Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
Open accessAbstract
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca(2+)/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
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DA can influence the persistence of aversive learning.
“studies also have indicated that DA can influence the persistence of aversive learning (Moncada et al., 2011; Ortiz et al., 2010; Rossato et al., 2009).”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Moncada et al., 2011
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- Authors
- Moncada, D., Ballarini, F., Martinez, M. C., Frey, J. U., & Viola, H.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, CP 1121 Buenos Aires, Argentina;
- Leibniz Institute for Neurobiology (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-07-18
- Volume
- 108
- Issue
- 31
- Pages
- 12931-12936
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3150922
- OpenAlex
- W2162052978
- Cited by
- 171
- References
- 47
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 18 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 15 · 2018: 17 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 18 · 2013: 9 · 2012: 10
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- long-term memory consolidation, passive avoidance, hippocampus, dopamine D1/D5 receptors, beta-adrenergic receptors, NMDA receptor, CaMKII, protein kinase A, ERK1/2, glutamatergic input, dopaminergic input, noradrenergic input
- MeSH terms
- Adrenergic beta-Antagonists, Animals, Avoidance Learning, Benzazepines, Dobutamine, Enzyme Inhibitors, Exploratory Behavior, Male, Memory, Short-Term, Neuronal Plasticity, Propranolol, Receptors, Adrenergic, beta, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Receptors, Dopamine D1, Excitatory Amino Acid Antagonists, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Receptors, Dopamine D5, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2, CA1 Region, Hippocampal, Memory, Long-Term
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