The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury
Open accessAbstract
The nitrite anion is reduced to nitric oxide (NO*) as oxygen tension decreases. Whereas this pathway modulates hypoxic NO* signaling and mitochondrial respiration and limits myocardial infarction in mammalian species, the pathways to nitrite bioactivation remain uncertain. Studies suggest that hemoglobin and myoglobin may subserve a fundamental physiological function as hypoxia dependent nitrite reductases. Using myoglobin wild-type ((+/+)) and knockout ((-/-)) mice, we here test the central role of myoglobin as a functional nitrite reductase that regulates hypoxic NO* generation, controls cellular respiration, and therefore confirms a cytoprotective response to cardiac ischemia-reperfusion (I/R) injury. We find that myoglobin is responsible for nitrite-dependent NO* generation and cardiomyocyte protein iron-nitrosylation. Nitrite reduction to NO* by myoglobin dynamically inhibits cellular respiration and limits reactive oxygen species generation and mitochondrial enzyme oxidative inactivation after I/R injury. In isolated myoglobin(+/+) but not in myoglobin(-/-) hearts, nitrite treatment resulted in an improved recovery of postischemic left ventricular developed pressure of 29%. In vivo administration of nitrite reduced myocardial infarction by 61% in myoglobin(+/+) mice, whereas in myoglobin(-/-) mice nitrite had no protective effects. These data support an emerging paradigm that myoglobin and the heme globin family subserve a critical function as an intrinsic nitrite reductase that regulates responses to cellular hypoxia and reoxygenation [corrected]
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There are a number of factors that have been demonstrated to reduce nitrite in the tissues, including deoxyhemoglobin, deoxymyoglobin, xanthine oxidoreductase, heme-based enzymes in the mitochondria and acidosis during ischemia [99,100].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [100]
In the citing paper
“A cytoprotective role of nitrite in the setting of myocardial, liver, kidney, and brain ischemia/reperfusion injury has previously been demonstrated.19,29,30”
From Dietary nitrate supplementation improves revascularization in chronic ischemia (2012) · cites this paper as [19]
In the citing paper
“Mb-mediated nitrite reduction has been reported to be important in both cardiomyocytes [55] and smooth muscle [56].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“As discussed below, a functional role for myoglobin in nitrite reduction and signaling is strongly supported by multiple studies in myoglobin knockout mice showing a reduction in nitrite mediated effects on mitochondrial respiration, cardiac function, ischemia reperfusion cytoprotection, and systemic hypoxic vasodilation [54–56].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“The efficacy of low concentrations of nitrite in mediating cytoprotection has been demonstrated in a variety of tissues in animal models including heart [8, 9, 55, 118–122] liver [9, 120, 123], brain [124–126], kidney [127, 128], hindlimb [129], and human forearm [23].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“This Mb-dependent effect was also demonstrated in vivo where nitrite administration reduced infract size from myocardial infarction by 61% in wild type mice”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“whereas administration of nitrite decreased infarct size in wild type hearts by 36% when subject to IR”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“Perfused hearts from wild type mice produced about twice as much NO from nitrite as knockouts ex vivo when subject to ischemia [55].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“and nitrite had no effect in knockout mice [55].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“nitrite had no effect on infarct size on heats from knockouts [55].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [55]
In the citing paper
“evidence that myoglobin/nitrite interactions can promote NO-signaling in the context of an ischemic insult to the heart has been established using multiple criteria including the use of myoglobin knockout mice [28, 33, 53, 60].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [33]
In the citing paper
“protection afforded by nitrite administration in a model of ischemia-reperfusion in the heart is lost when myoglobin knock-out mice are used instead of wild type animals and this coincides with a loss of NO formation detected by EPR [33].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [33]
In the citing paper
“the nitrite-induced S-nitrosation of complex I of the electron transport chain which decreases mitochondrial reactive species formation and subsequently confers protection against ischemia-reperfusion injury [104] [33, 86, 105, 106].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [33]
In the citing paper
“In these studies, genetic deletion of myoglobin in the heart significantly diminished the protective effect of sodium nitrite on myocardial ischemia-reperfusion [113, 114].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [114]
Citations
Cites
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Self-citationEnzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · cited 7×
“The application of 48 nmol sodium nitrite (50 l) into the left ventricular cavity occurred 5 min before reperfusion (16).”
BackgroundMethodInfluentialSelf-citationThe emerging biology of the nitrite anion
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609
Self-citationWebb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · cited 6×
“Recent studies have established a nitrite-induced reduction of infarct size in I/R (11, 16) and amelioration of cardiac function in murine hearts.”
BackgroundInfluentialRegulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602
Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 601
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599
Self-citationShiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555
Self-citationEnzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 414
Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype
Kristiansen, G., Rose, M., Geisler, C., Fritzsche, F., Gerhardt, J., Lüke, C., Ladhoff, A., Knüchel, R., Dietel, M., Moch, H., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605702 · Cited by 58
Nitrite as a mediator of ischemic preconditioning and cytoprotection
Murillo, D., Kamga, C., Mo, L., & Shiva, S. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.01.003 · Cited by 57
Self-citationKeeping the heart in balance: the functional interactions of myoglobin with nitrogen oxides
Flögel, U., Fago, A., & Rassaf, T. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.041681 · Cited by 57
Self-citationSandvik, G. K., Nilsson, G., & Jensen, F. B. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00538.2011 · Cited by 57
Vascular Effects of the Red Blood Cell Storage Lesion
Roback, J. D. (2011) · Hematology · doi:10.1182/asheducation-2011.1.475 · Cited by 57
Nitrite-Nitric Oxide Signaling and Cardioprotection
Totzeck, M., Hendgen-Cotta, U. B., & Rassaf, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_18 · Cited by 57
Self-citationYi, J., Orville, A. M., Skinner, J. M., Skinner, M. J., & Richter-Addo, G. B. (2010) · Biochemistry · doi:10.1021/bi100801g · Cited by 56
Maia, L. B., & Moura, J. J. G. (2018) · Redox Biology · doi:10.1016/j.redox.2018.08.020 · Cited by 57
Glancy, B. C., Hsu, L., Dao, L. H., Bakalar, M. H., French, S. A., Chess, D. J., Taylor, J. F., Picard, M. A., Aponte, A. M., Daniels, M. P., et al. (2014) · Microcirculation · doi:10.1111/micc.12098 · Cited by 56
The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution
Ebner, B., Panopoulou, G., Vinogradov, S. N., Kiger, L., Marden, M. C., Burmester, T., & Hankeln, T. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-370 · Cited by 55
Liu, X., Tong, J., Zweier, J. R., Follmer, D., Hemann, C. F., Ismail, R. S., & Zweier, J. L. (2013) · FEBS Journal · doi:10.1111/febs.12352 · Cited by 54
Merx, M. W., Gorressen, S., Sandt, A. M., Cortese-Krott, M. M., Ohlig, J., Stern, M., Rassaf, T., Gödecke, A., Gladwin, M. T., & Kelm, M. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-013-0398-1 · Cited by 53
“levels of circulating nitrite likely contribute to the greater tissue damage in BC-/EC? chimeras, as previously shown in WT mice [13, 14].”
MethodResultSelf-citationFunctional tuning and expanding of myoglobin by rational protein design
Lin, Y., Wang, J., & Lu, Y. (2014) · Science China Chemistry · doi:10.1007/s11426-014-5063-5 · Cited by 53
Kristiansen, G., Hu, J., Wichmann, D., Stiehl, D. P., Rose, M., Gerhardt, J., Bohnert, A., ten Haaf, A., Moch, H., Raleigh, J. A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.227553 · Cited by 53
Pedersen, C. L., Faggiano, S., Helbo, S., Gesser, H., & Fago, A. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.041624 · Cited by 52
Nitrite therapy is neuroprotective and safe in cardiac arrest survivors
Dezfulian, C., Alekseyenko, A., Dave, K. R., Raval, A. P., Do, R., Kim, F., & Pérez‐Pinzón, M. A. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.007 · Cited by 51
Underbakke, E. S., Sürmeli, N. B., Smith, B. C., Wynia‐Smith, S. L., & Marletta, M. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-08-097774-4.00320-x · Cited by 51
Cossins, A. R., & Berenbrink, M. (2008) · Nature · doi:10.1038/454416a · Cited by 51
Gelabert-Rebato, M., Wiebe, J. C., Martin-Rincon, M., Galvan-Alvarez, V., Curtelin, D., Perez-Valera, M., Juan Habib, J., Pérez-López, A., Vega, T., Morales-Alamo, D., et al. (2019) · Nutrients · doi:10.3390/nu11020344 · Cited by 49
The potential of stimulating nitric oxide formation in the treatment of hypertension
Pinheiro, L. C., Tanus-Santos, J. E., & de Castro, M. M. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1310840 · Cited by 50
Rix, P. J., Vick, A., Attkins, N., Barker, G. E., Bott, A. W., Alcorn, H. W., Gladwin, M. T., Shiva, S., Bradley, S. P., Hussaini, A., et al. (2014) · Clinical Pharmacokinetics · doi:10.1007/s40262-014-0201-y · Cited by 48
Self-citationOxygen Regulates Tissue Nitrite Metabolism
Curtis, E., Hsu, L. L., Noguchi, A. C., Geary, L., & Shiva, S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4242 · Cited by 46
Self-citationHendgen-Cotta, U. B., Kelm, M., & Rassaf, T. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.003 · Cited by 46
Self-citationSchwarze, K., Singh, A., & Burmester, T. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv114 · Cited by 48
Mitochondria and Nitric Oxide: Chemistry and Pathophysiology
Sarti, P., Arese, M., Forte, E., Giuffrè, A., & Mastronicola, D. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_4 · Cited by 46
Nitrite and myocardial ischaemia reperfusion injury. Where are we now?
