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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Open accessAbstract
With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time in the hippocampal formation of exercising mice. Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis. Moreover, exercise-induced increases in dentate gyrus CBV were found to correlate with postmortem measurements of neurogenesis. Second, using similar MRI technologies, we generated CBV maps over time in the hippocampal formation of exercising humans. As in mice, exercise was found to have a primary effect on dentate gyrus CBV, and the CBV changes were found to selectively correlate with cardiopulmonary and cognitive function. Taken together, these findings show that dentate gyrus CBV provides an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging.
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“A potential indirect measurement that has been established is the correlation between cerebral blood volume in the dentate gyrus, cognitive enhancements, and adult neurogenesis as a function of exercise (Pereira et al., 2007).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Pereira et al., 2007
In the citing paper
“For example, it has been shown that aerobic exercise increases the rate of neurogenesis in the dentate gyrus region of the rodent hippocampus and increases cerebral blood volume (CBV) in the same region in humans (Pereira et al., 2007; van Praag et al., 1999a,b).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“A previous human study by Pereira et al. (2007) reported a significant increase in CBV specifically in the dentate gyrus region of the hippocampus after three months of regular aerobic exercise in a group of eleven healthy adults.”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“previously published studies in rodents that have shown a robust vascular change within the hippocampus after a prolonged period of exercise (Pereira et al., 2007; Van der Borght et al., 2009; van Praag et al., 2005).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“the intervention in Pereira et al. (2007) is twice as long (3 months vs. 6 weeks).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“Increased hippocampal volume may in part be explained by exercise associated increases in neurogenesis in the dentate gyrus subfield of the hippocampus (97, 98), which is negatively impacted in PTSD (84).”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [98]
In the citing paper
“AE increases the rate of hippocampal neurogenesis, i.e., both the rate of cell proliferation as well as the survival of newborn granule cells (Cotman et al., 2007; Kempermann et al., 2010; Lucassen et al., 2010; Vivar et al., 2013) and despite being difficult to study in humans (Manganas et al., 2007; Ho et al., 2013; Jessberger and Gage, 2014), AE may also stimulate cell proliferation and DG”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
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Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Self-citationAngiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,379
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Self-citationRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citationAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588
L’examen Clinique en Psychologie
Rubé, P. (1959) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1959.13.4.989 · Cited by 3,299
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Self-citationExercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739
Research works printed but not linked: 3
- AC Maia, SM Malheiros, AJ da Rocha, CJ da Silva, AA Gabbai, FA Ferraz, JN Stavale Am J Neuroradiol 26, 777–783 (2005).
- HJ Aronen, FS Pardo, DN Kennedy, JW Belliveau, SD Packard, DW Hsu, FH Hochberg, AJ Fischman, BR Rosen Clin Cancer Res 6, 2189–2200 (2000).
- 10.1126/science.1083328 · DOI · Paper page
Cited by
Sorted by citations
Items 601–700 of 999
McEwen, S. C., Hardy, A., Ellingson, B. M., Jarrahi, B., Sandhu, N., Subotnik, K. L., Ventura, J., & Nuechterlein, K. H. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000983 · Cited by 29
Mansoor, M. A., Ibrahim, A., Hamide, A., Tran, T., Candreva, E., & Baltaji, J. (2025) · Physiologia · doi:10.3390/physiologia5020013 · Cited by 38
A Unique Mouse Model of Early Life Exercise Enables Hippocampal Memory and Synaptic Plasticity
Ivy, A. S., Yu, T., Kramár, E. A., Parievsky, S., Sohn, F., & Vu, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-66116-4 · Cited by 29
de Farias, J. M., Tramontin, N. D. S., Pereira, E. V., de Moraes, G. L., Furtado, B. A. G., Tietbohl, L. T. W., Pereira, B. D. C., Simon, K. U., & Muller, A. P. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02411-z · Cited by 29
Tang, J., Liang, X., Dou, X., Qi, Y., Yang, C., Luo, Y., Chao, F., Zhang, L., Xiao, Q., Jiang, L. H., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01747-3 · Cited by 33
Hwang, D., Kim, J., Kyun, S., Jang, I., Kim, T., Park, H., & Lim, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-33017-1 · Cited by 29
Does physical activity influence semantic memory activation in amnestic mild cognitive impairment?
