Cited by 445Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalitiesGenome Rearrangement Algorithms

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Mobile DNA in Health and Disease

Open access

Kazazian, Haig H., Moran, John V.·2017·New England Journal of Medicine

DOI 10.1056/nejmra1510092PMC PMC5980640

Open this paper in CoChat — free account

Abstract

More than half the human genome is derived from transposable elements (also known as mobile DNA or “jumping genes”); some of these elements have been repurposed over time in the service of evolution. “Live” mobile elements are a rare cause of genetic disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmra1510092

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. A., & Hirschhorn, J. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2344 · Cited by 2,891
The origin and behavior of mutable loci in maize
McClintock, B. (1950) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.36.6.344 · Cited by 1,752
The impact of retrotransposons on human genome evolution
Cordaux, R., & Batzer, M. A. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2640 · Cited by 1,692
Regulatory activities of transposable elements: from conflicts to benefits
Chuong, E. B., Elde, N. C., & Feschotte, C. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.139 · Cited by 1,489
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
PIWI-interacting small RNAs: the vanguard of genome defence
Siomi, M. C., Sato, K., Pezic, D., & Aravin, A. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3089 · Cited by 1,319
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
Bourc’his, D., & Bestor, T. H. (2004) · Nature · doi:10.1038/nature02886 · Cited by 1,279
Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition
Luan, D. D., Korman, M. H., Jakubczak, J. L., & Eickbush, T. H. (1993) · Cell · doi:10.1016/0092-8674(93)90078-5 · Cited by 1,173
Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition
Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139
Self-citation

