Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1× · see citing works

Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse

Bernstein, B., Kamal, M., Lindblad‐Toh, K., Bekiranov, S., Bailey, D. K., Huebert, D. J., McMahon, S., Karlsson, E. K., Kulbokas, E. J., Gingeras, T., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.001 · Cited by 1,509 · see citing works

Epigenetic regulation in psychiatric disorders

Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works

MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

Milne, T. A., Briggs, S. D., Brock, H. W., Martin, M. E., Gibbs, D. Y., Allis, C. D., & Hess, J. L. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00741-4 · Cited by 1,051 · see citing works

Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works

Altered Hox expression and segmental identity in Mll-mutant mice

Yu, B., Hess, J. L., Horning, S. E., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Nature · doi:10.1038/378505a0 · Cited by 872 · see citing works

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Schneider, R., Bannister, A. J., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2003) · Nature Cell Biology · doi:10.1038/ncb1076 · Cited by 792 · see citing works

Histone lysine methylation: a signature for chromatin function

Sims, R. J., Nishioka, K., & Reinberg, D. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.09.007 · Cited by 684 · see citing works

The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches

Lieberman, J. A., Perkins, D. O., Belger, A., Chakos, M., Jarskog, F., Boteva, K., & Gilmore, J. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01303-8 · Cited by 593 · see citing works

Reelin promoter hypermethylation in schizophrenia

Grayson, D. R., Jia, X., Chen, Y., Sharma, R. P., Mitchell, C. P., Guidotti, A., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503736102 · Cited by 553 · see citing works

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Tahiliani, M., Mei, P., Fang, R., Leonor, T., Rutenberg, M. S., Shimizu, F., Li, J., Rao, A., & Shi, Y. G. (2007) · Nature · doi:10.1038/nature05823 · Cited by 429 · see citing works

Global and Hox-specific roles for the MLL1 methyltransferase

Guenther, M. G., Jenner, R. G., Chevalier, B. S., Nakamura, T., Croce, C. M., Canaani, E., & Young, R. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503072102 · Cited by 357 · see citing works

Differential Hippocampal Expression of Glutamic Acid Decarboxylase 65 and 67 Messenger RNA in Bipolar Disorder and Schizophrenia

Heckers, S., Stone, D., Walsh, J., Shick, J., Koul, P., & Benes, F. M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.6.521 · Cited by 322 · see citing works

Pathophysiologically based treatment interventions in schizophrenia

Lewis, D. A., & González‐Burgos, G. (2006) · Nature Medicine · doi:10.1038/nm1478 · Cited by 320 · see citing works

Tails of Intrigue

Hampsey, M., & Reinberg, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00360-x · Cited by 309 · see citing works

MLL, a mammalian trithorax- group gene, functions as a transcriptional maintenance factor in morphogenesis

Yu, B., Hanson, R. D., Hess, J. L., Horning, S. E., & Korsmeyer, S. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10632 · Cited by 302 · see citing works

Critical Factors in Gene Expression in Postmortem Human Brain: Focus on Studies in Schizophrenia

Lipska, B. K., Deep‐Soboslay, A., Weickert, C. S., Hyde, T. M., Martin, C. E., Herman, M. M., & Kleinman, J. E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.019 · Cited by 281 · see citing works

Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

Straub, R. E., Lipska, B. K., Egan, M. F., Goldberg, T. E., Callicott, J. H., Mayhew, M. B., Vakkalanka, R., Kolachana, B. S., Kleinman, J. E., & Weinberger, D. R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001988 · Cited by 275 · see citing works

In psychosis, cortical interneurons overexpress DNA-methyltransferase 1

Veldić, M., Guidotti, A., Maloku, E., Davis, J. M., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409665102 · Cited by 269 · see citing works

Immunoprecipitation of native chromatin: NChIP.

