Cited by 1,435Schizophrenia research and treatmentFunctional Brain Connectivity StudiesMental Health and Psychiatry

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia

Open access

Whitfield-Gabrieli, Susan, Thermenos, Heidi W., Milanovic, Snezana, Tsuang, Ming T., Faraone, Stephen V., McCarley, Robert W., Shenton, Martha E., Green, Alan I., Nieto-Castanon, Alfonso, LaViolette, Peter, Wojcik, Joanne, Gabrieli, John D. E., Seidman, Larry J.·2009·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0809141106PMC PMC2633557

Open this paper in CoChat — free account

Abstract

We examined the status of the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia. During functional MRI, patients, relatives, and controls alternated between rest and performance of working memory (WM) tasks. As expected, controls exhibited task-related suppression of activation in the default network, including medial prefrontal cortex (MPFC) and posterior cingulate cortex/precuneus. Patients and relatives exhibited significantly reduced task-related suppression in MPFC, and these reductions remained after controlling for performance. Increased task-related MPFC suppression correlated with better WM performance in patients and relatives and with less psychopathology in all 3 groups. For WM task performance, patients and relatives had greater activation in right dorsolateral prefrontal cortex (DLPFC) than controls. During rest and task, patients and relatives exhibited abnormally high functional connectivity within the default network. The magnitudes of default network connectivity during rest and task correlated with psychopathology in the patients. Further, during both rest and task, patients exhibited reduced anticorrelations between MPFC and DLPFC, a region that was hyperactivated by patients and relatives during WM performance. Among patients, the magnitude of MPFC task suppression negatively correlated with default connectivity, suggesting an association between the hyperactivation and hyperconnectivity in schizophrenia. Hyperactivation (reduced task-related suppression) of default regions and hyperconnectivity of the default network may contribute to disturbances of thought in schizophrenia and risk for the illness.

Integrity signals

Registry

Crossref · 10.1073/pnas.0809141106

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function
Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043098 · Cited by 2,997
Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
Heinrichs, R. W., & Zakzanis, K. K. (1998) · Neuropsychology · doi:10.1037/0894-4105.12.3.426 · Cited by 2,798
Wandering minds: the default network and stimulus-independent thought
Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D. M., Grafton, S. T., & Macrae, C. N. (2007) · Science · doi:10.1126/science.1131295 · Cited by 2,792
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
Finding the self? An event-related fMRI study
Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., & Heatherton, T. F. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/08989290260138672 · Cited by 1,606 · cited 2×
“This network, especially the midline regions of the MPFC and PCC, overlaps with brain regions activated during self-referential cognitive or emotional tasks (11, 12).”
BackgroundMethod
The neural bases of momentary lapses in attention
Weissman, D. H., Roberts, K. C., Visscher, K. M., & Woldorff, M. G. (2006) · Nature Neuroscience · doi:10.1038/nn1727 · Cited by 1,566

Flagged first, then by citations

Show all 40 references

Research works printed but not linked: 1

LR Derogatis Symptom Checklist-90-Revised (SCL-90-R): Administration, Scoring and Procedures Manual (Clinical Psychometric Research, Towson, MD, 1983).