Griffiths, K., Lee, J. J., Frenneaux, M. P., Feelisch, M., & Madhani, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107819 · Cited by 46
Small ligand–globin interactions: Reviewing lessons derived from computer simulation
Capece, L., Boechi, L., Perissinotti, L. L., Arroyo, P., Bikiel, D. E., Smulevich, G., Marti, M. A., & Estrin, D. A. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.02.038 · Cited by 44
Gohil, K., Vasu, V. T., & Cross, C. E. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900575 · Cited by 44
Expression patterns and adaptive functional diversity of vertebrate myoglobins
Helbo, S., Weber, R. E., & Fago, A. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.01.037 · Cited by 46
Jesse, H. E., Nye, T. L., McLean, S., Green, J. D., Mann, B. E., & Poole, R. K. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.04.019 · Cited by 44
Reaction ofMycobacterium tuberculosisCytochrome P450 Enzymes with Nitric Oxide
Ouellet, H., Lang, J., Couture, M., & de Montellano, P. R. O. (2009) · Biochemistry · doi:10.1021/bi801595t · Cited by 43
A “green” diet-based approach to cardiovascular health? Is inorganic nitrate the answer?
Rathod, K. S., Velmurugan, S., & Ahluwalia, A. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500313 · Cited by 42
Fago, A., Jensen, F. B., Tota, B., Feelisch, M., Olson, K. R., Helbo, S., Lefevre, S., Mancardi, D., Palumbo, A., Sandvik, G. K., et al. (2012) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2012.01.011 · Cited by 43
Giordano, D., Borón, I., Abbruzzetti, S., Leuven, W. V., Nicoletti, F. P., Forti, F., Bruno, S., Cheng, C.-H. C., Moens, L. J., di Prisco, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044508 · Cited by 42
Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase
Mathai, C., Jourd’heuil, F. L., Lopez‐Soler, R. I., & Jourd’heuil, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101468 · Cited by 42
Brunori, M. (2009) · Protein Science · doi:10.1002/pro.300 · Cited by 42
Hypoxia Tolerance in Teleosts: Implications of Cardiac Nitrosative Signals
Gattuso, A., Garofalo, F., Cerra, M. C., & Imbrogno, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00366 · Cited by 42
Nitrite Reduces Acute Lung Injury and Improves Survival in a Rat Lung Transplantation Model
Sugimoto, R., Okamoto, T., Nakao, A., Zhan, J., Wang, Y., Kohmoto, J., Tokita, D., Farver, C. F., Tarpey, M. M., Billiar, T. R., et al. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2012.04169.x · Cited by 40
Self-citationMcclure, B. N., Sebranek, J. G., Kim, Y. H., & Sullivan, G. A. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.05.077 · Cited by 40
Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin
Zweier, J. L., & Ilangovan, G. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7881 · Cited by 40
Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases
Liu, Y., Croft, K. D., Hodgson, J. M., Mori, T., & Ward, N. C. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.006 · Cited by 41
To breathe or not to breathe: the haematopoietic stem/progenitor cells dilemma
Piccoli, C., Agriesti, F., Scrima, R., Falzetti, F., Ianni, M. D., & Capitanio, N. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12253 · Cited by 40
A novel physiological role for cardiac myoglobin in lipid metabolism
Hendgen-Cotta, U. B., Esfeld, S., Coman, C., Ahrends, R., Klein‐Hitpaß, L., Flögel, U., Rassaf, T., & Totzeck, M. (2017) · Scientific Reports · doi:10.1038/srep43219 · Cited by 41
Self-citationSingh, M., Arya, A., Kumar, R., Bhargava, K., & Sethy, N. K. (2012) · Nitric Oxide · doi:10.1016/j.niox.2011.12.002 · Cited by 38
Zager, R. A. (2015) · Translational research · doi:10.1016/j.trsl.2015.06.004 · Cited by 38
Functional properties of myoglobins from five whale species with different diving capacities
Helbo, S., & Fago, A. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.073726 · Cited by 38
