The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes
Open accessAbstract
To clarify the biological rationale for social regulation of gene expression, this study sought to identify the specific immune cell types that are transcriptionally sensitive to subjective social isolation (loneliness). Using reference distributions for the expression of each human gene in each major leukocyte subtype, we mapped the cellular origin of transcripts found to be differentially expressed in the circulating immune cells from chronically lonely individuals. Loneliness-associated genes derived primarily from plasmacytoid dendritic cells, monocytes, and, to a lesser extent, B lymphocytes. Those dynamics reflected per-cell changes in the expression of inducible genes and related more strongly to the subjective experience of loneliness than to objective social network size. Evolutionarily ancient myeloid antigen-presenting cells appear to have evolved a transcriptional sensitivity to socioenvironmental conditions that may allow them to shift basal gene expression profiles to counter the changing microbial threats associated with hostile vs. affine social conditions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Social isolation has also been related to the up-regulated expression of proinflammatory immune response genes and a reciprocal down-regulation of genes involved in antibody production”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as S. W. Cole, Hawkley, Arevalo, & Cacioppo, 2011
In the citing paper
“Genes up-regulated in socially isolated individuals included a set of transcripts that play a central role in inflammation (e.g., IL1B, IL8, PTGS2), whereas down-regulated transcripts were involved in Type I interferon innate antiviral responses (e.g., ISG, IFI, MX, and OAS family genes) and in antibody production (e.g., IGL, IGH, IGJ, and IGK) [5], [14], [15].”
From Human Social Genomics (2014) · cites this paper as [15]
In the citing paper
“Genome-wide transcriptional profiling of leukocytes from people experiencing chronic social isolation identified >200 genes that showed >50% difference in average expression levels relative to those observed in socially integrated people [14], [15].”
From Human Social Genomics (2014) · cites this paper as [15]
In the citing paper
“Bioinformatic decomposition of transcriptome shifts in the heterogenous leukocyte population initially identified the primary cellular mediators of CTRA transcriptome shifts as myeloid lineage immune cells such as monocytes and dendritic cells [15].”
From Human Social Genomics (2014) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
The genetical evolution of social behaviour. I
Hamilton, W. D. (1964) · Journal of Theoretical Biology · doi:10.1016/0022-5193(64)90038-4 · Cited by 15,725
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
BERKMAN, L. F., & SYME, S. L. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112674 · Cited by 5,341
The Revised UCLA Loneliness Scale: concurrent and discriminant validity evidence
Russell, D., Peplau, L. A., & Cutrona, C. E. (1980) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.39.3.472 · Cited by 5,173
The genetical evolution of social behaviour. II
Hamilton, W. D. O. (1964) · Journal of Theoretical Biology · doi:10.1016/0022-5193(64)90039-6 · Cited by 4,158
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Research works printed but not linked: 3
- CA Janeway, P Travers, M Walport, MJ Shlomchik Immunobiology (Garland Science, 5th Ed, New York, 2001).
- DM Knipe, et al. Fields Virology (Lippincott Williams & Wilkins, Philadelphia, 2007).
- S Wrzesinski J Uhlenhake J Fisher M Ernstoff Gene Expression Omnibus GSE11943: Human dendritic cell subtype gene arrays. Available at http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE11943. Accessed December 1 2010. (2008).
Cited by
Sorted by citations
Items 101–200 of 306
Castagné, R., Kelly‐Irving, M., Campanella, G., Guida, F., Krogh, V., Palli, D., Panico, S., Sacerdote, C., Tumino, R., Kleinjans, J. C. S., et al. (2016) · Scientific Reports · doi:10.1038/srep38705 · Cited by 50
Knight, J. M., Rizzo, J. D., Hari, P., Pasquini, M. C., Giles, K. E., D’Souza, A., Logan, B. R., Hamadani, M., Chhabra, S., Dhakal, B., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000765 · Cited by 53
Self-citationMoieni, M., Irwin, M. R., Seeman, T. E., Robles, T. F., Lieberman, M. D., Breen, E. C., Okimoto, S., Lengacher, C., Arevalo, J. M. G., Olmstead, R., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.11.014 · Cited by 51
Self-citationDepressive symptoms and immune transcriptional profiles in late adolescents
Chiang, J. J., Cole, S. W., Bower, J. E., Irwin, M. R., Taylor, S. E., Arevalo, J. M. G., & Fuligni, A. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.004 · Cited by 53
Self-citationRamondetta, L. M., Hu, W. M., Thaker, P. H., Urbauer, D. L., Chisholm, G. B., Westin, S. N., Sun, Y., Ramirez, P. T., Fleming, N. D., Sahai, S. K., et al. (2019) · Gynecologic Oncology · doi:10.1016/j.ygyno.2019.07.004 · Cited by 49
Self-citationiPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls
Prilutsky, D., Palmer, N., Smedemark-Margulies, N., Schlaeger, T. M., Margulies, D. M., & Kohane, I. S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.11.004 · Cited by 51
The Eudaimonics of Positive Emotions
Fredrickson, B. L. (2016) · International handbooks of quality-of-life · doi:10.1007/978-3-319-42445-3_12 · Cited by 54
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 53
Divergent gene expression responses to Complicated Grief and Non-complicated Grief
O'Connor, M., Schultze-Florey, C. R., Irwin, M. R., Arevalo, J. M. G., & Cole, S. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.017 · Cited by 47
Self-citationPersonality and gene expression: Do individual differences exist in the leukocyte transcriptome?