O'Neill, L., & Turner, B. (2003) · Methods · doi:10.1016/s1046-2023(03)00090-2 · Cited by 239 · see citing works

MLL associates specifically with a subset of transcriptionally active target genes

Milne, T. A., Dou, Y., Martin, M. E., Brock, H. W., Roeder, R. G., & Hess, J. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503630102 · Cited by 230 · see citing works

The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis

Petronis, A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.005 · Cited by 225 · see citing works

GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia

Huang, H., & Akbarian, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000809 · Cited by 223 · see citing works

Methylomics in psychiatry: Modulation of gene–environment interactions may be through DNA methylation

Abdolmaleky, H. M., Smith, C. L., Faraone, S. V., Shafa, R., Stone, W., Glatt, S. J., & Tsuang, M. T. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20142 · Cited by 216 · see citing works

GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss

Addington, A. M., Gornick, M., Duckworth, J., Sporn, A. L., Gogtay, N., Bobb, A., GREENSTEIN, D. K., Lenane, M., Gochman, P., Baker, N., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001599 · Cited by 207 · see citing works

What's atypical about atypical antipsychotic drugs?

Meltzer, H. Y. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.09.010 · Cited by 199 · see citing works

Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism

Hettema, J. M., An, S., Neale, M. C., Bukszár, J., van den Oord, E. J. C. G., Kendler, K. S., & Chen, X. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001845 · Cited by 175 · see citing works

The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells

Laeng, P., Pitts, R. L., Lemire, A. L., Drabik, C. E., Weiner, A., Tang, H., Thyagarajan, R., Mallon, B. S., & Altar, C. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02725.x · Cited by 169 · see citing works

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

Yokoyama, A., Kitabayashi, I., Ayton, P. M., Cleary, M. L., & Ohki, M. (2002) · Blood · doi:10.1182/blood-2002-04-1015 · Cited by 161 · see citing works

Chromatin Alterations Associated With Down-regulated Metabolic Gene Expression in the Prefrontal Cortex of Subjects With Schizophrenia

Akbarian, S., Ruehl, M. G., Bliven, E. E., Luiz, L. A., Peranelli, A. C., Baker, S. P., Roberts, R. C., Bunney, W. E., Conley, R. C., Jones, E. G., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.8.829 · Cited by 140 · see citing works

Erratum: Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism

Hettema, J. M., An, S., Neale, M. C., Bukszár, J., van den Oord, E. J. C. G., Kendler, K. S., & Chen, X.-X. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001858 · Cited by 137 · see citing works

Activity-dependent Changes in GAD and Preprotachykinin mRNAs in Visual Cortex of Adult Monkeys

Benson, D. L., Huntsman, M. M., & Jones, E. G. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.1.40 · Cited by 133 · see citing works

Neural Cell Adhesion Molecule-Secreting Transgenic Mice Display Abnormalities in GABAergic Interneurons and Alterations in Behavior

Pillai-Nair, N., Panicker, A. K., Rodriguiz, R. M., Gilmore, K. L., Demyanenko, G. P., Huang, Z. J., Wetsel, W. C., & Maness, P. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0565-05.2005 · Cited by 125 · see citing works

Postnatal Development of Prefrontal Inhibitory Circuits and the Pathophysiology of Cognitive Dysfunction in Schizophrenia

Lewis, D. A., Cruz, D. A., Eggan, S. M., & Erickson, S. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.008 · Cited by 121 · see citing works

Mice Lacking Dopamine D2and D3Receptors Have Spatial Working Memory Deficits

Glickstein, S. B., Hof, P. R., & Schmauss, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05619.2002 · Cited by 119 · see citing works

Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs

Lipska, B. K., Lerman, D. N., Khaing, Z. Z., Weickert, C. S., & Weinberger, D. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02738.x · Cited by 104 · see citing works

Chromatin immunoprecipitation in postmortem brain

Huang, H., Matevossian, A., Jiang, Y. P., & Akbarian, S. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.02.018 · Cited by 96 · see citing works

Developmental Regulation of Eed Complex Composition Governs a Switch in Global Histone Modification in Brain

Kim, S. Y., Levenson, J. M., Korsmeyer, S. J., Sweatt, J. D., & Schumacher, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608722200 · Cited by 71 · see citing works

Leaving a mark: the many footprints of the elongating RNA polymerase II

Eissenberg, J. C., & Shilatifard, A. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.02.004 · Cited by 66 · see citing works

Differential effects of long-term treatment with clozapine or haloperidol on GABAA receptor binding and GAD67 expression

