Cited by 110Protein Kinase Regulation and GTPase SignalingCalcium signaling and nucleotide metabolismPI3K/AKT/mTOR signaling in cancer

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

Open access

Saiardi, Adolfo, Nagata, Eiichiro, Luo, Hongbo R., Sawa, Akira, Luo, Xiaojiang, Snowman, Adele M., Snyder, Solomon H.·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.041614598PMC PMC30134

Open this paper in CoChat — free account

Abstract

Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5) P 3 ]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-Ins P 4 ) from Ins P 5 . Additionally, mIPMK forms Ins P 4 from Ins(1,4,5) P 3 and Ins P 5 from Ins(1,3,4,5) P 4 .

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.041614598

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
[22] Using CLUSTAL for multiple sequence alignments
Higgins, D. G., Thompson, J., & Gibson, T. J. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66024-8 · Cited by 1,571
Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C
Rebecchi, M. J., & Pentyala, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1291 · Cited by 1,000
A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export
York, J. D., John, A. R. O., Murphy, R., Ives, E. B., & Wente, S. R. (1999) · Science · doi:10.1126/science.285.5424.96 · Cited by 547
Synthesis of Diphosphoinositol Pentakisphosphate by a Newly Identified Family of Higher Inositol Polyphosphate Kinases
Saiardi, A., Erdjument-Bromage, H., Snowman, A. M., Tempst, P., & Snyder, S. H. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80055-x · Cited by 414
Self-citation
A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D. (2000) · Science · doi:10.1126/science.287.5460.2026 · Cited by 394
The FlyBase Database of the Drosophila Genome Projects and community literature
(1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.85 · Cited by 325
Prediction of the Coding Sequences of Unidentified Human Genes. VI. The Coding Sequences of 80 New Genes (KIAA0201-KIAA0280) Deduced by Analysis of cDNA Clones from Cell Line KG-1 and Brain
Nagase, T. (1996) · DNA Research · doi:10.1093/dnares/3.5.321 · Cited by 235

Show all 35 references

Research works printed but not linked: 2

S F Altschul, W Gish, W Miller, E W Myers, D J Lipman J Mol Biol 215, 403–410 (1990). · DOI · Paper page
B J Lynch, M M Muqit, T R Walker, E R Chilvers J Pharmacol Exp Ther 280, 974–982 (1997).