Nitric oxide improves the hemodynamic performance of the hypoxic goldfish (Carassius auratus) heart
Imbrogno, S., Capria, C., Tota, B., & Jensen, F. B. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.08.012 · Cited by 39
Nitric oxide and kidney oxygenation
Palm, F., Teerlink, T., & Hansell, P. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32831c4cdf · Cited by 37
Hypoxia modulates innate immune factors: A review
Mishra, K. P., Ganju, L., & Singh, S. B. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.07.008 · Cited by 37
Nitric Oxide Induction of Parkin Translocation in PTEN-induced Putative Kinase 1 (PINK1) Deficiency
Han, J., Kang, M., Kim, K., Han, P., Kim, H., Ha, J., & Son, J. H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.624767 · Cited by 37
Age-related vascular gene expression profiling in mice
Rammos, C., Hendgen-Cotta, U. B., Deenen, R., Pohl, J., Stock, P., Hinzmann, C., Kelm, M., & Rassaf, T. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.001 · Cited by 35
Self-citationMassa, C. B., Liu, Z., Taylor, S., Pettit, A. P., Stakheyeva, M. N., Korotkova, E. I., Popova, V., Atochina‐Vasserman, E. N., & Gow, A. J. (2021) · Antioxidants · doi:10.3390/antiox10071111 · Cited by 37
Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite
Dent, M. R., DeMartino, A. W., Tejero, J., & Gladwin, M. T. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c01048 · Cited by 35
Self-citationAmino acids in human nutrition and health
D’Mello, J. P. F. (2011) · CABI eBooks · doi:10.1079/9781845937980.0000 · Cited by 36
Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation
Braganza, A., Quesnelle, K. M., Bickta, J., Reyes, C., Wang, Y., Jessup, M., Croix, C. M. S., Arlotti, J. A., Singh, S. V., & Shiva, S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006673 · Cited by 36
Self-citationJones, D. A., Andiapen, M., Van-Eijl, T. J. A., Webb, A. J., Antoniou, S., SCHILLING, R. J., Ahluwalia, A., & Mathur, A. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002813 · Cited by 35
Assessment of the functional diversity of human myoglobin
Totzeck, M., Hendgen-Cotta, U. B., Rammos, C., Petrescu, A. M., Meyer, C. G., Balzer, J., Kelm, M., & Rassaf, T. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.001 · Cited by 34
Self-citationPinheiro, L. C., Oliveira‐Paula, G. H., Ferreira, G. C., de Paula, T. D., Duarte, D. Â., Costa-Neto, C. M., & Tanus-Santos, J. E. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101769 · Cited by 35
Extending the translational potential of targeting NO/ cGMP ‐regulated pathways in the CVS
Papapetropoulos, A., Hobbs, A. J., & Topouzis, S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12980 · Cited by 35
First Aid Kit for Hypoxic Survival: Sensors and Strategies
López‐Barneo, J., Nurse, C. A., Nilsson, G., Buck, L. T., Gassmann, M., & Bogdanova, A. Y. (2010) · Physiological and Biochemical Zoology · doi:10.1086/651584 · Cited by 34
Murata, I., Nozaki, R., Ooi, K., Ohtake, K., Kimura, S., Ueda, H., Nakano, G., Sonoda, K., Inoue, Y., Uchida, H., et al. (2012) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0b013e31824a76b5 · Cited by 33
Accelerated Evolutionary Rate of the Myoglobin Gene in Long-Diving Whales
Nery, M. F., Arroyo, J. I., & Opazo, J. C. (2013) · Journal of Molecular Evolution · doi:10.1007/s00239-013-9572-1 · Cited by 33
Zager, R. A., Johnson, A. C. M., & Frostad, K. B. (2016) · Kidney International · doi:10.1016/j.kint.2016.01.022 · Cited by 33
Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy
Oliveira‐Paula, G. H., & Tanus-Santos, J. E. (2018) · Current Drug Targets · doi:10.2174/1389450119666180816120816 · Cited by 33
Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle
Rayner, B. S., Hua, S., Sabaretnam, T., & Witting, P. K. (2009) · Biochemical Journal · doi:10.1042/bj20090716 · Cited by 33
Kumar, A. K., Anishkin, A., Adams, S. H., & Chintapalli, S. V. (2024) · Physiological Reviews · doi:10.1152/physrev.00031.2023 · Cited by 33
