Sex chromosome genes directly affect brain sexual differentiation

Hormones, Brain and Behavior

(2009) · Elsevier eBooks · doi:10.1016/c2009-1-03789-7 · Cited by 1,543 · see citing works

Plasma Testosterone and Progesterone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring*

WEISZ, J., & WARD, I. L. (1980) · Endocrinology · doi:10.1210/endo-106-1-306 · Cited by 830 · see citing works

Gender Differences in Dopaminergic Function in Striatum and Nucleus Accumbens

Becker, J. B. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00168-9 · Cited by 696 · see citing works

XY female mice resulting from a heritable mutation in the primary testis determining gene, <i>Tdy</i>

Lovell-Badge, R., & Robertson, E. (1990) · Development · doi:10.1242/dev.109.3.635 · Cited by 311 · see citing works

Sex differences in sex chromosome gene expression in mouse brain

Xu, J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.12.1409 · Cited by 269 · see citing works

Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities

Mahadevaiah, S. K. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.4.715 · Cited by 228 · see citing works

Sexual differentiation of monoaminergic neurons - genetic or epigenetic?

Reisert, I., & Pilgrim, C. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90047-x · Cited by 185 · see citing works

Transcription of the Y chromosomal gene,Sry, in adult mouse brain

Lahr, G., Maxson, S. C., Mayer, A., Just, W., Pilgrim, C., & Reisert, I. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00136-g · Cited by 123 · see citing works

TESTOSTERONE SECRETION BY FOETAL RAT TESTES IN VITRO

Picon, R. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0710231 · Cited by 100 · see citing works

Concepts of Genetic and Hormonal Induction of Vertebrate Sexual Differentiation in the Twentieth Century, with Special Reference to the Brain

Arnold, A. P. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50065-2 · Cited by 76 · see citing works

Differences Between Male and Female Brains - Developmental Mechanisms and Implications

Pilgrim, C., & Reisert, I. (1992) · Hormone and Metabolic Research · doi:10.1055/s-2007-1003334 · Cited by 66 · see citing works

Genotype-dependent sex differentiation of dopaminergic neurons in primary cultures of embryonic mouse brain

Sibug, R. M., Küppers, E., Beyer, C., Maxson, S. C., Pilgrim, C., & Reisert, I. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00024-7 · Cited by 60 · see citing works

Sex steroids do not alter sex differences in tyrosine hydroxylase activity of dopaminergic neurons in vitro

Beyer, C., Eusterschulte, B., Pilgrim, C., & Reisert, I. (1992) · Cell and Tissue Research · doi:10.1007/bf00645057 · Cited by 54 · see citing works

Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex

McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574 · see citing works

Neurobiological and Systemic Effects of Chronic Stress

McEwen, B. S. (2017) · Chronic Stress · doi:10.1177/2470547017692328 · Cited by 1,059 · see citing works

Sex differences in drug abuse

Becker, J. B., & Hu, M. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.07.003 · Cited by 1,003 · see citing works

Strategies and Methods for Research on Sex Differences in Brain and Behavior

Becker, J. B., Arnold, A. P., Berkley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E., Herman, J. P., Marts, S. A., Sadée, W., Steiner, M. S., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1142 · Cited by 799 · see citing works

Sex Differences in the Brain: The Not So Inconvenient Truth

McCarthy, M. M., Arnold, A. P., Ball, G. F., Blaustein, J. D., & De Vries, G. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5372-11.2012 · Cited by 724 · see citing works

The organizational–activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues

Arnold, A. P. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.011 · Cited by 625 · see citing works

What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues?

Arnold, A. P., & Chen, X. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.001 · Cited by 587 · see citing works

Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know

Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533 · see citing works

A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits

De Vries, G. J., Rissman, E. F., Simerly, R. B., Yang, L.-Y., Scordalakes, E. M., Auger, C. J., Swain, A., Lovell-Badge, R., Burgoyne, P. S., & Arnold, A. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09005.2002 · Cited by 509 · see citing works

Minireview: sex differences in adult and developing brains: compensation, compensation, compensation

De Vries, G. J. (2004) · Endocrinology · doi:10.1210/en.2003-1504 · Cited by 486 · see citing works

Sex differences in neural mechanisms mediating reward and addiction

Becker, J. B., & Chartoff, E. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0125-6 · Cited by 455 · see citing works

