levels of Switched Memory B Cells, Autoantibodies, and Immunoglobulins in Patients with Rheumatoid Arthritis
Scarsi, M., Paolini, L., Ricotta, D., Pedrini, A., Piantoni, S., Caimi, L., Tincani, A., & Airó, P. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.130905 · Cited by 73
Celastrol attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW264.7
Gan, K., Xu, L., Feng, X., Zhang, Q., Wang, F., Zhang, M., & Tan, W. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.12.012 · Cited by 76
IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1
Shiratori, T., Kyumoto‐Nakamura, Y., Kukita, A., Uehara, N., Zhang, J.-Q., Koda, K., Kamiya, M., Badawy, T., Tomoda, E., Xu, X., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602035 · Cited by 74
Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis
Fu, J., Nogueira, S. V., van Drongelen, V., Coit, P., Ling, S., Rosloniec, E. F., Sawalha, A. H., & Holoshitz, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722124115 · Cited by 77
Characterization of 1 H NMR Plasma Glycoproteins as a New Strategy To Identify Inflammatory Patterns in Rheumatoid Arthritis
Fuertes-Martín, R., Taverner, D., Vallvé, J.-C., Paredes, S., Masana, L., Correig, X., & Grau, N. A. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00411 · Cited by 73
Leptin in osteoarthritis and rheumatoid arthritis: Player or bystander?
Ait Eldjoudi, D., Cordero Barreal, A., Gonzalez-Rodríguez, M., Ruiz-Fernández, C., Farrag, Y., Farrag, M., Lago, F., Capuozzo, M., Gonzalez-Gay, M. A., Mera Varela, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052859 · Cited by 72
Can bone loss in rheumatoid arthritis be prevented?
Vis, M., Güler-Yüksel, M., & Lems, W. F. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2334-5 · Cited by 71
IL-17/Th17 mediated synovial inflammation is IL-22 independent
van Hamburg, J. P., Corneth, O. B. J., Paulissen, S. M. J., Davelaar, N., Asmawidjaja, P. S., Mus, A. M. C., & Lubberts, E. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202373 · Cited by 72
Evaluation of antiarthritic activity of nimbolide against Freund’s adjuvant induced arthritis in rats
Cui, X., Wang, R., Bian, P., Wu, Q., Seshadri, V. D., & Liu, L. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1649269 · Cited by 72
“75% in India and 1% adult population in the world are affected with this disease which creates a major health problem worldwide [1].”
Background
Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis
Biggioggero, M., Becciolini, A., Crotti, C., & Agape, E. (2019) · Drugs in Context · doi:10.7573/dic.212595 · Cited by 72
Innate Lymphoid Cells in Autoimmune Diseases
Clottu, A., Humbel, M., Fluder, N., Karampetsou, M. P., & Comte, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.789788 · Cited by 72
“Innate immunity is central to the pathogenesis of RA, with the presence of macrophages, mast cells, and NK cells in the synovial membrane, and neutrophils in the synovial fluid (69).”
BackgroundInfluential
Fluorinated polyamidoamine dendrimer-mediated miR-23b delivery for the treatment of experimental rheumatoid arthritis in rats
Han, H., Xing, J., Chen, W., Jia, J., & Li, Q. (2023) · Nature Communications · doi:10.1038/s41467-023-36625-7 · Cited by 73
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study
Ishibashi, T., Sato, B., Shibata, S., Sakai, T., Hara, Y., Naritomi, Y., Koyanagi, S., Hara, H., & Nagao, T. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.06.001 · Cited by 72
Statins and autoimmunity
Khattri, S., & Zandman‐Goddard, G. (2013) · Immunologic Research · doi:10.1007/s12026-013-8409-8 · Cited by 72
Tofacitinib: A Review of its Use in Adult Patients with Rheumatoid Arthritis
Scott, L. J. (2013) · Drugs · doi:10.1007/s40265-013-0065-8 · Cited by 72
CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells
Jing, W., Zhang, X., Sun, W., Hou, X., Yao, Z., & Zhu, Y. (2015) · BioMed Research International · doi:10.1155/2015/326042 · Cited by 72
How compelling are the data for Epstein–Barr virus being a trigger for systemic lupus and other autoimmune diseases?
