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Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate
Open accessAbstract
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-Ins P 4 ) from Ins P 5 . Additionally, mIPMK forms Ins P 4 from Ins(1,4,5) P 3 and Ins P 5 from Ins(1,3,4,5) P 4 .
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“IPMK, the mammalian homologue of Arg82, has been reported to phosphorylate Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P4 and then Ins(1,3,4,5,6)P540,41.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [40]
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Metadata
- Authors
- Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Snyder, Solomon H.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-02-13
- Volume
- 98
- Issue
- 5
- Pages
- 2306-2311
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC30134
- OpenAlex
- W1997739014
- Cited by
- 110
- References
- 35
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- U.S. Public Health Service (MH‐18501, DA-00074)
- National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
- National Institute on Drug Abuse (DA 00074, K05DA000074)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- inositol polyphosphate multikinase, inositol 1,4,5-trisphosphate, inositol pyrophosphates, inositol 1,3,4,5-tetrakisphosphate, enzyme cloning, mammalian enzymes
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Male, Molecular Sequence Data, Inositol 1,4,5-Trisphosphate, Rats, Sprague-Dawley, Sequence Homology, Amino Acid, In Situ Hybridization, Phosphotransferases (Alcohol Group Acceptor), DNA Primers, Rats
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