Sorted by citations

Back in the Water: The Return of the Inositol Phosphates
Irvine, R. F., & Schell, M. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073015 · Cited by 659
Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate
Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505
myo-Inositol-1,2,3,4,5,6-hexakisphosphate
Raboy, V. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00446-1 · Cited by 475
Nuclear Actin and Actin-Related Proteins in Chromatin Remodeling
Olave, I. A., Reck‐Peterson, S. L., & Crabtree, G. R. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135507 · Cited by 395
Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance
Fisher, S. K., Novak, J. E., & Agranoff, B. W. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01041.x · Cited by 393
Regulation of Akt Signaling by Sirtuins
Pillai, V. B., Sundaresan, N. R., & Gupta, M. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.300536 · Cited by 262
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L., & Schwabe, J. W. R. (2016) · Nature Communications · doi:10.1038/ncomms11262 · Cited by 244
Control of mammalian gene expression by selective mRNA export
Wickramasinghe, V. O., & Laskey, R. A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4010 · Cited by 238
How versatile are inositol phosphate kinases?
Shears, S. B. (2004) · Biochemical Journal · doi:10.1042/bj20031428 · Cited by 174
Inositol pyrophosphates: metabolism and signaling
Bennett, M., Onnebo, S. M. N., Azevedo, C., & Saiardi, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5446-z · Cited by 173
Self-citation
Regulation of nuclear processes by inositol polyphosphates
York, J. D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.014 · Cited by 172
A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine
Wilson, M., Bulley, S. J., Pisani, F., Irvine, R. F., & Saiardi, A. (2015) · Open Biology · doi:10.1098/rsob.150014 · Cited by 164
Self-citation
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes
Tsui, M. M. K., & York, J. D. (2009) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2009.12.002 · Cited by 165
Identification and Characterization of a Novel Inositol Hexakisphosphate Kinase
Saiardi, A., Nagata, E., Luo, H. R., Snowman, A. M., & Snyder, S. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106842200 · Cited by 159
Self-citation
Diphosphoinositol Polyphosphates: Metabolic Messengers?
Shears, S. B. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.055897 · Cited by 152
Inositol Diphosphate Signaling Regulates Telomere Length
York, S. J., Armbruster, B. N., Greenwell, P. W., Petes, T. D., & York, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412070200 · Cited by 153
An Essential Role for an Inositol Polyphosphate Multikinase, Ipk2, in Mouse Embryogenesis and Second Messenger Production
Frederick, J. P., Mattiske, D., Wofford, J. A., Megosh, L. C., Drake, L. Y., Chiou, S.-T., Hogan, B. L. M., & York, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503706102 · Cited by 139
Molecular and Biochemical Characterization of Two Plant Inositol Polyphosphate 6-/3-/5-Kinases
Stevenson, J. M., John, A. R. O., & York, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209112200 · Cited by 137
Inositol Hexakisphosphate Kinase Products Contain Diphosphate and Triphosphate Groups
Draškovič, P., Saiardi, A., Bhandari, R., Burton, A., Ilc, G., Kovačević, M., Snyder, S. H., & Podobnik, M. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.01.011 · Cited by 126
Self-citation
Inositol Polyphosphate Multikinase Is a Physiologic PI3-Kinase That Activates Akt/PKB
Maag, D., Maxwell, M. J., Hardesty, D. A., Boucher, K. L., Choudhari, N., Hanno, A. G., Ma, J. F., Snowman, A. S., Pietropaoli, J. W., Xu, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017831108 · Cited by 122
Self-citation
A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase
Sei, Y., Zhao, X., Forbes, J., Szymczak, S., Li, Q., Trivedi, A., Voellinger, M., Joy, G., Feng, J., Whatley, M., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.008 · Cited by 119
Characterization of a Selective Inhibitor of Inositol Hexakisphosphate Kinases
Padmanabhan, U., Dollins, D. E., Fridy, P. C., York, J. D., & Downes, C. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900752200 · Cited by 117
Inositol Polyphosphate Multikinase Is a Nuclear PI3-Kinase with Transcriptional Regulatory Activity
