Cited by 262Memory and Neural MechanismsStress Responses and CortisolMemory Processes and Influences

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Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

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Barsegyan, Areg, Mackenzie, Scott M., Kurose, Brian D., McGaugh, James L., Roozendaal, Benno·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1011975107PMC PMC2944727

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Abstract

It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effects on these two memory functions have generally been considered to be independently regulated processes. Here we report that a glucocorticoid receptor agonist administered into the medial prefrontal cortex (mPFC) of male Sprague-Dawley rats both enhances memory consolidation and impairs working memory. Both memory effects are mediated by activation of a membrane-bound steroid receptor and depend on noradrenergic activity within the mPFC to increase levels of cAMP-dependent protein kinase. These findings provide direct evidence that glucocorticoid effects on both memory consolidation and working memory share a common neural influence within the mPFC.

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Authors: Barsegyan, A., Mackenzie, S. M., Kurose, B. D., McGaugh, J. L., & Roozendaal, B.
Affiliations: University Medical Center Groningen (NL)
University of California, Irvine (US)
ORCID: Roozendaal, Benno
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-09
Volume: 107
Issue: 38
Pages: 16655-16660
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1011975107
PMC: PMC2944727
OpenAlex: W2085425790
Cited by: 262
References: 52
Citations by year: 2026: 5 · 2025: 6 · 2024: 9 · 2023: 17 · 2022: 13 · 2021: 14 · 2020: 11 · 2019: 24 · 2018: 17 · 2017: 13 · 2016: 27 · 2015: 15 · 2014: 22 · 2013: 26 · 2012: 14
FWCI: 13.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: glucocorticoids, memory consolidation, working memory, medial prefrontal cortex, glucocorticoid receptor, noradrenergic activity, protein kinase A, emotional memory, adrenal cortex hormones
MeSH terms: Amygdala, Androstanols, Animals, Corticosterone, Glucocorticoids, Male, Memory, Memory, Short-Term, Models, Neurological, Receptors, Adrenergic, beta, Receptors, Glucocorticoid, Signal Transduction, Rats, Sprague-Dawley, Prefrontal Cortex, Cyclic AMP-Dependent Protein Kinases, Rats

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Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism

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