Sorted by citations

Items 201–300 of 1,001

Connectome-wide network analysis of youth with Psychosis-Spectrum symptoms
Satterthwaite, T. D., Vandekar, S., Wolf, D. H., Bassett, D. S., Ruparel, K., Shehzad, Z. E., Craddock, R. C., Shinohara, R. T., Moore, T. M., Gennatas, E. D., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.66 · Cited by 107
Early and broadly defined psychosis risk mental states
Keshavan, M. S., DeLisi, L. E., & Seidman, L. J. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.10.006 · Cited by 111
Self-citation
Disrupted sensorimotor and social–cognitive networks underlie symptoms in childhood-onset schizophrenia
Berman, R. A., Gotts, S. J., McAdams, H. M., Greenstein, D. K., Lalonde, F. M., CLASEN, L. S., Watsky, R. E., Shora, L., Ordóñez, A. E., Raznahan, A., et al. (2015) · Brain · doi:10.1093/brain/awv306 · Cited by 116
Cerebellar networks in individuals at ultra high‐risk of psychosis: Impact on postural sway and symptom severity
Bernard, J. A., Dean, D. J., Kent, J. S., Orr, J. M., Pelletier‐Baldelli, A., Lunsford‐Avery, J. R., Gupta, T., & Mittal, V. A. (2014) · Human Brain Mapping · doi:10.1002/hbm.22458 · Cited by 113
Controversies and progress on standardization of large-scale brain network nomenclature
Uddin, L. Q., Betzel, R. F., Cohen, J. R., Damoiseaux, J. S., Brigard, F. D., Eickhoff, S. B., Fornito, A., Gratton, C., Gordon, E. M., Laird, A. R., et al. (2023) · Network Neuroscience · doi:10.1162/netn_a_00323 · Cited by 125
Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis
Meda, S. A., Stevens, M. C. G., Folley, B. S., Calhoun, V. D., & Pearlson, G. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007911 · Cited by 114
Salience–Default Mode Functional Network Connectivity Linked to Positive and Negative Symptoms of Schizophrenia
Hare, S., Ford, J. M., Mathalon, D. H., Damaraju, E., Bustillo, J., Belger, A., Lee, H. J., Mueller, B. A., Lim, K. O., Brown, G. G., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby112 · Cited by 118
The relationship between regional and inter‐regional functional connectivity deficits in schizophrenia
Zalesky, A., Fornito, A., Egan, G. F., Pantelis, C., & Bullmore, E. T. (2011) · Human Brain Mapping · doi:10.1002/hbm.21379 · Cited by 108
Basal functional connectivity within the anterior temporal network is associated with performance on declarative memory tasks
Gour, N., Ranjeva, J., Ceccaldi, M. P., Sylviane Confort-gouny, A., Barbeau, E. J., Soulier, E., Guye, M., Didic, M., & Félician, O. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.090 · Cited by 107
Schizophrenia-related abnormalities in the triple network: a meta-analysis of working memory studies
Wu, D., & Jiang, T. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00071-1 · Cited by 114
Complexity and schizophrenia
Fernández, A., Gómez, C., Hornero, R., & López-Ibor, J. J. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.015 · Cited by 110
Reduced prefrontal functional connectivity in the default mode network is related to greater psychopathology in subjects with high genetic loading for schizophrenia
Jang, J. H., Jung, W. H., Choi, J., Choi, C., Kang, D., Shin, N. Y., Hong, K. S., & Kwon, J. S. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.12.022 · Cited by 113
Correlated structural and functional brain abnormalities in the default mode network in schizophrenia patients
Salgado‐Pineda, P., Fakra, É., Delaveau, P., McKenna, P. J., Pomarol‐Clotet, E., & Blin, O. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.10.027 · Cited by 111
Myelin and Axon Abnormalities in Schizophrenia Measured with Magnetic Resonance Imaging Techniques
Du, F., Cooper, A. J., Thida, T., Shinn, A. K., Cohen, B. M., & Öngür, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.003 · Cited by 110
Phenotypic Variability in Resting-State Functional Connectivity: Current Status
Vaidya, C. J., & Gordon, E. M. (2013) · Brain Connectivity · doi:10.1089/brain.2012.0110 · Cited by 115
Mindfulness training preserves sustained attention and resting state anticorrelation between default‐mode network and dorsolateral prefrontal cortex: A randomized controlled trial
Bauer, C. C. C., Rozenkrantz, L., Caballero, C., Nieto-Castañón, A., Scherer, E., West, M. R., Mrazek, M. D., Phillips, D. T., Gabrieli, J. D. E., & Whitfield, S. (2020) · Human Brain Mapping · doi:10.1002/hbm.25197 · Cited by 112