Resnick, A. C., Snowman, A. M., Kang, B. N., Hurt, K. J., Snyder, S. H., & Saiardi, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506184102 · Cited by 119
Self-citation
Inositol phosphate synthesis and the nuclear processes they affect
Monserrate, J. P., & York, J. D. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.03.006 · Cited by 101
Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase
González, B., Schell, M. J., Letcher, A. J., Veprintsev, D. B., Irvine, R. F., & Williams, R. L. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.004 · Cited by 89
The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization
NALASKOWSKI, M. M., DESCHERMEIER, C., FANICK, W., & MAYR, G. W. (2002) · Biochemical Journal · doi:10.1042/bj20020327 · Cited by 89
A Molecular Basis for Inositol Polyphosphate Synthesis in Drosophila melanogaster
Seeds, A. M., Sandquist, J. C., Spana, E. P., & York, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408295200 · Cited by 89
Inositol pyrophosphates: structure, enzymology and function
Barker, C. J., Illies, C., Gaboardi, G. C., & Berggren, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0115-2 · Cited by 85
Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations
Xia, H., & Yang, G. (2005) · Cell Research · doi:10.1038/sj.cr.7290270 · Cited by 83
Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate
Sauer, K., & Cooke, M. P. (2010) · Nature reviews. Immunology · doi:10.1038/nri2745 · Cited by 81
The Pathway for the Production of Inositol Hexakisphosphate in Human Cells
Verbsky, J. W., Chang, S., Wilson, M. P., Mochizuki, Y., & Majerus, P. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411528200 · Cited by 80
Human Inositol Polyphosphate Multikinase Regulates Transcript-Selective Nuclear MRNA Export to Preserve Genome Integrity
Wickramasinghe, V. O., Savill, J. M., Chavali, S., Jonsdottir, A. B., Rajendra, E., Grüner, T., Laskey, R. A., Babu, M. M., & Venkitaraman, A. R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.031 · Cited by 80
Spatial Expression Patterns and Biochemical Properties Distinguish a Second myo-Inositol Monophosphatase IMPA2 from IMPA1
Ohnishi, T., Ohba, H., Seo, K.-C., Im, J., Sato, Y., Iwayama, Y., Furuichi, T., Chung, S., & Yoshikawa, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604474200 · Cited by 76
Antiproliferative Plant and Synthetic Polyphenolics Are Specific Inhibitors of Vertebrate Inositol-1,4,5-trisphosphate 3-Kinases and Inositol Polyphosphate Multikinase
Mayr, G. W., Windhorst, S., & Hillemeier, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500545200 · Cited by 73
The Human Homolog of the Rat Inositol Phosphate Multikinase Is an Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase
Chang, S., Miller, A. L., Feng, Y., Wente, S. R., & Majerus, P. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206134200 · Cited by 74
Ins(1,4,5)P3 metabolism and the family of IP3-3Kinases
Pattni, K., & Banting, G. S. (2003) · Cellular Signalling · doi:10.1016/j.cellsig.2003.10.009 · Cited by 72
Inositol pyrophosphates modulate hydrogen peroxide signalling
Onnebo, S. M. N., & Saiardi, A. (2009) · Biochemical Journal · doi:10.1042/bj20090241 · Cited by 69
Self-citation
Inositol phosphate kinases in the eukaryote landscape
Laha, D., Portela-Torres, P., Desfougères, Y., & Saiardi, A. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100782 · Cited by 62
Self-citation
Crystal Structure of the Catalytic Core of Inositol 1,4,5-Trisphosphate 3-Kinase
Miller, G. J., & Hurley, J. H. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.005 · Cited by 62
The enzymes of human diphosphoinositol polyphosphate metabolism
THOMAS, M. P., & Potter, B. V. L. (2013) · FEBS Journal · doi:10.1111/febs.12575 · Cited by 60
Molecular Definition of a Novel Inositol Polyphosphate Metabolic Pathway Initiated by Inositol 1,4,5-Trisphosphate 3-Kinase Activity in Saccharomyces cerevisiae
Seeds, A. M., Bastidas, R. J., & York, J. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505089200 · Cited by 56
SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle
Dziewulska, A., Dobosz, A. M., Dobrzyń, A., Smolinska, A., Kolczyńska, K., Ntambi, J. M., & Dobrzyń, P. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29026 · Cited by 54
Inositol phosphates in foods
Phillippy, B. Q. (2003) · Advances in food and nutrition research · doi:10.1016/s1043-4526(03)45002-x · Cited by 54
A Role for Rat Inositol Polyphosphate Kinases rIPK2 and rIPK1 in Inositol Pentakisphosphate and Inositol Hexakisphosphate Production in Rat-1 Cells
