The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1
Open accessAbstract
Cortical DNA-methyltransferase 1 (DNMT1) is preferentially expressed in interneurons secreting GABA where it very likely contributes to promoter CpG island hypermethylation, thus causing a down-regulation of promoter functions. To consolidate and expand on previous findings that, in the cortex of schizophrenia (SZ) brains, glutamic acid decarboxylase 67 (GAD 67 ) expression is down-regulated whereas that of DNMT1 is up-regulated, we studied both parameters in Brodmann's area (BA) 9 from the McLean 66 Cohort Collection (Harvard Brain Tissue Resource Center, Belmont, MA). In BA9 of SZ and bipolar disorder patients with psychosis, DNMT1 mRNA and protein expression preferentially increases in layer I, II, and IV interneurons, and this increase is paralleled by a decreased number of GAD 67 mRNA-positive neurons. The increase in DNMT1 and the decrease in GAD 67 -expressing neurons were unrelated to postmortem interval, pH, RNA quality, or to the presence, dose, or duration of antipsychotic (APS) medication, with the exception of a subgroup of SZ patients treated with a combination of valproate and APS in which the expression of DNMT1 failed to change. The DNMT1 increase and the GAD 67 decrease in BA9 interneurons are significant features of SZ and bipolar disorder with psychosis. Interestingly, the DNMT1 increase failed to occur when patients with psychosis received a combination of valproate and APS treatment but not APS monotherapy.
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Valproate Induces Replication-independent Active DNA Demethylation
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Global DNA Hypermethylation in Down Syndrome Placenta
Jin, S., Lee, Y. K., Lim, Y. C., Zheng, Z., Lin, X. M., Ng, D. P. Y., Holbrook, J. D., Law, H. Y., Kwek, K. Y. C., Yeo, G. S. H., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003515 · Cited by 99
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Metadata
- Authors
- Veldic, M., Guidotti, A., Maloku, E., Davis, J. M., & Costa, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-01-31
- Volume
- 102
- Issue
- 6
- Pages
- 2152-2157
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2144291844
- Cited by
- 268
- References
- 5
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- green
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