Bidirectional changes to hippocampal theta-gamma comodulation predict memory for recent spatial episodes
Open accessAbstract
Episodic memory requires the hippocampus, which is thought to bind cortical inputs into conjunctive codes. Local field potentials (LFPs) reflect dendritic and synaptic oscillations whose temporal structure may coordinate cellular mechanisms of plasticity and memory. We now report that single-trial spatial memory performance in rats was predicted by the power comodulation of theta (4-10 Hz) and low gamma (30-50 Hz) rhythms in the hippocampus. Theta-gamma comodulation (TGC) was prominent during successful memory retrieval but was weak when memory failed or was unavailable during spatial exploration in sample trials. Muscimol infusion into medial septum reduced the probability of TGC and successful memory retrieval. In contrast, patterned electrical stimulation of the fimbria-fornix increased TGC in amnestic animals and partially rescued memory performance in the water maze. The results suggest that TGC accompanies memory retrieval in the hippocampus and that patterned brain stimulation may inform therapeutic strategies for cognitive disorders.
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Theta/gamma coupling is functionally relevant for long-term memory processes and contributes to recall of stored information in rats and humans.
“The theta/gamma coupling has been shown to be functionally relevant for long-term memory processes (Tort et al., 2009) contributing to the recall of stored information both in rats (Shirvalkar et al., 2010) and in humans (Friese et al., 2013).”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Shirvalkar et al., 2010
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- Authors
- Shirvalkar, P. R., Rapp, P. R., & Shapiro, M. L.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- National Institute on Aging (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-03-29
- Volume
- 107
- Issue
- 15
- Pages
- 7054-7059
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2872428
- OpenAlex
- W2074984699
- Cited by
- 235
- References
- 39
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 7 · 2023: 9 · 2022: 17 · 2021: 19 · 2020: 20 · 2019: 20 · 2018: 23 · 2017: 16 · 2016: 21 · 2015: 17 · 2014: 19 · 2013: 10 · 2012: 7
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (F30AG034003)
- National Institute of Mental Health (MH073689, R01MH065658, MH65658, R01MH073689)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- episodic memory, spatial memory, memory retrieval, local field potentials, medial septum, muscimol, amnesia, water maze, rats, neural oscillations
- MeSH terms
- Animals, Behavior, Animal, Brain, Cognition Disorders, Electrodes, Electrophysiology, Hippocampus, Male, Memory, Muscimol, Maze Learning, Rats, Long-Evans, Septum of Brain, Fornix, Brain, Rats
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