Fujii, M., & York, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412006200 · Cited by 54
Crystal Structure of Inositol Phosphate Multikinase 2 and Implications for Substrate Specificity
Holmes, W., & Jogl, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606883200 · Cited by 51
Inositol Polyphosphate Multikinase Is a Coactivator of P53-Mediated Transcription and Cell Death
Xu, R., Sen, N., Paul, B. D., Snowman, A. M., Rao, F., Vandiver, M. S., Xu, J., & Snyder, S. H. (2013) · Science Signaling · doi:10.1126/scisignal.2003405 · Cited by 52
Self-citation
Conservation of PHO pathway in ascomycetes and the role of Pho84
Tomar, P., & Sinha, H. (2014) · Journal of Biosciences · doi:10.1007/s12038-014-9435-y · Cited by 48
Inositol Pentakisphosphate Mediates Wnt/β-Catenin Signaling
Gao, Y., & Wang, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702106200 · Cited by 48
Defining Signal Transduction by Inositol Phosphates
Shears, S. B., Ganapathi, S. B., Gokhale, N., Schenk, T. M. H., Wang, H., Weaver, J. D., Zaremba, A., & Zhou, Y. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_13 · Cited by 46
Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase
Brehm, M. A., Schenk, T. M. H., Zhou, X., Fanick, W., Lin, H., Windhorst, S., Nalaskowski, M. M., Kobras, M., Shears, S. B., & Mayr, G. W. (2007) · Biochemical Journal · doi:10.1042/bj20070382 · Cited by 45
Cell Signalling by Inositol Pyrophosphates
Saiardi, A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_14 · Cited by 42
Self-citation
Convergence of IPMK and LKB1-AMPK Signaling Pathways on Metformin Action
Bang, S., Chen, Y., Ahima, R. S., & Kim, S. F. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1134 · Cited by 45
Characterisation of structural genes involved in phytic acid biosynthesis in common bean (Phaseolus vulgaris L.)
Fileppi, M., Galasso, I., Tagliabue, G. M., Daminati, M. G., Campion, B., Doria, E., & Sparvoli, F. (2009) · Molecular Breeding · doi:10.1007/s11032-009-9344-1 · Cited by 40
Human cell toxicogenomic analysis of bromoacetic acid: A regulated drinking water disinfection by‐product
Muellner, M. G., Attene‐Ramos, M. S., Hudson, M. E., Wagner, E. D., & Plewa, M. J. (2009) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20530 · Cited by 40
Inositol Polyphosphate Multikinase: Metabolic Architect of Nuclear Inositides
Resnick, A. C. (2008) · Frontiers in Bioscience · doi:10.2741/2726 · Cited by 39
Structural analyses of inositol phosphate second messengers bound to signaling effector proteins
Blind, R. D. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2019.100667 · Cited by 36
Inositol Polyphosphate Multikinase Is a Coactivator for Serum Response Factor-Dependent Induction of Immediate Early Genes
Kim, E., Tyagi, R., Lee, J.-Y., Park, J., Kim, Y.-R., Beon, J., Chen, P. Y., Cha, J. Y., Snyder, S. H., & Kim, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320171110 · Cited by 38
Self-citation
The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity
Zhang, T., Caffrey, J. J., & Shears, S. B. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02351-1 · Cited by 37
Inositol Polyphosphate Multikinase Is a Transcriptional Coactivator Required for Immediate Early Gene Induction
Xu, R., Paul, B. D., Smith, D. R., Tyagi, R., Rao, F., Khan, A. B., Blech, D. J., Vandiver, M. S., Harraz, M. M., Guha, P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315551110 · Cited by 36
Self-citation
The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes
Cordeiro, C. D., Saiardi, A., & Docampo, R. (2017) · Molecular Microbiology · doi:10.1111/mmi.13766 · Cited by 34
Self-citation
Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells*
Yu, W., Ye, C., & Greenberg, M. L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.714816 · Cited by 35
Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network
Trung, M. N., Kieninger, S., Fandi, Z., Qiu, D., Liu, G., Mehendale, N. K., Saiardi, A., Jessen, H. J., Keller, B. G., & Fiedler, D. (2022) · ACS Central Science · doi:10.1021/acscentsci.2c01032 · Cited by 34
Self-citation
Inositol Trisphosphate Kinase and Diphosphoinositol Pentakisphosphate Kinase Enzymes Constitute the Inositol Pyrophosphate Synthesis Pathway in PlantsPreprint
Adepoju, O. A., Williams, S. P., Craige, B., Cridland, C. A., Sharpe, A. K., Brown, A. M., Land, E. S., Perera, I. Y., Mena, D., Sobrado, P., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/724914 · Cited by 32