Smith, J. C., Nielson, K. A., Woodard, J. L., Seidenberg, M., Verber, M., Durgerian, S., Antuono, P., Butts, A. M., Hantke, N. C., Lancaster, M. A., et al. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.04.001 · Cited by 29
Körperliche Aktivität als therapeutische Intervention bei Depression
Ledochowski, L., Stark, R., Ruedl, G., & Kopp, M. (2016) · Der Nervenarzt · doi:10.1007/s00115-016-0222-x · Cited by 32
Kim, J. W., Nam, S. M., Yoo, D. Y., Jung, H. Y., Kim, I. Y., Hwang, I. K., Seong, J. K., & Yoon, Y. S. (2017) · Neural Plasticity · doi:10.1155/2017/5863258 · Cited by 30
Hermanns, M., Haas, B. K., & Lisk, J. P. (2019) · Gerontology and Geriatric Medicine · doi:10.1177/2333721419842671 · Cited by 29
Castells-Sánchez, A., Roig-Coll, F., Lamonja-Vicente, N., Altés-Magret, M., Torán‐Monserrat, P., Vía, M., García‐Molina, A., Tormos, J. M., Heras, A., Alzamora, M. T., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00216 · Cited by 32
Callow, D. D., Won, J., Pena, G. S., Jordan, L. S., Arnold-Nedimala, N. A., Kommula, Y., Nielson, K. A., & Smith, J. C. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.645258 · Cited by 27
The influence of physiological and pathological perturbations on blood-brain barrier function
Zhao, N., Chung, T. D., Guo, Z., Jamieson, J. J., Liang, L. R., Linville, R. M., Pessell, A. F., Wang, L., & Searson, P. C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1289894 · Cited by 31
Pérez‐Domínguez, M., Tovar‐y‐Romo, L. B., & Zepeda, A. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0024 · Cited by 29
Endogenous neural precursor cells in health and disease
Bacigaluppi, M., Sferruzza, G., Butti, E., Ottoboni, L., & Martino, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146619 · Cited by 29
Is Adult Hippocampal Neurogenesis Really Relevant for the Treatment of Psychiatric Disorders?
Carli, M., Aringhieri, S., Kolachalam, S., Longoni, B., Grenno, G., Rossi, M., Gemignani, A., Fornai, F., Maggio, R., & Scarselli, M. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200818194948 · Cited by 29
Effects of Multicomponent Exercise on Cognitive Function in Elderly Korean Individuals
Kim, Y. J., Park, H., Park, J., Park, K. W., Lee, K., Kim, S., Chae, K., Park, M. H., Koh, S., & Na, H. R. (2020) · Journal of Clinical Neurology · doi:10.3988/jcn.2020.16.4.612 · Cited by 28
González-Férnandez, F. T., González‐Víllora, S., Baena‐Morales, S., Vicedo, J. C. P., Clemente, F. M., Bădicu, G., & Murawska‐Ciałowicz, E. (2021) · Biology · doi:10.3390/biology10111151 · Cited by 36
Exercise to Enhance Neurocognitive Function After Traumatic Brain Injury
Fogelman, D. R., & ZAFONTE, R. D. (2012) · PM&R · doi:10.1016/j.pmrj.2012.09.028 · Cited by 28
Abou-Dest, A., Albinet, C. T., Boucard, G., & Audiffren, M. F. (2012) · Journal of Aging Research · doi:10.1155/2012/273185 · Cited by 32
Akhavan, M. M., Foroutan, T., Safari, M., Sadighi‐Moghaddam, B., Emami-Abarghoie, M., & Rashidy‐Pour, A. (2012) · PubMed · Cited by 28
In vivo evidence of hippocampal dentate gyrus expansion in multiple sclerosis
Rocca, M. A., Longoni, G., Pagani, E., Boffa, G., Colombo, B., Rodegher, M., Martino, G., Falini, A., Comı, G., & Filippi, M. (2015) · Human Brain Mapping · doi:10.1002/hbm.22946 · Cited by 27
Saleem, M., Herrmann, N., Dinoff, A., Mielke, M. M., OH, P. I., Shammi, P., Cao, X., Venkata, S. L. V., Haughey, N. J., & Lanctôt, K. L. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161292 · Cited by 29
Palmer, J. A., Morris, J. K., Billinger, S. A., Lepping, R. J., Martin, L. E., Green, Z. D., & Vidoni, E. D. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac418 · Cited by 30
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
Methi, A., Islam, M. R., Kaurani, L., Sakib, M. S., Krüger, D. M., Pena, T., Burkhardt, S., Liebetanz, D., & Fischer, A. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03869-9 · Cited by 33
Rapid cellular genesis and apoptosis: Effects of exercise in the adult rat.
