The Basolateral Amygdala Interacts with the Medial Prefrontal Cortex in Regulating Glucocorticoid Effects on Working Memory Impairment
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Previous findings indicate that the basolateral complex of the amygdala (BLA) interacts with other brain regions in regulating stress hormone effects on memory functions. Lesions of the BLA or infusions of a β-adrenoceptor antagonist into the BLA block glucocorticoid effects on both memory consolidation and retrieval when administered either systemically or directly into the hippocampus. The present experiments examined BLA and β-adrenoceptor involvement in regulating glucocorticoid effects on spatial working memory, a task that depends on the medial prefrontal cortex (mPFC). Male Sprague Dawley rats with bilateral sham- or NMDA-induced lesions of the BLA received either corticosterone (1.0 or 3.0 mg/kg, i.p.) systemically or the specific glucocorticoid receptor agonist 11β,17β-dihydroxy-6,21-dimethyl-17α-pregna-4,6-trien-20yn-3-one (RU 28362; 3.0 or 10.0 ng in 0.5 μl) into the mPFC shortly before testing on a delayed alternation task in a T-maze. Both glucocorticoid treatments induced comparable impairments in working memory performance in sham-lesioned controls. Although lesions of the BLA alone did not affect working memory, BLA lesions blocked the impairment induced by either corticosterone or RU 28362. Likewise, systemic injections of the centrally acting β-adrenoceptor antagonist propranolol (2.0 mg/kg, i.p.) given before testing prevented corticosterone-induced working memory impairment. These findings indicate that BLA activity is essential for enabling glucocorticoid effects in the mPFC on working memory and suggest that stress hormone-induced modulation of working memory involves noradrenergic activation.
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High levels of glucocorticoids by themselves can impair working memory in animals and humans.
“studies in both animals76 and humans77 have shown that high levels of glucocorticoids by themselves can impair working memory.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [76]
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Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05473.1999 · Cited by 2,001 · see citing works
Stress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182 · see citing works
Self-citationMoghaddam, B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13387.x · Cited by 567 · see citing works
Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter
Gründemann, D., Schechinger, B., Rappold, G., & Schömig, E. (1998) · Nature Neuroscience · doi:10.1038/1557 · Cited by 374 · cited 2× · see citing works
“…levels in the mPFC (Thomas et al., 1994) by stimulating GRs in noradrenergic cell populations in the brainstem (Härfstrand et al., 1987; McEwen, 1987; Roozendaal et al., 1999b) or by locally blocking extraneuronal norepinephrine reuptake mechanisms in the mPFC (Grundemann et al., 1998).”
BackgroundMaroun, M., & Richter-Levin, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04406.2003 · Cited by 293 · see citing works
Roozendaal, B., Williams, C. L., & McGaugh, J. L. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00537.x · Cited by 140 · see citing works
Self-citationPérez-Jaranay, J. M., & Vives, F. (1991) · Brain Research · doi:10.1016/0006-8993(91)91357-7 · Cited by 122 · see citing works
Taylor, J. R., Birnbaum, S., Ubriani, R., & Arnsten, A. F. T. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-j0001.1999 · Cited by 120 · cited 3× · see citing works
“Evidence from lesion, pharmacological, and clinical studies indicates that working memory relies on the integrity of the prefrontal cortex (Brito et al., 1982; Fuster, 1991; Taylor et al., 1999; Levy and Farrow, 2001).”
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Research works printed but not linked: 2
- Mazure CM (1995) Does stress cause psychiatric illness? In: Progress in psy- chiatry (Spiegel D, ed), p 270. Washington, DC: American Psychiatric Press.
- Roozendaal B, de Quervain DJ-F, Schelling G, McGaugh JL (2004) A sys- temically administered -adrenoceptor antagonist blocks corticosterone- induced impairment of contextual memory retrieval in rats. Neurobiol Learn Mem, in press.
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Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · see citing works
Stress, memory and the amygdala
Roozendaal, B., McEwen, B. S., & Chattarji, S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2651 · Cited by 1,760 · see citing works
Self-citationLupien, S. J., Maheu, F., Tu, M., Fiocco, A., & Schramek, T. E. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2007.02.007 · Cited by 1,474 · see citing works
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428 · see citing works
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · see citing works
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079 · see citing works
Liston, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968 · see citing works
Stress effects on memory: An update and integration
Schwabe, L., Joëls, M., Roozendaal, B., Wolf, O. T., & Oitzl, M. S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.002 · Cited by 714 · see citing works
Self-citationStress prompts habit behavior in humans
Schwabe, L., & Wolf, O. T. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0979-09.2009 · Cited by 606 · see citing works
Levin, R., & Nielsen, T. A. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.3.482 · Cited by 554 · see citing works
Psychosocial stress induces working memory impairments in an n-back paradigm.
Schoofs, D., Preuß, D., & Wolf, O. T. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.004 · Cited by 483 · see citing works
Stress-induced prefrontal reorganization and executive dysfunction in rodents
Holmes, A., & Wellman, C. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.11.005 · Cited by 469 · see citing works
Roozendaal, B., & McGaugh, J. L. (2011) · Behavioral Neuroscience · doi:10.1037/a0026187 · Cited by 445 · see citing works
Self-citationA meta-analytic review of the effects of acute cortisol administration on human memory
Het, S., Ramlow, G., & Wolf, O. T. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.005 · Cited by 414 · see citing works
Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy
Mitra, R., & Sapolsky, R. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705615105 · Cited by 409 · see citing works
Roozendaal, B., Okuda, S., de Quervain, D. J.-F., & McGaugh, J. L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.049 · Cited by 382 · see citing works
Self-citationMyers, B., McKlveen, J. M., & Herman, J. P. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.12.003 · Cited by 318 · see citing works
Beta-adrenergic Modulation of Cognitive Flexibility during Stress
Alexander, J. K., Hillier, A., Smith, R. M., Tivarus, M. E., & Beversdorf, D. Q. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.3.468 · Cited by 306 · see citing works
Cognitive emotion regulation fails the stress test
Raio, C. M., Orederu, T. A., Palazzolo, L., Shurick, A. A., & Phelps, E. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305706110 · Cited by 302 · see citing works
Barsegyan, A., Mackenzie, S. M., Kurose, B. D., McGaugh, J. L., & Roozendaal, B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011975107 · Cited by 262 · see citing works
Self-citationNeighborhood matters: divergent patterns of stress-induced plasticity across the brain
Chattarji, S., Tomar, A., Suvrathan, A., Ghosh, S., & Rahman, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4115 · Cited by 248 · see citing works
Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex
Shansky, R. M., & Lipps, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00123 · Cited by 205 · see citing works
“Systemic injection of corticosterone in rats significantly reduces Delayed Alternation accuracy, and infusion of the GR agonist RU 28362 into the PFC similarly impairs working memory (Roozendaal et al., 2004).”
BackgroundButts, K. A., Weinberg, J., Young, A. H., & Phillips, A. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111746108 · Cited by 182 · see citing works
Blair, C., Family Life Project Investigators, Granger, D. A., Kivlighan, K. T., Mills-Koonce, R., Willoughby, M., Greenberg, M. T., Hibel, L. C., & Fortunato, C. K. (2008) · Developmental Psychology · doi:10.1037/0012-1649.44.4.1095 · Cited by 177 · see citing works
Schwabe, L., Tegenthoff, M., Höffken, O., & Wolf, O. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1304-12.2012 · Cited by 162 · see citing works
Time-dependent corticosteroid modulation of prefrontal working memory processing
Henckens, M. J. A. G., van Wingen, G. A., Joëls, M., & Fernández, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019128108 · Cited by 155 · see citing works
Schwabe, L., Tegenthoff, M., Hoffken, O., & Wolf, O. T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0734-10.2010 · Cited by 150 · see citing works
Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences
Roozendaal, B., Barsegyan, A., & Lee, S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67006-x · Cited by 154 · see citing works
Self-citationThe beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys
Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.022 · Cited by 147 · see citing works
Long-Term Effects of Brief Acute Stress on Cellular Signaling and Hippocampal LTP
Ahmed, T., Frey, J. U., & Korz, V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4901-05.2006 · Cited by 111 · see citing works
The effects of sex and hormonal status on restraint-stress-induced working memory impairment
Shansky, R. M., Rubinow, K., Brennan, A., & Arnsten, A. F. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-8 · Cited by 107 · see citing works
Atsak, P., Roozendaal, B., & Campolongo, P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.047 · Cited by 98 · see citing works
Self-citationGarcía-Bueno, B., Madrigal, J. L. M., Pérez-Nievas, B. G., & Leza, J. C. (2008) · Endocrinology · doi:10.1210/en.2007-0482 · Cited by 97 · see citing works
Tripathi, S. J., Chakraborty, S., Srikumar, B. N., Raju, T. R., & Shankaranarayana Rao, B. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.07.016 · Cited by 43 · see citing works
- Authors
- Roozendaal, B., McReynolds, J. R., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-02-11
- Volume
- 24
- Issue
- 6
- Pages
- 1385-1392
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730337
- OpenAlex
- W2098925242
- Cited by
- 327
- References
- 8
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 11 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 51 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 22 · 2015: 15 · 2014: 13 · 2013: 11 · 2012: 14
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- basolateral amygdala, medial prefrontal cortex, glucocorticoids, corticosterone, working memory, stress hormones, beta-adrenoceptor antagonism, propranolol, noradrenergic activation, RU 28362, NMDA lesions, delayed alternation task
- MeSH terms
- Adrenergic beta-Agonists, Adrenergic beta-Antagonists, Amygdala, Analysis of Variance, Androstanols, Animals, Corticosterone, Glucocorticoids, Male, Memory Disorders, Memory, Short-Term, Neural Pathways, Propranolol, Rats, Sprague-Dawley, Prefrontal Cortex, Maze Learning, Rats
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