Storage of 7 +/- 2 short-term memories in oscillatory subcycles
Abstract
Psychophysical measurements indicate that human subjects can store approximately seven short-term memories. Physiological studies suggest that short-term memories are stored by patterns of neuronal activity. Here it is shown that activity patterns associated with multiple memories can be stored in a single neural network that exhibits nested oscillations similar to those recorded from the brain. Each memory is stored in a different high-frequency ("40 hertz") subcycle of a low-frequency oscillation. Memory patterns repeat on each low-frequency (5 to 12 hertz) oscillation, a repetition that relies on activity-dependent changes in membrane excitability rather than reverberatory circuits. This work suggests that brain oscillations are a timing mechanism for controlling the serial processing of short-term memories.
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Behavioral tasks can modulate phase amplitude coupling, which has been implicated in sensory integration, memory processes, and attentional selection.
“Behavioral tasks can modulate phase amplitude coupling which has been implicated in sensory integration, memory processes, and attentional selection previously (54–56).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [54]
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Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome
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- Authors
- Lisman, J. E., & Idiart, M. A. P.
- Affiliations
- Brandeis University (US)
- Venue
- Science
- Published
- 1995-03-10
- Volume
- 267
- Issue
- 5203
- Pages
- 1512-1515
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058491602
- Cited by
- 1,471
- References
- 30
- Citations by year
- 2026: 33 · 2025: 52 · 2024: 55 · 2023: 49 · 2022: 64 · 2021: 57 · 2020: 43 · 2019: 69 · 2018: 63 · 2017: 64 · 2016: 56 · 2015: 56 · 2014: 55 · 2013: 59 · 2012: 58
- FWCI
- 16.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS027337, NS-27337)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- short-term memory, memory storage, neural oscillations, low-frequency oscillations, artificial neural networks, serial processing, timing mechanism
- MeSH terms
- Computer Simulation, Feedback, Hippocampus, Humans, Interneurons, Membrane Potentials, Memory, Short-Term, Models, Neurological, Nerve Net, Neurons, Pyramidal Cells
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