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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Open accessAbstract
With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time in the hippocampal formation of exercising mice. Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis. Moreover, exercise-induced increases in dentate gyrus CBV were found to correlate with postmortem measurements of neurogenesis. Second, using similar MRI technologies, we generated CBV maps over time in the hippocampal formation of exercising humans. As in mice, exercise was found to have a primary effect on dentate gyrus CBV, and the CBV changes were found to selectively correlate with cardiopulmonary and cognitive function. Taken together, these findings show that dentate gyrus CBV provides an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging.
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“A potential indirect measurement that has been established is the correlation between cerebral blood volume in the dentate gyrus, cognitive enhancements, and adult neurogenesis as a function of exercise (Pereira et al., 2007).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Pereira et al., 2007
In the citing paper
“For example, it has been shown that aerobic exercise increases the rate of neurogenesis in the dentate gyrus region of the rodent hippocampus and increases cerebral blood volume (CBV) in the same region in humans (Pereira et al., 2007; van Praag et al., 1999a,b).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“A previous human study by Pereira et al. (2007) reported a significant increase in CBV specifically in the dentate gyrus region of the hippocampus after three months of regular aerobic exercise in a group of eleven healthy adults.”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“previously published studies in rodents that have shown a robust vascular change within the hippocampus after a prolonged period of exercise (Pereira et al., 2007; Van der Borght et al., 2009; van Praag et al., 2005).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“the intervention in Pereira et al. (2007) is twice as long (3 months vs. 6 weeks).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“Increased hippocampal volume may in part be explained by exercise associated increases in neurogenesis in the dentate gyrus subfield of the hippocampus (97, 98), which is negatively impacted in PTSD (84).”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [98]
In the citing paper
“AE increases the rate of hippocampal neurogenesis, i.e., both the rate of cell proliferation as well as the survival of newborn granule cells (Cotman et al., 2007; Kempermann et al., 2010; Lucassen et al., 2010; Vivar et al., 2013) and despite being difficult to study in humans (Manganas et al., 2007; Ho et al., 2013; Jessberger and Gage, 2014), AE may also stimulate cell proliferation and DG”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
In the citing paper
“This coincides with studies that have demonstrated a greater cerebral blood flow in the human hippocampus (Pereira et al., 2007; Burdette et al., 2010; Maass et al., 2015), some of which have correlated this increase with improved performance on episodic memory tasks (Pereira et al., 2007; Maass et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Pereira et al., 2007
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Koopmans, P. J., Barth, M., Orzada, S., & Norris, D. G. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.042 · Cited by 160
Roles of myokines in exercise-induced improvement of neuropsychiatric function
Kim, S., Choi, J., Moon, S., Park, D., Kwak, H., & Kang, J. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02253-8 · Cited by 177
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“For example, it has been shown that aerobic exercise increases the rate of neurogenesis in the dentate gyrus region of the rodent hippocampus and increases cerebral blood volume (CBV) in the same region in humans (Pereira et al., 2007; van Praag et al., 1999a,b).”
BackgroundMethodResultInfluentialPhysical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
Smith, J. C., Nielson, K. A., Woodard, J. L., Seidenberg, M., Durgerian, S., Hazlett, K. E., Figueroa, C. M., Kandah, C. C., Kay, C. D., Matthews, M. A., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00061 · Cited by 172
Thomas, B. P., Yezhuvath, U. S., Tseng, B. Y., Liu, P., Levine, B. D., Zhang, R., & Lu, H. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24090 · Cited by 150
Ischemic stroke and neurogenesis in the subventricular zone
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Shimada, H., Makizako, H., Doi, T., Park, H., Tsutsumimoto, K., Verghese, J., & Suzuki, T. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.09.019 · Cited by 159
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“Increased hippocampal volume may in part be explained by exercise associated increases in neurogenesis in the dentate gyrus subfield of the hippocampus (97, 98), which is negatively impacted in PTSD (84).”
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155
A review of cardiorespiratory fitness-related neuroplasticity in the aging brain
Hayes, S. M., Hayes, J. P., Cadden, M., & Verfaellie, M. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00031 · Cited by 154
Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose
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Running rewires the neuronal network of adult-born dentate granule cells
Vivar, C., Peterson, B. D., & van Praag, H. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.031 · Cited by 143
Neuroprotective effects of yoga practice: age-, experience-, and frequency-dependent plasticity
Villemure, C., ÄŒeko, M., Cotton, V. A., & Bushnell, M. C. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00281 · Cited by 159
Wahl, D., Solon‐Biet, S. M., Cogger, V. C., Fontana, L., Simpson, S. J., Couteur, D. G. L., & Ribeiro, R. V. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104481 · Cited by 155
Lisdahl, K. M., & Price, J. S. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617712000276 · Cited by 163
Exercise, Energy Intake, Glucose Homeostasis, and the Brain
van Praag, H., Fleshner, M., Schwartz, M. W., & Mattson, M. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2814-14.2014 · Cited by 157
Preventing Alzheimer’s Disease and Cognitive Decline
April, & Natcher, W. H. (2010) · Cited by 148
Chen, C., & Nakagawa, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101868 · Cited by 178
Metadata
- Authors
- Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A.
- Affiliations
- *The Taub Institute for Research on Alzheimer's Disease and the Aging Brain,
- Neurosurgery,
- Psychiatry, and
- Salk Institute for Biological Studies (US)
- Columbia University Irving Medical Center (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-03-27
- Volume
- 104
- Issue
- 13
- Pages
- 5638-5643
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1838482
- OpenAlex
- W2145944042
- Cited by
- 1,353
- References
- 59
- Citations by year
- 2026: 34 · 2025: 48 · 2024: 45 · 2023: 46 · 2022: 61 · 2021: 72 · 2020: 116 · 2019: 84 · 2018: 69 · 2017: 83 · 2016: 82 · 2015: 94 · 2014: 82 · 2013: 85 · 2012: 88
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- National Institute on Aging (AG025161, R01AG025161, P50AG008702)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- adult neurogenesis, physical activity, dentate gyrus, cerebral blood volume, angiogenesis, hippocampus, cardiopulmonary function, cognitive function, cognitive aging
- MeSH terms
- Adult, Aging, Animals, Brain Mapping, Female, Hippocampus, Humans, Male, Mice, Inbred C57BL, Middle Aged, Neovascularization, Pathologic, Neurons, Exercise, Dentate Gyrus, Mice
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