Show all 99 references

Research works printed but not linked: 1

Miki Y, 1992, Cancer Res, 52, 643

Sorted by citations

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
Rodriguez-Martin, B., Alvarez, E. G., Baez-Ortega, A., Zamora, J., Supek, F., Demeulemeester, J., Santamarina, M., Ju, Y. S., Temes, J., Garcia-Souto, D., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0562-0 · Cited by 451
Self-citation
Measuring and interpreting transposable element expression
Lanciano, S., & Cristofari, G. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0251-y · Cited by 415
DNA damage and repair in age-related inflammation
Zhao, Y., Simon, M. A., Seluanov, A., & Gorbunova, V. A. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00751-y · Cited by 400
Transposable elements in human genetic disease
Payer, L. M., & Burns, K. H. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0165-8 · Cited by 366
Genomic Analysis in the Age of Human Genome Sequencing
Lappalainen, T., Scott, A. J., Brandt, M. K., & Hall, I. M. (2019) · Cell · doi:10.1016/j.cell.2019.02.032 · Cited by 319
Cytoplasmic DNA: sources, sensing, and role in aging and disease
Miller, K. N., Victorelli, S. G., Salmonowicz, H., Dasgupta, N., Liu, T., Passos, J. F., & Adams, P. D. (2021) · Cell · doi:10.1016/j.cell.2021.09.034 · Cited by 288
Transposable elements shape the evolution of mammalian development
Senft, A. D., & Macfarlan, T. S. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00385-1 · Cited by 287
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
Zhang, L., Richards, A. L., Barrasa, M. I., Hughes, S. H., Young, R. A., & Jaenisch, R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105968118 · Cited by 279
Functional Long Non-coding RNAs Evolve from Junk Transcripts
Palazzo, A. F., & Koonin, E. V. (2020) · Cell · doi:10.1016/j.cell.2020.09.047 · Cited by 252
The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution
Yang, P., Wang, Y., & Macfarlan, T. S. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.08.006 · Cited by 227
Transposable elements: genome innovation, chromosome diversity, and centromere conflict
Klein, S. J., & O’Neill, R. J. (2018) · Chromosome Research · doi:10.1007/s10577-017-9569-5 · Cited by 223
Nanopore Sequencing Enables Comprehensive Transposable Element Epigenomic Profiling
Ewing, A. D., Smits, N., Sanchez-Luque, F. J., Faivre, J., Brennan, P. M., Richardson, S. R., Cheetham, S. W., & Faulkner, G. J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.024 · Cited by 200
LINE-1 Evasion of Epigenetic Repression in Humans
Sanchez-Luque, F. J., Kempen, M.-J. H. C., Gerdes, P., Vargas-Landin, D. B., Richardson, S. R., Troskie, R.-L., Jesuadian, J. S., Cheetham, S. W., Carreira, P. E., Salvador-Palomeque, C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.05.024 · Cited by 161
Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line
Aldén, M., Falla, F. O., Yang, D., Barghouth, M., Luan, C., Rasmussen, M., & Marinis, Y. Z. D. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44030073 · Cited by 184
The Arms Race Between KRAB–Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals
Bruno, M., Mahgoub, M., & Macfarlan, T. S. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043717 · Cited by 160
Centromere Repeats: Hidden Gems of the Genome
Hartley, G. A., & O'Neill, R. J. W. (2019) · Genes · doi:10.3390/genes10030223 · Cited by 161
Endogenous retroviruses in the origins and treatment of cancer
Jansz, N., & Faulkner, G. J. (2021) · Genome biology · doi:10.1186/s13059-021-02357-4 · Cited by 158
The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection
Sultana, T., van Essen, D., Siol, O., Bailly-Bechet, M., Philippe, C., Zine El Aabidine, A., Pioger, L., Nigumann, P., Saccani, S., Andrau, J.-C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.036 · Cited by 154
Recent advances in single-cell sequencing technologies
Wen, L., & Tang, F. (2022) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbac002 · Cited by 127
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
Dueva, R., & Iliakis, G. E. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa022 · Cited by 139
Structures, functions and adaptations of the human LINE-1 ORF2 protein
Baldwin, E. T., van Eeuwen, T., Hoyos, D., Zalevsky, A. O., Tchesnokov, E. P., Sánchez, R., Miller, B. D., Stefano, L. H. D., Ruiz, F. X., Hancock, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06947-z · Cited by 145
HBV-Integration Studies in the Clinic: Role in the Natural History of Infection
Pollicino, T., & Caminiti, G. (2021) · Viruses · doi:10.3390/v13030368 · Cited by 121
Pedigree-based estimation of human mobile element retrotransposition ratesPreprint
