Histone modifications, DNA methylation, and Schizophrenia
Open accessAbstract
Studies have demonstrated that several schizophrenia candidate genes are especially susceptible to changes in transcriptional activity as a result of histone modifications and DNA methylation. Increased expression of epigenetic enzymes which generally reduce transcription have been reported in schizophrenia postmortem brain samples. An abnormal chromatin state leading to reduced candidate gene expression can be explained by aberrant coordination of epigenetic mechanisms in schizophrenia. Dynamic epigenetic processes are difficult to study using static measures such as postmortem brain samples. Therefore, we have developed a model using cultured peripheral blood mononuclear cells (PBMCs) capable of pharmacologically probing these processes in human subjects. This approach has revealed several promising findings indicating that schizophrenia subject PBMC chromatin may be less capable of responding to agents which normally 'open' chromatin. We suggest that the ability to appropriately modify chromatin structure may be a factor in treatment response. Several pharmacological approaches for targeting epigenetic processes are reviewed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some transcription factors that lack a methyl-CpG binding domain can interact with methylated DNA.
“evidence is emerging to suggest that transcription factors lacking a MBD can also interact with methylated DNA”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works
Epigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232 · see citing works
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868 · see citing works
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,734 · see citing works
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works
Comprehensive analysis of CpG islands in human chromosomes 21 and 22
Takai, D., & Jones, P. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052410099 · Cited by 1,507 · see citing works
Histones and histone modifications
Peterson, C. L., & Laniel, M.-A. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.007 · Cited by 1,313 · see citing works
Lehnertz, B., Ueda, Y., Derijck, A. A. H. A., Braunschweig, U., Perez-Burgos, L., Kubicek, S., Chen, T., Li, E., Jenuwein, T., & Peters, A. H. F. M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00432-9 · Cited by 1,248 · see citing works
Recovery of learning and memory is associated with chromatin remodelling
Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227 · see citing works
Guidotti, A., Auta, J., Davis, J. M., Gerevini, V. D. G., Dwivedi, Y., Grayson, D. R., Impagnatiello, F., Pandey, G. N., Pesold, C., Sharma, R. P., et al. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1061 · Cited by 1,203 · see citing works
Self-citationCellular Memory and the Histone Code
Turner, B. M. (2002) · Cell · doi:10.1016/s0092-8674(02)01080-2 · Cited by 1,142 · see citing works
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
Rountree, M. R., Bachman, K. E., & Baylin, S. B. (2000) · Nature Genetics · doi:10.1038/77023 · Cited by 1,056 · see citing works
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation
Fuks, F., Hurd, P. J., Wolf, D., Nan, X., Bird, A. P., & Kouzarides, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210256200 · Cited by 994 · see citing works
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
Fuks, F., Burgers, W. A., Brehm, A., Hughes‐Davies, L., & Kouzarides, T. (2000) · Nature Genetics · doi:10.1038/71750 · Cited by 988 · see citing works
Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L., & Wolffe, A. P. (2000) · Nature Genetics · doi:10.1038/77124 · Cited by 942 · see citing works
Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase
Kubicek, S., O'Sullivan, R. J., August, E. M., Hickey, E. R., Zhang, Q., Teodoro, M. L., Rea, S., Mechtler, K., Kowalski, J. A., Homon, C. A., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.017 · Cited by 859 · see citing works
Hockly, E., Richon, V. M., Woodman, B., Smith, D. L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi‐Noori, S., Mahal, A., Lowden, P. A. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437870100 · Cited by 847 · see citing works
Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail
Jacobs, S. A., & Khorasanizadeh, S. (2002) · Science · doi:10.1126/science.1069473 · Cited by 834 · see citing works
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum
Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764 · see citing works
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
Fuks, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg332 · Cited by 756 · see citing works
A Separate Disease Within the Syndrome of Schizophrenia
