The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch
Open accessAbstract
In mammals and birds, sex differences in brain function and disease are thought to derive exclusively from sex differences in gonadal hormone secretions. For example, testosterone in male mammals acts during fetal and neonatal life to cause masculine neural development. However, male and female brain cells also differ in genetic sex; thus, sex chromosome genes acting within cells could contribute to sex differences in cell function. We analyzed the sexual phenotype of the brain of a rare gynandromorphic finch in which the right half of the brain was genetically male and the left half genetically female. The neural song circuit on the right had a more masculine phenotype than that on the left. Because both halves of the brain were exposed to a common gonadal hormone environment, the lateral differences indicate that the genetic sex of brain cells contributes to the process of sexual differentiation. Because both sides of the song circuit were more masculine than that of females, diffusible factors such as hormones of gonadal or neural origin also likely played a role in sexual differentiation.
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Self-citationSexual Dimorphism in Vocal Control Areas of the Songbird Brain
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Self-citationHormone-Induced Sexual Differentiation of Brain and Behavior in Zebra Finches
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Sex chromosome genes directly affect brain sexual differentiation
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Sexual differentiation of the vertebrate nervous system
Morris, J. A., Jordan, C. L., & Breedlove, S. M. (2004) · Nature Neuroscience · doi:10.1038/nn1325 · Cited by 627
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Self-citationMinireview: sex differences in adult and developing brains: compensation, compensation, compensation
De Vries, G. J. (2004) · Endocrinology · doi:10.1210/en.2003-1504 · Cited by 486
Sex chromosomes and brain gender
Arnold, A. P. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1494 · Cited by 368
Self-citationDosage compensation is less effective in birds than in mammals
Itoh, Y., Melamed, E., Yang, X., Kampf, K., Wang, S., Yehya, N., Van Nas, A., Replogle, K., Band, M. R., Clayton, D. F., et al. (2007) · Journal of Biology · doi:10.1186/jbiol53 · Cited by 353
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Metadata
- Authors
- Agate, R. J., Grisham, W., Wade, J., Mann, S., Wingfield, J., Schanen, C., Palotie, A., & Arnold, A. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-04-02
- Volume
- 100
- Issue
- 8
- Pages
- 4873-4878
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113027392
- Cited by
- 256
- References
- 28
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Agate, R. J., Grisham, W., Wade, J., Mann, S., Wingfield, J., Schanen, C., Palotie, A., & Arnold, A. P. (2003). Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0636925100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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