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling
Wilson, M., & Saiardi, A. (2017) · Topics in Current Chemistry · doi:10.1007/s41061-016-0099-y · Cited by 28
Self-citation
Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism
Malabanan, M. M., & Blind, R. D. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150225 · Cited by 29
The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe
Pascual-Ortiz, M., Walla, E., Fleig, U. N., & Saiardi, A. (2021) · Journal of Fungi · doi:10.3390/jof7080626 · Cited by 26
Self-citation
Molecular characterization of ThIPK2, an inositol polyphosphate kinase gene homolog from Thellungiella halophila, and its heterologous expression to improve abiotic stress tolerance in Brassica napus
Zhu, J., Zhang, J., Tang, R., Lv, Q., Wang, Q., Yang, L., & Zhang, H. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01235.x · Cited by 28
Genetics of Inositol Polyphosphates
Raboy, V., & Bowen, D. E. (2006) · Springer eBooks · doi:10.1007/0-387-27600-9_4 · Cited by 25
Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology
Seeds, A. M., Frederick, J. P., Tsui, M. M. K., & York, J. D. (2007) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2006.12.019 · Cited by 24
Regulation of Inositol 1,4,5-Trisphosphate 3-Kinases by Calcium and Localization in Cells
Lloyd-Burton, S. M., Yu, J. C. H., Irvine, R. F., & Schell, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610253200 · Cited by 21
Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis
Park, S. E., Lee, D., Jeong, J. W., Lee, S.-H., Park, S. J., Ryu, J., Oh, S. K., Yang, H., Fang, S., & Kim, S. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.08.004 · Cited by 20
InsP3 in Plant Cells
Im, Y. J., Phillippy, B. Q., & Perera, I. Y. (2009) · Plant cell monographs · doi:10.1007/978-3-642-03873-0_10 · Cited by 18
IP3-4kinase Arg1 regulates cell wall homeostasis and surface architecture to promoteCryptococcus neoformansinfection in a mouse model
Li, C., Lev, S., Desmarini, D., Kaufman‐Francis, K., Saiardi, A., Silva, A. P. G., Mackay, J. P., Thompson, P. E., Sorrell, T. C., & Djordjevic, J. T. (2017) · Virulence · doi:10.1080/21505594.2017.1385692 · Cited by 18
Self-citation
Phospholipids and inositol phosphates linked to the epigenome
Uličná, L., Paprčková, D., Fáberová, V., & Hozák, P. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1690-9 · Cited by 18
A lysine accumulation phenotype of ScIpk2Δ mutant yeast is rescued by Solanum tuberosum inositol phosphate multikinase
Caddick, S. E. K., Harrison, C. J., Stavridou, I., Johnson, S., & Brearley, C. A. (2007) · Biochemical Journal · doi:10.1042/bj20061772 · Cited by 12
IP6K gene identification in plant genomes by tag searching
Fassetti, F., Leone, O., Palopoli, L., Rombo, S. E., & Saiardi, A. (2011) · BMC Proceedings · doi:10.1186/1753-6561-5-s2-s1 · Cited by 10
Self-citation
Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients
Duman, H., Bahçeci, İ., Çinier, G., Duman, H., Bakırcı, E. M., & Çetın, M. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2018.1510946 · Cited by 10
Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity
Rango, F. D., Crocco, P., Iannone, F., Saiardi, A., Passarino, G., Dato, S., & Rose, G. (2019) · Genes · doi:10.3390/genes10020125 · Cited by 9
Self-citation
Biochemical Analysis of Inositol Phosphate Kinases
Otto, J. C., Mulugu, S., Fridy, P. C., Chiou, S., Armbruster, B. N., Ribeiro, A. A., & York, J. D. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)34010-x · Cited by 9
Biomarker screening in preeclampsia: an RNA-sequencing approach based on data from multiple studies
Rezk, M., Grasegger, L., Brandstetter, N., Pol-Edern, L. R., Stelzl, P., Oppelt, P., & Arbeithuber, B. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003226 · Cited by 10
Regulation of NGF ‐driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC 12 cells
Koenig, S., Moreau, C., Dupont, G., Scoumanne, A., & Erneux, C. (2015) · FEBS Journal · doi:10.1111/febs.13300 · Cited by 8
Arg1 from Cryptococcus neoformans lacks PI3 kinase activity and conveys virulence roles via its IP 3-4 kinase activity
Desmarini, D., Liu, G., Jessen, H. J., Bowring, B. G., Connolly, A. M., Crossett, B., & Djordjevic, J. T. (2024) · mBio · doi:10.1128/mbio.00608-24 · Cited by 7
Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
Gaugler, P., Gaugler, V., Kamleitner, M., & Schaaf, G. (2020) · Journal of Visualized Experiments · doi:10.3791/61495 · Cited by 7
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate
Riley, A. M., Unterlass, J. E., Konieczny, V., Taylor, C. W., Helleday, T., & Potter, B. V. L. (2018) · MedChemComm · doi:10.1039/c8md00149a · Cited by 7
A novel Entamoeba histolytica inositol phosphate kinase catalyzes the formation of 5PP-Ins(1,2,3,4,6)P5
Löser, B., Nalaskowski, M. M., Fanick, W., Lin, H., Tannich, E., & Mayr, G. W. (2011) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2011.09.008 · Cited by 5
Zebrafish inositol polyphosphate kinases: New effectors of cilia and developmental signaling
Sarmah, B., & Wente, S. R. (2009) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2009.10.018 · Cited by 4
The expanding landscape of inositol phosphate signaling network in land plants
Ghosh, R., Yadav, R., Pullagurla, N. J., Rana, P., & Laha, D. (2025) · FEBS Letters · doi:10.1002/1873-3468.70236 · Cited by 3
Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates
Caldwell, K. K., Sosa, M., & Buckley, C. T. (2006) · Cell Communication and Signaling · doi:10.1186/1478-811x-4-2 · Cited by 3
Photo-releasable derivatives of inositol pyrophosphates
Hauke, S., Bittner, T., Jessen, H. J., & Schultz, C. (2020) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2020.04.036 · Cited by 3
Inositol Polyphosphates
Resnick, A. C., & Saiardi, A. (2008) · Wiley eBooks · doi:10.1002/9780470048672.wecb252 · Cited by 3
Self-citation
Functions of Inositol Polyphosphate and Inorganic Polyphosphate in Yeast and Amoeba
Saiardi, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-41073-9_5 · Cited by 1
Self-citation
Inositol Polyphosphate Regulation of Nuclear Function
York, J. D. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50520-9 · Cited by 2
Dietary myo-inositol exerts pleiotropic effects on T cell activation, antioxidant defense and fatty acid metabolism to enhance anti-bacterial immunity in tilapia
Fang, Z., Zheng, Y., Zhang, M., Xie, J., Shen, C., Zhu, Y., Jiang, Q., Lu, Y., Wei, X., & Yang, J. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111251 · Cited by 1
IP6K Gene Discovery in Plant mtDNA
Fassetti, F., Leone, O., Palopoli, L., Rombo, S. E., & Saiardi, A. (2011) · Lecture notes in computer science · doi:10.1007/978-3-642-21946-7_5 · Cited by 1
Self-citation
Structural Studies of Arabidopsis Thaliana Inositol Polyphosphate Multi-Kinase
Endo-Streeter, S. (2009) · DukeSpace (Duke University)
Biochemie und Molekulargenetik 2001
Cramer, P., Rappsilber, J., Mann, M., Kroll, W., & Schultz, C. (2002) · Nachrichten aus der Chemie · doi:10.1002/nadc.20020500309
Intracellular signaling of phosphorylated insitol compounds : A study in pancreatic beta-cells and hippocampal neurons
Yu, J. H. (2004) · Figshare
Review Inositol pyrophosphates: metabolism and signaling
Bennett, M. C., Onnebo, S. M. N., Azevedo, C., & Saiardi, A. (2006)
Self-citation
Novel regulatory mechanisms of inositol biosynthesis in Saccharomyces cerevisiae and mammalian cells, and implications for the mechanism underlying VPA-induced glucose 6-phosphate depletion
Yu, W. (2016) · Human Biology
The biological activity of rare carbohydrates and cyclitols in Coptotermes formosanus
Veillon, L. J. (2011) · doi:10.31390/gradschool_dissertations.3417

Authors: Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H.
Affiliations: Johns Hopkins University (US)
Corresponding author: Snyder, Solomon H.
ORCID: Saiardi, Adolfo
Nagata, Eiichiro
Luo, Hongbo R.
Sawa, Akira
Snyder, Solomon H.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-02-13
Volume: 98
Issue: 5
Pages: 2306-2311
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.041614598
PMC: PMC30134
OpenAlex: W1997739014
Cited by: 110
References: 35
Citations by year: 2026: 3 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 3
FWCI: 2.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: U.S. Public Health Service (MH‐18501, DA-00074)
National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
National Institute on Drug Abuse (DA 00074, K05DA000074)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: inositol polyphosphate multikinase, inositol 1,4,5-trisphosphate, inositol pyrophosphates, inositol 1,3,4,5-tetrakisphosphate, enzyme cloning, mammalian enzymes
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Male, Molecular Sequence Data, Inositol 1,4,5-Trisphosphate, Rats, Sprague-Dawley, Sequence Homology, Amino Acid, In Situ Hybridization, Phosphotransferases (Alcohol Group Acceptor), DNA Primers, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks