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Cited by 183

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini

Open access
Taverna, Sean D., Ueberheide, Beatrix M., Liu, Yifan, Tackett, Alan J., Diaz, Robert L., Shabanowitz, Jeffrey, Chait, Brian T., Hunt, Donald F., Allis, C. David·2007·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0610993104
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Abstract

Individual posttranslational modifications (PTMs) on histones have well established roles in certain biological processes, notably transcriptional programming. Recent genomewide studies describe patterns of covalent modifications, such as H3 methylation and acetylation at promoters of specific target genes, or “bivalent domains,” in stem cells, suggestive of a possible combinatorial interplay between PTMs on the same histone. However, detection of long-range PTM associations is often problematic in antibody-based or traditional mass spectrometric-based analyses. Here, histone H3 from a ciliate model was analyzed as an enriched source of transcriptionally active chromatin. Using a recently developed mass spectrometric approach, combinatorial modification states on single, long N-terminal H3 fragments (residues 1–50) were determined. The entire modification status of intact N termini was obtained and indicated correlations between K4 methylation and H3 acetylation. In addition, K4 and K27 methylation were identified concurrently on one H3 species. This methodology is applicable to other histones and larger polypeptides and will likely be a valuable tool in understanding the roles of combinatorial patterns of PTMs.

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Metadata

Authors
Taverna, S. D., Ueberheide, B. M., Liu, Y., Tackett, A. J., Diaz, R. L., Shabanowitz, J., Chait, B. T., Hunt, D. F., & Allis, C. D.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2007-02-13
Volume
104
Issue
7
Pages
2086-2091
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0610993104
OpenAlex
W2171825994
Cited by
183
References
5
FWCI
7.66
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. https://app.cochat.ai/papers/10.1073/pnas.0610993104
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Taverna, S. D., Ueberheide, B. M., Liu, Y., Tackett, A. J., Diaz, R. L., Shabanowitz, J., Chait, B. T., Hunt, D. F., & Allis, C. D. (2007). Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0610993104

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.