Cited by 235Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Bidirectional changes to hippocampal theta-gamma comodulation predict memory for recent spatial episodes

Open access
Shirvalkar, Prasad R., Rapp, Peter R., Shapiro, Matthew L.·2010·Proceedings of the National Academy of Sciences

Abstract

Episodic memory requires the hippocampus, which is thought to bind cortical inputs into conjunctive codes. Local field potentials (LFPs) reflect dendritic and synaptic oscillations whose temporal structure may coordinate cellular mechanisms of plasticity and memory. We now report that single-trial spatial memory performance in rats was predicted by the power comodulation of theta (4-10 Hz) and low gamma (30-50 Hz) rhythms in the hippocampus. Theta-gamma comodulation (TGC) was prominent during successful memory retrieval but was weak when memory failed or was unavailable during spatial exploration in sample trials. Muscimol infusion into medial septum reduced the probability of TGC and successful memory retrieval. In contrast, patterned electrical stimulation of the fimbria-fornix increased TGC in amnestic animals and partially rescued memory performance in the water maze. The results suggest that TGC accompanies memory retrieval in the hippocampus and that patterned brain stimulation may inform therapeutic strategies for cognitive disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.0911184107

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Theta/gamma coupling is functionally relevant for long-term memory processes and contributes to recall of stored information in rats and humans.

    “The theta/gamma coupling has been shown to be functionally relevant for long-term memory processes (Tort et al., 2009) contributing to the recall of stored information both in rats (Shirvalkar et al., 2010) and in humans (Friese et al., 2013).”

    From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Shirvalkar et al., 2010

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Shirvalkar, P. R., Rapp, P. R., & Shapiro, M. L.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • National Institute on Aging (US)
Venue
Proceedings of the National Academy of Sciences
Published
2010-03-29
Volume
107
Issue
15
Pages
7054-7059
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2074984699
Cited by
235
References
39
Citations by year
2026: 4 · 2025: 13 · 2024: 7 · 2023: 9 · 2022: 17 · 2021: 19 · 2020: 20 · 2019: 20 · 2018: 23 · 2017: 16 · 2016: 21 · 2015: 17 · 2014: 19 · 2013: 10 · 2012: 7
FWCI
5.81
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (F30AG034003)
  • National Institute of Mental Health (MH073689, R01MH065658, MH65658, R01MH073689)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
episodic memory, spatial memory, memory retrieval, local field potentials, medial septum, muscimol, amnesia, water maze, rats, neural oscillations
MeSH terms
Animals, Behavior, Animal, Brain, Cognition Disorders, Electrodes, Electrophysiology, Hippocampus, Male, Memory, Muscimol, Maze Learning, Rats, Long-Evans, Septum of Brain, Fornix, Brain, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review