Draborg, A. H., Izarzugaza, J. M. G., & Houen, G. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000289 · Cited by 72
Gut microbiota in autoimmunity: potential for clinical applications
Kim, D.-H., Yoo, S., & Kim, W. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0796-7 · Cited by 72
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis
Nordal, H. H., Brokstad, K. A., Solheim, M. H., Halse, A., Kvien, T. K., & Hammer, H. B. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1201-0 · Cited by 72
Biomarkers for rheumatoid arthritis: From molecular processes to diagnostic applications-current concepts and future perspectives
Nakken, B., Papp, G., Bosnes, V., Zeher, M., Nagy, G., & Szodoray, P. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.05.010 · Cited by 72
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
Svensson, M. N. D., Doody, K. M., Schmiedel, B. J., Bhattacharyya, S., Panwar, B., Wiede, F., Yang, S. K., Santelli, E., Wu, D. J., Sacchetti, C., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123267 · Cited by 72
“Rheumatoid arthritis (RA) is a chronic autoimmune, systemic inflammatory disorder that primarily affects diarthrodial joints(1).”
Background
Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: Multi-functionalization as an emerging strategy to optimize therapeutic efficacy
Fang, G., Zhang, Q., Pang, Y., Thu, H. E., & Hussain, Z. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.027 · Cited by 75
Comprehensive TCR repertoire analysis of CD4+ T-cell subsets in rheumatoid arthritis
Jiang, X., Wang, S., Zhou, C., Wu, J., Jiao, Y., Lin, L., Lü, X., Yang, B., Zhang, W., Xiao, X., et al. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102432 · Cited by 72
Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase
Zhao, X., Liu, J., Zhang, C., Yu, N., Lu, Z., Zhang, S., Li, Y., Li, Q., Liu, J., Liu, D., et al. (2021) · International Journal of Oral Science · doi:10.1038/s41368-021-00136-2 · Cited by 71
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Martiniaková, M., Bíro, R., Kováčová, V., Babikova, M., Zemanová, N., Mondočková, V., & Omelka, R. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02418-8 · Cited by 80
Exposure to abatacept or rituximab in the first trimester of pregnancy in three women with autoimmune diseases
Ojeda‐Uribe, M., Afif, N., Dahan, É., Sparsa, L., Haby, C., Sibilia, J., Ternant, D., & Ardizzone, M. (2013) · Clinical Rheumatology · doi:10.1007/s10067-012-2156-4 · Cited by 71
Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models
Waterborg, C. E. J., Beermann, S., Broeren, M. G. A., Bennink, M. B., Koenders, M. I., van Lent, P. L. E. M., van den Berg, W. B., van der Kraan, P. M., & van de Loo, F. A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00742 · Cited by 75
Human disorders associated with inflammation and the evolving role of natural products to overcome
Kishore, N., Kumar, P., Shanker, K., & Verma, A. K. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.034 · Cited by 71

Authors: McInnes, I. B., & Schett, G.
Affiliations: University of Glasgow (GB)
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID: McInnes, Iain B.
Schett, Georg
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2011-12-08
Volume: 365
Issue: 23
Pages: 2205-2219
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra1004965
OpenAlex: W2110826367
Cited by: 5,514
References: 100
Citations by year: 2026: 313 · 2025: 415 · 2024: 439 · 2023: 443 · 2022: 469 · 2021: 493 · 2020: 465 · 2019: 409 · 2018: 399 · 2017: 394 · 2016: 379 · 2015: 300 · 2014: 276 · 2013: 204 · 2012: 111
FWCI: 27.90
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: rheumatoid arthritis, pathogenesis, immune mechanisms, disease-modifying antirheumatic drugs, mortality reduction
MeSH terms: Arthritis, Rheumatoid, Humans, Antirheumatic Agents, Gene-Environment Interaction

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The Pathogenesis of Rheumatoid Arthritis

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