The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Open accessAbstract
Rather than being a passive, haphazard process of wear and tear, lifespan can be modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in laboratory animals. Complete or partial loss-of-function mutations in genes encoding components of the insulin/IGFI pathway result in extension of life span in yeasts, worms, flies, and mice. This remarkable conservation throughout evolution suggests that altered signaling in this pathway may also influence human lifespan. On the other hand, evolutionary tradeoffs predict that the laboratory findings may not be relevant to human populations, because of the high fitness cost during early life. Here, we studied the biochemical, phenotypic, and genetic variations in a cohort of Ashkenazi Jewish centenarians, their offspring, and offspring-matched controls and demonstrated a gender-specific increase in serum IGFI associated with a smaller stature in female offspring of centenarians. Sequence analysis of the IGF1 and IGF1 receptor ( IGF1R ) genes of female centenarians showed overrepresentation of heterozygous mutations in the IGF1R gene among centenarians relative to controls that are associated with high serum IGFI levels and reduced activity of the IGFIR as measured in transformed lymphocytes. Thus, genetic alterations in the human IGF1R that result in altered IGF signaling pathway confer an increase in susceptibility to human longevity, suggesting a role of this pathway in modulation of human lifespan.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The activity of IGF-1/IGFR that elevates PI3K/Akt/mTor has been shown to act against longevity in animal [110] and human studies [111,112].”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [111]
Experimental — accuracy not yet measuredIn the citing paper
“Polymorphisms in two IIS pathway genes, the IGF-1 receptor and the downstream FOXO3 transcription factor, have been associated with longevity and healthy ageing in humans (62–64).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [63]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity
Kimchi-Sarfaty, C., Oh, J. M., Kim, I.-W., Sauna, Z. E., Calcagno, A. M., Ambudkar, S. V., & Gottesman, M. M. (2007) · Science · doi:10.1126/science.1135308 · Cited by 2,416
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol
Cohen, J. C., Kiss, R. S., Pertsemlidis, A., Marcel, Y. L., McPherson, R., & Hobbs, H. H. (2004) · Science · doi:10.1126/science.1099870 · Cited by 1,108
Woods, K. A., Camacho‐Hübner, C., Savage, M. O., & Clark, A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351805 · Cited by 1,083
A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs
Sutter, N. B., Bustamante, C. D., Chase, K., GRAY, M. M., Zhao, K., Zhu, L., Padhukasahasram, B., Karlins, E., Davis, S. R., Jones, P. G., et al. (2007) · Science · doi:10.1126/science.1137045 · Cited by 673
IGF-I Receptor Mutations Resulting in Intrauterine and Postnatal Growth Retardation
Abuzzahab, M. J., Schneider, A., Goddard, A. D., Grigorescu, F., Lautier, C., Keller, E., Kieß, W., Klammt, J., Kratzsch, J., Osgood, D. P., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa010107 · Cited by 624
Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity
Barzilai, N. (2003) · JAMA · doi:10.1001/jama.290.15.2030 · Cited by 578
Self-citation
Research works printed but not linked: 2
- J Dupont, D LeRoith Horm Res 55, 22–26 (2001).
- LG Louie, MC King Am J Hum Genet 48, 637–638 (1991).
Cited by
Sorted by citations
Items 101–200 of 701
The Life History of Whole-Organism Performance
Lailvaux, S. P., & Husak, J. F. (2014) · The Quarterly Review of Biology · doi:10.1086/678567 · Cited by 147
NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?