Self-citation
Decreased small-world functional network connectivity and clustering across resting state networks in schizophrenia: an fMRI classification tutorial
Anderson, A., & Cohen, M. S. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00520 · Cited by 107
The neurocognitive consequences of the wandering mind: a mechanistic account of sensory-motor decoupling
Kam, J. W. Y., & Handy, T. C. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00725 · Cited by 122
Effects of an Alpha 7-Nicotinic Agonist on Default Network Activity in Schizophrenia
Tregellas, J. R., Tanabe, J., Rojas, D. C., Shatti, S., D, A. O. M., Johnson, L. L., Martín, L., Soti, F. S., Kem, W. R., Leonard, S. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.004 · Cited by 106
Abnormal default-mode network homogeneity in first-episode, drug-naive schizophrenia at rest
Guo, W., Yao, D., Jiang, J., Su, Q., Zhang, Z., Zhang, J., Yu, L., & Xiao, C. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.021 · Cited by 106
Static and Dynamic Characteristics of Cerebral Blood Flow During the Resting State in Schizophrenia
Kindler, J., Jann, K., Homan, P., Hauf, M., Walther, S., Strik, W. K., Dierks, T., & Hubl, D. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt180 · Cited by 105
Brainnetome: A new -ome to understand the brain and its disorders
Jiang, T. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.002 · Cited by 104
A review of neuroimaging studies of young relatives of individuals with schizophrenia: A developmental perspective from schizotaxia to schizophrenia
Thermenos, H. W., Keshavan, M. S., Juelich, R. J., Molokotos, E. K., Whitfield, S., Brent, B., Makris, N., & Seidman, L. J. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32170 · Cited by 105
Self-citation
Constituents and functional implications of the rat default mode network
Hsu, L., Liang, X., Gu, H., Brynildsen, J. K., Stark, J. A., Ash, J. A., Lin, C., Lu, H., Rapp, P. R., Stein, E. A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601485113 · Cited by 101
Differences in resting corticolimbic functional connectivity in bipolar I euthymia
Torrisi, S., Moody, T. D., Vizueta, N., Thomason, M. E., Monti, M. M., Townsend, J. D., Bookheimer, S. Y., & Altshuler, L. L. (2013) · Bipolar Disorders · doi:10.1111/bdi.12047 · Cited by 105
Neuroimaging in Psychiatric Disorders
Masdeu, J. C. (2011) · Neurotherapeutics · doi:10.1007/s13311-010-0006-0 · Cited by 106
Enhanced functional networks in absolute pitch
Loui, P., Zamm, A., & Schlaug, G. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.030 · Cited by 104
White matter defects in first episode psychosis patients: A voxelwise analysis of diffusion tensor imaging
Pérez‐Iglesias, R., Tordesillas‐Gutiérrez, D., Barker, G. J., McGuire, P. K., Roiz‐Santiáñez, R., Mata, I. F., de Lucas, E. M., Quintana, F. U., Vázquez‐Barquero, J. L., & Crespo‐Facorro, B. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.07.016 · Cited by 105
Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network
Kottaram, A., Johnston, L. A., Cocchi, L., Ganella, E. P., Everall, I., Pantelis, C., Ramamohanarao, K., & Zalesky, A. (2019) · Human Brain Mapping · doi:10.1002/hbm.24519 · Cited by 100
Temporally anticorrelated brain networks during working memory performance reveal aberrant prefrontal and hippocampal connectivity in patients with schizophrenia
Wolf, R. C., Vasić, N., Sambataro, F., Höse, A., Frasch, K., Schmid, M., & Walter, H. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.032 · Cited by 105
Brain differences between persistent and remitted attention deficit hyperactivity disorder
Mattfeld, A. T., Gabrieli, J. D. E., Biederman, J., Spencer, T., Brown, A., Kotte, A., Kagan, E., & Whitfield-Gabrieli, S. (2014) · Brain · doi:10.1093/brain/awu137 · Cited by 96
Self-citation
Modeling a model: Mouse genetics, 22q11.2 Deletion Syndrome, and disorders of cortical circuit development
Meechan, D. W., Maynard, T. M., Tucker, E. S., Fernandez, A., Karpinski, B. A., Rothblat, L. A., & LaMantia, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.004 · Cited by 105
Dysconnectivity Within the Default Mode in First-Episode Schizophrenia: A Stochastic Dynamic Causal Modeling Study With Functional Magnetic Resonance Imaging
de Bastos-Leite, A. J., Ridgway, G. R., Silveira, C., Norton, A., Reis, S., & Friston, K. J. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu080 · Cited by 101
Abnormalities in large scale functional networks in unmedicated patients with schizophrenia and effects of risperidone
Kraguljac, N. V., White, D. M., Hadley, J. A., Visscher, K., Knight, D. C., Hoef, L. V., Falola, B., & Lahti, A. C. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.11.015 · Cited by 100
Common and distinct dysfunctional patterns contribute to triple network model in schizophrenia and depression: A preliminary study
Jiang, Y., Duan, M., Chen, X., Chang, X., He, H., Li, Y., Luo, C., & Yao, D. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.007 · Cited by 103
Bidirectional effects on interhemispheric resting‐state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation
Watanabe, T., Hanajima, R., Shirota, Y., Ohminami, S., Tsutsumi, R., Terao, Y., Ugawa, Y., Hirose, S., Miyashita, Y., Konishi, S., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22300 · Cited by 99
The brain and its resting state activity—Experimental and methodological implications
Northoff, G., Duncan, N. W., & Hayes, D. J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.002 · Cited by 109
Impaired neural replay of inferred relationships in schizophrenia
Nour, M. M., Liu, Y., Arumuham, A., Kurth-Nelson, Z. L., & Dolan, R. J. (2021) · Cell · doi:10.1016/j.cell.2021.06.012 · Cited by 101
Perception of Biological Motion in Schizophrenia and Healthy Individuals: A Behavioral and fMRI Study
Kim, J., Park, S., & Blake, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019971 · Cited by 97
Superior Temporal Sulcus Disconnectivity During Processing of Metaphoric Gestures in Schizophrenia
Straube, B., Green, A., Saß, K., & Kircher, T. T. J. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt110 · Cited by 98
Self-citation
Understanding the Emergence of Neuropsychiatric Disorders With Network Neuroscience
Bassett, D. S., Xia, C. H., & Satterthwaite, T. D. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.03.015 · Cited by 98
Automatic Bayesian Classification of Healthy Controls, Bipolar Disorder, and Schizophrenia Using Intrinsic Connectivity Maps From fMRI Data
Arribas, J. I., Calhoun, V. D., & Adalı, T. (2010) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2010.2080679 · Cited by 100
A Schizophrenia Risk Gene, ZNF804A, Influences Neuroanatomical and Neurocognitive Phenotypes
Lencz, T., Szeszko, P. R., DeRosse, P., Burdick, K. E., Bromet, E. J., Bilder, R. M., & Malhotra, A. K. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.102 · Cited by 96
Default-Mode-Like Network Activation in Awake Rodents
Upadhyay, J., Baker, S. J., Chandran, P., Miller, L. N., Lee, Y., Marek, G. J., Sakoğlu, Ü., Chin, C., Luo, F. R., Fox, G. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027839 · Cited by 100
Analysis of the Complexity Measures in the EEG of Schizophrenia Patients
Akar, S. A., Kara, S., Lati̇foğlu, F., & Bilgiç, V. (2015) · International Journal of Neural Systems · doi:10.1142/s0129065716500088 · Cited by 96
Converging models of schizophrenia – Network alterations of prefrontal cortex underlying cognitive impairments
Sakurai, T., Gamo, N. J., Hikida, T., Kim, S.-H., Murai, T., Tomoda, T., & Sawa, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.010 · Cited by 102
Association between resting-state functional connectivity and empathizing/systemizing
Takeuchi, H., Taki, Y., Nouchi, R., Sekiguchi, A., Hashizume, H., Sassa, Y., Kotozaki, Y., Miyauchi, C. M., Yokoyama, R., Iizuka, K., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.031 · Cited by 99
The default mode network as a biomarker for monitoring the therapeutic effects of meditation
Simon, R., & EngstrÃ¶m, M. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00776 · Cited by 95
Prenatal lead exposure impacts cross-hemispheric and long-range connectivity in the human fetal brain
Thomason, M. E., Hect, J. L., Rauh, V. A., Trentacosta, C., Wheelock, M. D., Eggebrecht, A. T., Espinoza-Heredia, C., & Burt, S. A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.02.017 · Cited by 94
fMRI evidence for abnormal resting-state functional connectivity in euthymic bipolar patients
