The role of tissue fluorescence in in vivo optical bioimaging
Open accessAbstract
The technological advancements made in optics and semiconductors (e.g., cameras and laser diodes) working with infrared have brought interest in optical bioimaging back to the forefront of research investigating in vivo medical imaging techniques. The definition of the near-infrared transparency windows has turned optical imaging into more than just a method for topical imaging applications. Moreover, this has focused attention back to tissue fluorescence, emissions by tissues and organs that occur when excited by external illumination sources. Most endogenous fluorophores emit in the blue to green range of the electromagnetic spectrum and the resulting tissue fluorescence can be employed in studies from cells to tissue metabolism or avoided by shifting to the red if seen as unwanted autofluorescence. With the more recent move to infrared, it was discovered that autofluorescence is not limited to the visible but also strongly affects in vivo imaging in the infrared. In this Tutorial, we give an overview on tissue fluorescence and tissue interactions with excitation light as well as their effect on in vivo imaging. Furthermore, potential sources of tissue fluorescence in the near-infrared are identified and we describe approaches for successful biomedical imaging in the biological windows, taking into consideration infrared autofluorescence and summarizing techniques for avoiding it in in vivo imaging experiments.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Use of a near-IR fluorophore coupled to rhBMP-2 should reduce the likelihood that the observed signals are associated with tissue autofluorescence.
“Our use of a near-IR fluorophore coupled to rhBMP-2 should reduce the likelihood of the observed signals being associated with autofluorescence of the tissues [42].”
From Keratin Scaffold Formulation Impacts rhBMP-2 Biodistribution and Bone Regeneration in a Rat Femur Defect Model (2025) · cites this paper as [42]
Cites
Chlorophyll fluorescence—a practical guide
Maxwell, K., & Johnson, G. N. (2000) · Journal of Experimental Botany · doi:10.1093/jexbot/51.345.659 · Cited by 9,347 · see citing works
Chlorophyll Fluorescence: A Probe of Photosynthesis In Vivo
Baker, N. R. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092759 · Cited by 4,672 · see citing works
Chlorophyll Fluorescence And Photosynthesis: The Basics
Krause, G. H., & Weis, E. (1991) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.pp.42.060191.001525 · Cited by 4,278 · see citing works
Optical properties of biological tissues: A review
Jacques, S. L. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/11/r37 · Cited by 4,008 · see citing works
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839 · see citing works
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,013 · see citing works
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848 · see citing works
In vivo near-infrared fluorescence imaging
Frangioni, J. V. (2003) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2003.08.007 · Cited by 2,655 · see citing works
Fluorometric analysis of chlorophyll a in the presence of chlorophyll b and pheopigments
Welschmeyer, N. A. (1994) · Limnology and Oceanography · doi:10.4319/lo.1994.39.8.1985 · Cited by 2,615 · see citing works
Fluorescence Lifetime Measurements and Biological Imaging
Berezin, M. Y., & Achilefu, S. A. (2010) · Chemical Reviews · doi:10.1021/cr900343z · Cited by 2,401 · see citing works
Biodegradable luminescent porous silicon nanoparticles for in vivo applications
Park, J., Gu, L., von Maltzahn, G., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2009) · Nature Materials · doi:10.1038/nmat2398 · Cited by 1,895 · see citing works
A broadband achromatic metalens for focusing and imaging in the visible
Chen, W. T., Zhu, A. Y., Sanjeev, V., Khorasaninejad, M., Shi, Z., Lee, E., & Capasso, F. (2017) · Nature Nanotechnology · doi:10.1038/s41565-017-0034-6 · Cited by 1,877 · see citing works
Bashkatov, A. N., Genina, E. A., Kochubey, V. I., & Tuchin, V. V. (2005) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/38/15/004 · Cited by 1,720 · see citing works
The IUPAC Compendium of Chemical Terminology
Romero Vallejo, C. C. (2008) · International Union of Pure and Applied Chemistry (IUPAC) eBooks · doi:10.1351/goldbook · Cited by 1,473 · see citing works
QUANTITATIVE OPTICAL SPECTROSCOPY FOR TISSUE DIAGNOSIS
Richards‐Kortum, R., & Sevick-Muraca, E. M. (1996) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.47.1.555 · Cited by 1,181 · see citing works
Hu, Z., Fang, C., Li, B., Zhang, Z., Cao, C., Cai, M., Su, S., Sun, X., Shi, X., Li, C., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0494-0 · Cited by 1,126 · see citing works
Maldiney, T., Bessière, A., Séguin, J., Teston, E., Sharma, S. K., Viana, B., Bos, A. J. J., Dorenbos, P., Bessodes, M., Gourier, D., et al. (2014) · Nature Materials · doi:10.1038/nmat3908 · Cited by 1,101 · see citing works
The physical and chemical properties of eumelanin
Meredith, P., & Sarna, T. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00345.x · Cited by 1,033 · see citing works
Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing
Zhang, K. Y., Yu, Q., Wei, H., Liu, S., Zhao, Q., & Huang, W. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00425 · Cited by 922 · see citing works
Cell and tissue autofluorescence research and diagnostic applications
Monici, M. (2005) · Biotechnology Annual Review · doi:10.1016/s1387-2656(05)11007-2 · Cited by 887 · see citing works
Chlorophyll fluorescence as a tool in plant physiology
Krause, G. H., & Weis, E. (1984) · Photosynthesis Research · doi:10.1007/bf00028527 · Cited by 853 · see citing works
Nanoprobes with near-infrared persistent luminescence for in vivo imaging
de Chermont, Q. L. M., Chanéac, C., Séguin, J., Pellé, F., Maitrejean, S., Jolivet, J., Gourier, D., Bessodes, M., & Scherman, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702427104 · Cited by 835 · see citing works
Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging
Fan, Y., Wang, P., Lu, Y., Wang, R., Zhou, L., Zheng, X., Li, X., Piper, J. A., & Zhang, F. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0221-0 · Cited by 800 · see citing works
Two-Photon Fluorescence Spectroscopy and Microscopy of NAD(P)H and Flavoprotein
Huang, S., Heikal, A. A., & Webb, W. W. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75621-x · Cited by 763 · see citing works
Retrieval of foliar information about plant pigment systems from high resolution spectroscopy
Ustin, S. L., Gitelson, A. A., Jacquemoud, S., Schaepman, M. E., Asner, G. P., Gamon, J. A., & Zarco‐Tejada, P. J. (2009) · Remote Sensing of Environment · doi:10.1016/j.rse.2008.10.019 · Cited by 749 · see citing works
Hemmer, E., Benayas, A., Légaré, F., & Vetrone, F. (2016) · Nanoscale Horizons · doi:10.1039/c5nh00073d · Cited by 732 · see citing works
Lanthanides in Luminescent Thermometry
Brites, C. D. S., Millán, Á., & Carlos, L. D. (2016) · Elsevier eBooks · doi:10.1016/bs.hpcre.2016.03.005 · Cited by 542 · see citing works
Flock, S. T., Patterson, M. S., Wilson, B. C., & Wyman, D. R. (1989) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1989.1173624 · Cited by 490 · see citing works
Review of light parameters and photobiomodulation efficacy: dive into complexity
Zein, R., Selting, W. J., & Hamblin, M. R. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.23.12.120901 · Cited by 465 · see citing works
A literature review and novel theoretical approach on the optical properties of whole blood
Bosschaart, N., Edelman, G. J., Aalders, M. C. G., van Leeuwen, T. G. J. M., & Faber, D. J. (2013) · Lasers in Medical Science · doi:10.1007/s10103-013-1446-7 · Cited by 463 · see citing works
Near-Infrared Autofluorescence Imaging of the Fundus: Visualization of Ocular Melanin
Keilhauer, C. N., & Delori, F. ̧. C. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0122 · Cited by 398 · see citing works
Georgakoudi, I., Jacobson, B. C., Mueller, M. G., Sheets, E. E., Badizadegan, K., Carr-Locke, D. L., Crum, C. P., Boone, C. W., Dasari, R. R., Dam, J. V., et al. (2002) · PubMed · Cited by 378 · see citing works
Comment on the modified Beer–Lambert law for scattering media
Sassaroli, A., & Fantini, S. (2004) · Physics in Medicine and Biology · doi:10.1088/0031-9155/49/14/n07 · Cited by 352 · see citing works
Hybrid Rhodamine Fluorophores in the Visible/NIR Region for Biological Imaging
Wang, L., Du, W., Hu, Z., Uvdal, K., Li, L., & Huang, W. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901061 · Cited by 349 · see citing works
Biological imaging without autofluorescence in the second near-infrared region
Diao, S., Hong, G., Antaris, A. L., Blackburn, J. L., Cheng, K., Cheng, Z., & Dai, H. (2015) · Nano Research · doi:10.1007/s12274-015-0808-9 · Cited by 346 · see citing works
Transmission in near‐infrared optical windows for deep brain imaging
Shi, L., Sordillo, L. A., Rodríguez‐Contreras, A., & Alfano, R. (2016) · Journal of Biophotonics · doi:10.1002/jbio.201500192 · Cited by 346 · see citing works
Upconverting and NIR emitting rare earth based nanostructures for NIR-bioimaging
Hemmer, E., Venkatachalam, N., Hyodo, H., Hattori, A., Ebina, Y., Kishimoto, H., & Soga, K. (2013) · Nanoscale · doi:10.1039/c3nr02286b · Cited by 343 · see citing works
Variability and application of the chlorophyll fluorescence emission ratio red/far-red of leaves
Buschmann, C. (2007) · Photosynthesis Research · doi:10.1007/s11120-007-9187-8 · Cited by 342 · see citing works
Mansfield, J. R., Gossage, K. W., Hoyt, C. C., & Levenson, R. M. (2005) · Journal of Biomedical Optics · doi:10.1117/1.2032458 · Cited by 311 · see citing works
Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo
Yoo, H., Kim, J. W., Shishkov, M. S., Namati, E., Morse, T. F., Shubochkin, R. L., McCarthy, J. R., Ntziachristos, V., Bouma, B. E., Jaffer, F. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2555 · Cited by 307 · see citing works
Jichlinski, P., Guillou, L., Karlsen, S. J., Malmström, P., Jocham, D., Brennhovd, B., Johansson, E., GÄRTNER, T., Lange, N., van den Bergh, H., et al. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000060782.52358.04 · Cited by 278 · see citing works
Guiding Rules for Selecting a Nanothermometer
Quintanilla, M., & Liz-Márzan, L. (2018) · Nano Today · doi:10.1016/j.nantod.2018.02.012 · Cited by 277 · see citing works
The status of in vivo autofluorescence spectroscopy and imaging for oral oncology
de Veld, D. C. G., Witjes, M. J. H., Sterenborg, H. J. C. M., & Roodenburg, J. L. N. (2004) · Oral Oncology · doi:10.1016/j.oraloncology.2004.07.007 · Cited by 263 · see citing works
High-sensitivity imaging of time-domain near-infrared light transducer
Gu, Y., Guo, Z., Yuan, W., Kong, M., Liu, Y., Liu, Y., Gao, Y., Feng, W., Wang, F., Zhou, J., et al. (2019) · Nature Photonics · doi:10.1038/s41566-019-0437-z · Cited by 249 · see citing works
Raman spectroscopy of in vivo cutaneous melanin
Huang, Z., Lui, H., Chen, X. K., Alajlan, A., McLean, D. I., & Zeng, H. (2004) · Journal of Biomedical Optics · doi:10.1117/1.1805553 · Cited by 248 · see citing works
Shibuki, K., Hishida, R., Murakami, H., Kudoh, M., Kawaguchi, T., Watanabe, M., Watanabe, S., Kouuchi, T., & Tanaka, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040709 · Cited by 240 · see citing works
Mayevsky, A., & Chance, B. (1982) · Science · doi:10.1126/science.7201167 · Cited by 232 · see citing works
Lange, N., Jichlinski, P., Zellweger, M., Forrer, M., Martí, A., Guillou, L., Kučera, P., Wagnières, G., & van den Bergh, H. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690338 · Cited by 229 · see citing works
In vivo absorption and scattering spectroscopy of biological tissues
Taroni, P., Pifferi, A., Torricelli, A. M., Comelli, D., & Cubeddu, R. (2003) · Photochemical & Photobiological Sciences · doi:10.1039/b209651j · Cited by 220 · see citing works
In Vivo Fundus Autofluorescence in Macular Dystrophies
von Rückmann, A. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150611006 · Cited by 218 · see citing works
You say lipofuscin, we say ceroid: Defining autofluorescent storage material
Seehafer, S. S., & Pearce, D. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.006 · Cited by 212 · see citing works
Temporal Multiplexed in Vivo Upconversion Imaging
Li, H., Tan, M., Wang, X., Li, F., Zhang, Y., Zhao, L., Yang, C., & Chen, G. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b11641 · Cited by 209 · see citing works
Villa, I., Vedda, A., Cantarelli, I. X., Pedroni, M., Piccinelli, F., Bettinelli, M., Speghini, A., Quintanilla, M., Vetrone, F., Rocha, U., et al. (2014) · Nano Research · doi:10.1007/s12274-014-0549-1 · Cited by 202 · see citing works
Self-citationInorganic nanoparticles for optical bioimaging
Jaque, D., Richard, C., Viana, B., Soga, K., Liu, X., & García‐Solé, J. (2016) · Advances in Optics and Photonics · doi:10.1364/aop.8.000001 · Cited by 200 · see citing works
NON‐INVASIVE TECHNIQUE FOR OBTAINING FLUORESCENCE EXCITATION AND EMISSION SPECTRA IN VIVO
Pottier, R., Chow, Y. F. A., Laplante, J. P., Truscott, T. G., Kennedy, J. C., & Beiner, L. A. (1986) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1986.tb04726.x · Cited by 176 · see citing works
Collagen and Elastin Biomaterials for the Fabrication of Engineered Living Tissues
Miranda-Nieves, D., & Chaikof, E. L. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00250 · Cited by 175 · see citing works
Flavoprotein Autofluorescence Imaging of Neuronal Activation in the Cerebellar Cortex In Vivo
Reinert, K. C., Dunbar, R. L., Gao, W., Chen, G., & Ebner, T. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01275.2003 · Cited by 172 · see citing works
Lifetime-Encoded Infrared-Emitting Nanoparticles for in Vivo Multiplexed Imaging
Ortgies, D. H., Tan, M., Ximendes, E. C., del Rosal, B., Hu, J., Xu, L., Wang, X., Rodríguez, E. M., Jacinto, C., Fernández, N., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b09189 · Cited by 169 · see citing works
Self-citationSilicon Nitride Metalenses for Close-to-One Numerical Aperture and Wide-Angle Visible Imaging
Fan, Z.-B., Shao, Z.-K., Xie, M.-Y., Pang, X.-N., Ruan, W.-S., Zhao, F.-L., Chen, Y.-J., Yu, S.-Y., & Dong, J. (2018) · Physical Review Applied · doi:10.1103/physrevapplied.10.014005 · Cited by 164 · see citing works
Marmorstein, A. D., Marmorstein, L. Y., Sakaguchi, H., & Hollyfield, J. G. (2002) · PubMed · Cited by 154 · see citing works
Zuurbier, C. J., Emons, V. M., & İnce, C. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01002.2001 · Cited by 148 · see citing works
Infrared‐Emitting QDs for Thermal Therapy with Real‐Time Subcutaneous Temperature Feedback
del Rosal, B., Carrasco, E., Ren, F., Benayas, A., Vetrone, F., Sanz-Rodrı́guez, F., Ma, D., Juarranz, Á., & Jaque, D. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201601953 · Cited by 145 · see citing works
Porphyrins as Theranostic Agents from Prehistoric to Modern Times
Zhang, Y.-M., & Lovell, J. (2012) · Theranostics · doi:10.7150/thno.4908 · Cited by 140 · see citing works
Diversity of human hair pigmentation as studied by chemical analysis of eumelanin and pheomelanin
Ito, S., & Wakamatsu, K. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04278.x · Cited by 139 · see citing works
In Vivo Spectral Distortions of Infrared Luminescent Nanothermometers Compromise Their Reliability
Shen, Y., Lifante, J., Fernández, N., Jaque, D., & Ximendes, E. C. (2020) · ACS Nano · doi:10.1021/acsnano.9b08824 · Cited by 134 · see citing works
Self-citationOvercoming Autofluorescence: Long‐Lifetime Infrared Nanoparticles for Time‐Gated In Vivo Imaging
del Rosal, B., Ortgies, D. H., Fernández, N., Sanz-Rodrı́guez, F., Jaque, D., & Rodríguez, E. M. (2016) · Advanced Materials · doi:10.1002/adma.201603583 · Cited by 130 · see citing works
Self-citationSPECTROSCOPIC AND MICROSCOPIC CHARACTERISTICS OF HUMAN SKIN AUTOFLUORESCENCE EMISSION
Zeng, H., MacAulay, C. E., Palcic, B., & McLean, D. I. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb09881.x · Cited by 126 · see citing works
Diet and Abdominal Autofluorescence Detected by in Vivo Fluorescence Imaging of Living Mice
Inoue, Y., Izawa, K., Kiryu, S., Tojo, A., & Ohtomo, K. (2008) · Molecular Imaging · doi:10.2310/7290.2008.0003 · Cited by 124 · see citing works
Anisotropy of light propagation in biological tissue
Kienle, A., Forster, F. K., & Hibst, R. (2004) · Optics Letters · doi:10.1364/ol.29.002617 · Cited by 123 · see citing works
Htun, N., Chen, Y., Lim, B., Schiller, T. L., Maghzal, G. J., Huang, A. L., Elgass, K., Rivera, J., Schneider, H. G., Wood, B. R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00138-x · Cited by 119 · see citing works
In vivoautofluorescence in the biological windows: the role of pigmentation
del Rosal, B., Villa, I., Jaque, D., & Sanz-Rodrı́guez, F. (2015) · Journal of Biophotonics · doi:10.1002/jbio.201500271 · Cited by 118 · see citing works
Cutaneous melanin exhibiting fluorescence emission under near-infrared light excitation
Huang, Z., Zeng, H., Hamzavi, I. H., Alajlan, A., Tan, E., McLean, D. I., & Lui, H. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2204007 · Cited by 116 · see citing works
Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator
Haining, R. L., & Achat‐Mendes, C. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.202928 · Cited by 116 · see citing works
Tan, M., del Rosal, B., Zhang, Y., Rodríguez, E. M., Hu, J., Zhou, Z., Fan, R., Ortgies, D. H., Fernández, N., Chaves‐Coira, I., et al. (2018) · Nanoscale · doi:10.1039/c8nr02382d · Cited by 114 · see citing works
Self-citationMonitoring of Vital Signs for Long-Term Survival of Mice under Anesthesia: FIGURE 1.Preprint
Ewald, A. J., Werb, Z., & Egeblad, M. (2011) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5563 · Cited by 109 · see citing works
Imaging liver biology in vivo using conventional confocal microscopy
Marques, P. E., Antunes, M. M., David, B. A., Pereira, R. V. S., Teixeira, M. M., & Menezes, G. B. (2015) · Nature Protocols · doi:10.1038/nprot.2015.006 · Cited by 107 · see citing works
Monte Carlo procedure for investigating light propagation and imaging of highly scattering media
Sassaroli, A., Blumetti, C., Martelli, F., Alianelli, L., Contini, D., Ismaelli, A., & Zaccanti, G. (1998) · Applied Optics · doi:10.1364/ao.37.007392 · Cited by 107 · see citing works
High-Contrast Visualization of Upconversion Luminescence in Mice Using Time-Gating Approach
Zheng, X., Zhu, X., Lu, Y., Zhao, J., Feng, W., Jia, G., Wang, F., Li, F., & Jin, D. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04626 · Cited by 103 · see citing works
Strategies to Overcome Autofluorescence in Nanoprobe‐Driven In Vivo Fluorescence Imaging
del Rosal, B., & Benayas, A. (2018) · Small Methods · doi:10.1002/smtd.201800075 · Cited by 100 · see citing works
The nature of the chromophore responsible for naturally occurring fluorescence in mouse skin
Weagle, G. E., Paterson, P. E., Kennedy, J. C., & Pottier, R. (1988) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(88)85051-6 · Cited by 86 · see citing works
Detecting the Near Infrared Autofluorescence of the Human Parathyroid
Solórzano, C. C., Thomas, G., Baregamian, N., & Mahadevan-Jansen, A. M. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000003700 · Cited by 84 · see citing works
Xing, P., Chen, H., Xiang, H., & Zhao, Y. (2017) · Advanced Materials · doi:10.1002/adma.201705633 · Cited by 76 · see citing works
Liu, T., Jung, H., Liu, J., Droettboom, M., & Tam, J. (2017) · Biomedical Optics Express · doi:10.1364/boe.8.004348 · Cited by 69 · see citing works
Coda, S., Thompson, A. J., Kennedy, G. T., Roche, K. L., Ayaru, L., Bansi, D. S., Stamp, G., Thillainayagam, A. V., French, P. M. W., & Dunsby, C. W. (2014) · Biomedical Optics Express · doi:10.1364/boe.5.000515 · Cited by 66 · see citing works
Near-infrared autofluorescence in thyroid and parathyroid surgery
Marco, A. N. D., & Palazzo, F. F. (2020) · Gland Surgery · doi:10.21037/gs.2020.01.04 · Cited by 66 · see citing works
Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) of Macular Pigment
Sauer, L., Andersen, K. M., Li, B., Gensure, R. H., Hammer, M., & Bernstein, P. S. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-23886 · Cited by 65 · see citing works
Near-infrared autofluorescence imaging of cutaneous melanins and human skin in vivo
Han, X., Lui, H., McLean, D. I., & Zeng, H. (2009) · Journal of Biomedical Optics · doi:10.1117/1.3103310 · Cited by 64 · see citing works
FLUORESCENCE MICROSCOPY IN BIOLOGY
Ellinger, P. (1940) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1940.tb00761.x · Cited by 61 · see citing works
Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy
Sauer, L., Andersen, K. M., Dysli, C., Zinkernagel, M. S., Bernstein, P. S., & Hammer, M. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.23.9.091415 · Cited by 61 · see citing works
Fluorescence lifetime in cardiovascular diagnostics
Marcu, L. (2010) · Journal of Biomedical Optics · doi:10.1117/1.3327279 · Cited by 60 · see citing works
Triplet Excited State Energies and Phosphorescence Spectra of (Bacterio)Chlorophylls
Hartzler, D. A., Niedzwiedzki, D. M., Bryant, D. A., Blankenship, R. E., Pushkar, Y., & Savikhin, S. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp500539w · Cited by 53 · see citing works
Grieve, K. F., Gofas-Salas, E., Ferguson, R. D., Sahel, J., Pâques, M., & Rossi, E. A. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.005946 · Cited by 50 · see citing works
Papayan, G. V., Петрищев, Н. Н., & Galagudza, M. M. (2014) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2014.05.003 · Cited by 49 · see citing works
Analysis of skin tissues spatial fluorescence distribution by the Monte Carlo simulation
Churmakov, D. Y., Meglinski, I. V., Piletsky, S. A., & Greenhalgh, D. A. (2003) · CERN Document Server (European Organization for Nuclear Research) · Cited by 49 · see citing works
Bhaumik, S., DePuy, J., & Klimash, J. W. (2007) · Lab Animal · doi:10.1038/laban0907-40 · Cited by 47 · see citing works
Non-invasive measurement of skin autofluorescence to evaluate diabetic complications
Yamanaka, M., Matsumura, T., Ohno, R.-I., Fujiwara, Y., Shinagawa, M., Sugawa, H., Hatano, K., Shirakawa, J., Kinoshita, H., Ito, K., et al. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-132 · Cited by 47 · see citing works
Analysis of skin tissues spatial fluorescence distribution by the Monte Carlo simulation
Churmakov, D. Y., Meglinski, I. V., Piletsky, S. A., & Greenhalgh, D. A. (2003) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/36/14/311 · Cited by 46 · see citing works
Autofluorescence of various rodent tissues and human skin tumour samples
Andersson, P. S., Kjellén, E., Montan, S., Svanberg, K., & Svanberg, S. R. (1987) · Lasers in Medical Science · doi:10.1007/bf02594130 · Cited by 45 · see citing works
Wang, S., Zhao, J., Lui, H., He, Q., & Zeng, H. (2012) · Skin Research and Technology · doi:10.1111/j.1600-0846.2012.00632.x · Cited by 45 · see citing works
Third therapeutic spectral window for deep tissue imaging
Sordillo, L. A., Pratavieira, S., Pu, Y., Salas-Ramirez, K. Y., Shi, L., Zhang, L., Budansky, Y., & Alfano, R. R. (2014) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2040604 · Cited by 42 · see citing works
Dowson, J. H., Armstrong, D., Koppang, N., Lake, B. D., & Jolly, R. D. (1982) · Acta Neuropathologica · doi:10.1007/bf00691656 · Cited by 42 · see citing works
Gillbro, T., Sundström, V., Sandström, Å., Spangfort, M. D., & Andersson, B. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80166-6 · Cited by 40 · see citing works
Shao, X., Zheng, W., & Huang, Z. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3589099 · Cited by 39 · see citing works
Müller, P. L., Birtel, J., Herrmann, P., Holz, F. G., Issa, P. C., & Gliem, M. (2019) · Translational Vision Science & Technology · doi:10.1167/tvst.8.6.46 · Cited by 37 · see citing works
Hu, J., Ortgies, D. H., Aguilar, R., Fernández, N., Porto, L. L., Rodríguez, E. M., García‐Solé, J., Jaque, D., Alfonso, F., & Rivero, F. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703276 · Cited by 36 · see citing works
Self-citationSafe delivery of optical power from space
Smith, M. R., Fork, R. L., & Cole, S. T. (2001) · Optics Express · doi:10.1364/oe.8.000537 · Cited by 35 · see citing works
How the melanin concentration in the skin affects the fluorescence-spectroscopy signal formation
Владимирович, Д. В., & Dunaev, A. (2016) · Journal of Optical Technology · doi:10.1364/jot.83.000043 · Cited by 35 · see citing works
Naturally-occurring porphyrins in a spontaneous-tumour bearing mouse model
Croce, A. C., Santamaria, G., Simone, U. D., Lucchini, F., Freitas, I., & Bottiroli, G. F. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00375a · Cited by 34 · see citing works
Autofluorescence Spectroscopy for Monitoring Metabolism in Animal Cells and Tissues
Croce, A. C., & Bottiroli, G. F. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6788-9_2 · Cited by 34 · see citing works
Cheng, S., Shen, B., Yuan, W., Zhou, X., Liu, Q., Kong, M., Shi, Y., Yang, P., Feng, W., & Li, F. (2019) · ACS Central Science · doi:10.1021/acscentsci.8b00763 · Cited by 32 · see citing works
Characterization of Retinitis Pigmentosa Using Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO)
Andersen, K. M., Sauer, L., Gensure, R. H., Hammer, M., & Bernstein, P. S. (2018) · Translational Vision Science & Technology · doi:10.1167/tvst.7.3.20 · Cited by 31 · see citing works
Heiferman, M. J., & Fawzi, A. A. (2016) · Retina · doi:10.1097/iae.0000000000001254 · Cited by 29 · see citing works
Near-Infrared Autofluorescence in Choroideremia: Anatomic and Functional Correlations
Birtel, J., Salvetti, A. P., Jolly, J. K., Xue, K., Gliem, M., Müller, P. L., Holz, F. G., MacLaren, R. E., & Issa, P. C. (2018) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2018.10.021 · Cited by 29 · see citing works
Optomechanical Time-Gated Fluorescence Imaging Using Long-Lived Silicon Quantum Dot Nanoparticles
Yang, W., Srivastava, P. K., Han, S., Jing, L., Tu, C., & Chen, S. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00517 · Cited by 29 · see citing works
A recipe for the preparation of a rodent food that eliminates chlorophyll-based tissue fluorescence
Holmes, H., Kennedy, J. C., Pottier, R., Rossi, F., & Weagle, G. E. (1995) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(95)90099-3 · Cited by 28 · see citing works
Schneckenburger, H., Koenig, K., Dienersberger, T., & Hahn, R. (1994) · Optical Engineering · doi:10.1117/12.177101 · Cited by 27 · see citing works
Biochemical sites of gene action for melanogenesis in mammals
Prota, G., & Searle, A. G. (1978) · Genetics Selection Evolution · doi:10.1186/1297-9686-10-1-1 · Cited by 26 · see citing works
Autofluorescence properties of skin and applications in dermatology
Zeng, H., McLean, D. I., MacAulay, C. E., & Lui, H. (2000) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.403940 · Cited by 26 · see citing works
Paavo, M., de Carvalho, J. R. L., Lee, W., Sengillo, J. D., Tsang, S. H., & Sparrow, J. R. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27366 · Cited by 25 · see citing works
Krasnovsky, А. А., & Kovalev, Y. V. (2014) · Biochemistry (Moscow) · doi:10.1134/s000629791404004x · Cited by 23 · see citing works
Bertrand, M.-J., Abran, M., Maafi, F., Busseuil, D., Merlet, N., Mihalache-Avram, T., Geoffroy, P., Tardif, P.-L., Abulrob, A., Arbabi‐Ghahroudi, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38970-4 · Cited by 22 · see citing works
Hammer, M., Sauer, L., Klemm, M., Peters, S., Schultz, R., & Haueisen, J. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.003078 · Cited by 21 · see citing works
Shao, X., Zheng, W., & Huang, Z. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.08.040 · Cited by 19 · see citing works
Surgical preparation of rats and mice for intravital microscopic imaging of abdominal organs
Rhodes, G. J. (2017) · Methods · doi:10.1016/j.ymeth.2017.07.003 · Cited by 19 · see citing works
Akbar, N., Sokolovski, S. G., Dunaev, A., Belch, J. J. F., Урихаевич, Р. Э., & Khan, F. (2014) · Journal of Microscopy · doi:10.1111/jmi.12135 · Cited by 18 · see citing works
Oh, J. K., Lima de Carvalho, J. R., Ryu, J., Tsang, S. H., & Sparrow, J. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-65763-x · Cited by 18 · see citing works
Dowson, J. H. (1983) · Acta Neuropathologica · doi:10.1007/bf00691985 · Cited by 14 · see citing works
The near‐infrared autofluorescence fingerprint of the brain
Lifante, J., del Rosal, B., Chaves‐Coira, I., Fernández, N., Jaque, D., & Ximendes, E. C. (2020) · Journal of Biophotonics · doi:10.1002/jbio.202000154 · Cited by 14 · see citing works
Self-citationMonte Carlo modeling of tissue autofluorescence measurement and imaging
Zeng, H., MacAulay, C. E., Palcic, B., & McLean, D. I. (1994) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.175985 · Cited by 12 · see citing works
Grain quality evaluation by computer vision
Jayas, D. S., & Singh, C. B. (2012) · Elsevier eBooks · doi:10.1533/9780857095770.3.400 · Cited by 12 · see citing works
Fluorescing fatty acids in rat fatty liver models
Croce, A. C., Ferrigno, A., Pasqua, L. G. D., Berardo, C., Mannucci, B., Bottiroli, G. F., & Vairetti, M. (2016) · Journal of Biophotonics · doi:10.1002/jbio.201600195 · Cited by 12 · see citing works
Autofluorescence imaging for recurrence detection in skin cancer postoperative scars
Tamošiūnas, M., Ploriņa, E. V., Lange, M., Derjabo, A., Kuzmina, I., Bļizņuks, D., & Spīgulis, J. (2020) · Journal of Biophotonics · doi:10.1002/jbio.201900162 · Cited by 12 · see citing works
In vivo autofluorescence spectrofluorometry of central serotonin
Crespi, F., Croce, A. C., Fiorani, S., Masala, B., Heidbreder, C. A., & Bottiroli, G. F. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.06.019 · Cited by 10 · see citing works
FLUORESCENCE MICROSCOPY AND THE LIVING CELL
Wittekind, D. H. (1964) · Journal of the Royal Microscopical Society · doi:10.1111/j.1365-2818.1964.tb00515.x · Cited by 7 · see citing works
Valor, A., Romeu, E. J. A., Escobedo, G., Campos-Espinosa, A., Romero-Bello, I. I., Moreno-González, J., Fabila-Bustos, D. A., Stolik, S., de la Rosa, J., & Guzmán, C. (2019) · Molecules · doi:10.3390/molecules24173150 · Cited by 7 · see citing works
NIR Autofluorescence: Molecular Origins and Emerging Clinical Applications
del Rosal, B., Thomas, G., Mahadevan-Jansen, A. M., & Stoddart, P. R. (2020) · Springer eBooks · doi:10.1007/978-3-030-32036-2_2 · Cited by 7 · see citing works
Optical Properties of Tissues in the Near Infrared: Their Relevance for Optical Bioimaging
Marcos-Vidal, A., Vaquero, J. J., & Ripoll, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-32036-2_1 · Cited by 6 · see citing works
Gutierrez‐Herrera, E., Sanchez-Perez, C. A., Pérez-García, A., Castañeda, M., Franco, W., & Hernández-Ruiz, J. (2020) · Journal of Fluorescence · doi:10.1007/s10895-019-02484-z · Cited by 3 · see citing works
Near Infrared-Emitting Bioprobes for Low-Autofluorescence Imaging Techniques
Ortgies, D. H., & Rodríguez, E. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-32036-2_9 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
3 of the 142 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Near-infrared luminescence high-contrast in vivo biomedical imaging
Chen, Y., Wang, S., & Zhang, F. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-022-00002-8 · Cited by 582 · see citing works
Luminescence based temperature bio-imaging: Status, challenges, and perspectives
Bednarkiewicz, A., Drabik, J., Trejgis, K., Jaque, D., Ximendes, E. C., & Marciniak, Ł. (2021) · Applied Physics Reviews · doi:10.1063/5.0030295 · Cited by 158 · see citing works
Self-citationChallenges for optical nanothermometry in biological environments
Quintanilla, M., Henriksen‐Lacey, M., Renero‐Lecuna, C., & Liz‐Marzán, L. M. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00069e · Cited by 126 · see citing works
Chen, Y., Spinelli, S., Gu, Z., & Pan, Z. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137473 · Cited by 48 · see citing works
Nanoparticles based image-guided thermal therapy and temperature feedback
Jacinto, C., Silva, W. F., Garcia, J., Zaragosa, G. P., Ilem, C. N. D., Sales, T. O., Santos, H. D. A., Conde, B. I. C., Barbosa, H. P., Malik, S., et al. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01416b · Cited by 22 · see citing works
Intraoperative ureter identification with a novel fluorescent catheter
Barberio, M., Al‐Taher, M., Felli, É., Ashoka, A. H., Marescaux, J., Klymchenko, A. S., & Diana, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-84121-z · Cited by 22 · see citing works
Bandyopadhyay, K., Singh, S., Chaturvedi, V. K., Singh, A. K., & Verma, A. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00911a · Cited by 23 · see citing works
Translational error in mice increases with ageing in an organ-dependent manner
Böttger, E. C., Kumar, H. S., Steiner, A. C., Sotirakis, E., Thiam, K., Isnard, P., Seebeck, P., Wolfer, D. P., Shcherbakov, D., & Akbergenov, R. (2025) · Nature Communications · doi:10.1038/s41467-025-57203-z · Cited by 20 · see citing works
Jafarzadeh, S., Bargahi, N., Shamloo, H. B., & Soleymani, J. (2022) · RSC Advances · doi:10.1039/d2ra00035k · Cited by 18 · see citing works
Ganegamage, S. K., & Heagy, M. D. (2022) · Current Organic Chemistry · doi:10.2174/1385272826666220811102939 · Cited by 17 · see citing works
Mohizin, A., Imran, J. H., Lee, K. S., & Kim, J. K. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00335-x · Cited by 15 · see citing works
Simultaneous visualization of multiple radionuclides in vivo
Yagishita, A., Takeda, S., Katsuragawa, M., Kawamura, T., Matsumura, H., Orita, T., Umeda, I. O., Yabu, G., Caradonna, P., Takahashi, T., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00866-6 · Cited by 12 · see citing works
The role of temperature in the photoluminescence quantum yield (PLQY) of Ag 2 S-based nanocrystals
Wang, P., Morales-Márquez, R., Cervás, G., Medel, A. H., Ogáyar, M. P., de Aberasturi, D. J., de Isidro, A., Torres‐Pardo, A., Palomares, F. J., Garcia‐Orrit, S., et al. (2024) · Materials Horizons · doi:10.1039/d4mh01016g · Cited by 10 · see citing works
Self-citationYao, J., López-Peña, G., Lifante, J., de la Cruz, M. D. C. I., Marin, R., Rodríguez, E. M., Jaque, D., & Ortgies, D. H. (2022) · Optical Materials X · doi:10.1016/j.omx.2022.100225 · Cited by 10 · see citing works
Self-citationNanoparticle-Based Techniques for Bladder Cancer Imaging: A Review
Boschi, F., & Malatesta, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043812 · Cited by 9 · see citing works
López-Peña, G., Simón‐Fuente, S., Ortgies, D. H., Molina, M. Á., Rodríguez, E. M., Sanz-Rodrı́guez, F., & Ribagorda, M. (2022) · Cancers · doi:10.3390/cancers15010102 · Cited by 8 · see citing works
Self-citationGerasimova, E. N., Cherednikova, A., Feoktistova, V. M., Fatkhutdinova, L. I., Feng, L., & Zyuzin, M. V. (2025) · Laser & Photonics Review · doi:10.1002/lpor.202500691 · Cited by 8 · see citing works
Lee, C., Park, D., Shiu, W.-T., Liu, Y., & Liu, L. (2025) · Nanomaterials · doi:10.3390/nano15030247 · Cited by 7 · see citing works
Organic radio-afterglow materials for cancer theranostics
Xiang, S., Ren, K., Li, X., Sun, W., Lin, K., & Peng, Z. (2025) · Materials Today · doi:10.1016/j.mattod.2025.08.037 · Cited by 6 · see citing works
Impact of e‐cigarette liquid on porcine lung tissue—Ex vivo confocal Raman micro‐spectroscopy study
Jaafar, A., Albarazanchi, A. K. H., Kadhim, M. J., Darvin, M. E., Váczi, T., Tuchin, V. V., & Vereš, M. (2023) · Journal of Biophotonics · doi:10.1002/jbio.202300336 · Cited by 6 · see citing works
Chen, Y., Spinelli, S., & Pan, Z. (2024) · Journal of Materials Chemistry C · doi:10.1039/d4tc01323a · Cited by 6 · see citing works
Dual-ratio approach for detection of point fluorophores in biological tissue
Blaney, G. P., Ivich, F., Sassaroli, A., Niedre, M. J., & Fantini, S. (2023) · Journal of Biomedical Optics · doi:10.1117/1.jbo.28.7.077001 · Cited by 6 · see citing works
Jiang, L., Chen, Z., & Fan, Y. (2024) · 化学学报 · doi:10.6023/a24070218 · Cited by 7 · see citing works
Biologically Synthesized Gold Nanoparticles as a Near-Infrared-Based Bioimaging Agent
Haque, S., & Patra, C. R. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0027 · Cited by 5 · see citing works
Telescope imaging beyond the Rayleigh limit in extremely low SNR
Choi, H., Choi, S., Menart, P., Deka, A., & Jacob, Z. (2024) · New Journal of Physics · doi:10.1088/1367-2630/ad6a7d · Cited by 4 · see citing works