Totzeck, M., Hendgen-Cotta, U. B., Kelm, M., & Rassaf, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105951 · Cited by 32
Self-citationBalance of Nitric Oxide and Reactive Oxygen Species in Myocardial Reperfusion Injury and Protection
Folino, A., Losano, G., & Rastaldo, R. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182a50c45 · Cited by 32
Inorganic nitrite modulates miRNA signatures in acute myocardial in vivo ischemia/reperfusion
Hendgen-Cotta, U. B., Messiha, D., Esfeld, S., Deenen, R., Rassaf, T., & Totzeck, M. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1282158 · Cited by 31
Self-citationZhang, W., Su, D., Li, P., Zhang, J., Liu, J., Wang, H., Zhang, W., & Tang, B. (2019) · Chemical Communications · doi:10.1039/c9cc04585f · Cited by 31
Regulating the nitrite reductase activity of myoglobin by redesigning the heme active center
Wu, L.-B., Yuan, H., Gao, S., You, Y., Nie, C., Wen, G., Lin, Y., & Tan, X. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.04.007 · Cited by 32
Myoglobin oxygen affinity in aquatic and terrestrial birds and mammals
Wright, T. J., & Davis, R. W. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.119321 · Cited by 30
Jia, H., Zong, M., Zheng, G., & Li, N. (2019) · ACS Catalysis · doi:10.1021/acscatal.8b04890 · Cited by 30
Acid-induced nitrite reduction of nonheme iron( ii )-nitrite: mimicking biological Fe–NiR reactions
kulbir, K., Das, S. K., Devi, T., Ghosh, S., Sahoo, S. C., & Kumar, P. (2023) · Chemical Science · doi:10.1039/d2sc06704h · Cited by 30
The exercising heart at altitude
Calbet, J. A. L., Robach, P., & Lundby, C. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0148-6 · Cited by 30
Myoglobin’s novel role in nitrite-induced hypoxic vasodilation
Hendgen-Cotta, U. B., Kelm, M., & Rassaf, T. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2013.06.006 · Cited by 30
Self-citationNitrite is a positive modulator of the Frank-Starling response in the vertebrate heart
Angelone, T., Gattuso, A., Imbrogno, S., Mazza, R., & Tota, B. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00616.2011 · Cited by 30
Khoo, N. K. H., Mo, L., Zharikov, S. I., Kamga, C., Quesnelle, K. M., Golin-Bisello, F., Li, L., Wang, Y., & Shiva, S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.009 · Cited by 32
Self-citationNeto‐Neves, E. M., Pinheiro, L. C., Nogueira, R. C., Portella, R. L., Batista, R. I. M., & Tanus-Santos, J. E. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.06.012 · Cited by 29
Kelpke, S. S., Chen, B., Bradley, K. M., Teng, X., Chumley, P., Brandon, A., Yancey, B., Moore, B., Head, H., Viera, L., et al. (2012) · Kidney International · doi:10.1038/ki.2012.116 · Cited by 28
Meller, S., Bicker, A., Montani, M., Ikenberg, K., Rostamzadeh, B., Sailer, V. W., Wild, P. J., Dietrich, D., Uhl, B., Sulser, T., et al. (2014) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-014-1646-y · Cited by 28
Keszler, Á., Brandal, G., Baumgardt, S. L., Ge, Z., Pratt, P. F., Riess, M. L., & Bienengraeber, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00305 · Cited by 28
He, L., Chu, Y., Yang, J., He, J., Hua, Y., Chen, Y., Benavides, G. A., Rowe, G. C., Zhou, L., Ballinger, S. W., et al. (2022) · Cells · doi:10.3390/cells11132111 · Cited by 27
Allosteric modulation by S-nitrosation in the low-O2affinity myoglobin from rainbow trout
Helbo, S., & Fago, A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00374.2010 · Cited by 27
Stefano, G. B., & Kream, R. M. (2011) · Medical Science Monitor · doi:10.12659/msm.881972 · Cited by 27
Jensen, F. B., Hansen, M. N., Montesanti, G., & Wang, T. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.093179 · Cited by 27
Stickrath, A. B., Mara, M. W., Lockard, J. V., Harpham, M. R., Huang, J., Zhang, X., Attenkofer, K., & Chen, L. X. (2012) · The Journal of Physical Chemistry B · doi:10.1021/jp3086705 · Cited by 27