Kirkpatrick, B. W., Buchanan, R. W., Ross, D. E., & Carpenter, W. T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.2.165 · Cited by 651 · see citing works
Neural stem cell proliferation is decreased in schizophrenia, but not in depression
Reif, A., Fritzen, S., Finger, M., Strobel, A., Lauer, M., Schmitt, A., & Lesch, K.-P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001791 · Cited by 630 · see citing works
Kim, H. J., Rowe, M. K., Ren, M., Hong, J., Chen, P.-S., & Chuang, D. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.120188 · Cited by 557 · see citing works
Dnmt3a binds deacetylases and is recruited by a sequence‐specific repressor to silence transcription
Fuks, F., Burgers, W. A., Godin, N., Kasai, M., & Kouzarides, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2536 · Cited by 555 · see citing works
Reelin promoter hypermethylation in schizophrenia
Grayson, D. R., Jia, X., Chen, Y., Sharma, R. P., Mitchell, C. P., Guidotti, A., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503736102 · Cited by 553 · see citing works
Self-citationProof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia
D, A. O. M., Harris, J. G., Johnson, L. L., Pender, V., Kongs, S., Allensworth, D., Ellis, J., Zerbe, G. O., Leonard, S. S., Stevens, K. E., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.630 · Cited by 531 · see citing works
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
Greiner, D., Bonaldi, T., Eskeland, R., Roemer, E., & Imhof, A. (2005) · Nature Chemical Biology · doi:10.1038/nchembio721 · Cited by 524 · see citing works
Hashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K., & Lewis, D. A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002011 · Cited by 490 · see citing works
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
Abdolmaleky, H. M., Cheng, K.-H., Faraone, S. V., Wilcox, M., Glatt, S. J., Gao, F., Smith, C. L., Shafa, R., Aeali, B., Carnevale, J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl253 · Cited by 462 · see citing works
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
Epsztejn‐Litman, S., Feldman, N., Abu-Remaileh, M., Shufaro, Y., Gerson, A., Ueda, J., Deplus, R., Fuks, F., Shinkai, Y., Cedar, H., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1476 · Cited by 454 · see citing works
Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications
Lee, M. G., Wynder, C., Schmidt, D. M., McCafferty, D. G., & Shiekhattar, R. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.05.004 · Cited by 438 · see citing works
Bachman, K. E., Rountree, M. R., & Baylin, S. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104661200 · Cited by 438 · see citing works
Hong, L., Schroth, G. P., Matthews, H. R., Yau, P., & Bradbury, E. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54150-8 · Cited by 432 · see citing works
Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges
Atadja, P. W. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.019 · Cited by 425 · see citing works
Abdolmaleky, H. M., Cheng, K., Russo, A. L., Smith, C. L., Faraone, S. V., Wilcox, M., Shafa, R., Glatt, S. J., Nguyen, G. H., Ponte, J. F., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30140 · Cited by 390 · see citing works
Tremolizzo, L., Carboni, G., Ruzicka, W. B., Mitchell, C. P., Sugaya, I., Tueting, P. A., Sharma, R. P., Grayson, D. R., Costa, E., & Guidotti, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262658999 · Cited by 381 · see citing works
Self-citationEpigenetics, DNA Methylation, and Chromatin Modifying Drugs
Moshe Szyf, A. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061008-103102 · Cited by 372 · see citing works
Akbarian, S., & Huang, H. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.001 · Cited by 362 · see citing works
Ryu, H., Smith, K., Camelo, S. I., Carreras, I., Lee, J., Iglesias, A. H., Dangond, F., Cormier, K. A., Cudkowicz, M. E., H. Brown, R., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03077.x · Cited by 353 · see citing works
Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3272-07.2007 · Cited by 352 · see citing works
Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
Hu, E., Dul, E., Sung, C.-M., Chen, Z., Kirkpatrick, R. B., Zhang, G., Johanson, K., Liu, R., Lago, A. M., Hofmann, G. A., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.055541 · Cited by 350 · see citing works
Valproate Induces Replication-independent Active DNA Demethylation
Detich, N., Bovenzi, V., & Szyf, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303740200 · Cited by 345 · see citing works
The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain
Kim, H. J., Leeds, P., & Chuang, D. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06212.x · Cited by 332 · see citing works
Monozygotic Twins Exhibit Numerous Epigenetic Differences: Clues to Twin Discordance?
