Cited by 231Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolRegulation of Appetite and Obesity

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Pleasurable behaviors reduce stress via brain reward pathways

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Ulrich-Lai, Yvonne M., Christiansen, Anne M., Ostrander, Michelle M., Jones, Amanda A., Jones, Kenneth R., Choi, Dennis C., Krause, Eric G., Evanson, Nathan K., Furay, Amy R., Davis, Jon F., Solomon, Matia B., de Kloet, Annette D., Tamashiro, Kellie L., Sakai, Randall R., Seeley, Randy J., Woods, Stephen C., Herman, James P.·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1007740107PMC PMC2996660

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Abstract

Individuals often eat calorically dense, highly palatable "comfort" foods during stress for stress relief. This article demonstrates that palatable food intake (limited intake of sucrose drink) reduces neuroendocrine, cardiovascular, and behavioral responses to stress in rats. Artificially sweetened (saccharin) drink reproduces the stress dampening, whereas oral intragastric gavage of sucrose is without effect. Together, these results suggest that the palatable/rewarding properties of sucrose are necessary and sufficient for stress dampening. In support of this finding, another type of natural reward (sexual activity) similarly reduces stress responses. Ibotenate lesions of the basolateral amygdala (BLA) prevent stress dampening by sucrose, suggesting that neural activity in the BLA is necessary for the effect. Moreover, sucrose intake increases mRNA and protein expression in the BLA for numerous genes linked with functional and/or structural plasticity. Lastly, stress dampening by sucrose is persistent, which is consistent with long-term changes in neural activity after synaptic remodeling. Thus, natural rewards, such as palatable foods, provide a general means of stress reduction, likely via structural and/or functional plasticity in the BLA. These findings provide a clearer understanding of the motivation for consuming palatable foods during times of stress and influence therapeutic strategies for the prevention and/or treatment of obesity and other stress-related disorders.

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Authors: Ulrich-Lai, Y. M., Christiansen, A. M., Ostrander, M. M., Jones, A. A., Jones, K. R., Choi, D. C., Krause, E. G., Evanson, N. K., Furay, A. R., Davis, J. F., Solomon, M. B., de Kloet, A. D., Tamashiro, K. L., Sakai, R. R., Seeley, R. J., Woods, S. C., & Herman, J. P.
Affiliations: Departments of aPsychiatry and Behavioral Neuroscience and
Emory University (US)
University of Washington (US)
Johns Hopkins University (US)
University of Cincinnati (US)
ORCID: Krause, Eric G.
Evanson, Nathan K.
Davis, Jon F.
Solomon, Matia B.
Tamashiro, Kellie L.
Seeley, Randy J.
Woods, Stephen C.
Herman, James P.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-11-08
Volume: 107
Issue: 47
Pages: 20529-20534
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1007740107
PMC: PMC2996660
OpenAlex: W2006105580
Cited by: 231
References: 60
Citations by year: 2026: 9 · 2025: 11 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 16 · 2020: 12 · 2019: 15 · 2018: 15 · 2017: 14 · 2016: 15 · 2015: 17 · 2014: 10 · 2013: 15 · 2012: 20
FWCI: 6.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Cincinnati Children's Hospital Medical Center
National Institutes of Health (MH049698, DK056863)
National Institute of Mental Health (R01MH049698, MH 069725, MH049698, R01MH069725)
National Institute of Diabetes and Digestive and Kidney Diseases (DK014877, DK054890, DK-056863, DK-066596, DK078906, R01DK054890, F32DK067820, R01DK017844, K01DK078906, P01DK056863, DK067820, R01DK066596)
National Institute of Neurological Disorders and Stroke (F31NS047791)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: stress reduction, palatable food, sucrose, comfort food, brain reward system, basolateral amygdala, saccharin, natural reward, sexual activity, neuroendocrine stress response, synaptic plasticity, obesity, stress-related disorders
MeSH terms: Amygdala, Analysis of Variance, Animals, Behavior, Animal, Cardiovascular Physiological Phenomena, Hormones, Male, Stress, Psychological, Sucrose, Telemetry, Microarray Analysis, Rats, Pleasure

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Pleasurable behaviors reduce stress via brain reward pathways

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