Vedhara, K., Gill, S., Eldesouky, L., Campbell, B. K., Arevalo, J. M. G., Ma, J., & Cole, S. W. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.028 · Cited by 49
Self-citationYi, B., Рыкова, М. П., Feuerecker, M., Jäger, B., Ladinig, C., Basner, M., Hoerl, M., Matzel, S., Kaufmann, I., Strewe, C., et al. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.018 · Cited by 51
The Potential Impact of Social Genomics on Wound Healing
Fayne, R. A., Borda, L. J., Egger, A. N., & Tomic‐Canic, M. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.1095 · Cited by 48
Nervous system regulation of the cancer genome
Cole, S. W. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.11.008 · Cited by 41
Self-citationPopulation Disparities in Mental Health: Insights From Cultural Neuroscience
Chiao, J. Y., & Blizinsky, K. D. (2013) · American Journal of Public Health · doi:10.2105/ajph.2013.301440 · Cited by 44
Falling in love is associated with immune system gene regulation
Murray, D. R., Haselton, M. G., Fales, M. R., & Cole, S. W. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.043 · Cited by 39
Self-citationReed, R. G., & Raison, C. L. (2016) · Springer eBooks · doi:10.1007/978-3-7091-1890-0_5 · Cited by 43
Loneliness and biological responses to acute stress in people with Type 2 diabetes
Hackett, R. A., Poole, L., Hunt, E., Panagi, L., & Steptoe, A. (2019) · Psychophysiology · doi:10.1111/psyp.13341 · Cited by 41
Social isolation and loneliness: Undervalued risk factors for disease states and mortality
Kanbay, M., Tanrıöver, C., Çöpür, S., Peltek, İ. B., Mutlu, A., Mallamaci, F., & Zoccali, C. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14032 · Cited by 49
MacCormack, J. K., Gaudier‐Diaz, M. M., Armstrong‐Carter, E., Arevalo, J. M. G., Meltzer-Brody, S. E., Sloan, E. K., Cole, S. W., & Muscatell, K. A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00897-0 · Cited by 39
Self-citationCarlson, L. E., Zelinski, E. L., Speca, M., Balneaves, L. G., Jones, J. M., Mina, D. S., Wayne, P. M., Campbell, T. S., Giese‐Davis, J., Faris, P., et al. (2017) · Contemporary Clinical Trials · doi:10.1016/j.cct.2017.05.015 · Cited by 39
Self-citationFlentje, A., Kober, K. M., Carrico, A. W., Neilands, T. B., Flowers, E., Heck, N. C., & Aouizerat, B. E. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.016 · Cited by 38
Canli, T., Yu, L., Yu, X., Zhao, H., Fleischman, D. A., Wilson, R. S., Jager, P. L. D., & Bennett, D. A. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0086-2 · Cited by 36
Loneliness and Social Isolation: Risk Factors Long Overdue for Surveillance
Alspach, J. G. (2013) · Critical Care Nurse · doi:10.4037/ccn2013377 · Cited by 45
Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer
Kober, K. M., Dunn, L. B., Mastick, J., Cooper, B. A., Langford, D. J., Melisko, M., Venook, A. P., Chen, L.-M., Wright, F., Hammer, M. J., et al. (2016) · Biological Research For Nursing · doi:10.1177/1099800416629209 · Cited by 35
Dolberg, P., Shiovitz‐Ezra, S., & Ayalon, L. (2016) · European Journal of Ageing · doi:10.1007/s10433-016-0391-2 · Cited by 33
Analysis of Tumor Biology to Advance Cancer Health Disparity Research
Smith, C. J., Minas, T. Z., & Ambs, S. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.06.019 · Cited by 35
Das, A. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2018.10.021 · Cited by 38
Pervasive Effects of Aging on Gene Expression in Wild Wolves
Charruau, P., Johnston, R. A., Stahler, D. R., Lea, A. J., Snyder‐Mackler, N., Smith, D. W., vonHoldt, B. M., Cole, S. W., Tung, J., & Wayne, R. K. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw072 · Cited by 32
Self-citationDieckmann, L., Cole, S. W., & Kumsta, R. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0730-0 · Cited by 35