Zink, M., Schmitt, A., May, B., Müller, B., Demirakça, T., Braus, D. F., & Henn, F. A. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00088-4 · Cited by 61 · see citing works

Mutational screening and association study of glutamate decarboxylase 1 as a candidate susceptibility gene for bipolar affective disorder and schizophrenia

Lundorf, M. D., Buttenschøn, H. N., Foldager, L., Blackwood, D. H. R., Muir, W. J., Murray, V., Pelosi, A. J., Kruse, T. A., Ewald, H., & Mors, O. N. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30137 · Cited by 53 · see citing works

The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex

Chertkow, Y., Weinreb, O., Youdim, M. B. H., & Silver, H. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005626 · Cited by 39 · see citing works

Acute Clozapine Suppresses Synchronized Pyramidal Synaptic Network Activity by Increasing Inhibition in the Ferret Prefrontal Cortex

Gao, W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00400.2006 · Cited by 24 · see citing works

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) · Nature Neuroscience · doi:10.1038/nn.3922 · Cited by 755 · see citing works

GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia

González‐Burgos, G., & Lewis, D. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn070 · Cited by 568 · see citing works

Histone Methylation Regulates Memory Formation

Gupta, S., Kim, S. Y., Artis, S., Molfese, D. L., Schumacher, A., Sweatt, J. D., Paylor, R. E., & Lubin, F. D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3732-09.2010 · Cited by 562 · see citing works

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

Abel, T. G., & Zukin, R. S. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.002 · Cited by 495 · see citing works

Epigenetic basis of mental illness

Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342 · see citing works

Expression of GABA Signaling Molecules KCC2, NKCC1, and GAD1 in Cortical Development and Schizophrenia

Hyde, T. M., Lipska, B. K., Ali, T., Mathew, S., Law, A. J., Metitiri, O. E., Straub, R. E., Ye, T., Colantuoni, C., Herman, M. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1234-11.2011 · Cited by 325 · see citing works

The role of histone modifications: from neurodevelopment to neurodiseases

Park, J., Lee, K., Kim, K., & Yi, S.-J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01078-9 · Cited by 321 · see citing works

Epigenetic principles and mechanisms underlying nervous system functions in health and disease

Mehler, M. F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.10.001 · Cited by 292 · see citing works

Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation

Dong, E., Nelson, M., Grayson, D. R., Costa, E., & Guidotti, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805493105 · Cited by 284 · see citing works

A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex

Mellios, N., Huang, H.-S., Grigorenko, A., Rogaev, E., & Akbarian, S. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn201 · Cited by 239 · see citing works

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

Grayson, D. R., & Guidotti, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.125 · Cited by 267 · see citing works

Molecular Determinants of Dysregulated GABAergic Gene Expression in the Prefrontal Cortex of Subjects with Schizophrenia

Mellios, N., Huang, H.-S., Baker, S. P., Galdzicka, M., Ginns, E., & Akbarian, S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.019 · Cited by 266 · see citing works

Alterations of cortical GABA neurons and network oscillations in schizophrenia

Gonzalez-Burgos, G., Hashimoto, T., & Lewis, D. A. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0124-8 · Cited by 260 · see citing works

GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia

González‐Burgos, G., Fish, K. N., & Lewis, D. A. (2011) · Neural Plasticity · doi:10.1155/2011/723184 · Cited by 244 · see citing works

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

Cheung, I., Shulha, H. P., Jiang, Y., Matevossian, A., Wang, J., Weng, Z., & Akbarian, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001702107 · Cited by 235 · see citing works

An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy

Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229 · see citing works

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

Guidotti, A., Auta, J., Chen, Y., Davis, J. M., Dong, E., Gavin, D. P., Grayson, D. R., Matrisciano, F., Pinna, G., Satta, R., et al. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.021 · Cited by 220 · see citing works

Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders

Ramazi, S., Allahverdi, A., & Zahiri, J. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00099-2 · Cited by 219 · see citing works

Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects

Hurd, Y. L., Manzoni, O. J., Pletnikov, M. V., Lee, F. S., Bhattacharyya, S., & Melis, M. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1165-19.2019 · Cited by 218 · see citing works

Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia

Lewis, D. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.003 · Cited by 217 · see citing works

Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene

Takata, A., Xu, B., Ionita-Laza, I., Roos, J. L., Gogos, J. A., & Karayiorgou, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.043 · Cited by 204 · see citing works

Epigenetic Regulation in Human Brain—Focus on Histone Lysine Methylation

Akbarian, S., & Huang, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.015 · Cited by 214 · see citing works

Epigenetics in the Nervous System: Figure 1.

