The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Behavioral tagging is a general mechanism of long-term memory formation
Open accessAbstract
In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag.
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Cites
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BackgroundResultInfluentialBDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?
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Cited by
Sorted by citations
BDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043
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“Later work by the same group established the general applicability of this novelty-induced enhancement of LTM to other tasks including object recognition memory and taste conditioning, the latter being mediated by information storage in a cortical network including the insular corte”
BackgroundHippocampo-cortical coupling mediates memory consolidation during sleep
Maingret, N., Girardeau, G., Todorova, R., Goutierre, M., & Zugaro, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4304 · Cited by 667
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“Complementary results have been obtained using different learning tasks including taste memory, spatial object recognition, contextual fear conditioning and spatial memory [37,143,144].”
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“Arc may also be involved in a specific type of memory facilitating process called “behavioral tagging” (Moncada and Viola, 2007; Ballarini et al., 2009; Wang et al., 2010; Moncada et al., 2011).”
Background
Metadata
- Authors
- Ballarini, F., Moncada, D., Martinez, M. C., Alen, N., & Viola, H.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Paraguay 2155, 3° Piso, CP 1121, Buenos Aires, Argentina; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-08-25
- Volume
- 106
- Issue
- 34
- Pages
- 14599-14604
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2732837
- OpenAlex
- W2146205533
- Cited by
- 301
- References
- 39
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 38 · 2023: 23 · 2022: 15 · 2021: 18 · 2020: 22 · 2019: 15 · 2018: 22 · 2017: 14 · 2016: 24 · 2015: 18 · 2014: 23 · 2013: 13 · 2012: 9
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- long-term memory formation, synaptic tagging and capture, short-term memory, hippocampal-dependent memory, contextual fear conditioning, conditioned taste aversion, protein synthesis, memory consolidation, rats
- MeSH terms
- Animals, Behavior, Animal, Conditioning, Psychological, Discrimination Learning, Fear, Hippocampus, Learning, Male, Memory, Memory, Short-Term, Neuronal Plasticity, Psychomotor Performance, Saccharin, Sodium Chloride, Spatial Behavior, Taste, Time Factors, Rats, Wistar, Long-Term Potentiation, Neocortex, Rats
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