Sahoo, S., Meijles, D. N., & Pagano, P. J. (2016) · Clinical Science · doi:10.1042/cs20150087 · Cited by 147
Dissecting Aging and Senescence—Current Concepts and Open Lessons
Schmeer, C. W., Kretz, A., Wengerodt, D., Stojiljkovic, M. R., & Witte, O. W. (2019) · Cells · doi:10.3390/cells8111446 · Cited by 156
Genome-environment interactions that modulate aging: powerful targets for drug discovery
de Magalhães, J. P., Wuttke, D., Wood, S. H., Plank, M., & Vora, C. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004499 · Cited by 136
Anti-aging pharmacology: Promises and pitfalls
Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 148
Regulation of GH and GH Signaling by Nutrients
Caputo, M., Pigni, S., Agosti, E., Daffara, T., Ferrero, A., Filigheddu, N., & Prodam, F. (2021) · Cells · doi:10.3390/cells10061376 · Cited by 159
Impact of reduced insulin‐like growth factor‐1/insulin signaling on aging in mammals: novel findings
Bartke, A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00387.x · Cited by 143
Neuroendocrine Regulation of Growth Hormone Secretion
Steyn, F. J., Tolle, V., Chen, C., & Epelbaum, J. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150002 · Cited by 173
IGF-1 and bone: New discoveries from mouse models
Yakar, S., Courtland, H., & Clemmons, D. R. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.234 · Cited by 139
Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease
O’Neill, C., Kiely, A. P., Coakley, M. F., Manning, S., & Long-Smith, C. M. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120080 · Cited by 140
Mice as a Mammalian Model for Research on the Genetics of Aging
Yuan, R., Peters, L. L., & Paigen, B. J. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.4 · Cited by 142
Gazit, N., Vertkin, I., Shapira, I., Helm, M. S., Slomowitz, E., Sheiba, M., Mor, Y., Rizzoli, S. O., & Slutsky, I. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.034 · Cited by 145
Münch, D., Amdam, G. V., & Wolschin, F. (2008) · Functional Ecology · doi:10.1111/j.1365-2435.2008.01419.x · Cited by 139
The evolutionary theories of aging revisited - a mini-review
Ljubuncic, P., & Reznick, A. Z. (2009) · Gerontology · doi:10.1159/000200772 · Cited by 133
Growth Hormone and Aging: Updated Review
Bartke, A. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180018 · Cited by 137
Integrating the stress response: lessons for neurodegenerative diseases from C. elegans
Prahlad, V., & Morimoto, R. I. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.11.002 · Cited by 136
Gaillard, J., & Lemaître, J. (2017) · Evolution · doi:10.1111/evo.13379 · Cited by 137
Ashpole, N. M., Logan, S., Yabluchanskiy, A., Mitschelen, M. C., Han, Y., Farley, J. A., Hodges, E. L., Ungvari, Z. I., Csiszár, A., Chen, S., et al. (2017) · GeroScience · doi:10.1007/s11357-017-9971-0 · Cited by 133
IGF-1, oxidative stress and atheroprotection
Higashi, Y., Sukhanov, S., Anwar, A., Shai, S., & Delafontaine, P. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.12.005 · Cited by 129
The Epidemiology of Longevity and Exceptional Survival
Newman, A. B., & Murabito, J. M. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs013 · Cited by 126
Drugs that modulate aging: the promising yet difficult path ahead
Kennedy, B. K., & Pennypacker, J. K. (2014) · Translational research · doi:10.1016/j.trsl.2013.11.007 · Cited by 127
TGF-ß Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging
Luo, S., Shaw, W. M., Ashraf, J. M., & Murphy, C. T. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000789 · Cited by 127
Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species
Tian, X., Seluanov, A., & Gorbunova, V. A. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.07.004 · Cited by 130
The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
Fernandes, S., & Demetriades, C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.707372 · Cited by 131
Gender and longevity: Why do men die earlier than women? Comparative and experimental evidence
Regan, J. C., & Partridge, L. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.016 · Cited by 134
IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population
Andreassen, M., Raymond, I. E., Kistorp, C., Hildebrandt, P. R., Faber, J. O., & Kristensen, L. Ø. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0452 · Cited by 124
Will calorie restriction work in humans?
Cava, E., & Fontana, L. (2013) · Aging · doi:10.18632/aging.100581 · Cited by 124
Paaby, A. B., Blacket, M. J., Hoffmann, A. A., & SCHMIDT, P. S. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2009.04508.x · Cited by 122
Fibroblast growth factor 21: a regulator of metabolic disease and health span
Xie, T., & Leung, P. S. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00101.2017 · Cited by 121
Cancer—Incidence, prevalence and mortality in the oldest-old. A comprehensive review
Nolen, S. C., Evans, M. A., Fischer, A., Corrada, M. M., Kawas, C. H., & Bota, D. A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.05.002 · Cited by 126
Molecular signatures of longevity: Insights from cross-species comparative studies
Ma, S., & Gladyshev, V. N. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.007 · Cited by 120
Insulin-like Growth Factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review
Frater, J., Lie, D., Bartlett, P. F., & McGrath, J. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.12.002 · Cited by 125
(2011) · Europe PMC (PubMed Central)
Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation
Chia, D. J. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1099 · Cited by 118
Aguiar-Oliveira, M. H., Oliveira, F. T., Pereira, R. M. C., Oliveira, C. R. P., Blackford, A., Valenca, E. H. O., Santos, E. G., Gois-Junior, M. B., Meneguz-Moreno, R. A., Araujo, V. P., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1879 · Cited by 118
Integrating evolutionary and molecular genetics of aging
Flatt, T., & SCHMIDT, P. S. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.07.010 · Cited by 116
Growth hormone in the aging male
Sattler, F. R. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.003 · Cited by 116
40 YEARS of IGF1: IGF1: the Jekyll and Hyde of the aging brain
Gubbi, S., Quipildor, G. F., Barzilai, N., Huffman, D. M., & Milman, S. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0093 · Cited by 118
Self-citationGhazi, A., Henis‐Korenblit, S., & Kenyon, C. J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000639 · Cited by 116
RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans
Paola Sebastiani, B., Montano, M. A., Puca, A. A., Solovieff, N., Kojima, T., Wang, M. C., Melista, E., Meltzer, M., Fischer, S. E. J., Andersen, S. L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008210 · Cited by 111
Self-citationSingle-gene mutations and healthy ageing in mammals
Bartke, A. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0281 · Cited by 110
How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude
Podshivalova, K., Kerr, R. A., & Kenyon, C. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.062 · Cited by 109
What Can We Learn About Human Disease from the Nematode C. elegans?