Kerr, A. L., & Swain, R. A. (2011) · Behavioral Neuroscience · doi:10.1037/a0022332 · Cited by 27
Glioblastoma Multiforme: Relationship to Subventricular Zone and Recurrence
Kimura, M., Lee, Y., Miller, C. R., & Castillo, M. (2013) · The Neuroradiology Journal · doi:10.1177/197140091302600507 · Cited by 27
The interplay between neuropathology and activity based rehabilitation after traumatic brain injury
Kreber, L. A., & Griesbach, G. S. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.016 · Cited by 31
Kim, J. H., Liu, Q. F., Urnuhsaikhan, E., Jeong, H. J., Jeon, M. Y., & Jeon, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1239-x · Cited by 27
Zhou, X.-L., Wang, L., Wang, J., Zhou, L., & Shen, X. (2020) · Medicine · doi:10.1097/md.0000000000020105 · Cited by 27
On the measurement of absolute cerebral blood volume (CBV) using vascular‐space‐occupancy (VASO) MRI
Uh, J., Lewis‐Amezcua, K., Varghese, R., & Lu, H. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21872 · Cited by 27
Physical Activity and Fitness Effects on Cognition and Brain Health in Children and Older Adults
Chaddock, L., Voss, M. W., & Kramer, A. F. (2012) · Kinesiology Review · doi:10.1123/krj.1.1.37 · Cited by 28
No Genes for Intelligence in the Fluid Genome
Ho, M. (2013) · Advances in child development and behavior · doi:10.1016/b978-0-12-397946-9.00004-x · Cited by 26
Milbocker, K. A., Smith, I. F., & Klintsova, A. Y. (2023) · Brain Plasticity · doi:10.3233/bpl-230151 · Cited by 29
Georgi, E., Petermann, F., & Schipper, M. (2013) · Social Neuroscience · doi:10.1080/17470919.2013.855253 · Cited by 26
Effect of voluntary running on expression of myokines in brains of rats with depression
Algaidi, S. A., Eldomiaty, M. A., Elbastwisy, Y. M., Almasry, S. M., Desouky, M. K., & Elnaggar, A. M. (2019) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738419833533 · Cited by 26
Bosch, B. M., Bringard, A., Ferretti, G., Schwartz, S., & Iglói, K. (2017) · Neurophotonics · doi:10.1117/1.nph.4.4.041404 · Cited by 26
Effect of physical exercise on hippocampal volume in adults: Systematic review and meta-analysis
Feter, N., Penny, J. C., Freitas, M. P., & Rombaldi, A. J. (2018) · Science & Sports · doi:10.1016/j.scispo.2018.02.011 · Cited by 31
Cho, J.-W., Jung, S.-Y., Kim, D.-Y., Chung, Y.-R., Choi, H.-H., Jeon, J. W., & Han, J. (2018) · International Neurourology Journal · doi:10.5213/inj.1836224.112 · Cited by 26
Kronman, C. A., Kern, K. L., Nauer, R. K., Dunne, M. F., Storer, T. W., & Schön, K. (2019) · Hippocampus · doi:10.1002/hipo.23169 · Cited by 26
Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
Zheng, J. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12212 · Cited by 25
The Therapeutic Role of Exercise and Probiotics in Stressful Brain Conditions
Martínez‐Guardado, I., Arboleya, S., Pérez, F. J. G., Kaliszewska, A., Gueimonde, M., & Arias, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073610 · Cited by 27
Der Zusammenhang von Fitness, kognitiver Leistungsfähigkeit und Gehirnzustand im Schulkindalter
Hillman, C. H., & Schott, N. (2013) · Zeitschrift für Sportpsychologie · doi:10.1026/1612-5010/a000085 · Cited by 33
Lewandowski, N. M., Bordelon, Y. M., Brickman, A. M., Angulo, S. L., Khan, U., Muraskin, J., Griffith, E. Y., Wasserman, P., Menalled, L., Vonsattel, J. P., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.014 · Cited by 26
Self-citationBorogovac, A., Habeck, C. G., Small, S. A., & Asllani, I. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.89 · Cited by 26
Self-citationLai, J.-H., Chen, K., Wu, J. C.-C., Olson, L., Brené, S., Huang, C.-Z., Chen, Y., Kang, S.-J., Ma, K., Hoffer, B. J., et al. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146301 · Cited by 26
Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity
Uh, J., Lewis‐Amezcua, K., Martin‐Cook, K., Cheng, Y., Weiner, M., Diaz-Arrastia, R. R., Devous, M. D., Shen, D. G., & Lu, H. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.12.010 · Cited by 26
Role of BDNF val66met polymorphism in modulating exercised-induced emotional memories
Keyan, D., & Bryant, R. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.013 · Cited by 25
The Mechanism of Physical Activity-induced Amelioration of Parkinson’s Disease: A Narrative Review
Gronek, P., Haas, A. N., Czarny, W., Podstawski, R., Delabary, M. D. S., Clark, C. C. T., Boraczyński, M., Tarnas, M., Wycichowska, P., Pawlaczyk, M., et al. (2021) · Aging and Disease · doi:10.14336/ad.2020.0407 · Cited by 27
Amaya, Y., Abe, T., Kanbara, K., Shizuma, H., Akiyama, Y., & Fukunaga, M. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00332-x · Cited by 32
Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions
Voss, M. W., & Jain, S. (2022) · Physiology · doi:10.1152/physiol.00038.2021 · Cited by 26
MacIntosh, B. J., Swardfager, W., Crane, D., Ranepura, N., Saleem, M., OH, P. I., Stefanovic, B., Herrmann, N., & Lanctôt, K. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091251 · Cited by 25
Exercise and the Brain: Neurogenesis, Synaptic Plasticity, Spine Density, and Angiogenesis
Wang, Z., & van Praag, H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3293-7_1 · Cited by 31
Bär, K., Herbsleb, M., Schumann, A., de la Cruz, F., Gabriel, H. W., & Wagner, G. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00145 · Cited by 27
Heisz, J. J., Vandermorris, S., Wu, J., McIntosh, A. R., & Ryan, J. D. (2014) · Health Psychology · doi:10.1037/hea0000046 · Cited by 26
Cerebral blood flow is not modulated following acute aerobic exercise in preadolescent children
Pontifex, M. B., Gwizdala, K. L., Weng, T. B., Zhu, D. C., & Voss, M. W. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.10.007 · Cited by 25
Non-pharmacological Approaches to Cognitive Enhancement
Kelly, A. M. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_14 · Cited by 25
Effect of cognitively engaging physical activity on executive functions in children
Bulten, R., Bedard, C., Graham, J. D., & Cairney, J. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.841192 · Cited by 32
Effects of Cardiorespiratory Fitness on Cerebral Oxygenation in Healthy Adults: A Systematic Review
Salzman, T., Dupuy, O., & Fraser, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.838450 · Cited by 26
Effects of Diet and/or Exercise in Enhancing Spinal Cord Sensorimotor Learning
Joseph, M. S., Ying, Z., Zhuang, Y., Zhong, H., Wu, A., Bhatia, H. S., Cruz, R., Tillakaratne, N. J. K., Roy, R. R., Edgerton, V. R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041288 · Cited by 25
Poor physical fitness is independently associated with mild cognitive impairment in elderly Koreans
Lee, S., Han, J., Jin, Y.-U., Lee, I., Hong, H., & Kang, H. (2015) · Biology of Sport · doi:10.5604/20831862.1185889 · Cited by 24
Iyalomhe, O., Chen, Y., Allard, J. S., Ntekim, O. E., Johnson, S. M., Bond, V., Goerlitz, D. S., Li, J., & Obisesan, T. O. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.05.005 · Cited by 25
Demirakca, T., Brusniak, W., Tunc-Skarka, N., Wolf, I., Meier, S., Matthäus, F., Ende, G., Schulze, T. G., & Diener, C. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.803600 · Cited by 23
Esteras, N., Alquézar, C., Bartolomé, F. B., Antequera, D., Barrios, L., Carro, E., Cerdán, S., & Martín‐Requero, Á. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111967 · Cited by 23
Can aerobic exercise protect against dementia?