Feusier, J. E., Watkins, W. S., Thomas, J., Farrell, A., Witherspoon, D. J., Baird, L. M., Ha, H., Xing, J., & Jorde, L. B. (2019) · Genome Research · doi:10.1101/gr.247965.118 · Cited by 123
Mosaicism in Human Health and Disease
Thorpe, J., Osei‐Owusu, I., Avigdor, B. E., Tupler, R. G., & Pevsner, J. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-041720-093403 · Cited by 121
De novo structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families
Belyeu, J. R., Brand, H., Wang, H., Zhao, X., Pedersen, B. S., Feusier, J. E., Gupta, M., Nicholas, T. J., Brown, J., Baird, L. M., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.02.012 · Cited by 110
New Understanding of the Relevant Role of LINE-1 Retrotransposition in Human Disease and Immune Modulation
Zhang, X. L., Zhang, R., & Yu, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00657 · Cited by 116
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia
Gu, Z., Liu, Y., Zhang, Y., Cao, H., Lyu, J., Wang, X., Wylie, A., Newkirk, S. J., Jones, A. E., Lee, M., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00829-8 · Cited by 111
Identification and characterization of occult human-specific LINE-1 insertions using long-read sequencing technology
Zhou, W., Emery, S. B., Flasch, D. A., Wang, Y., Kwan, K. Y., Kidd, J. M., Moran, J. V., & Mills, R. E. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1173 · Cited by 98
Self-citation
Mouse germ line mutations due to retrotransposon insertions
Gagnier, L., Belancio, V. P., & Mager, D. L. (2019) · Mobile DNA · doi:10.1186/s13100-019-0157-4 · Cited by 100
RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability
Xiong, F., Wang, R., Lee, J.-H., Li, S., Chen, S.-F., Liao, Z., Hasani, L. A., Nguyen, P. T.-M., Zhu, X., Krakowiak, J., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00515-8 · Cited by 107
Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients
Balestrieri, E., Minutolo, A., Petrone, V., Fanelli, M., Iannetta, M., Malagnino, V., Zordan, M., Vitale, P., Charvet, B., Horvat, B., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103341 · Cited by 86
Hijacking Oogenesis Enables Massive Propagation of LINE and Retroviral Transposons
Wang, L., Dou, K., Moon, S., Tan, F. J., & Zhang, Z. Z. (2018) · Cell · doi:10.1016/j.cell.2018.06.040 · Cited by 82
Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites
Tao, J., Wang, Q., Mendez‐Dorantes, C., Burns, K. H., & Chiarle, R. (2022) · Nature Communications · doi:10.1038/s41467-022-31322-3 · Cited by 91
Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis
Yang, F., Su, W., Chung, O. W., Tracy, L., Wang, L., Ramsden, D. A., & Zhang, Z. Z. (2023) · Nature · doi:10.1038/s41586-023-06327-7 · Cited by 86
Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals
Zhao, B., Wu, Q., Ye, A. Y., Guo, J., Zheng, X., Yang, X., Yan, L., Liu, Q.-R., Hyde, T. M., Wei, L., et al. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008043 · Cited by 83
LINE-1 ORF2p expression is nearly imperceptible in human cancers
Ardeljan, D., Wang, X., Oghbaie, M., Taylor, M. S., Husband, D., Deshpande, V., Steranka, J. P., Gorbounov, M., Yang, W. R., Sie, B. M., et al. (2019) · Mobile DNA · doi:10.1186/s13100-019-0191-2 · Cited by 86
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
Garza, R., Atacho, D. A. M., Adami, A., Gerdes, P., Vinod, M., Hsieh, P., Karlsson, O., Horváth, V., Johansson, P. A., Pandiloski, N., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh9543 · Cited by 88
The Immunological Conundrum of Endogenous Retroelements
Kassiotis, G. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-033341 · Cited by 81
Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors
Ying, X., Chen, Q., Yang, Y., Wu, Z., Zeng, W., Miao, C., Huang, Q., & Ai, K. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02186-6 · Cited by 87
L1 retrotransposition in the soma: a field jumping ahead
Faulkner, G. J., & Billon, V. (2018) · Mobile DNA · doi:10.1186/s13100-018-0128-1 · Cited by 85
The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV
Treger, R. S., Pope, S. D., Kong, Y., Tokuyama, M., Taura, M., & Iwasaki, A. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.022 · Cited by 74
Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription
Wilkinson, M. E., Frangieh, C. J., Macrae, R. K., & Zhang, F. (2023) · Science · doi:10.1126/science.adg7883 · Cited by 79
Template and target-site recognition by human LINE-1 in retrotransposition
Thawani, A., Ariza, A. J. F., Nogales, E., & Collins, K. (2023) · Nature · doi:10.1038/s41586-023-06933-5 · Cited by 82
LINE‐1 retrotransposons in healthy and diseased human brain