Apfeld, J., & Alper, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7471-9_4 · Cited by 116
IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
Sadagurski, M., Cheng, Z., Rozzo, A., Palazzolo, I., Kelley, G. R., Dong, X., Krainc, D., & White, M. F. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46305 · Cited by 107
Mediation of vertebrate life historiesviainsulin‐like growth factor‐1
Dantzer, B., & Swanson, E. M. (2011) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2011.00204.x · Cited by 110
Antiaging agents: safe interventions to slow aging and healthy life span extension
Liu, J. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00339-y · Cited by 112
Nucleophagy: from homeostasis to disease
Papandreou, M., & Tavernarakis, N. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0266-5 · Cited by 107
Tissue‐specific insulin signaling in the regulation of metabolism and aging
Zhang, J., & Liu, F. (2014) · IUBMB Life · doi:10.1002/iub.1293 · Cited by 105
Genetic variation in insulin/IGF-1 signaling pathways and longevity
Ziv, E., & Hu, D. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.002 · Cited by 102
Knight, A. L., Yan, X., Hamamichi, S., Ajjuri, R. R., Mazzulli, J. R., Zhang, M. W., Daigle, J. G., Zhang, S., Borom, A. R., Roberts, L. R., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.017 · Cited by 103
Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
Tazearslan, C., Huang, J., Barzilai, N., & Suh, Y. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00697.x · Cited by 101
Self-citationDelaying aging is neuroprotective in Parkinson’s disease: a genetic analysis in C. elegans models
Cooper, J. F., Dues, D. J., Spielbauer, K. K., Machiela, E., Senchuk, M. M., & Raamsdonk, J. M. V. (2015) · npj Parkinson s Disease · doi:10.1038/npjparkd.2015.22 · Cited by 101
Insulin, insulin-like growth factors and neoplasia
Pollak, M. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.08.004 · Cited by 100
Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1
Selman, C., Partridge, L., & Withers, D. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016144 · Cited by 103
Why is the dog an ideal model for aging research?
Gilmore, K. M., & Greer, K. A. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.08.008 · Cited by 101
IGF1R mutations as cause of SGA
Klammt, J., Kiess, W., & Pfäffle, R. W. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.09.012 · Cited by 96
Longevity effect of IGF ‐1 R +/− mutation depends on genetic background‐specific receptor activation
Xu, J., Gontier, G., Chaker, Z., Lacube, P., Dupont, J., & Holzenberger, M. (2013) · Aging Cell · doi:10.1111/acel.12145 · Cited by 96
IGF-I and the aging mammalian brain
Piriz, J., Muller, A. P., Trejo, J. L., & Torres‐Alemán, I. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.022 · Cited by 93
The role of insulin/IGF-like signaling in C. elegans longevity and aging
Kaletsky, R. L., & Murphy, C. T. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.001040 · Cited by 94
Genetics of human longevity within an eco-evolutionary nature-nurture framework
Giuliani, C., Garagnani, P., & Franceschi, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312562 · Cited by 92
Genetics and genomics of human ageing
Wheeler, H. E., & Kim, S. K. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0259 · Cited by 98
Zhang, Y., Zhang, W.-H., Zhang, P., Li, Q., Sun, Y., Wang, J., Zhang, S. O., Cai, T., Zhan, C., & Dong, M. (2022) · Nature Communications · doi:10.1038/s41467-022-33850-4 · Cited by 99
Connecting serum IGF-1, body size, and age in the domestic dog
Greer, K. A., Hughes, L. M., & Masternak, M. M. (2010) · AGE · doi:10.1007/s11357-010-9182-4 · Cited by 93
Peroxiredoxins, gerontogenes linking aging to genome instability and cancerPreprint
Nyström, T., Yang, J., & Molin, M. (2012) · Genes & Development · doi:10.1101/gad.200006.112 · Cited by 95
Deelen, J., Beekman, M., Capri, M., Franceschi, C., & Slagboom, P. E. (2013) · BioEssays · doi:10.1002/bies.201200148 · Cited by 94
Macroautophagy and aging: The impact of cellular recycling on health and longevity
Nieto-Torres, J. L., & Hansen, M. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101020 · Cited by 93
Growth hormone and aging: A challenging controversy
Bartke, A. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s3697 · Cited by 93
Vitale, G., Brugts, M. P., Ogliari, G., Castaldi, D., Fatti, L. M., Varewijck, A. J., Lamberts, S. W., Monti, D., Bucci, L., Cevenini, E., et al. (2012) · Aging · doi:10.18632/aging.100484 · Cited by 90
Whole-Genome Sequencing of the World’s Oldest People
Gierman, H. J., Fortney, K., Roach, J. C., Coles, N. S., Li, H., Glusman, G., Markov, G. J., Smith, J., Hood, L., Coles, L. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112430 · Cited by 88
The role of hydrogen sulfide in aging and age-related pathologies
Perridon, B. W., Leuvenink, H. G. D., Hillebrands, J., van Goor, H., & Bos, E. M. (2016) · Aging · doi:10.18632/aging.101026 · Cited by 90
Growth hormone, inflammation and aging
Masternak, M. M., & Bartke, A. (2012) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v2i0.17293 · Cited by 89
Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF‐16/FOXO
Landis, J. N., & Murphy, C. T. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22244 · Cited by 97
Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females
Junnila, R. K., Duran‐Ortiz, S., Suer, O., Sustarsic, E. G., Berryman, D. E., List, E. O., & Kopchick, J. J. (2016) · Endocrinology · doi:10.1210/en.2016-1649 · Cited by 88
Parrella, E., Maxim, T., Maialetti, F., Zhang, L., Wan, J., Wei, M., Cohen, P., Fontana, L., & Longo, V. D. (2013) · Aging Cell · doi:10.1111/acel.12049 · Cited by 89
Self-citationDAF-16 target identification in C. elegans: past, present and future
Tullet, J. M. A. (2014) · Biogerontology · doi:10.1007/s10522-014-9527-y · Cited by 90
Pehar, M., O’Riordan, K. J., Burns‐Cusato, M., Andrzejewski, M. E., del Alcazar, C. R. G., Bürger, C., Scrable, H. J., & Puglielli, L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00547.x · Cited by 89
Li, Z., Wang, L., Wang, L., Feng, G., Yuan, X., Liu, C., Xu, K., Li, Y., Wan, H., Zhang, Y., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.09.004 · Cited by 83
Quipildor, G. F., Mao, K., Hu, Z., Novaj, A., Cui, M., Gulinello, M. E., Branch, C. A., Gubbi, S., Patel, K., Moellering, D. R., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00065-3 · Cited by 85
Aging and cancer cell biology, 2009
Campisi, J., & Yaswen, P. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00475.x · Cited by 88
Jęśko, H. M., Stępień, A., Lukiw, W. J., & Strosznajder, R. P. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1286-3 · Cited by 85
Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
Salvioli, S., Capri, M., Bucci, L., Lanni, C., Racchi, M., Uberti, D. L., Memo, M., Mari, D., Govoni, S. M., & Franceschi, C. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0639-6 · Cited by 87
Extending healthy ageing: nutrient sensitive pathway and centenarian population
Davinelli, S., Willcox, D. C., & Scapagnini, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-9 · Cited by 85
Smith-Vikos, T., Liu, Z., Parsons, C., Gorospe, M., Ferrucci, L., Gill, T. M., & Slack, F. J. (2016) · Aging · doi:10.18632/aging.101106 · Cited by 86
Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., CHARGE Longevity Working Group, et al. (2016) · Aging Cell · doi:10.1111/acel.12490 · Cited by 83
Self-citationComprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
Gombar, S., Jung, H. J., Dong, F., Calder, B. R., Atzmon, G., Barzilai, N., Tian, X., Pothof, J., Hoeijmakers, J. H. J., Campisi, J., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-353 · Cited by 81
Self-citationIntracellular protein glycosylation modulates insulin mediated lifespan in C. elegans
Rahman, M. M., Stuchlick, O., Elkarim, E. A., Stuart, R., Kipreos, E. T., & Wells, L. (2010) · Aging · doi:10.18632/aging.100208 · Cited by 79
Disorders of growth hormone/insulin-like growth factor secretion and action
Backeljauw, P. F., Dattani, M., Cohen, P., & Rosenfeld, R. G. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00019-6 · Cited by 79
Self-citationAntiaging effects of bioactive molecules isolated from plants and fungi
Martel, J., Ojcius, D. M., Ko, Y., Chang, C., & Young, J. D. (2019) · Medicinal Research Reviews · doi:10.1002/med.21559 · Cited by 79
Lu, Y.-X., Regan, J. C., Eßer, J., Drews, L. F., Weinseis, T., Stinn, J., Hahn, O., Miller, R. A., Grönke, S., & Partridge, L. (2021) · eLife · doi:10.7554/elife.62233 · Cited by 76
Lundgren, S., Kuitunen, S., Pietiläinen, K. H., Hurme, M., Kähönen, M. A. P., Männistö, S., Perola, M., Lehtimäki, T. J., Raitakari, O. T., Kaprio, J. A., et al. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13528 · Cited by 84
Why Is Aging Conserved and What Can We Do about It?