Graff‐Radford, N. R. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt65 · Cited by 26
Cognitive Impairments of Sleep-Deprived Ovariectomized (OVX) Female Rats by Voluntary Exercise
Rajizadeh, M. A., Esmaeilpour, K., Motamedy, S., Borzadaran, F. M., & Sheibani, V. (2020) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.10.505 · Cited by 26
Alfini, A. J., Won, J., Weiss, L. R., Nyhuis, C. C., Shackman, A. J., Spira, A. P., & Smith, J. C. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa149 · Cited by 29
Effects of acute aerobic exercise on mnemonic discrimination performance in older adults
Callow, D. D., Pena, G. S., Stark, C. E. L., & Smith, J. C. (2022) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617722000492 · Cited by 29
Zalouli, V., Rajavand, H., Bayat, M., Khaleghnia, J., Sharifianjazi, F., Jafarinazhad, F., & Beheshtizadeh, N. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115078 · Cited by 27
RetractedPoorer aerobic fitness relates to reduced integrity of multiple memory systems
Pontifex, M. B., Parks, A. C., O’Neil, P. C., Egner, A. R., Warning, J. T., Pfeiffer, K. A., & Fenn, K. M. (2014) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-014-0265-z · Cited by 25
Smith, P. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.013 · Cited by 24
Xu, H., Tian, X., Wang, Y., Lin, J., Zhu, B., Chen, Z., Wang, B., Zhang, X., Sun, Y., Li, N., et al. (2024) · Biology · doi:10.3390/biology13100809 · Cited by 30
Hugenschmidt, C. E., Leng, X., Lyles, M. F., Michael, L., Dougherty, A. M., Babcock, P., Baker, L. D., Brinkley, T. E., & Nicklas, B. J. (2019) · Obesity · doi:10.1002/oby.22525 · Cited by 23
Luvuno, M., Khathi, A., & Mabandla, M. V. (2020) · Scientific Reports · doi:10.1038/s41598-020-72098-0 · Cited by 21
Wnt Signaling in the Adult Hippocampal Neurogenic Niche
Arredondo, S. B., Valenzuela-Bezanilla, D., Santibanez, S. H., & Varela‐Nallar, L. (2022) · Stem Cells · doi:10.1093/stmcls/sxac027 · Cited by 21
Lowe, C. J., Staines, R. W., & Hall, P. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000361 · Cited by 25
Xu, B., Sun, A., He, Y., Qian, F., Liu, L., Chen, Y., & Luo, H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.002 · Cited by 21
Candela, F., Zucchetti, G., Magistro, D., & Rabaglietti, E. (2015) · Activities Adaptation & Aging · doi:10.1080/01924788.2014.977191 · Cited by 22
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Yao, M., Qu, Y., Zheng, Y., & Guo, H. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111130 · Cited by 26
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Ammothumkandy, A., Corona, L., Rāviņa, K., Wolseley, V., Nelson, J., Atai, N., Abedi, A., Jimenez, N., Armacost, M., D’Orazio, L. M., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.11.002 · Cited by 23
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Salvan, P., Wassenaar, T. M., Wheatley, C., Beale, N., Cottaar, M., Papp, D. S., Bastiani, M., Fitzgibbon, S. P., Duff, E., Andersson, J., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1260-20.2020 · Cited by 19
Steventon, J. J., Chandler, H. L., Foster, C., Dingsdale, H., Germuska, M. A., Massey, T. H., Parker, G. D., Wise, R. G., & Murphy, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-01630-7 · Cited by 25
Lattanzi, D., Savelli, D., Pagliarini, M., Cuppini, R., & Ambrogini, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126866 · Cited by 20
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Vidoni, E. D., Morris, J. K., Palmer, J. A., Li, Y., White, D., Kueck, P. J., John, C. S., Honea, R. A., Lepping, R. J., Lee, P., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265860 · Cited by 22