Suarez, N. A., Macia, Á., & Muotri, A. R. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22567 · Cited by 80
Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs
Hardy, M., Audemard, E. O., Migneault, F., Feghaly, A., Brochu, S., Gendron, P., Boilard, É., Major, F., Dieudé, M., Hébert, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43591-y · Cited by 75
Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration
Ambati, M., Apicella, I., Wang, S.-B., Narendran, S., Leung, H., Pereira, F., Nagasaka, Y., Huang, P., Varshney, A., Baker, K. L., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102975118 · Cited by 70
Towards targeting transposable elements for cancer therapy
Liang, Y., Qu, X., Shah, N. M., & Wang, T. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-023-00653-8 · Cited by 79
SARS-CoV-2 RNA reverse-transcribed and integrated into the human genomePreprint
Zhang, L., Richards, A. L., Khalil, A. S., Wogram, E., Ma, H., Young, R. A., & Jaenisch, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.12.422516 · Cited by 70
The Gypsy Endogenous Retrovirus Drives Non-Cell-Autonomous Propagation in a Drosophila TDP-43 Model of Neurodegeneration
Chang, Y.-H., & Dubnau, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.07.071 · Cited by 68
Transposable elements as new players in neurodegenerative diseases
Ravel‐Godreuil, C., Znaidi, R., Bonnifet, T., Joshi, R. L., & Fuchs, J. (2021) · FEBS Letters · doi:10.1002/1873-3468.14205 · Cited by 77
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration
Fukuda, S., Varshney, A., Fowler, B. J., Wang, S.-B., Narendran, S., Ambati, K., Yasuma, T., Magagnoli, J., Leung, H., Hirahara, S., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022751118 · Cited by 65
Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
Ambati, J., Magagnoli, J., Leung, H., Wang, S.-B., Andrews, C. A., Fu, D., Pandey, A., Sahu, S., Narendran, S., Hirahara, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18528-z · Cited by 66
The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
Tristán-Ramos, P., Rubio-Roldán, A., Peris, G., Sánchez, L., Amador‐Cubero, S., Viollet, S., Cristofari, G., & Heras, S. R. (2020) · Nature Communications · doi:10.1038/s41467-020-19430-4 · Cited by 72
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
Pereira, G., Sánchez, L., Schaughency, P., Rubio-Roldán, A., Choi, J. A., Planet, E., Batra, R., Turelli, P., Trono, D., Ostrow, L. W., et al. (2018) · Mobile DNA · doi:10.1186/s13100-018-0138-z · Cited by 70
Self-citation
Cas9 targeted enrichment of mobile elements using nanopore sequencing
McDonald, T. L., Zhou, W., Castro, C. P., Mumm, C., Switzenberg, J. A., Mills, R. E., & Boyle, A. P. (2021) · Nature Communications · doi:10.1038/s41467-021-23918-y · Cited by 70
Role of Transposable Elements in Gene Regulation in the Human Genome
Ali, A., Han, K., & Liang, P. (2021) · Life · doi:10.3390/life11020118 · Cited by 76
Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
Tharp, M. E., Malki, S., & Bortvin, A. L. (2020) · Nature Communications · doi:10.1038/s41467-019-14055-8 · Cited by 60
Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections
Xiang, X., Tao, Y., DiRusso, J., Hsu, F., Zhang, J., Xue, Z., Pontis, J., Trono, D., Liu, W., & Clark, A. T. (2022) · Nature Communications · doi:10.1038/s41467-022-28105-1 · Cited by 53
L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution
Nguyen, T. H. M., Carreira, P. E., Sanchez-Luque, F. J., Schauer, S. N., Fagg, A. C., Richardson, S. R., Davies, C. M., Jesuadian, J. S., Kempen, M.-J. H. C., Troskie, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.090 · Cited by 60
What impact does oocyte vitrification have on epigenetics and gene expression?
Barberet, J., Barry, F., Choux, C., Guilleman, M., Karoui, S., Simonot, R., Bruno, C., & Fauque, P. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00911-8 · Cited by 59
DNA methylation profiles after ART during human lifespan: a systematic review and meta-analysis
Barberet, J., Ducreux, B., Guilleman, M., Simon, E. G., Bruno, C., & Fauque, P. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmac010 · Cited by 58
RNA: a double-edged sword in genome maintenance
Zong, D., Oberdoerffer, P., Batista, P. J., & Nussenzweig, A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0263-7 · Cited by 61
Integrative and Analytical Review of the 5-Alpha-Reductase Type 2 Deficiency Worldwide
Batista, R. L., & Mendonca, B. B. (2020) · The Application of Clinical Genetics · doi:10.2147/tacg.s198178 · Cited by 58
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs
Wang, S.-B., Narendran, S., Hirahara, S., Varshney, A., Pereira, F., Apicella, I., Ambati, M., Ambati, V. L., Yerramothu, P., Ambati, K., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abi4493 · Cited by 57
Single-Cell Analysis Reveals Unexpected Cellular Changes and Transposon Expression Signatures in the Colonic Epithelium of Treatment-Naïve Adult Crohn’s Disease Patients
Kanke, M., Ng, M. M. K., Connelly, S. V., Singh, M., Schaner, M. R., Shanahan, M. T., Wolber, E. A., Beasley, C., Lian, G., Jain, A., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.02.005 · Cited by 54
The retrotransposon R2 maintains Drosophila ribosomal DNA repeats
Nelson, J. O., Slicko, A., & Yamashita, Y. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221613120 · Cited by 53
Factors Regulating the Activity of LINE1 Retrotransposons
Protasova, M., Андреева, Т. В., & Rogaev, E. I. (2021) · Genes · doi:10.3390/genes12101562 · Cited by 58
LINE-1 activation in the cerebellum drives ataxia
Takahashi, T., Stoiljković, M., Song, E., Gao, X., Yasumoto, Y., Kudo, E., Carvalho, F., Kong, Y., Park, A., Shanabrough, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.011 · Cited by 54
All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons
Chen, Y., Luo, S., Hu, Y., Mao, B., Wang, X., Lu, Z., Shan, Q., Zhang, J., Wang, S., Feng, G., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.020 · Cited by 50
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
Herrmann, A., Wittmann, S., Thomas, D., Shepard, C., Kim, B., Ferreirós, N., & Gramberg, T. (2018) · Mobile DNA · doi:10.1186/s13100-018-0116-5 · Cited by 59
Aberrant expression of select piRNA-pathway genes does not reactivate piRNA silencing in cancer cells
Genzor, P., Cordts, S. C., Bokil, N. V., & Haase, A. D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904498116 · Cited by 52
Structural basis for DNA targeting by the Tn7 transposon
Shen, Y., Gómez-Blanco, J., Petassi, M. T., Peters, J. E., Ortega, J., & Guarné, A. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00724-8 · Cited by 51
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity
Fukuda, S., Narendran, S., Varshney, A., Nagasaka, Y., Wang, S.-B., Ambati, K., Apicella, I., Pereira, F., Fowler, B. J., Yasuma, T. R., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj3658 · Cited by 51
Adaptive homeostasis and the p53 isoform network
Mehta, S. Y., Campbell, H. G., Drummond, C. J., Li, K., Murray, K., Slatter, T. L., Bourdon, J., & Braithwaite, A. W. (2021) · EMBO Reports · doi:10.15252/embr.202153085 · Cited by 50
Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements
Li, Z., Duan, S., Hua, X., Xu, X., Li, Y., Menolfi, D., Zhou, H., Lü, C., Zha, S., Goff, S. P., et al. (2023) · Nature · doi:10.1038/s41586-023-06711-3 · Cited by 50
Somatic mutations in the human brain: implications for psychiatric research
Nishioka, M., Bundo, M., Iwamoto, K., & Kato, T. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0129-y · Cited by 47
Retrotransposons as a Source of DNA Damage in Neurodegeneration
Pezé-Heidsieck, E., Bonnifet, T., Znaidi, R., Ravel‐Godreuil, C., Massiani-Beaudoin, O., Joshi, R. L., & Fuchs, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.786897 · Cited by 53
mRNA Vaccines: Why Is the Biology of Retroposition Ignored?
Domazet‐Lošo, T. (2022) · Genes · doi:10.3390/genes13050719 · Cited by 47
Potential health risks of mRNA-based vaccine therapy: A hypothesis
Acevedo‐Whitehouse, K. A., & Bruno, R. (2023) · Medical Hypotheses · doi:10.1016/j.mehy.2023.111015 · Cited by 56
Early life exposures, neurodevelopmental disorders, and transposable elements
Lapp, H. E., & Hunter, R. G. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100174 · Cited by 45
Human copy number variants are enriched in regions of low mappability
Monlong, J., Cossette, P., Meloche, C., Rouleau, G. A., Girard, S., & Bourque, G. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky538 · Cited by 49
Contribution of unfixed transposable element insertions to human regulatory variation
Goubert, C., Zevallos, N. A., & Feschotte, C. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0331 · Cited by 45
OUP accepted manuscript
Liang, C., Ke, Q., Liu, Z., Ren, J., Zhang, W., Hu, J., Wang, Z., Chen, H., Xia, K., Lai, X., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac146 · Cited by 50
The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders
Frost, B., & Dubnau, J. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-082823-020615 · Cited by 45
Virome capture sequencing does not identify active viral infection in unicentric and idiopathic multicentric Castleman disease