Favre, P., Baciu, M., Pichat, C., Bougerol, T., & Polosan, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.054 · Cited by 100
Changes in the brain intrinsic organization in both on-task state and post-task resting state
Wang, Z., Liu, J., Zhong, N., Qin, Y., Zhou, H., & Li, K. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.051 · Cited by 97
Coping With COVID-19: Mindfulness-Based Approaches for Mitigating Mental Health Crisis
Antonova, E., Schlosser, K., Pandey, R., & Kumari, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.563417 · Cited by 89
Neuroimaging in schizophrenia: A review article
Dabiri, M., Firouzabadi, F. D., Yang, K., Barker, P. B., Lee, R. R., & Yousem, D. M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042814 · Cited by 104
Decreased resting-state interhemispheric coordination in first-episode, drug-naive paranoid schizophrenia
Guo, W., Xiao, C., Liu, G., Wooderson, S. C., Zhang, Z., Zhang, J., Yu, L., & Liu, J. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.012 · Cited by 93
Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications
Gaspar, P. A., Bustamante, M. L., Hernán Silva, I., & Aboitiz, F. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06325.x · Cited by 91
Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia
Cheung, V., Chiu, C. P. Y., Law, C. W., Cheung, C. C. G., Hui, C. L. M., Chan, K. K. S., Sham, P. C., Deng, M., Tai, K. S., Khong, P., et al. (2010) · Psychological Medicine · doi:10.1017/s003329171000156x · Cited by 92
Correcting for Blood Arrival Time in Global Mean Regression Enhances Functional Connectivity Analysis of Resting State fMRI-BOLD Signals
Erdoğan, S. B., Tong, Y., Hocke, L. M., Lindsey, K. P., & Frederick, B. B. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00311 · Cited by 92
Increased functional connectivity between the default mode and salience networks in unmedicated adults with obsessive-compulsive disorder: Default Mode and Salience Networks in OCD
Posner, J., Song, I., Lee, S., Rodriguez, C. I., Moore, H., Marsh, R., & Blair Simpson, H. (2017) · Human Brain Mapping · doi:10.1002/hbm.23408 · Cited by 89
Creativity and schizotypy from the neuroscience perspective
Fink, A., Weber, B., Koschutnig, K., Benedek, M., Reishofer, G., Ebner, F., Papousek, I., & Weiss, E. M. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0210-6 · Cited by 93
A Computer-Aided Diagnosis System With EEG Based on the P3b Wave During an Auditory Odd-Ball Task in Schizophrenia
Mayo, L. S., San‐José‐Revuelta, L. M., & Arribas, J. I. (2016) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2016.2558824 · Cited by 92
Parietal hyper‐connectivity, aberrant brain organization, and circuit‐based biomarkers in children with mathematical disabilities
Jolles, D., Ashkenazi, S., Kochalka, J., Evans, T. M., Richardson, J. L., Rosenberg‐Lee, M., Zhao, H., Supekar, K., Chen, T., & Menon, V. (2016) · Developmental Science · doi:10.1111/desc.12399 · Cited by 98
Variation in longevity gene KLOTHO is associated with greater cortical volumes
Yokoyama, J. S., Sturm, V. E., Bonham, L. W., Klein, E., Arfanakis, K., Yu, L., Coppola, G., Kramer, J. H., Bennett, D. A., Miller, B. L., et al. (2015) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.161 · Cited by 91
Brain connectivity and psychiatric comorbidity in adolescents with Internet gaming disorder
Han, D. H., Kim, S. M., Bae, S., Renshaw, P. F., & Anderson, J. S. (2015) · Addiction Biology · doi:10.1111/adb.12347 · Cited by 95
Task-related fronto-striatal functional connectivity during working memory performance in schizophrenia
Quidé, Y., Morris, R. W., Shepherd, A. M., Rowland, J. E., & Green, M. J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.08.009 · Cited by 90
Exploring brain functional connectivity in rest and sleep states: a fNIRS study
Nguyen, T. H., Babawale, O., Kim, T., Jo, H. J., Liu, H., & Kim, J. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-33439-2 · Cited by 87
Functional neuroimaging in psychiatry and the case for failing better
Nour, M. M., Liu, Y., & Dolan, R. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.005 · Cited by 92
Reorganization of Functional Connectivity of the Language Network in Patients with Brain Gliomas