Jiang, Y., Langley, B. C., Lubin, F. D., Renthal, W. R., Wood, M. A., Yasui, D. H., Kumar, A., Nestler, E. J., Akbarian, S., & Beckel-Mitchener, A. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3797-08.2008 · Cited by 214 · see citing works

Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions

Fukuchi, M., Nii, T., Ishimaru, N., Minamino, A., Hara, D., Takasaki, I., Tabuchi, A., & Tsuda, M. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.05.002 · Cited by 202 · see citing works

Epigenetic Signatures of Autism: Trimethylated H3K4 Landscapes in Prefrontal Neurons

Shulha, H. P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.151 · Cited by 196 · see citing works

Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Richetto, J., & Meyer, U. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.03.008 · Cited by 183 · see citing works

Isolation of neuronal chromatin from brain tissue

Jiang, Y., Matevossian, A., Huang, H.-S., Straubhaar, J., & Akbarian, S. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-42 · Cited by 193 · see citing works

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0601-3 · Cited by 168 · see citing works

Epigenetic mechanisms in schizophrenia

Roth, T. L., Lubin, F. D., Sodhi, M., & Kleinman, J. E. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.009 · Cited by 168 · see citing works

The regulation of glutamic acid decarboxylases in GABA neurotransmission in the brain

Lee, S. E., Lee, Y., & Lee, G. H. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01196-z · Cited by 171 · see citing works

Regulation of histone H3K4 methylation in brain development and disease

Shen, E., Shulha, H. P., Weng, Z., & Akbarian, S. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0514 · Cited by 165 · see citing works

Epigenetic dysregulation in cognitive disorders

Gräff, J., & Mansuy, I. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06787.x · Cited by 163 · see citing works

Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory

Jakovcevski, M., Ruan, H., Shen, E. Y., Dincer, A., Javidfar, B., Ma, Q., Peter, C., Cheung, I. K., Mitchell, A., Jiang, Y., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3004-14.2015 · Cited by 138 · see citing works

GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia

Xu, M., & Wong, A. H. C. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.172 · Cited by 159 · see citing works

Deficits in Transcriptional Regulators of Cortical Parvalbumin Neurons in Schizophrenia

Volk, D. W., Matsubara, T., Li, S., Sengupta, E. J., Георгиев, Д., Minabe, Y., Sampson, A. R., Hashimoto, T., & Lewis, D. A. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12030305 · Cited by 155 · see citing works

Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects

Glausier, J. R., Fish, K. N., & Lewis, D. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.152 · Cited by 147 · see citing works

The Reelin and GAD67 Promoters Are Activated by Epigenetic Drugs That Facilitate the Disruption of Local Repressor Complexes

Kundaković, M., Chen, Y., Guidotti, A., & Grayson, D. R. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051763 · Cited by 149 · see citing works

Altered Cortical Expression of GABA-Related Genes in Schizophrenia: Illness Progression vs Developmental Disturbance

Hoftman, G. D., Volk, D. W., Bazmi, H. H., Li, S., Sampson, A. R., & Lewis, D. A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt178 · Cited by 146 · see citing works

Neuroprogression in schizophrenia: Pathways underpinning clinical staging and therapeutic corollaries

Davis, J., Moylan, S., Harvey, B. H., Maes, M. H. J., & Berk, M. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414533012 · Cited by 147 · see citing works

Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain

Ratnu, V. S., Emami, M. R., & Bredy, T. W. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23886 · Cited by 144 · see citing works

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

Delgado‐Morales, R., Agís‐Balboa, R. C., Esteller, M., & Berdasco, M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0365-z · Cited by 143 · see citing works

Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons

Miller, M. L., Chadwick, B., Dickstein, D. L., Purushothaman, I., Egervari, G., Rahman, T., Tessereau, C., Hof, P. R., Roussos, P., Shen, L., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0243-x · Cited by 134 · see citing works

