The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Defining the origins of Ras/p53-mediated squamous cell carcinoma
Open accessAbstract
The precise identity of cancer cells of origin and the molecular events of tumor initiation in epidermal squamous cell carcinoma (SCC) are unknown. Here we show that malignancy potential is related to the developmental capacity of the initiating cancer cell in a genetically defined, intact, and inducible in vivo model. Specifically, these data demonstrate that SCCs can originate from inside the hair follicle stem cell (SC) niche or from immediate progenitors, whereas more developmentally restricted progeny, the transit amplifying (TA) cells, are unable to generate even benign tumors in the same genetic context. Using a temporal model of tumorigenesis in situ, we highlight the phenotypes of cancer progression from the hair follicle SC niche, including hyperplasia, epithelial to mesenchymal transition, and SCC formation. Furthermore, we provide insights into the inability of hair follicle TA cells to respond to tumorigenic stimuli.
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Cites
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299 · cited 1×
“EMTs also exhibit decreased expression of epithelial-specific markers, such as keratin 5 (Krt5) and E-cadherin (E-cad) (37, 41, 42).”
BackgroundSunburn and p53 in the onset of skin cancer
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Self-citationLgr5 marks cycling, yet long-lived, hair follicle stem cells
Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
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Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
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Cited by
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
Su, F., Viros, A., Milagre, C., Trunzer, K., Bollag, G., Spleiss, O., Reis-Filho, J. S., Kong, X., Koya, R. C., Flaherty, K. T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105358 · Cited by 1,038
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
Nassar, D., & Blanpain, C. (2016) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044438 · Cited by 869
A model for RAS mutation patterns in cancers: finding the sweet spot
Li, S., Balmain, A., & Counter, C. M. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0076-6 · Cited by 384
Chromatin dynamics during cellular reprogramming
Apostolou, E., & Hochedlinger, K. (2013) · Nature · doi:10.1038/nature12749 · Cited by 398
Clinical and Therapeutic Implications of Cancer Stem Cells
Clarke, M. F. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1804280 · Cited by 355
Metadata
- Authors
- White, A. C., Tran, K., Khuu, J., Dang, C., Cui, Y., Binder, S. W., & Lowry, W. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-04-18
- Volume
- 108
- Issue
- 18
- Pages
- 7425-7430
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2047926803
- Cited by
- 184
- References
- 10
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- green
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- White, A. C., Tran, K., Khuu, J., Dang, C., Cui, Y., Binder, S. W., & Lowry, W. E. (2011). Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1012670108
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