The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
Open accessAbstract
Calorie restriction can extend life span in a variety of species including mammals, flies, nematodes, and yeast. Despite the importance of this nearly universal effect, little is understood about the molecular mechanisms that mediate the life-span-extending effect of calorie restriction in metazoans. Sir2 is known to be involved in life span determination and calorie restriction in yeast mother cells. In nematodes increased Sir2 can extend life span, but a direct link to calorie restriction has not been demonstrated. We now report that Sir2 is directly involved in the calorie-restriction life-span-extending pathway in Drosophila . We demonstrate that an increase in Drosophila Sir2 (dSir2) extends life span, whereas a decrease in dSir2 blocks the life-span-extending effect of calorie reduction or rpd3 mutations. These data lead us to propose a genetic pathway by which calorie restriction extends life span and provides a framework for genetic and pharmacological studies of life span extension in metazoans.
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“and subsequent reports indicated that enhanced expression of the worm (sir-2.1) and fly (dSir2) orthologs could extend lifespan in both invertebrate model systems (Rogina and Helfand, 2004; Tissenbaum and Guarente, 2001).”
From The Hallmarks of Aging (2013) · cites this paper as Rogina and Helfand, 2004
In the citing paper
“Homologues of Sir2 (called sirtuins) have subsequently been shown to mediate some of the effects of caloric restriction in flies (82) and mammals (83,84).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [82]
In the citing paper
“Strikingly, overexpression or pharmacologic activation of Sir2 in worms and flies also extends life span (Rogina and Helfand, 2004; Tissenbaum and Guarente, 2001; Wood et al., 2004”
From DNA Repair, Genome Stability, and Aging (2005) · cites this paper as Rogina and Helfand, 2004
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Metadata
- Authors
- Rogina, B., & Helfand, S. L.
- Affiliations
- UConn Health (US)
- Corresponding author
- Helfand, Stephen L.
- ORCID
- Rogina, Blanka
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-11
- Volume
- 101
- Issue
- 45
- Pages
- 15998-16003
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC528752
- OpenAlex
- W1997145913
- Cited by
- 1,361
- References
- 35
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 30 · 2023: 30 · 2022: 39 · 2021: 42 · 2020: 42 · 2019: 55 · 2018: 78 · 2017: 55 · 2016: 73 · 2015: 79 · 2014: 56 · 2013: 89 · 2012: 75
- FWCI
- 21.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ellison Medical Foundation
- Patrick and Catherine Weldon Donaghue Medical Research Foundation
- Yale University
- Hospital for Sick Children
- Stockholms Universitet
- National Institutes of Health (5r03es011463-02)
- National Institute on Aging (AG 23088, RF1AG024353, AG16667, R03AG020816, R01AG023088, R01AG016667, R37AG016667, AG20816)
- National Institute of Environmental Health Sciences (ES11463)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Sir2, sirtuins, caloric restriction, lifespan extension, longevity, Drosophila, Rpd3, sirtuin deacetylase, aging, gene pathways
- MeSH terms
- Animals, Drosophila melanogaster, Female, Histone Deacetylases, Longevity, Male, Models, Biological, Mutation, Repressor Proteins, Transcription Factors, Gene Expression, Genes, Insect, Drosophila Proteins, Caloric Restriction, Sirtuins, Histone Deacetylase 1
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