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Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism
Open accessAbstract
It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effects on these two memory functions have generally been considered to be independently regulated processes. Here we report that a glucocorticoid receptor agonist administered into the medial prefrontal cortex (mPFC) of male Sprague-Dawley rats both enhances memory consolidation and impairs working memory. Both memory effects are mediated by activation of a membrane-bound steroid receptor and depend on noradrenergic activity within the mPFC to increase levels of cAMP-dependent protein kinase. These findings provide direct evidence that glucocorticoid effects on both memory consolidation and working memory share a common neural influence within the mPFC.
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“Glucocorticoids have been shown to accentuate the effects of catecholamines in both the PFC and the amygdala69, thus coordinating and exaggerating the switch from thoughtful to habitual responding during exposure to stress (Fig. 1).”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [69]
In the citing paper
“a highly responsive system facilitates social learning, enhances mental activities in localized domains, focuses attention, and primes memory storage, thus improving cognitive processes for dealing with environmental opportunities and threats (Barsegyan et al., 2010; Flinn, 2006; Roozendaal, 2000; van Marle et al., 2009)”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Barsegyan et al., 2010
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Metadata
- Authors
- Barsegyan, A., Mackenzie, S. M., Kurose, B. D., McGaugh, J. L., & Roozendaal, B.
- Affiliations
- University Medical Center Groningen (NL)
- University of California, Irvine (US)
- ORCID
- Roozendaal, Benno
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-09
- Volume
- 107
- Issue
- 38
- Pages
- 16655-16660
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2944727
- OpenAlex
- W2085425790
- Cited by
- 262
- References
- 52
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 9 · 2023: 17 · 2022: 13 · 2021: 14 · 2020: 11 · 2019: 24 · 2018: 17 · 2017: 13 · 2016: 27 · 2015: 15 · 2014: 22 · 2013: 26 · 2012: 14
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- glucocorticoids, memory consolidation, working memory, medial prefrontal cortex, glucocorticoid receptor, noradrenergic activity, protein kinase A, emotional memory, adrenal cortex hormones
- MeSH terms
- Amygdala, Androstanols, Animals, Corticosterone, Glucocorticoids, Male, Memory, Memory, Short-Term, Models, Neurological, Receptors, Adrenergic, beta, Receptors, Glucocorticoid, Signal Transduction, Rats, Sprague-Dawley, Prefrontal Cortex, Cyclic AMP-Dependent Protein Kinases, Rats
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