Pitt, J. N., & Kaeberlein, M. R. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002131 · Cited by 81
Sonntag, W. E., Csiszár, A., de Cabo, R., Ferrucci, L., & Ungvari, Z. I. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls115 · Cited by 77
Growth Factors, Nutrient Signaling, and Cardiovascular Aging
Fontana, L., Vinciguerra, M., & Longo, V. D. (2012) · Circulation Research · doi:10.1161/circresaha.111.246470 · Cited by 76
Evolution of longevity improves immunity in Drosophila
Fabian, D., Garschall, K., Klepsatel, P., Santos-Matos, G., Sucena, É., Kapun, M., Lemaître, B., Schlötterer, C., Arking, R., & Flatt, T. (2018) · Evolution Letters · doi:10.1002/evl3.89 · Cited by 71
Alper, S., McElwee, M. K., Apfeld, J., Lackford, B. L., Freedman, J. H., & Schwartz, D. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057323 · Cited by 74
Chen, A. T., Guo, C., Itani, O. A., Budaitis, B. G., Williams, T. W., Hopkins, C. E., McEachin, R. C., Pande, M., Grant, A. R., Yoshina, S., et al. (2015) · Genetics · doi:10.1534/genetics.115.177998 · Cited by 74
Wallborn, T., Wüller, S., Klammt, J., Kruis, T., Kratzsch, J., Schmidt, G., Schlicke, M., Müller, E. C., van de Leur, H. S., Kieß, W., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2404 · Cited by 76
Temporal requirements of insulin/IGF‐1 signaling for proteotoxicity protection
Cohen, E., Du, D., Joyce, D., Kapernick, E. A., Volovik, Y., Kelly, J. W., & Dillin, A. G. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00541.x · Cited by 78
The somatotropic axis and longevity in mice
Brown‐Borg, H. M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2015 · Cited by 74
Insulin and JNK: optimizing metabolic homeostasis and lifespan
Karpac, J., & Jasper, H. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.11.004 · Cited by 73
Metadata
- Authors
- Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P.
- Affiliations
- Albert Einstein College of Medicine (US)
- Yeshiva University (US)
- University of California, Los Angeles (US)
- Johns Hopkins University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-03-04
- Volume
- 105
- Issue
- 9
- Pages
- 3438-3442
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2265137
- OpenAlex
- W2096452837
- Cited by
- 703
- References
- 36
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 15 · 2023: 26 · 2022: 33 · 2021: 40 · 2020: 38 · 2019: 37 · 2018: 41 · 2017: 55 · 2016: 39 · 2015: 36 · 2014: 38 · 2013: 35 · 2012: 54
- FWCI
- 18.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG024391, P01AG027734, R01AG024391, R03AG023292, AG023292)
- National Institute of General Medical Sciences (R01GM099321)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- IGF-1 receptor, centenarians, human longevity, lifespan extension, heterozygous mutation, female offspring, height, evolutionary trade-offs
- MeSH terms
- Aged, 80 and over, DNA Mutational Analysis, Family Health, Heterozygote, Humans, Insulin-Like Growth Factor I, Jews, Longevity, Lymphocytes, Mutation, Sex Factors, Cohort Studies, Receptor, IGF Type 1, Body Size
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