Petronis, A., Gottesman, I. I., Kan, P., Kennedy, J. L., Basile, V. S., Paterson, A. D., & Popendikytė, V. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006988 · Cited by 312 · see citing works
DNA Methyltransferase Contributes to Delayed Ischemic Brain Injury
Endres, M., Meisel, A., Biniszkiewicz, D., Namura, S., Prass, K., Ruscher, K., Lipski, A., Jaenisch, R., Moskowitz, M. A., & Dirnagl, U. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03175.2000 · Cited by 310 · see citing works
Veldić, M., Caruncho, H. J., Liu, W. S., Davis, J. M., Satta, R., Grayson, D. R., Guidotti, A., & Costa, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637013100 · Cited by 303 · see citing works
Fatemi, S. H., Stary, J. M., Earle, J. A., Araghi‐Niknam, M., & Eagan, E. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.02.017 · Cited by 300 · see citing works
Huang, Y., Greene, E., Stewart, T. M., Goodwin, A. C., Baylin, S. B., Woster, P. M., & Casero, R. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700720104 · Cited by 292 · see citing works
Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity
Kim, D., Frank, C. L., Dobbin, M. M., Tsunemoto, R. K., Tu, W., Peng, P. L., Guan, J.-S., Lee, B.-H., Moy, L. Y., Giusti, P., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.015 · Cited by 286 · see citing works
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation
Dong, E., Nelson, M., Grayson, D. R., Costa, E., & Guidotti, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805493105 · Cited by 284 · see citing works
On the epigenetic regulation of the human reelin promoter
Chen, Y. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf401 · Cited by 274 · see citing works
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1
Veldić, M., Guidotti, A., Maloku, E., Davis, J. M., & Costa, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409665102 · Cited by 269 · see citing works
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
Guidotti, A., Auta, J., Davis, J. M., Dong, E., Grayson, D. R., Veldic, M., Zhang, X., & Costa, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2212-8 · Cited by 262 · see citing works
Tremolizzo, L., Doueiri, M.-S., Dong, E., Grayson, D. R., Davis, J. M., Pinna, G., Tueting, P. A., Rodriguez‐Menendez, V., Costa, E., & Guidotti, A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.046 · Cited by 257 · see citing works
Faraco, G., Pancani, T., Formentini, L., Mascagni, P., Fossati, G., Leoni, F., Moroni, F., & Chiarugi, A. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027912 · Cited by 252 · see citing works
Iwamoto, K., Bundo, M., Yamada, K., Takao, H., Iwayama‐Shigeno, Y., Yoshikawa, T., & Kato, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0766-05.2005 · Cited by 243 · see citing works
Barr, R. S., Maravić, M. C., Jubelt, L. E., Mufti, R. S., Dyer, M. A., Weiss, A. P., Deckersbach, T., Kelly, J. F., Freudenreich, O., GOFF, D. C., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301423 · Cited by 238 · see citing works
Luu, T. H., Morgan, R. J., Leong, L., Lim, D. W., McNamara, M., Portnow, J., Frankel, P. H., Smith, D. D., Doroshow, J. H., Gandara, D. R., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0122 · Cited by 237 · see citing works
Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review
Acharya, M. R., Sparreboom, A., Venitz, J., & Figg, W. D. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.014167 · Cited by 231 · see citing works
Simonini, M. V., Camargo, L. M., Dong, E., Maloku, E., Veldić, M., Costa, E., & Guidotti, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510341103 · Cited by 229 · see citing works
The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis
Petronis, A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.005 · Cited by 225 · see citing works
GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia
Huang, H., & Akbarian, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000809 · Cited by 223 · see citing works
Abdolmaleky, H. M., Smith, C. L., Faraone, S. V., Shafa, R., Stone, W., Glatt, S. J., & Tsuang, M. T. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20142 · Cited by 216 · see citing works
Epigenetic Regulation in Human Brain—Focus on Histone Lysine Methylation
Akbarian, S., & Huang, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.015 · Cited by 214 · see citing works
Satta, R., Maloku, E., Zhubi, A., Pibiri, F., Hajós, M., Costa, E., & Guidotti, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808699105 · Cited by 202 · see citing works
Dong, E., Agís‐Balboa, R. C., Simonini, M. V., Grayson, D. R., Costa, E., & Guidotti, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505394102 · Cited by 198 · see citing works
Sharma, R. P., Grayson, D. R., & Gavin, D. P. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.09.020 · Cited by 192 · see citing works
Self-citationZebularine: a new drug for epigenetic therapy
Yoo, C. B., Cheng, J. C., & Jones, P. A. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320910 · Cited by 191 · see citing works
Dong, E., Guidotti, A., Grayson, D. R., & Costa, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700529104 · Cited by 189 · see citing works
