Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 491

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

Baba, Masaya, Hong, Seung-Beom, Sharma, Nirmala, Warren, Michelle B., Nickerson, Michael L., Iwamatsu, Akihiro, Esposito, Dominic, Gillette, William K., Hopkins, Ralph F., Hartley, James L., Furihata, Mutsuo, Oishi, Shinya, Zhen, Wei, Burke, Terrence R., Linehan, W. Marston, Schmidt, Laura S., Zbar, Berton·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0603781103
Open this paper in CoChat — free account

Abstract

Birt–Hogg–Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(FLCN) gene, which encodes a tumor-suppressor protein, folliculin (FLCN), with unknown function. The tumor-suppressor proteins encoded by genes responsible for several other hamartoma syndromes, LKB1, TSC1/2, and PTEN, have been shown to be involved in the mammalian target of rapamycin (mTOR) signaling pathway. Here, we report the identification of the FLCN-interacting protein, FNIP1, and demonstrate its interaction with 5′ AMP-activated protein kinase (AMPK), a key molecule for energy sensing that negatively regulates mTOR activity. FNIP1 was phosphorylated by AMPK, and its phosphorylation was reduced by AMPK inhibitors, which resulted in reduced FNIP1 expression. AMPK inhibitors also reduced FLCN phosphorylation. Moreover, FLCN phosphorylation was diminished by rapamycin and amino acid starvation and facilitated by FNIP1 overexpression, suggesting that FLCN may be regulated by mTOR and AMPK signaling. Our data suggest that FLCN, mutated in Birt–Hogg–Dubé syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.0603781103

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 4 references

Research works printed but not linked: 37

  1. 10.1001/archderm.1977.01640120042005 · DOI · Paper page
  2. JR Toro, G Glenn, P Duray, T Darling, G Weirich, B Zbar, WM Linehan, ML Turner Arch Dermatol 135, 1195–1202 (1999).
  3. B Zbar, WG Alvord, G Glenn, M Turner, CP Pavlovich, L Schmidt, M Walther, P Choyke, G Weirich, SM Hewitt, et al. Cancer Epidemiol Biomarkers Prev 11, 393–400 (2002).
  4. 10.1097/00000478-200212000-00002 · DOI · Paper page
  5. 10.1086/323744 · DOI · Paper page
  6. 10.1038/sj.onc.1204703 · DOI
  7. 10.1016/S1535-6108(02)00104-6 · DOI · Paper page
  8. 10.1136/jmg.39.12.906 · DOI
  9. 10.1086/430842 · DOI · Paper page
  10. 10.1093/jnci/dji154 · DOI
  11. 10.1038/modpathol.3800152 · DOI
  12. 10.1038/ng1494 · DOI · Paper page
  13. 10.1016/j.ccr.2004.06.020 · DOI
  14. 10.1016/j.ceb.2005.02.008 · DOI · Paper page
  15. 10.1016/j.ceb.2005.09.009 · DOI · Paper page
  16. 10.1038/34432 · DOI · Paper page
  17. 10.1038/ng0198-38 · DOI · Paper page
  18. 10.1101/gad.1199104 · DOI · Paper page
  19. 10.1007/s004390000348 · DOI · Paper page
  20. 10.1002/humu.10257 · DOI · Paper page
  21. 10.1126/stke.2122003re15 · DOI
  22. 10.1038/sj.onc.1207542 · DOI · Paper page
  23. 10.2174/1566524043359656 · DOI
  24. 10.1016/j.tibs.2003.11.005 · DOI · Paper page
  25. 10.1242/jcs.01540 · DOI · Paper page
  26. 10.1002/bies.10009 · DOI · Paper page
  27. 10.1042/bj3450437 · DOI · Paper page
  28. 10.1111/j.1432-1033.1989.tb15185.x · DOI · Paper page
  29. 10.1016/S0092-8674(03)00929-2 · DOI · Paper page
  30. 10.1016/j.ydbio.2005.11.039 · DOI
  31. 10.1016/j.ccr.2004.06.007 · DOI · Paper page
  32. 10.1073/pnas.96.8.4240 · DOI · Paper page
  33. 10.1016/S0955-0674(99)80029-5 · DOI · Paper page
  34. 10.1038/ncb840 · DOI · Paper page
  35. 10.1002/elps.1150130129 · DOI
  36. 10.1002/(SICI)1097-0231(199608)10:11<1371::AID-RCM682>3.0.CO;2-5 · DOI
  37. 10.1038/sj.onc.1206373 · DOI

Cited by

Metadata

Authors
Baba, M., Hong, S.-B., Sharma, N., Warren, M. B., Nickerson, M. L., Iwamatsu, A., Esposito, D., Gillette, W. K., Hopkins, R. F., Hartley, J. L., Furihata, M., Oishi, S., Zhen, W., Burke, T. R., Linehan, W. M., Schmidt, L. S., & Zbar, B.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2006-10-17
Volume
103
Issue
42
Pages
15552-15557
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0603781103
OpenAlex
W2032848771
Cited by
491
References
4
FWCI
6.51
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.