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

Perišić, T., Zimmermann, N., Kirmeier, T., Asmus, M., Tuorto, F., Uhr, M., Holsboer, F., Rein, T., & Zschocke, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.188 · Cited by 133 · see citing works

Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics

Lally, J., Gaughran, F., Timms, P. W., & Curran, S. R. (2016) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s115741 · Cited by 131 · see citing works

Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling

Guidotti, A., Dong, E., Kundakovic, M., Satta, R., Grayson, D. R., & Costa, E. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.010 · Cited by 130 · see citing works

Histone modifications, DNA methylation, and Schizophrenia

Gavin, D. P., & Sharma, R. P. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.010 · Cited by 121 · see citing works

Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B

Jiang, Y., Jakovcevski, M., Bharadwaj, R., Connor, C., Schroeder, F. A., Lin, C. L., Straubhaar, J., Martin, G., & Akbarian, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1314-10.2010 · Cited by 118 · see citing works

Epigenetics-beyond the genome in alcoholism.

Starkman, B. G., Sakharkar, A. J., & Pandey, S. C. (2012) · Europe PMC (PubMed Central) · Cited by 118 · see citing works

Epigenetic approaches to psychiatric disorders

Ptak, C., & Petronis, A. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.1/cptak · Cited by 118 · see citing works

Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia

Hoftman, G. D., Datta, D., & Lewis, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.022 · Cited by 109 · see citing works

Balancing histone methylation activities in psychiatric disorders

Peter, C. J., & Akbarian, S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.003 · Cited by 110 · see citing works

Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers

Khavari, B., & Cairns, M. J. (2020) · Cells · doi:10.3390/cells9081837 · Cited by 106 · see citing works

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

Gavin, D. P., Sharma, R. P., Chase, K. A., Matrisciano, F., Dong, E., & Guidotti, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.221 · Cited by 104 · see citing works

Epigenetics of major psychosis: progress, problems and perspectives

Labrie, V., Pai, S., & Petronis, A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.04.002 · Cited by 102 · see citing works

Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid–Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder

Ruzicka, W. B., Subburaju, S., & Benes, F. M. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.49 · Cited by 101 · see citing works

Genetics of Eating Disorders

Bulik, C. M., Blake, L. E., & Austin, J. (2019) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.10.007 · Cited by 117 · see citing works

Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome

Connor, C., Dincer, A., Straubhaar, J., Galler, J. R., Houston, I. B., & Akbarian, S. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.037 · Cited by 100 · see citing works

Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

Scuto, M. C., Rampulla, F., Reali, G. M., Spanò, S. M., Salinaro, A. T., & Calabrese, V. (2024) · Antioxidants · doi:10.3390/antiox13040484 · Cited by 98 · see citing works

Epigenetic impacts of endocrine disruptors in the brain

Walker, D. M., & Gore, A. C. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.09.002 · Cited by 94 · see citing works

NMDA receptor hypofunction for schizophrenia revisited: Perspectives from epigenetic mechanisms

Snyder, M. A., & Gao, W. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.03.010 · Cited by 93 · see citing works

White matter neuron alterations in schizophrenia and related disorders

Connor, C., Crawford, B. C., & Akbarian, S. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.07.236 · Cited by 92 · see citing works

Epigenetic Determinants of Healthy and Diseased Brain Aging and Cognition

Akbarian, S., Beeri, M. S., & Haroutunian, V. H. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1459 · Cited by 93 · see citing works

Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

Marinova, Z., Leng, Y., Leeds, P. R., & Chuang, D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.022 · Cited by 91 · see citing works

Epigenetic Impacts on Neurodevelopment: Pathophysiological Mechanisms and Genetic Modes of Action

Zahir, F., & Brown, C. J. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318213565e · Cited by 93 · see citing works

Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268

Kimoto, S., Bazmi, H. H., & Lewis, D. A. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010004 · Cited by 91 · see citing works

Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice

Shen, E., Ahern, T. H., Cheung, I. K., Straubhaar, J., Dincer, A., Houston, I. B., Vries, G. J. D., Akbarian, S., & Forger, N. G. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.006 · Cited by 91 · see citing works

DNA methylation in schizophrenia: progress and challenges of epigenetic studies

Nishioka, M., Bundo, M., Kasai, K., & Iwamoto, K. (2012) · Genome Medicine · doi:10.1186/gm397 · Cited by 90 · see citing works

Current status and future prospects for epigenetic psychopharmacology

Boks, M. P., de Jong, N. M., Kas, M. J. H., Vinkers, C. H., Fernandes, C., Kahn, R. S., Mill, J., & Ophoff, R. A. (2012) · Epigenetics · doi:10.4161/epi.7.1.18688 · Cited by 89 · see citing works

Methamphetamine-Associated Memory Is Regulated by a Writer and an Eraser of Permissive Histone Methylation

Aguilar‐Valles, A., Vaissière, T., Griggs, E. M., Mikaelsson, M. A., Takács, I. F., Young, E. J., Rumbaugh, G., & Miller, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.014 · Cited by 89 · see citing works

Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia

Jiang, Z., Cowell, R. M., & Nakazawa, K. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00116 · Cited by 89 · see citing works

Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia

Kano, S., Colantuoni, C., Han, F., Zhou, Z., Yuan, Q., Wilson, A., Takayanagi, Y., Lee, Y., Rapoport, J. L., Eaton, W. W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.120 · Cited by 88 · see citing works

Translational potential of olfactory mucosa for the study of neuropsychiatric illness

Borgmann‐Winter, K. E., Willard, S. L., Sinclair, D., Mirza, N. A., Turetsky, B. I., Berretta, S., & Hahn, C.-G. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.141 · Cited by 89 · see citing works

Delays in GABAergic interneuron development and behavioral inhibition after prenatal stress

Lussier, S. J., & Stevens, H. E. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22376 · Cited by 89 · see citing works

Epigenetic mechanisms in schizophrenia

Akbarian, S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/sakbarian · Cited by 89 · see citing works

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities

Nagahama, K., Sakoori, K., Watanabe, T., Kishi, Y., Kawaji, K., Koebis, M., Nakao, K., Gotoh, Y., Aiba, A., Uesaka, N., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108126 · Cited by 94 · see citing works

Cognitive Dysfunction and Prefrontal Cortical Circuit Alterations in Schizophrenia: Developmental Trajectories

Dienel, S. J., Schoonover, K. E., & Lewis, D. A. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.03.002 · Cited by 81 · see citing works

DNA methylation changes in schizophrenia and bipolar disorder

Connor, C., & Akbarian, S. (2008) · Epigenetics · doi:10.4161/epi.3.2.5938 · Cited by 84 · see citing works

Broad domains of histone H3 lysine 4 trimethylation in transcriptional regulation and disease

Park, S., Kim, G. W., Kwon, S. H., & Lee, J. (2020) · FEBS Journal · doi:10.1111/febs.15219 · Cited by 83 · see citing works

Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders

Guidotti, A., Grayson, D. R., & Caruncho, H. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00089 · Cited by 83 · see citing works

Environmental regulation of the neural epigenome

Caldji, C., Hellstrom, I. C., Zhang, T.-Y., Diorio, J., & Meaney, M. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.032 · Cited by 82 · see citing works

Sex Differences in Brain Epigenetics

Menger, Y., Bettscheider, M., Murgatroyd, C., & Spengler, D. (2010) · Epigenomics · doi:10.2217/epi.10.60 · Cited by 82 · see citing works

Spatial genome organization and cognition

Rajarajan, P., Espeso‐Gil, S., Brennand, K., & Akbarian, S. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.124 · Cited by 80 · see citing works

HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia‐like animals

Večeřa, J., Bártová, E., Krejčí, J., Legartová, S., Komůrková, D., Kučerová, J., Štark, T., Dražanová, E., Kašpárek, T., Šulcová, A., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25914 · Cited by 80 · see citing works

Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits

Carlyle, B. C., Duque, A., Kitchen, R. R., Bordner, K. A., Coman, D., Doolittle, E., Papademetris, X., Hyder, F., Taylor, J. R., & Simen, A. A. (2012) · Development and Psychopathology · doi:10.1017/s095457941200079x · Cited by 80 · see citing works

Epigenetic Mechanisms

Lubin, F. D., Gupta, S., Parrish, R. R., Grissom, N. M., & Davis, R. L. (2011) · The Neuroscientist · doi:10.1177/1073858411386967 · Cited by 97 · see citing works

Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs

Dong, E., Tueting, P. A., Matrisciano, F., Grayson, D. R., & Guidotti, A. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.191 · Cited by 80 · see citing works

Sensitive Periods in Epigenetics: Bringing us Closer to Complex Behavioral Phenotypes

Nagy, C., & Turecki, G. (2012) · Epigenomics · doi:10.2217/epi.12.37 · Cited by 78 · see citing works

Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains

Bai, G., Cheung, I. K., Shulha, H. P., Coelho, J. E., Li, P., Dong, X., Jakovcevski, M., Wang, Y., Grigorenko, A. P., Jiang, Y. P., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu561 · Cited by 76 · see citing works

An Update on the Epigenetics of Psychotic Diseases and Autism

Abdolmaleky, H. M., Zhou, J., & Thiagalingam, S. (2015) · Epigenomics · doi:10.2217/epi.14.85 · Cited by 75 · see citing works

Epigenetics in the Human Brain

Houston, I. B., Peter, C. J., Mitchell, A., Straubhaar, J., Rogaev, E. I., & Akbarian, S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.78 · Cited by 75 · see citing works

Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia

Mellios, N., Galdzicka, M. M., Ginns, E. I., Baker, S. P., Rogaev, E. I., Xu, J., & Akbarian, S. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq091 · Cited by 75 · see citing works

Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post‐mortem brain of patients with schizophrenia and Psychotic bipolar disorder

Abdolmaleky, H. M., Pajouhanfar‎, S., Faghankhani, M., Joghataei, M. T., Mostafavi, A., & Thiagalingam, S. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32361 · Cited by 73 · see citing works

Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT

Marenco, S., Farmer, A. S., van der Veen, J. W. C., Geramita, M. A., Stern, A., Barnett, A. S., Kolachana, B. S., Radulescu, E., Zhang, F., Callicott, J. H., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.35 · Cited by 71 · see citing works

Coordinated Cell Type–Specific Epigenetic Remodeling in Prefrontal Cortex Begins before Birth and Continues into Early Adulthood

Shulha, H. P., Cheung, I. K., Guo, Y., Akbarian, S., & Weng, Z. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003433 · Cited by 72 · see citing works

Histone lysine methylation: critical regulator of memory and behavior

Jarome, T. J., & Lubin, F. D. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0008 · Cited by 70 · see citing works

Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain

Dincer, A., Gavin, D. P., Xu, K., Zhang, B., Dudley, J. T., Schadt, E. E., & Akbarian, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.169 · Cited by 65 · see citing works

Understanding epigenetics of schizophrenia in the backdrop of its antipsychotic drug therapy

Swathy, B., & Banerjee, M. (2017) · Epigenomics · doi:10.2217/epi-2016-0106 · Cited by 69 · see citing works

Activation of Group II Metabotropic Glutamate Receptors Promotes DNA Demethylation in the Mouse Brain

Matrisciano, F., Dong, E., Gavin, D. P., Nicoletti, F., & Guidotti, A. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.070896 · Cited by 68 · see citing works

Genetics of Schizophrenia

van de Leemput, J., Hess, J., Glatt, S. J., & Tsuang, M. T. (2016) · Advances in genetics · doi:10.1016/bs.adgen.2016.08.001 · Cited by 68 · see citing works

Methylation and schizophrenia

Flight, M. H. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2282 · Cited by 8 · see citing works

GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia

Huang, H., & Akbarian, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000809 · Cited by 223 · see citing works

Epigenetic Determinants of Altered Gene Expression in Schizophrenia: a Dissertation

Huang, H. (2008) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/h312-hs12

Brain metabolic patterns correlate with symptom onset in preclinical HD

(2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0675

Pathogenic histone modifications in schizophrenia are targets for therapy

Abdolmaleky, H., & Thiagalingam, S. (2021) · Epigenetics in Psychiatry · doi:10.1016/b978-0-12-417114-5.00011-5 · Cited by 7 · see citing works