Briganti, C., Sestieri, C., Mattei, P. A., Esposito, R., Galzio, R. J., Tartaro, A., Romani, G. L., & Caulo, M. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3064 · Cited by 89
Altered Global Signal Topography in Schizophrenia
Yang, G., Murray, J. D., Glasser, M. F., Pearlson, G. D., Krystal, J. H., Schleifer, C., Repovš, G., & Anticevic, A. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw297 · Cited by 88
Failure of Schizophrenia Patients to Overcome Salient Distractors During Working Memory Encoding
Hahn, B., Robinson, B. M., Kaiser, S. T., Harvey, A. N., Beck, V. M., Leonard, C. J., Kappenman, E. S., Luck, S. J., & Gold, J. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.014 · Cited by 88
“For example, PSZ reportedly display hyperactivity during task performance in brain regions that mediate task-independent thought, and this was suggested to reflect a misdirection of attentional resources to internal events (53).”
Background
Frontal white matter integrity as an endophenotype for schizophrenia: diffusion tensor imaging in monozygotic twins and patients’ nonpsychotic relatives
Camchong, J. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.035.2009 · Cited by 88
Bipolar depressed patients show both failure to activate and failure to de-activate during performance of a working memory task
Fernández‐Corcuera, P., Salvador, R. M., Monté, G. C., Sarró, S., Goikolea, J. M., Amann, B. L., Moro, N., Sans-Sansa, B., Ortiz‐Gil, J., Vieta, E., et al. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.009 · Cited by 90
Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/hippocampus and various nodes of the default mode network
Regen, W., Kyle, S. D., Nissen, C., Feige, B., Baglioni, C., Hennig, J., Riemann, D. W., & Spiegelhalder, K. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140290 · Cited by 91
Abnormal regional homogeneity as a potential imaging biomarker for adolescent-onset schizophrenia: A resting-state fMRI study and support vector machine analysis
Wang, S., Zhang, Y., Lv, L., Wu, R., Fan, X., Zhao, J., & Guo, W. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.05.038 · Cited by 86
Functional network connectivity impairments and core cognitive deficits in schizophrenia
Adhikari, B. M., Hong, L. E., Sampath, H., Chiappelli, J., Jahanshad, N., Thompson, P. M., Rowland, L. M., Calhoun, V. D., Du, X. M., Chen, S., et al. (2019) · Human Brain Mapping · doi:10.1002/hbm.24723 · Cited by 89
Decreased Efficiency of Task-Positive and Task-Negative Networks During Working Memory in Schizophrenia
Metzak, P. D., Riley, J. D., Wang, L., Whitman, J. C., Ngan, E. T. C., & Woodward, T. S. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq154 · Cited by 87
The neuropsychology of self-reflection in psychiatric illness
Philippi, C. L., & Koenigs, M. R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.004 · Cited by 100
Aberrant Salience Is Related to Dysfunctional Self-Referential Processing in Psychosis
Pankow, A., Katthagen, T., Diner, S., Deserno, L., Boehme, R., Kathmann, N., Gleich, T., Gaebler, M., Walter, H., Heinz, A., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv098 · Cited by 86
The genetics of colored sequence synesthesia: Suggestive evidence of linkage to 16q and genetic heterogeneity for the condition
Tomson, S. N., Avidan, N., Lee, K. D., Sarma, A. K., Tushe, R., Milewicz, D. M., Bray, M. S., Leal, S. M., & Eagleman, D. M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.071 · Cited by 88
Reliability correction for functional connectivity: Theory and implementation
Mueller, S., Wang, D., Fox, M., Pan, R., Lu, J., Li, K., Sun, W., Buckner, R. L., & Liu, H. (2015) · Human Brain Mapping · doi:10.1002/hbm.22947 · Cited by 92
Evidence of a dissociation pattern in default mode subnetwork functional connectivity in schizophrenia
Wang, H., Zeng, L., Chen, Y., Yin, H. J., Tan, Q., & Hu, D. (2015) · Scientific Reports · doi:10.1038/srep14655 · Cited by 93
Concise Review: The Promise of Human Induced Pluripotent Stem Cell-Based Studies of Schizophrenia
Brennand, K., & Gage, F. H. (2011) · Stem Cells · doi:10.1002/stem.762 · Cited by 87
Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy
Caciagli, L., Paquola, C., He, X., Vollmar, C., Centeno, M., Wandschneider, B., Braun, U., Trimmel, K., Vos, S. B., Sidhu, M. K., et al. (2022) · Brain · doi:10.1093/brain/awac150 · Cited by 83
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution
Stoliker, D., Egan, G. F., Friston, K. J., & Razi, A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000508 · Cited by 96
Dissociations between glucose metabolism and blood oxygenation in the human default mode network revealed by simultaneous PET-fMRI
Jonasson, L. S., Grill, F., Hahn, A., Rischka, L., Lanzenberger, R. R., Lundmark, V. P., Riklund, K., Axelsson, J., & Rieckmann, A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021913118 · Cited by 87
Transcranial stimulation of alpha oscillations up-regulates the default mode network
Clancy, K. J., Andrzejewski, J. A., You, Y., Rosenberg, J. T., Ding, M., & Li, W. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110868119 · Cited by 81
Neural substrates of reward anticipation and outcome in schizophrenia: a meta-analysis of fMRI findings in the monetary incentive delay task
Zeng, J., Yan, J., Cao, H., Su, Y., Song, Y. Y., Luo, Y., & Yang, X. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02201-8 · Cited by 89
Abnormal autonomic and associated brain activities during rest in autism spectrum disorder
Eilam‐Stock, T., Xu, P., Cao, M., Gu, X., Dam, N. T. V., Anagnostou, E. A., Kolevzon, A. L., Soorya, L. V., Park, Y., Siller, M., et al. (2014) · Brain · doi:10.1093/brain/awt294 · Cited by 88
Modulating spontaneous brain activity using repetitive transcranial magnetic stimulation
van der Werf, Y. D., Sanz‐Arigita, E., Menning, S., & van den Heuvel, O. A. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-145 · Cited by 87
Evolving Notions of Schizophrenia as a Developmental Neurocognitive Disorder
Seidman, L. J., & Mirsky, A. F. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717001114 · Cited by 87
Self-citation
Real-time fMRI neurofeedback reduces auditory hallucinations and modulates resting state connectivity of involved brain regions: Part 2: Default mode network -preliminary evidence
Bauer, C. C. C., Okano, K., Ghosh, S., Lee, Y. J., Melero, H., Angeles, C. D. L., Nestor, P. G., del Re, E. C., Northoff, G., Niznikiewicz, M. A., et al. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112770 · Cited by 78
A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology
Bogdan, R., Hyde, L. W., & Hariri, A. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.35 · Cited by 84
Regional contraction of brain surface area involves three large-scale networks in schizophrenia
Palaniyappan, L. K., Mallikarjun, P. K., Joseph, V., White, T. P., & Liddle, P. F. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.03.020 · Cited by 81
Identifying Individuals with Antisocial Personality Disorder Using Resting-State fMRI
Tang, Y., Jiang, W., Liao, J., Wang, W., & Luo, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060652 · Cited by 84
Relating Anatomical and Social Connectivity: White Matter Microstructure Predicts Emotional Empathy
Parkinson, C. M., & Wheatley, T. P. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs347 · Cited by 90
Altered default mode and fronto-parietal network subsystems in patients with schizophrenia and their unaffected siblings
Chang, X., Shen, H., Wang, L., Liu, Z., Wei, X., Hu, D., & Miao, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.024 · Cited by 84
Creativity and Mental Illness
Carson, S. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316979839.016 · Cited by 86
From State-to-Trait Meditation: Reconfiguration of Central Executive and Default Mode Networks
Bauer, C. C. C., Whitfield-Gabrieli, S., Díaz, J. L., Pasaye, E. H., & Barrios, F. A. (2019) · eneuro · doi:10.1523/eneuro.0335-18.2019 · Cited by 81
The thalamic reticular nucleus: A functional hub for thalamocortical network dysfunction in schizophrenia and a target for drug discovery
Pratt, J. A., & MORRIS, B. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114565805 · Cited by 83
Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia
Yu, R., Hsieh, M. H., Wang, H. S., Liu, C., Liu, C., Hwang, T., Chien, Y., Hwu, H., & Tseng, W. I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057516 · Cited by 81
Cognitive Disinhibition, Creativity, and Psychopathology
Carson, S. (2014) · Wiley eBooks · doi:10.1002/9781118367377.ch11 · Cited by 79