Kuratomi, G., Iwamoto, K., Bundo, M., Kusumi, I., Kato, N., Iwata, N., Ozaki, N., & Kato, T. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002001 · Cited by 188 · see citing works
Hutnick, L. K., Golshani, P., Namihira, M., Xue, Z., Matynia, A., Yang, X. W., Silva, A. J., Schweizer, F. E., & Fan, G. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp222 · Cited by 181 · see citing works
Kundaković, M., Chen, Y., Costa, E., & Grayson, D. R. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030635 · Cited by 168 · see citing works
Histone Deacetylase Inhibitors Decrease Cocaine But Not Sucrose Self-Administration in Rats
Romieu, P., Host, L., Gobaille, S., Sandner, G., Aunis, D., & Zwiller, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0379-08.2008 · Cited by 162 · see citing works
Kundaković, M., Chen, Y., Guidotti, A., & Grayson, D. R. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051763 · Cited by 149 · see citing works
Smoking and Vulnerability for Schizophrenia
de León, J. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.3.405 · Cited by 143 · see citing works
Akbarian, S., Ruehl, M. G., Bliven, E. E., Luiz, L. A., Peranelli, A. C., Baker, S. P., Roberts, R. C., Bunney, W. E., Conley, R. C., Jones, E. G., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.8.829 · Cited by 140 · see citing works
Methylation Status of the Reelin Promoter Region in the Brain of Schizophrenic Patients
Tochigi, M., Iwamoto, K., Bundo, M., Komori, A., Sasaki, T., Kato, N., & Kato, T. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.003 · Cited by 134 · see citing works
DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures
Noh, J. S., Sharma, R. P., Veldić, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409648102 · Cited by 132 · see citing works
Self-citationZhubi, A., Veldić, M., Puri, N. V., Kadriu, B., Caruncho, H. J., Loza, I. B., Sershen, H. W., Lajtha, Á., Smith, R. C., Guidotti, A., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.020 · Cited by 129 · see citing works
Use of Antidepressant Drugs in Schizophrenia
Siris, S. G. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770350094009 · Cited by 123 · see citing works
Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia
Jubelt, L. E., Barr, R. S., GOFF, D. C., Logvinenko, T., Weiss, A. P., & Evins, A. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1133-8 · Cited by 122 · see citing works
Sharma, R. P., Rosen, C., Kartan, S., Guidotti, A., Costa, E., Grayson, D. R., & Chase, K. A. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.07.015 · Cited by 107 · see citing works
Self-citationS-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis
Guidotti, A., Ruzicka, W. B., Grayson, D. R., Veldić, M., Pinna, G., Davis, J. M., & Costa, E. (2007) · Neuroreport · doi:10.1097/wnr.0b013e32800fefd7 · Cited by 101 · see citing works
The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics
Costa, E. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00121-7 · Cited by 100 · see citing works
Sharma, R. P. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.03.001 · Cited by 92 · see citing works
Self-citationGavin, D. P., Kartan, S., Chase, K. A., Jayaraman, S., & Sharma, R. P. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.12.006 · Cited by 91 · see citing works
Self-citationSodium phenylbutyrate in Huntington's disease: A dose‐finding study
Hogarth, P., Lovrečić, L., & Krainc, D. (2007) · Movement Disorders · doi:10.1002/mds.21632 · Cited by 89 · see citing works
The DNA methylation machinery as a target for anticancer therapy
Moshe Szyf, A. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(96)00002-2 · Cited by 84 · see citing works
The effects of L-methionine (without MAOI) in schizophrenia
Antun, F., Burnett, G. B., Cooper, A. J., Daly, R. J., Smythies, J., & Zealley, A. K. (1971) · Journal of Psychiatric Research · doi:10.1016/0022-3956(71)90009-4 · Cited by 80 · see citing works
Hauschild, A., Trefzer, U., Garbe, C., Kaehler, K. C., Ugurel, S., Kiecker, F., Eigentler, T., Krissel, H., Schott, A., & Schadendorf, D. (2008) · Melanoma Research · doi:10.1097/cmr.0b013e328307c248 · Cited by 79 · see citing works
Benes, F. M., Lim, B., Matzilevich, D., Subburaju, S., & Walsh, J. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810153105 · Cited by 79 · see citing works
Histone deacetylase inhibitors decrease reelin promoter methylation in vitro
Mitchell, C. P., Chen, Y., Kundaković, M., Costa, E., & Grayson, D. R. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03040.x · Cited by 78 · see citing works
Golshani, P., Hutnick, L. K., Schweizer, F. E., & Fan, G. (2005) · Thalamus & Related Systems · doi:10.1017/s1472928807000222 · Cited by 77 · see citing works
Gavin, D. P., Kartan, S., Chase, K. A., Grayson, D. R., & Sharma, R. P. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.026 · Cited by 68 · see citing works
Self-citationGavin, D. P., Rosen, C., Chase, K. A., Grayson, D. R., Tun, N., & Sharma, R. P. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0932 · Cited by 63 · see citing works