Mehla, J., Deibel, S. H., Karem, H., Hossain, S., Lacoursiere, S. G., Sutherland, R. J., Mohajerani, M. H., & McDonald, R. J. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01085-6 · Cited by 22
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Hartman-Stein, P. E., & Rue, A. L. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0636-6 · Cited by 43
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Darlix, A., Gozé, C., Rigau, V., Bauchet, L., Taillandier, L., & Duffau, H. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.11.014 · Cited by 21
Трофимов, А. Н., Strekalova, T. V., Mortimer, N., Zubareva, O. E., Schwarz, A. P., Svirin, E. P., Umriukhin, A., Svistunov, A. A., Lesch, K., & Клименко, В. М. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9720-2 · Cited by 21
Kern, K. L., Storer, T. W., & Schön, K. (2020) · Human Brain Mapping · doi:10.1002/hbm.25259 · Cited by 20
Li, Q., Liu, J., Michaud, M., Schwartz, M. L., & Madri, J. A. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090354 · Cited by 21
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Kim, Y. S. (2014) · Hanyang Medical Reviews · doi:10.7599/hmr.2014.34.2.60 · Cited by 21
Brain Aging and Regeneration after Injuries: an Organismal approach.
Buga, A.-M., Vintilescu, R., Pop, O. T., & Popa‐Wagner, A. (2011) · Europe PMC (PubMed Central) · Cited by 19
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Camfield, D., Fontana, R. D. S., Wesnes, K. A., Mills, J. G., & Croft, R. J. (2017) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2017.1325827 · Cited by 22
Islam, M. R., Luo, R., Valaris, S., Haley, E. B., Takase, H., Chen, Y. I., Dickerson, B. C., Schön, K., Arai, K., Nguyen, C. T., et al. (2019) · Brain Plasticity · doi:10.3233/bpl-190090 · Cited by 21
Borg, M. L., Lemus, M. B., Reichenbach, A., Selathurai, A., Oldfield, B. J., Andrews, Z. B., & Watt, M. J. (2014) · Diabetes · doi:10.2337/db13-1762 · Cited by 21
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Bullock, A., Mizzi, A. L., Kovačević, A., & Heisz, J. J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00063 · Cited by 23
Coleman, M. B., Offen, K., & Markant, J. C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01405 · Cited by 24
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Yi, Y., Song, Y., & Lu, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00024 · Cited by 21
Metadata
- Authors
- Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A.
- Affiliations
- *The Taub Institute for Research on Alzheimer's Disease and the Aging Brain,
- Neurosurgery,
- Psychiatry, and
- Salk Institute for Biological Studies (US)
- Columbia University Irving Medical Center (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-03-27
- Volume
- 104
- Issue
- 13
- Pages
- 5638-5643
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1838482
- OpenAlex
- W2145944042
- Cited by
- 1,353
- References
- 59
- Citations by year
- 2026: 34 · 2025: 48 · 2024: 45 · 2023: 46 · 2022: 61 · 2021: 72 · 2020: 116 · 2019: 84 · 2018: 69 · 2017: 83 · 2016: 82 · 2015: 94 · 2014: 82 · 2013: 85 · 2012: 88
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- National Institute on Aging (AG025161, R01AG025161, P50AG008702)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- adult neurogenesis, physical activity, dentate gyrus, cerebral blood volume, angiogenesis, hippocampus, cardiopulmonary function, cognitive function, cognitive aging
- MeSH terms
- Adult, Aging, Animals, Brain Mapping, Female, Hippocampus, Humans, Male, Mice, Inbred C57BL, Middle Aged, Neovascularization, Pathologic, Neurons, Exercise, Dentate Gyrus, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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