The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Drosophila germ-line modulation of insulin signaling and lifespan
Open accessAbstract
Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not understood, and it is unknown whether such effects are evolutionarily conserved. Here we report that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling. Long-lived germ-line-less flies show increased production of Drosophila insulin-like peptides ( dilps ) and hypoglycemia but simultaneously exhibit several characteristics of IIS impedance, as indicated by up-regulation of the Drosophila FOXO (dFOXO) target genes 4E-BP and l ( 2 ) efl and the insulin/IGF-binding protein IMP-L2 . These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved.
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Cites
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Insulin signalling and the regulation of glucose and lipid metabolism
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis
Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523
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Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Insulin/IGF-like signalling, the central nervous system and aging
Broughton, S., & Partridge, L. (2009) · Biochemical Journal · doi:10.1042/bj20082102 · Cited by 228
Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis
Barth, J. M. I., Szabad, J., Hafen, E., & Köhler, K. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.157 · Cited by 165
The role of estrogen deficiency in skin ageing and wound healing
Emmerson, E., & Hardman, M. J. (2012) · Biogerontology · doi:10.1007/s10522-011-9322-y · Cited by 118
A steroid receptor-microRNA switch regulates life span in response to signals from the gonad
Shen, Y., Wollam, J., Magner, D., Karalay, O., & Antebi, A. (2012) · Science · doi:10.1126/science.1228967 · Cited by 102
Dietary restriction: standing up for sirtuins
Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. D., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., et al. (2010) · Science · doi:10.1126/science.329.5995.1012 · Cited by 76
Self-citationDietary ursolic acid improves health span and life span in male Drosophila melanogaster
Staats, S., Wagner, A. E., Lüersen, K., Künstner, A., Meyer, T., Kahns, A. K., Derer, S., Graspeuntner, S., Rupp, J., Busch, H., et al. (2019) · BioFactors · doi:10.1002/biof.1467 · Cited by 48
Metadata
- Authors
- Flatt, T., Min, K.-J., D'Alterio, C., Villa-Cuesta, E., Cumbers, J., Lehmann, R., Jones, D. L., & Tatar, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-04-29
- Volume
- 105
- Issue
- 17
- Pages
- 6368-6373
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2033908049
- Cited by
- 298
- References
- 5
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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