The genetics of sex differences in brain and behavior

Ngun, T. C., Ghahramani, N., Sánchez, F. J., Bocklandt, S., & Vilain, E. J. N. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.10.001 · Cited by 437 · see citing works

From stem cells to neurons and glia: a Soxist's view of neural development

Wegner, M., & Stolt, C. C. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.08.008 · Cited by 426 · see citing works

Genes that escape from X inactivation

Berletch, J. B., Yang, F., Xu, J., Carrel, L., & Disteche, C. M. (2011) · Human Genetics · doi:10.1007/s00439-011-1011-z · Cited by 384 · see citing works

Sex chromosomes and brain gender

Arnold, A. P. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1494 · Cited by 368 · see citing works

Dopaminergic dynamics underlying sex-specific cocaine reward

Calipari, E. S., Juarez, B., Morel, C., Walker, D. M., Cahill, M. E., Ribeiro, E., Roman-Ortiz, C., Ramakrishnan, C., Deisseroth, K., Han, M.-H., et al. (2017) · Nature Communications · doi:10.1038/ncomms13877 · Cited by 359 · see citing works

Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway

Du, L., Bayır, H., Lai, Y., Zhang, X., Kochanek, P. M., Watkins, S. C., Graham, S. H., & Clark, R. S. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405461200 · Cited by 351 · see citing works

Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation

Dewing, P., Shi, T., Horvath, S., & Vilain, E. J. N. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00339-5 · Cited by 348 · see citing works

Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis

Becker, J. B., Perry, A. N., & Westenbroek, C. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-14 · Cited by 315 · see citing works

The role of bisphenol A in shaping the brain, epigenome and behavior

Wolstenholme, J. T., Rissman, E. F., & Connelly, J. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.10.001 · Cited by 309 · see citing works

Biological Basis of Sex Differences in the Propensity to Self-administer Cocaine

Hu, M., Crombag, H. S., Robinson, T. E., & Becker, J. B. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300301 · Cited by 303 · see citing works

Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones

Mong, J. A., Baker, F. C., Mahoney, M. M., Paul, K. N., Schwartz, M. D., Semba, K., & Silver, R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4175-11.2011 · Cited by 295 · see citing works

Recognizing resilience: Learning from the effects of stress on the brain

McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.001 · Cited by 292 · see citing works

Sexual dimorphism in mammalian gene expression

Rinn, J. L., & Snyder, M. P. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.03.005 · Cited by 285 · see citing works

Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia–ischaemia

Zhu, C., Xu, F., Wang, X., Shibata, M., Uchiyama, Y., Blomgren, K., & Hagberg, H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03639.x · Cited by 272 · see citing works

Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch

Agate, R. J., Grisham, W., Wade, J., Mann, S. M., Wingfield, J. C., Schanen, C., Palotie, A. V., & Arnold, A. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0636925100 · Cited by 256 · see citing works

Sex Chromosome Complement and Gonadal Sex Influence Aggressive and Parental Behaviors in Mice

Gatewood, J. D., Wills, A., Shetty, S. R. J., Xu, J., Arnold, A. P., Burgoyne, P. S., & Rissman, E. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3743-05.2006 · Cited by 247 · see citing works

Sex differences in autoimmune diseases

Voskuhl, R. R. (2011) · Biology of Sex Differences · doi:10.1186/2042-6410-2-1 · Cited by 246 · see citing works

Genomic and epigenomic mechanisms of glucocorticoids in the brain

Gray, J. D., Kogan, J. F., Marrocco, J., & McEwen, B. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.97 · Cited by 242 · see citing works

Do you know the sex of your cells?

Shah, K., McCormack, C. E., & Bradbury, N. A. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00281.2013 · Cited by 219 · see citing works

Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes

Vawter, M. P., Evans, S. J., Choudary, P. V., Tomita, H., Meador-Woodruff, J., Molnar, M., Li, J. Z., López, J. F., Myers, R. M., Cox, D. R., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300337 · Cited by 204 · see citing works

The end of gonad-centric sex determination in mammals

Arnold, A. P. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.10.004 · Cited by 198 · see citing works

Representing Sex in the Brain, One Module at a Time

Yang, C. F., & Shah, N. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.029 · Cited by 197 · see citing works

Sex differences in Parkinson's disease and other movement disorders

Smith, K. M., & Dahodwala, N. A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.03.010 · Cited by 186 · see citing works

Pathways to ischemic neuronal cell death: are sex differences relevant?

