The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism
Open accessAbstract
It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effects on these two memory functions have generally been considered to be independently regulated processes. Here we report that a glucocorticoid receptor agonist administered into the medial prefrontal cortex (mPFC) of male Sprague-Dawley rats both enhances memory consolidation and impairs working memory. Both memory effects are mediated by activation of a membrane-bound steroid receptor and depend on noradrenergic activity within the mPFC to increase levels of cAMP-dependent protein kinase. These findings provide direct evidence that glucocorticoid effects on both memory consolidation and working memory share a common neural influence within the mPFC.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Glucocorticoids have been shown to accentuate the effects of catecholamines in both the PFC and the amygdala69, thus coordinating and exaggerating the switch from thoughtful to habitual responding during exposure to stress (Fig. 1).”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [69]
In the citing paper
“a highly responsive system facilitates social learning, enhances mental activities in localized domains, focuses attention, and primes memory storage, thus improving cognitive processes for dealing with environmental opportunities and threats (Barsegyan et al., 2010; Flinn, 2006; Roozendaal, 2000; van Marle et al., 2009)”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Barsegyan et al., 2010
Citations
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296
Self-citationStress, memory and the amygdala
Roozendaal, B., McEwen, B. S., & Chattarji, S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2651 · Cited by 1,760
Self-citationStress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182 · cited 1×
“This dose of corticosterone is known to induce plasma corticosterone levels that resemble moderate stress (50).”
BackgroundSelf-citationAnxiety and affective style: role of prefrontal cortex and amygdala
Davidson, R. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01328-2 · Cited by 1,170
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931
Karst, H., Berger, S., Turiault, M., Tronche, F., Schütz, G., & Joëls, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507572102 · Cited by 774
Enhanced memory for emotional material following stress-level cortisol treatment in humans
Buchanan, T. W., & Lovallo, W. R. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00058-5 · Cited by 762
Cited by
Sorted by citations
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079
Dynamic adaptation of large-scale brain networks in response to acute stressors
Hermans, E. J., Henckens, M. J. A. G., Joëls, M., & Fernández, G. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.006 · Cited by 988
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752
Stress effects on memory: An update and integration
Schwabe, L., Joëls, M., Roozendaal, B., Wolf, O. T., & Oitzl, M. S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.002 · Cited by 714
Self-citation
Metadata
- Authors
- Barsegyan, A., Mackenzie, S. M., Kurose, B. D., McGaugh, J. L., & Roozendaal, B.
- Affiliations
- University Medical Center Groningen (NL)
- University of California, Irvine (US)
- ORCID
- Roozendaal, Benno
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-09
- Volume
- 107
- Issue
- 38
- Pages
- 16655-16660
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2944727
- OpenAlex
- W2085425790
- Cited by
- 262
- References
- 52
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 9 · 2023: 17 · 2022: 13 · 2021: 14 · 2020: 11 · 2019: 24 · 2018: 17 · 2017: 13 · 2016: 27 · 2015: 15 · 2014: 22 · 2013: 26 · 2012: 14
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- glucocorticoids, memory consolidation, working memory, medial prefrontal cortex, glucocorticoid receptor, noradrenergic activity, protein kinase A, emotional memory, adrenal cortex hormones
- MeSH terms
- Amygdala, Androstanols, Animals, Corticosterone, Glucocorticoids, Male, Memory, Memory, Short-Term, Models, Neurological, Receptors, Adrenergic, beta, Receptors, Glucocorticoid, Signal Transduction, Rats, Sprague-Dawley, Prefrontal Cortex, Cyclic AMP-Dependent Protein Kinases, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