Compensatory mechanisms in myoglobin deficient mice preserve NO homeostasis
Park, J. W., Piknova, B., Dey, S., Noguchi, C. T., & Schechter, A. N. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.06.001 · Cited by 27
Pohl, J., Hendgen-Cotta, U. R., Rammos, C., Luedike, P., Mull, E., Stoppe, C., Jülicher, K., Lue, H., Merx, M. W., Kelm, M., et al. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-05-0436 · Cited by 26
Self-citationKoebke, K. J., Pauly, D. J., Lerner, L., Liu, X., & Pacheco, A. A. (2013) · Inorganic Chemistry · doi:10.1021/ic400697a · Cited by 26
Liang, Z., Chen, H., Gong, X., Shi, B., Lin, L., Tao, F.-Y., Wu, Q., Fang, M., Li, H., Lu, C., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.745693 · Cited by 26
Pulsed pressure assisted brining of porcine meat
Jin, G., He, L., Wang, Q., Liu, C., Jin, Y., Huang, F., & Ma, M. (2014) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2013.12.014 · Cited by 26
Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function
Neye, N., Enigk, F., Shiva, S., Habazettl, H., Plesnila, N., Kuppe, H., Gladwin, M. T., & Kuebler, W. M. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2605-1 · Cited by 26
Self-citationBicker, A., Dietrich, D., Gleixner, E. M., Kristiansen, G., Gorr, T. A., & Hankeln, T. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt438 · Cited by 26
de Prati, A. C., Podesser, B. K., Faggian, G. G., Scarabelli, T. M., Mazzucco, A., Darra, E., Rungatscher, A., Hallström, S., & Suzuki, H. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-08-0554 · Cited by 26
Effects of endothelial nitric oxide synthase tagSNPs haplotypes on nitrite levels in black subjects
Metzger, I. F., Luizon, M. R., Lacchini, R., Ishizawa, M. H., & Tanus-Santos, J. E. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.10.002 · Cited by 25
Guo, Y., Sanganalmath, S. K., Wu, W., Zhu, X., Huang, Y., Tan, W. F., Ildstad, S. T., Li, Q., & Bolli, R. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0253-9 · Cited by 25
Aggarwal, S., Randhawa, P. K., Singh, N., & Jaggi, A. S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.03.021 · Cited by 25
Vlasova, E. A., Hessenauer‐Ilicheva, N., Salnikov, D. S., Kudrik, E. V., Makarov, S. V., & van Eldik, R. (2009) · Dalton Transactions · doi:10.1039/b906478h · Cited by 24
Singamsetty, S., Watanabe, Y., Guo, L., Corey, C. G., Wang, Y., Tejero, J., McVerry, B. J., Gladwin, M. T., Shiva, S., & O'Donnell, C. P. (2015) · The Journal of Physiology · doi:10.1113/jp270386 · Cited by 26
Self-citation
Metadata
- Authors
- Hendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., Kelm, M., & Rassaf, T.
- Affiliations
- Universitätsklinikum Aachen (DE)
- National Institutes of Health (US)
- Osnabrück University (DE)
- Heinrich Heine University Düsseldorf (DE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-07-22
- Volume
- 105
- Issue
- 29
- Pages
- 10256-10261
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2481313
- OpenAlex
- W2096118264
- Cited by
- 418
- References
- 41
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 13 · 2021: 14 · 2020: 12 · 2019: 23 · 2018: 15 · 2017: 23 · 2016: 27 · 2015: 36 · 2014: 30 · 2013: 35 · 2012: 46
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Update notices
- correction (2008-08-26)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- myoglobin, nitrite reductase, nitric oxide, myocardial ischemia-reperfusion injury, hypoxia, cellular respiration, reactive oxygen species, cardioprotection, myocardial infarction, nitrite
- MeSH terms
- Aconitate Hydratase, Animals, Cell Survival, Heme, Male, Mitochondria, Heart, Myocardial Infarction, Myocardium, Myoglobin, Nitric Oxide, Nitrites, Oxidation-Reduction, Myocardial Reperfusion Injury, Reactive Oxygen Species, Mice, Knockout, Ventricular Dysfunction, Left, Cell Respiration, Nitrate Reductase, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