Authors: Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., Shenton, M. E., Green, A. I., Nieto-Castanon, A., LaViolette, P., Wojcik, J., Gabrieli, J. D. E., & Seidman, L. J.
Affiliations: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, and Poitras Center for Affective Disorders Research, Cambridge, MA 02139;
Beth Israel Deaconess Medical Center (US)
Harvard University (US)
SUNY Upstate Medical University (US)
Brigham and Women's Hospital (US)
Dartmouth College (US)
Harvard–MIT Division of Health Sciences and Technology (US)
ORCID: Milanovic, Snezana
Tsuang, Ming T.
Faraone, Stephen V.
McCarley, Robert W.
Shenton, Martha E.
Green, Alan I.
LaViolette, Peter
Gabrieli, John D. E.
Seidman, Larry J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2009-01-27
Volume: 106
Issue: 4
Pages: 1279-1284
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0809141106
PMC: PMC2633557
OpenAlex: W2115687188
Cited by: 1,435
References: 40
Citations by year: 2026: 31 · 2025: 65 · 2024: 42 · 2023: 60 · 2022: 76 · 2021: 84 · 2020: 68 · 2019: 90 · 2018: 84 · 2017: 93 · 2016: 114 · 2015: 124 · 2014: 109 · 2013: 121 · 2012: 94
FWCI: 55.49
Type: journal article
Language: en
Update notices: correction (2009-03-17)
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Institute of Mental Health (MH 65562, MH62157, MH-50740, R37MH043518, R25 MH60485, MH- 43518, MH40799, R01MH043518, R25MH060485, R01MH050740, R21MH062157, R01MH040799, R01MH063951, R01MH065562, MH-63951)
National Center for Research Resources (P41-RR-14075, P41RR014075)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, default mode network, hyperconnectivity, hyperactivation, medial prefrontal cortex, dorsolateral prefrontal cortex, working memory, functional connectivity, psychopathology, resting-state brain activity
MeSH terms: Brain Mapping, Family, Humans, Memory, Nerve Net, Rest, Schizophrenia, Schizophrenic Psychology, Task Performance and Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks