Cohen, Pinchas

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism

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A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan

Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., et al. (2015) · Cell Metabolism

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

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The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S.-J., Mehta, H., Hevener, A. L., de Cabo, R., et al. (2015) · Cell Metabolism

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

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Functionally significant insulin-like growth factor I receptor mutations in centenarians

Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

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Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., et al. (2017) · Science Translational Medicine

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

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Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

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Humanin: a harbinger of mitochondrial-derived peptides

Lee, C., Yen, K., & Cohen, P. (2013) · Trends in Endocrinology & Metabolism

Mitochondrial Function and PathologyCell death mechanisms and regulation

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MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis

Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., et al. (2021) · Nature Communications

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

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The mitochondrial-Derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction

Sreekumar, P. G., Ishikawa, K., Spee, C., Mehta, H. H., Wan, J., Yen, K., Cohen, P., Kannan, R., & Hinton, D. R. (2016) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsMitochondrial Function and Pathology

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MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism

Lee, C., Kim, K. H., & Cohen, P. (2016) · Free Radical Biology and Medicine

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

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Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

Mao, K., Quipildor, G. F., Tabrizian, T., Novaj, A., Guan, F., Walters, R. O., Delahaye, F., Hubbard, G. B., Ikeno, Y., Ejima, K., et al. (2018) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

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Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

Miller, B., Silverstein, A., Flores, M., Cao, K., Kumagai, H., Mehta, H. H., Yen, K., Kim, S. J., & Cohen, P. (2021) · Scientific Reports

SARS-CoV-2 and COVID-19 Researchinterferon and immune responses

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The Oxygen Paradox, the French Paradox, and age-related diseases

Davies, J. M. S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L., Derbré, F., et al. (2017) · GeroScience

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Gentamicin pharmacokinetics in neonates undergoing extracorporal membrane oxygenation

COHEN, P., COLLART, L., PROBER, C. G., FISCHER, A. F., & BLASCHKE, T. F. (1990) · The Pediatric Infectious Disease Journal

Antibiotics Pharmacokinetics and EfficacyPharmaceutical studies and practices

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IGF‐I regulates the age‐dependent signaling peptide humanin

Lee, C., Wan, J., Miyazaki, B., Fang, Y., Guevara‐Aguirre, J., Yen, K., Longo, V., Bartke, A., & Cohen, P. (2014) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

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Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk

Brandhorst, S., Levine, M. E., Wei, M., Shelehchi, M., Morgan, T. E., Nayak, K. S., Dorff, T., Hong, K., Crimmins, E. M., Cohen, P., et al. (2024) · Nature Communications

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

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High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men

Woodhead, J. S. T., D’Souza, R. F., Hedges, C. P., Wan, J., Berridge, M. V., Cameron-Smith, D., Cohen, P., Hickey, A. J. R., Mitchell, C. J., & Merry, T. L. (2020) · Journal of Applied Physiology

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Increased Expression of the Mitochondrial Derived Peptide, MOTS-c, in Skeletal Muscle of Healthy Aging Men Is Associated with Myofiber Composition

D’Souza, R. F., Woodhead, J. S. T., Hedges, C. P., Zeng, N., Wan, J., Kumagai, H., Lee, C., Cohen, P., Cameron-Smith, D., Mitchell, C. J., et al. (2020) · Aging

Mitochondrial Function and PathologyMuscle Physiology and Disorders

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Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

Kim, S.-J., Devgan, A., Miller, B., Lee, S. M., Kumagai, H., Wilson, K. A., Wassef, G., Wong, R., Mehta, H. H., Cohen, P., et al. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

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Insulin Resistance in Cushing's Syndrome

Karnieli, E., Cohen, P., Barzilai, N., Ish-Shalom, Z., Armoni, M., Rafaelov, R., & Barzilai, D. (1985) · Hormone and Metabolic Research

Pituitary Gland Disorders and TreatmentsPancreatic function and diabetes

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MOTS-c modulates skeletal muscle function by directly binding and activating CK2

Kumagai, H., Kim, S.-J., Miller, B., Zempo, H., Tanisawa, K., Natsume, T., Lee, S. H., Wan, J., Leelaprachakul, N., Kumagai, M. E., et al. (2024) · iScience

Muscle Physiology and DisordersMitochondrial Function and Pathology

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