Nabel, C. S., Sameroff, S. C., Shilling, D. J., Alapat, D. V., Ruth, J. R., Kawano, M., Sato, Y., Stone, K., Spetalen, S., Valdivieso, F., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218660 · Cited by 45
No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing
Smits, N., Rasmussen, J., Bodea, G. O., Amarilla, A. A., Gerdes, P., Sanchez-Luque, F. J., Ajjikuttira, P., Modhiran, N., Liang, B., Faivre, J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109530 · Cited by 46
NOS2 and S -nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression
Switzer, C., Cho, H.-J., Eykyn, T. R., Lavender, P., & Eaton, P. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200022119 · Cited by 45
The Molecular Basis of 5α-Reductase Type 2 Deficiency
Batista, R. L., & Mendonca, B. B. (2022) · Sexual Development · doi:10.1159/000525119 · Cited by 47
Retrotransposon activation during Drosophila metamorphosis conditions adult antiviral responses
Wang, L., Tracy, L., Su, W., Yang, F., Yu, F., Silverman, N. S., & Zhang, Z. Z. (2022) · Nature Genetics · doi:10.1038/s41588-022-01214-9 · Cited by 42
A new therapeutic approach for type 1 diabetes: Rationale for GNbAC1, an anti‐HERV‐W‐Env monoclonal antibody
Curtin, F., Bernard, C., Levet, S., Perron, H., Porchet, H. C., Médina, J., Malpass, S., Lloyd, D., Simpson, R., & on behalf of the RAINBOW‐T1D investigators (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13357 · Cited by 44
Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells of aging fruit flies
Chang, Y., Keegan, R. M., Prazak, L., & Dubnau, J. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000278 · Cited by 40
Retrotransposons as Drivers of Mammalian Brain Evolution
Ferrari, R., Grandi, N., Tramontano, E., & Dieci, G. (2021) · Life · doi:10.3390/life11050376 · Cited by 47
Transposon expression in the Drosophila brain is driven by neighboring genes and diversifies the neural transcriptomePreprint
Treiber, C. D., & Waddell, S. (2020) · Genome Research · doi:10.1101/gr.259200.119 · Cited by 40
Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders
Balestrieri, E., Matteucci, C., Cipriani, C., Grelli, S., Ricceri, L., Calamandrei, G., & Vallebona, P. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236050 · Cited by 38
Curation Guidelines for de novo Generated Transposable Element Families
Storer, J. M., Hubley, R. M., Rosen, J. R., & Smit, A. F. A. (2021) · Current Protocols · doi:10.1002/cpz1.154 · Cited by 39
Polymorphic mobile element insertions contribute to gene expression and alternative splicing in human tissues
Cao, X., Zhang, Y., Payer, L. M., Lords, H. J., Steranka, J. P., Burns, K. H., & Xing, J. (2020) · Genome biology · doi:10.1186/s13059-020-02101-4 · Cited by 41
Protein-nucleic acid interactions of LINE-1 ORF1p
Naufer, M. N., Furano, A. V., & Williams, M. C. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.019 · Cited by 42
ERVcaller: identifying polymorphic endogenous retrovirus and other transposable element insertions using whole-genome sequencing data
Chen, X., & Li, D. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz205 · Cited by 38
Defensive Function of Transposable Elements in Bacteria
Fan, C., Wu, Y.-H., Decker, C. M., Rohani, R., Salazar, M. G., Ye, H., Cui, Z., Schmidt, F., & Huang, W. E. (2019) · ACS Synthetic Biology · doi:10.1021/acssynbio.9b00218 · Cited by 35
Human TRIM5α senses and restricts LINE-1 elements
Volkmann, B., Wittmann, S., Lagisquet, J., Deutschmann, J., Eissmann, K., Ross, J. J., Biesinger, B., & Gramberg, T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922366117 · Cited by 41

Authors: Kazazian, H. H., & Moran, J. V.
Affiliations: Johns Hopkins University (US)
ORCID: Moran, John V.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2017-07-27
Volume: 377
Issue: 4
Pages: 361-370
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra1510092
PMC: PMC5980640
OpenAlex: W2737372261
Cited by: 445
References: 99
Citations by year: 2026: 29 · 2025: 65 · 2024: 54 · 2023: 55 · 2022: 64 · 2021: 50 · 2020: 47 · 2019: 46 · 2018: 32 · 2017: 3
FWCI: 3.64
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (U01MH106892)
National Institute of General Medical Sciences (R01GM099875, P50GM107632)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
Keywords: mobile DNA, transposable elements, human genome, genetic disorders, evolution, genome evolution
MeSH terms: Disease, DNA Transposable Elements, Female, Hemophilia A, Humans, Male, Mutagens, RNA, Transcription, Genetic, Genome, Human, Retroelements, Long Interspersed Nucleotide Elements, Genomic Instability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mobile DNA in Health and Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks