Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 523

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Major events in the genome evolution of vertebrates: Paranome age and size differ considerably between ray-finned fishes and land vertebrates

Open access
Vandepoele, Klaas, De Vos, Wouter, Taylor, John S., Meyer, Axel, Van de Peer, Yves·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0307968100
Open this paper in CoChat — free account

Abstract

It has been suggested that fish have more genes than humans. Whether most of these additional genes originated through a complete (fish-specific) genome duplication or through many lineage-specific tandem gene or smaller block duplications and family expansions continues to be debated. We analyzed the complete genome of the pufferfish Takifugu rubripes (Fugu) and compared it with the paranome of humans. We show that most paralogous genes of Fugu are the result of three complete genome duplications. Both relative and absolute dating of the complete predicted set of protein-coding genes suggest that initial genome duplications, estimated to have occurred at least 600 million years ago, shaped the genome of all vertebrates. In addition, analysis of >150 block duplications in the Fugu genome clearly supports a fish-specific genome duplication (≈320 million years ago) that coincided with the vast radiation of most modern ray-finned fishes. Unlike the human genome, Fugu contains very few recently duplicated genes; hence, many human genes are much younger than fish genes. This lack of recent gene duplication, or, alternatively, the accelerated rate of gene loss, is possibly one reason for the drastic reduction of the genome size of Fugu observed during the past 100 million years or so, subsequent to the additional genome duplication that ray-finned fishes but not land vertebrates experienced.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.0307968100

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 4 references

Research works printed but not linked: 46

  1. Ohno S. (1970) Evolution by Gene Duplication (Springer New York). · DOI · Paper page
  2. 10.1242/dev.1994.Supplement.125 · DOI · Paper page
  3. Garcia-Fernandez, J. & Holland, P. W. (1996) Int. J. Dev. Biol. 1996, Suppl. 1, 71S-72S.
  4. 10.1016/S0960-9822(06)00284-3 · DOI
  5. 10.1038/ng855 · DOI · Paper page
  6. 10.1023/A:1022600813840 · DOI
  7. 10.1101/gr.874803 · DOI · Paper page
  8. 10.1101/gr.200601 · DOI · Paper page
  9. 10.1007/PL00006499 · DOI · Paper page
  10. 10.1098/rstb.2001.1035 · DOI · Paper page
  11. 10.1101/gr.445702 · DOI
  12. 10.1023/A:1022640512023 · DOI
  13. 10.1093/oxfordjournals.molbev.a003723 · DOI
  14. 10.1101/gr.160001 · DOI
  15. 10.1093/molbev/msg017 · DOI
  16. 10.1038/366265a0 · DOI · Paper page
  17. 10.1126/science.282.5394.1711 · DOI · Paper page
  18. 10.1093/genetics/154.4.1773 · DOI · Paper page
  19. Málaga-Trillo, E. & Meyer, A (2001) Am. Zool. 41, 676-686.
  20. 10.1101/gr.164800 · DOI · Paper page
  21. 10.1101/gr.164600 · doi:10.1101/gr.164600
  22. 10.1101/gr.221802 · DOI
  23. 10.1101/gr.9.10.960 · DOI
  24. 10.1101/gr.640303 · DOI · Paper page
  25. 10.1098/rstb.2001.0975 · DOI · Paper page
  26. 10.1002/(SICI)1521-1878(199806)20:6<511::AID-BIES10>3.0.CO;2-3 · DOI · Paper page
  27. 10.1016/S0955-0674(99)00039-3 · DOI · Paper page
  28. 10.1126/science.1072104 · DOI · Paper page
  29. 10.1016/S0960-9822(01)00280-9 · DOI
  30. 10.1101/gr.165601 · DOI · Paper page
  31. 10.1038/35057039 · DOI · Paper page
  32. Takezaki, N., Rzhetsky, A. & Nei, M. (1995) Mol. Biol. Evol. 12, 823-833.7476128
  33. 10.1007/BF02101113 · DOI · Paper page
  34. 10.1038/17594 · DOI · Paper page
  35. Schultze H.-P. & Cumbaa S. L. (2001) in Major Events in Early Vertebrate Evolution ed. Ahlberg P. E. (Taylor and Francis London) pp. 315-332.
  36. 10.1038/nature00871 · DOI
  37. 10.1016/S0168-9525(03)00053-2 · DOI · Paper page
  38. 10.1101/gr.400202 · DOI
  39. 10.1073/pnas.212522399 · DOI · Paper page
  40. 10.1105/tpc.014019 · DOI · Paper page
  41. Carrol R. L. (1997) Patterns and Processes of Vertebrate Evolution (Cambridge Univ. Press Cambridge U.K.).
  42. 10.1016/S0014-5793(96)01351-8 · DOI · Paper page
  43. 10.1101/gr.841703 · DOI
  44. 10.1016/S0168-9525(01)02492-1 · DOI · Paper page
  45. 10.1126/science.1072047 · DOI · Paper page
  46. 10.1016/S0959-437X(98)80039-7 · DOI · Paper page

Cited by

See all 523

Metadata

Authors
Vandepoele, K., De Vos, W., Taylor, J. S., Meyer, A., & Van de Peer, Y.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2004-02-02
Volume
101
Issue
6
Pages
1638-1643
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0307968100
OpenAlex
W2128983351
Cited by
523
References
4
FWCI
56.23
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Major events in the genome evolution of vertebrates: Paranome age and size differ considerably between ray-finned fishes and land vertebrates. https://app.cochat.ai/papers/10.1073/pnas.0307968100
The paper
Vandepoele, K., De Vos, W., Taylor, J. S., Meyer, A., & Van de Peer, Y. (2004). Major events in the genome evolution of vertebrates: Paranome age and size differ considerably between ray-finned fishes and land vertebrates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307968100

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.