Self-citationGenomic Discordance Between Monozygotic Twins Discordant for Schizophrenia
Tsujita, T., Niikawa, N., Yamashita, H., Imamura, A., Hamada, A., Nakane, Y., & Okazaki, Y. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.3.422 · Cited by 63 · see citing works
Bromberg, A., Levine, J., Nemetz, B., Belmaker, R. H., & Agam, G. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.009 · Cited by 60 · see citing works
Replication of heterochromatin: insights into mechanisms of epigenetic inheritance
Wallace, J. A., & Orr‐Weaver, T. L. (2005) · Chromosoma · doi:10.1007/s00412-005-0024-6 · Cited by 58 · see citing works
Constitutive heterochromatin of chromosome 1 and Duffy blood group alleles in schizophrenia
Kosower, N. S., Gerad, L., Goldstein, M., et al. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600209 · Cited by 53 · see citing works
The negative symptoms of schizophrenia and the monoamine oxidase inhibitors
Bucci, L. (1987) · Psychopharmacology · doi:10.1007/bf00690936 · Cited by 45 · see citing works
Biochemical Correlates of Behavior in Schizophrenic Patients
Berlet, H. H. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01730060039006 · Cited by 41 · see citing works
Altered chromatin ultrastructure in neutrophils of schizophrenics
Issidorides, M. R., Stefanis, C. N., Varsou, E., et al. (1975) · Nature · doi:10.1038/258612a0 · Cited by 39 · see citing works
Gavin, D. P., & Sharma, R. P. (2009) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2009/409562 · Cited by 27 · see citing works
Self-citationWarren, K. E., McCully, C. L., Dvinge, H., et al. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0622-5 · Cited by 26 · see citing works
Amino Acid Conjugates: Metabolites of 2-Propylpentanoic Acid (Valproic Acid) in Epileptic Patients
Gopaul, V. S., Tang, W., Farrell, K., et al. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.1.114 · Cited by 21 · see citing works
Erythrocyte and brain methionine adenosyltransferase activities in patients with schizophrenia
Gomes–Trolin, C., Yassin, M. S., Gottfries, C. G., Regland, B., Grenfeldt, B., Hallman, J., Prince, J. A., & Oreland, L. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050132 · Cited by 14 · see citing works
Wyatt, R. J., Termini, B. A., & Davis, J. (1971) · Schizophrenia Bulletin · doi:10.1093/schbul/1.4.45 · Cited by 9 · see citing works
Harlap, S., Perrin, M. C., Deutsch, L., Kleinhaus, K., Fennig, S., Nahon, D., Teitelbaum, A., Friedlander, Y., & Malaspina, D. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.022 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Gottesman I Shields J 1982 Schizophrenia: The Epigenetic Puzzle Cambridge University Press Cambridge, United Kingdom
Cited by
Sorted by citations
Transcription factors as readers and effectors of DNA methylation
Zhu, H., Wang, G., & Qian, J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.83 · Cited by 649 · see citing works
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
Jaffe, A. E., Gao, Y., Deep-Soboslay, A., Tao, R., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2016) · Nature Neuroscience · doi:10.1038/nn.4181 · Cited by 511 · see citing works
An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229 · see citing works
D'Addario, C., Dell'Osso, B., Palazzo, M. C., Benatti, B., Lietti, L., Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.10 · Cited by 192 · see citing works
Rusiecki, J. A., Byrne, C., Galdzicki, Z., Srikantan, V., Chen, L., Poulin, M., Yan, L., & Baccarelli, A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00056 · Cited by 99 · see citing works
Male-Specific Association between Dopamine Receptor D4 Gene Methylation and Schizophrenia
Cheng, J., Wang, Y., Zhou, K., Wang, L., Li, J., Zhuang, Q., Xu, X., Xu, L., Zhang, K., Dai, D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089128 · Cited by 60 · see citing works
Understanding the Neuroepigenetic Constituents of Suicide Brain
Roy, B., & Dwivedi, Y. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2018.01.007 · Cited by 17 · see citing works
Enhancement of psychotherapy using epigenetic modulating drugs
Gavin, D. P., Chase, K. A., & Sharma, R. P. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.03.042 · Cited by 6 · see citing works
Self-citation
- Authors
- Gavin, D. P., & Sharma, R. P.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Sharma, Rajiv P.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 34
- Issue
- 6
- Pages
- 882-888
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC2848916
- OpenAlex
- W2026504919
- Cited by
- 121
- References
- 112
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 14 · 2012: 15
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-069839, K01MH069839)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- schizophrenia, histone modifications, DNA methylation, epigenetics, chromatin structure, candidate genes, postmortem brain, peripheral blood mononuclear cells, chromatin accessibility, epigenetic enzymes, treatment response, epigenetic drug targets
- MeSH terms
- Animals, Histones, Humans, Models, Genetic, Schizophrenia, DNA Methylation, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
