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“Control” laboratory rodents are metabolically morbid: Why it matters
Open accessAbstract
Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects.
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“The efficacy of drugs is affected by physical fitness/activity status (104, 328) in addition to genetic disposition.”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [328]
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Zilberter, T. (2011) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2011.00008 · Cited by 15
Hegab, A. E., Ozaki, M., Meligy, F. Y., Nishino, M., Kagawa, S., Ishii, M., & Betsuyaku, T. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2792 · Cited by 17
Metadata
- Authors
- Martin, B., Ji, S., Maudsley, S., & Mattson, M. P.
- Affiliations
- National Institute on Aging (US)
- National Institutes of Health (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-03
- Volume
- 107
- Issue
- 14
- Pages
- 6127-6133
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2852022
- OpenAlex
- W2081308389
- Cited by
- 354
- References
- 109
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 22 · 2023: 14 · 2022: 20 · 2021: 17 · 2020: 19 · 2019: 35 · 2018: 19 · 2017: 18 · 2016: 20 · 2015: 18 · 2014: 35 · 2013: 19 · 2012: 36
- FWCI
- 23.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- laboratory rodents, sedentary behavior, obesity, impaired glucose tolerance, metabolic disorders, oxidative stress, inflammation, physical activity, energy intake, animal models of human disease, premature mortality
- MeSH terms
- Animals, Body Weight, Obesity, Morbid, Physical Conditioning, Animal, Models, Animal, Caloric Restriction, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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