The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Microcantilever resonance-based DNA detection with nanoparticle probes
Abstract
Microcantilevers are used to detect DNA strands with a specific sequence using gold nanoparticle modified DNA. The hybridization reactions lead to the attachment of gold nanoparticles. After the amplification process by catalyzing the nucleation of silver, the shift of the cantilever frequency signals the binding events. The method can detect target DNA at a concentration of 0.05 nM or lower. Combined with stringency washing, a single base pair mismatched DNA strand can be discriminated. The cantilever is 1/100 times smaller than its macroscopic counterpart (quartz crystal microbalance), and can be mass produced as miniaturized sensor arrays by current processing technology. Multiple DNA detection is possible by coating multiple cantilevers with various capture DNA strands and monitoring the change in their resonance frequencies.
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Cited by
Gold Nanoparticles in Chemical and Biological Sensing
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Nanomedicine—Challenge and Perspectives
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Micro- and nanomechanical sensors for environmental, chemical, and biological detection
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Metadata
- Authors
- Su, M., Li, S., & Dravid, V. P.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2003-05-19
- Volume
- 82
- Issue
- 20
- Pages
- 3562-3564
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W2005956428
- Cited by
- 253
- References
- 16
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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