Lang, J. T., & McCullough, L. D. (2008) · Journal of Translational Medicine · doi:10.1186/1479-5876-6-33 · Cited by 186 · see citing works

Sex Differences in Epigenetic Regulation of the Estrogen Receptor-α Promoter within the Developing Preoptic Area

Kurian, J. R., Olesen, K. M., & Auger, A. P. (2010) · Endocrinology · doi:10.1210/en.2009-0649 · Cited by 185 · see citing works

The control of sexual differentiation of the reproductive system and brain

WILSON, C. A., & Davies, D. C. (2007) · Reproduction · doi:10.1530/rep-06-0078 · Cited by 184 · see citing works

Visualizing Sexual Dimorphism in the Brain

Shah, N. M., Pisapia, D. J., Maniatis, S., Mendelsohn, M. M., Nemes, A., & Axel, R. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.008 · Cited by 183 · see citing works

Etiologies underlying sex differences in autism spectrum disorders

Schaafsma, S. M., & Pfaff, D. W. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.006 · Cited by 178 · see citing works

Sex differences in dopamine release regulation in the striatum

Zachry, J. E., Nolan, S. O., Brady, L. J., Kelly, S. J., Siciliano, C. A., & Calipari, E. S. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00915-1 · Cited by 167 · see citing works

Are XX and XY brain cells intrinsically different?

Arnold, A. P., & Burgoyne, P. S. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.11.001 · Cited by 166 · see citing works

Minireview: Sex Chromosomes and Brain Sexual Differentiation

Arnold, A. P., Xu, J., Grisham, W., Chen, X., Kim, Y., & Itoh, Y. (2003) · Endocrinology · doi:10.1210/en.2003-1491 · Cited by 164 · see citing works

A Yin-Yang Effect between Sex Chromosome Complement and Sex Hormones on the Immune Response

Palaszynski, K. M., Smith, D. L., Kamrava, S., Burgoyne, P. S., Arnold, A. P., & Voskuhl, R. R. (2005) · Endocrinology · doi:10.1210/en.2005-0284 · Cited by 163 · see citing works

Mouse Models for Evaluating Sex Chromosome Effects that Cause Sex Differences in Non‐Gonadal Tissues

Arnold, A. P. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01831.x · Cited by 157 · see citing works

A stain upon the silence: genes escaping X inactivation

Brown, C. J., & Greally, J. M. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00177-x · Cited by 157 · see citing works

Significance of Neonatal Testicular Sex Steroids to Defeminize Anteroventral Periventricular Kisspeptin Neurons and the GnRH/LH Surge System in Male Rats1

Homma, T., SAKAKIBARA, M., Yamada, S., Kinoshita, M., Iwata, K., Tomikawa, J., Kanazawa, T., Matsui, H., Takatsu, Y., Ohtaki, T., et al. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.078311 · Cited by 153 · see citing works

Sex chromosome complement regulates habit formation

Quinn, J. J., Hitchcott, P. K., Umeda, E. A., Arnold, A. P., & Taylor, J. R. (2007) · Nature Neuroscience · doi:10.1038/nn1994 · Cited by 148 · see citing works

Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1

Diggs‐Andrews, K. A., Brown, J. A., Gianino, S. M., Rubin, J. B., Wozniak, D. F., & Gutmann, D. H. (2013) · Annals of Neurology · doi:10.1002/ana.24093 · Cited by 148 · see citing works

Biological factors underlying sex differences in neurological disorders

Loke, H., Harley, V. R., & Lee, J. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.05.024 · Cited by 141 · see citing works

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

Du, S., Itoh, N., Askarinam, S., Hill, H., Arnold, A. P., & Voskuhl, R. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307091111 · Cited by 131 · see citing works

Four Core Genotypes and XY* mouse models: Update on impact on SABV research

Arnold, A. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.021 · Cited by 130 · see citing works

The Human Placental Sexome Differs between Trophoblast Epithelium and Villous Vessel Endothelium

Cvitic, S., Longtine, M. S., Hackl, H., Wagner, K., Nelson, M. D., Desoye, G., & Hiden, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079233 · Cited by 127 · see citing works

Dissociation of Genetic and Hormonal Influences on Sex Differences in Alcoholism-Related Behaviors

Barker, J. M., Torregrossa, M. M., Arnold, A. P., & Taylor, J. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0548-10.2010 · Cited by 127 · see citing works

Plasticity of Pelvic Autonomic Ganglia and Urogenital Innervation

Keast, J. R. (2006) · International review of cytology · doi:10.1016/s0074-7696(06)48003-7 · Cited by 121 · see citing works

Genomic imprinting and the social brain

Isles, A. R., Davies, W., & Wilkinson, L. S. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1942 · Cited by 119 · see citing works

Sex differences in microRNA regulation of gene expression: no smoke, just miRs

Morgan, C. P., & Bale, T. L. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-22 · Cited by 118 · see citing works

Sex Differences in the Serotonergic Influence on the Hypothalamic-Pituitary-Adrenal Stress Axis

Goel, N., & Bale, T. L. (2010) · Endocrinology · doi:10.1210/en.2009-1180 · Cited by 113 · see citing works

Four Core Genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels

Itoh, Y., Mackie, R., Kampf, K., Domadia, S., Brown, J. D., O’Neill, R., & Arnold, A. P. (2015) · BMC Research Notes · doi:10.1186/s13104-015-0986-2 · Cited by 109 · see citing works

Organizational and Activational Effects of Testosterone on Masculinization of Female Physiological and Behavioral Stress Responses

Goel, N., & Bale, T. L. (2008) · Endocrinology · doi:10.1210/en.2008-0433 · Cited by 109 · see citing works

Gender-Related Differences in Apoptotic Pathways After Neonatal Cerebral Ischemia

Renolleau, S., Fau, S., & Charriaut‐Marlangue, C. (2007) · The Neuroscientist · doi:10.1177/1073858407308889 · Cited by 106 · see citing works

The human testis‐determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism

Czech, D., Lee, J., Sim, H., Parish, C. L., Vilain, E. J. N., & Harley, V. R. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07782.x · Cited by 101 · see citing works

Neural mechanisms underlying sex-specific behaviors in vertebrates

Dulac, C. G., & Kimchi, T. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.01.009 · Cited by 99 · see citing works

Separate effects of sex hormones and sex chromosomes on brain structure and function revealed by high-resolution magnetic resonance imaging and spatial navigation assessment of the Four Core Genotype mouse model

Corre, C., Friedel, M., Vousden, D. A., Metcalf, A., Spring, S., Qiu, L. R., Lerch, J. P., & Palmert, M. R. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0952-0 · Cited by 98 · see citing works

Gonadal Steroid Action and Brain Sex Differentiation in the Rat

Sakuma, Y. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01856.x · Cited by 91 · see citing works

Sex difference in neural tube defects in p53‐null mice is caused by differences in the complement of X not Y genes

Chen, X., Watkins, R., Délot, E. C., Reliene, R., Schiestl, R. H., Burgoyne, P. S., & Arnold, A. P. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20581 · Cited by 90 · see citing works

Evolutionary Neuroandrogenic Theory and Universal Gender Differences in Cognition and Behavior

Ellis, L. (2011) · Sex Roles · doi:10.1007/s11199-010-9927-7 · Cited by 89 · see citing works

Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice

Gioiosa, L., Chen, X., Watkins, R., Klanfer, N., Bryant, C. D., Evans, C. J., & Arnold, A. P. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.09.003 · Cited by 89 · see citing works

Regional volumes and spatial volumetric distribution of gray matter in the gender dysphoric brain

Hoekzema, E. A., Schagen, S. E. E., Kreukels, B. P. C., Veltman, D. J., Cohen‐Kettenis, P. T., de Waal, H. A. D., & Bakker, J. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.01.016 · Cited by 88 · see citing works

Transcriptome analysis of male–female differences in prefrontal cortical development

Weickert, C. S., Elashoff, M. R., Richards, A., Sinclair, D., Bahn, S., Pääbo, S., Khaitovich, P., & Webster, M. J. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.5 · Cited by 86 · see citing works

Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood

Sánchez‐Cárdenas, C., Fontanaud, P., He, Z., Lafont, C., Meunier, A., Schaeffer, M., Carmignac, D. F., Molino, F., Coutry, N., Bonnefont, X., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010849107 · Cited by 86 · see citing works

A new view of sexual differentiation of mammalian brain

McCarthy, M. M. (2020) · Journal of Comparative Physiology A · doi:10.1007/s00359-019-01376-8 · Cited by 85 · see citing works

Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY , in experimental Parkinson’s disease

Lee, J., Pinares-Garcia, P., Loke, H., Ham, S., Vilain, E. J. N., & Harley, V. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900406116 · Cited by 84 · see citing works

DDX3Y, a Male-Specific Region of Y Chromosome Gene, May Modulate Neuronal Differentiation

Vakilian, H., Mirzaei, M., Tabar, M. S., Pooyan, P., Rezaei, L. H., Parker, L. M., Haynes, P. A., Gourabi, H., Baharvand, H., & Salekdeh, G. H. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00512 · Cited by 82 · see citing works

Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression

Voskuhl, R. R., Sawalha, A. H., & Itoh, Y. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458517737394 · Cited by 82 · see citing works

X chromosome number causes sex differences in gene expression in adult mouse striatum

Chen, X., Grisham, W., & Arnold, A. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06610.x · Cited by 79 · see citing works

Sex Differences in Brain and Behavior: Hormones Versus Genes

Bocklandt, S., & Vilain, E. J. N. (2007) · Advances in genetics · doi:10.1016/s0065-2660(07)59009-7 · Cited by 76 · see citing works

Gender differences in long-term beneficial effects of erythropoietin given after neonatal stroke in postnatal day-7 rats

Wen, T. C., Rogido, M. R., Peng, H., Genetta, T., Moore, J. E., & Sola, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.057 · Cited by 75 · see citing works

Association of the Human Y Chromosome with Cholesterol Levels in the General Population

Charchar, F. J., Tomaszewski, M., Łacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W., & Dominiczak, A. F. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000113291.39267.0a · Cited by 75 · see citing works

Sex differences in cerebral ischemia: Possible molecular mechanisms

Siegel, C. S., Turtzo, L. C., & McCullough, L. D. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22406 · Cited by 74 · see citing works

Two Perspectives on the Origin of Sex Differences in the Brain

Arnold, A. P., Rissman, E. F., & Vries, G. J. D. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.018 · Cited by 74 · see citing works

Neuroendocrine consequences of androgen excess in female rodents

Foecking, E. M., McDevitt, M. A., Acosta‐Martínez, M., Horton, T. H., & Levine, J. E. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.12.013 · Cited by 72 · see citing works

Cell‐autonomous sex determination outside of the gonad

Arnold, A. P., Chen, X., Link, J. C., Itoh, Y., & Reue, K. (2013) · Developmental Dynamics · doi:10.1002/dvdy.23936 · Cited by 70 · see citing works

Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus

Armoskus, C., Moreira, D., Bollinger, K., Jimenez, O., Taniguchi, S., & Tsai, H. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.017 · Cited by 70 · see citing works

The Role of the Y Chromosome in Brain Function

Kopsida, E., Stergiakouli, E., Lynn, P. M. Y., Wilkinson, L. S., & Davies, W. (2009) · The Open Neuroendocrinology Journal · doi:10.2174/1876528900902010020 · Cited by 70 · see citing works

Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation

Sharma, J., Johnston, M. V., & Hossain, M. A. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-9 · Cited by 67 · see citing works

X-chromosome regulation and sex differences in brain anatomy

Raznahan, A., & Distèche, C. M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.024 · Cited by 67 · see citing works

Sex-Dependent Gene Expression in Human Pluripotent Stem Cells

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Xu, J., Watkins, R., & Arnold, A. P. (2005) · Gene Expression Patterns · doi:10.1016/j.modgep.2005.06.011 · Cited by 64 · see citing works

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Xu, J., & Disteche, C. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.049 · Cited by 63 · see citing works

Female-specific target sites for both oestrogen and androgen in the teleost brain

Hiraki‐Kajiyama, T., Takeuchi, A., Tsumaki, T., Zempo, B., Kanda, S., Oka, Y., Nagahama, Y., & Okubo, K. (2012) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2012.2011 · Cited by 63 · see citing works

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Sex genes for genomic analysis in human brain: internal controls for comparison of probe level data extraction.

Galfalvy, H., Erraji-Benchekroun, L., Smyrniotopoulos, P., Pavlidis, P., Ellis, S. P., Mann, J. J., Sibille, E. L., & Arango, V. (2003) · BMC Bioinformatics · doi:10.1186/1471-2105-4-37 · Cited by 60 · see citing works

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