Saul, J. M., Bohnert, J. S., O’Brien, M., Alnuaimi, S., Carnwath, T. P., Dunivan, Q., Coffin, D. W., & Smith, T. L. (2025) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00747-4 · Cited by 3 · see citing works
Orlova, A. V., Kozhevnikova, V. Y., Goloveshkin, A. S., Bolshakova, A. V., & Utochnikova, V. V. (2025) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.5c02305 · Cited by 3 · see citing works
Development of an NIR imaging technique in ex-vivo studies for needle-free jet injection systems
Majeed, A. M. A., Imran, J. H., & Kim, J. K. (2022) · doi:10.1117/12.2609152 · Cited by 3 · see citing works
Matsuda, T., Sakai, S., Okazaki, K.-I., & Nagai, T. (2024) · ACS Sensors · doi:10.1021/acssensors.3c02398 · Cited by 3 · see citing works
Khare, H. A., Bazban‐Shotorbani, S., Binderup, T., Kjær, A., & Kamaly, N. (2025) · Diagnostics · doi:10.3390/diagnostics15172140 · Cited by 2 · see citing works
Theranostic Nanoparticles in Cancer Diagnosis and Treatment
Maity, D., Sahoo, S. R., Tiwari, A., Ajith, S., & Saha, S. (2022) · Springer eBooks · doi:10.1007/978-3-031-09636-5_7 · Cited by 2 · see citing works
In Vivo Bioluminescence and Fluorescence Imaging: Optical Tool for Cancer Research
Lainšček, D., Golob-Urbanc, A., & Orehek, S. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3714-2_11 · Cited by 2 · see citing works
In vivo grading of lipids in fatty liver by near‐infrared autofluorescence and reflectance
Lifante, J., de la Fuente‐Fernández, M., Roman, M. N., Fernández, N., Jaque, D., Granado, M., & Ximendes, E. C. (2022) · Journal of Biophotonics · doi:10.1002/jbio.202200208 · Cited by 2 · see citing works
Self-citationIaboni, M., Coppo, A., Remotti, D., Queliti, R., Blasi, F., Bussi, S., Cabella, C., & Poggi, L. (2023) · Analytical Biochemistry · doi:10.1016/j.ab.2023.115251 · Cited by 2 · see citing works
Three-term conjugate gradient method for X-ray luminescence computed tomography
Hou, Y., Tang, Z., Yi, H., Guo, H., Yu, J., & He, X. (2021) · Journal of the Optical Society of America A · doi:10.1364/josaa.423149 · Cited by 2 · see citing works
Persistent Luminescence and in Vivo Bioimaging
Nath, S. G., & Anila, E. I. (2024) · Progress in optical science and photonics · doi:10.1007/978-981-97-4943-0_7 · Cited by 1 · see citing works
Camarero, P., López‐Méndez, R., Díez, D. L., Haro‐González, P., Cantelar, E., & Quintanilla, M. (2025) · Advanced Optical Materials · doi:10.1002/adom.202501200 · Cited by 1 · see citing works
Advances and Opportunities in NIR-II Endoscopy: From Diagnosis to Therapeutic Applications
Luo, J., Du, X., Wang, S., Yao, C., & Wang, J. (2026) · Diagnostics · doi:10.3390/diagnostics16070986 · Cited by 1 · see citing works
“KAITEKI” Society Illuminated by Near-Infrared Emission
AKIYAMA, S. (2022) · Journal of the Japan Society of Colour Material · doi:10.4011/shikizai.95.67
In Vivo Fluorescence Imaging and Its Role in Multimodal Bioimaging
Nath, S. G., & Anila, E. I. (2025) · Biological and medical physics, biomedical engineering · doi:10.1007/978-981-96-1124-9_2
Hori, S., Hayashi, H., Iwao, K., Nakamura, A., Sumiyoshi, H., Inagaki, Y., Ohtsuka, M., & Miura, H. (2025) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.25-0092
Optical and Photoacoustic Imaging
Napp, J., Markus, M. A., & Alves, F. (2026) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-032-15314-2_15
Park, D., Lee, B., Ma, J.-H., Kim, Y., Hwang, J. S., Lee, H. W., Yoo, M. H., Kim, U.-K., & Kwon, T.-J. (2026) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2026.100675
- Authors
- Lifante, J., Shen, Y., Ximendes, E., Martín Rodríguez, E., & Ortgies, D. H.
- Affiliations
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Universidad Autónoma de Madrid (ES)
- Nanobiology Group, Instituto Ramón y Cajal de Investigación Sanitaria 1 , IRYCIS, Ctra. Colmenar km. 9.100, 28034 Madrid, Spain
- Corresponding author
- Ortgies, Dirk H.
- Venue
- Journal of Applied Physics
- Publisher
- AIP Publishing
- Published
- 2020-11-04
- Volume
- 128
- Issue
- 17
- ISSN
- 0021-8979 (ISSN-L)
- 1089-7550
- OpenAlex
- W3094875912
- Cited by
- 43
- References
- 142
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 8 · 2023: 6 · 2022: 11 · 2021: 4
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Applied Physics (publishedVersion, cc-by)
- Biblos-e Archivo (Universidad Autónoma de Madrid) (publishedVersion)
- Hispana (submittedVersion)
- Funders
- Horizon 2020 Framework Programme - FET Open (NanoTBTech)
- Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal (IMP18_38(2018/0265))
- European Cooperation in Science and Technology (CA17140)
- Ministerio de Economía, Industria y Competitividad, Gobierno de España (MAT2016-75362-C3-1-R)
- Comunidad de Madrid (B2017/BMD-3867RENIMCM)
- Ministerio de Ciencia, Innovación y Universidades (PID2019-106211RB-I00, FJC2018-036734-I)
- Instituto de Salud Carlos III (PI16/00812, PI19/00565, CD17/00210)
- China Scholarship Council (201806870023)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Keywords
- tissue fluorescence, near-infrared autofluorescence, endogenous fluorophores, biological window, excitation light, infrared imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review