Self-citationChildhood maltreatment and monocyte gene expression among women with breast cancer
Bower, J. E., Kuhlman, K. R., Ganz, P. A., Irwin, M. R., Crespi, C. M., & Cole, S. W. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.001 · Cited by 36
Self-citationOpening the Social: Sociological Imagination in Life Course Studies
Dannefer, D., Kelley‐Moore, J. A., & Huang, W. (2015) · Handbooks of sociology and social research · doi:10.1007/978-3-319-20880-0_4 · Cited by 33
Differential transcriptome expression in human nucleus accumbens as a function of loneliness
Canli, T., Wen, R., Wang, X., Mikhailik, A., Yu, L., Fleischman, D. A., Wilson, R. S., & Bennett, D. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.186 · Cited by 33
Leech, T., Evison, S. E. F., Armitage, S. A. O., Sait, S. M., & Bretman, A. J. (2019) · Journal of Evolutionary Biology · doi:10.1111/jeb.13509 · Cited by 31
Well-Being, Aging, and Immunity
Friedman, E. M. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195394399.013.0003 · Cited by 33
Cacioppo, J. T., & Cacioppo, S. (2018) · Archives of Scientific Psychology · doi:10.1037/arc0000036 · Cited by 31
Self-citationAnzivino, R., Conti, G., Nardo, W. D., Fetoni, A. R., Picciotti, P. M., Marra, C., Guglielmi, V., Fortunato, S., Forli, F., Paludetti, G., et al. (2019) · American Journal of Audiology · doi:10.1044/2019_aja-heal18-18-0176 · Cited by 32
Bekhbat, M., Goldsmith, D. R., Woolwine, B. J., Haroon, E., Miller, A. H., & Felger, J. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01258-z · Cited by 34
Padin, A. C., Hébert, J. R., Woody, A., Wilson, S. J., Shivappa, N., Belury, M. A., Malarkey, W. B., Sheridan, J. F., & Kiecolt‐Glaser, J. K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.031 · Cited by 35
Cruces, J., Venero, C., Pereda-Pérez, I., & la Fuente, M. D. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.09.011 · Cited by 33
Pathogens, odors, and disgust in rodents
Kavaliers, M., Ossenkopp, K., & Choleris, E. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.037 · Cited by 28
Divergent transcriptional profiles in pediatric asthma patients of low and high socioeconomic status
Miller, G. E., Chen, E., Shalowitz, M. U., Story, R. E., Leigh, A. K. K., Ham, P. J., Arevalo, J. M. G., & Cole, S. W. (2018) · Pediatric Pulmonology · doi:10.1002/ppul.23983 · Cited by 29
Self-citationKnight, J. M., Rizzo, J. D., Wang, T., He, N., Logan, B. R., Spellman, S. R., Lee, S. J., Verneris, M. R., Arevalo, J. M. G., & Cole, S. W. (2019) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkz073 · Cited by 28
Self-citationInvestigating skewness to understand gene expression heterogeneity in large patient cohorts
Church, B. V., Williams, H. T., & Mar, J. C. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-3252-0 · Cited by 29
Immune suppression of IgG response against dairy proteins in major depression
Rudzki, L., Pawlak, D., Pawlak, K., Waszkiewicz, N., Małus, A., Konarzewska, B., Gałęcka, M., Bartnicka, A., Ostrowska, L., & Szulc, A. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1431-y · Cited by 27
Brown, K., Roux, A. V. D., Smith, J. A., Needham, B. L., Mukherjee, B., Ware, E. B., Liu, Y., Cole, S. W., Seeman, T. E., & Kardia, S. L. R. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104654 · Cited by 27
Self-citationCacioppo, J. T., & Cacioppo, S. (2013) · Perspectives on Psychological Science · doi:10.1177/1745691613507456 · Cited by 32
Self-citationHearing loss and dementia in older adults: A narrative review
Huang, A., & Lin, F. R. (2023) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000001042 · Cited by 27
Genomic mechanisms of fatigue in survivors of colorectal cancer
Black, D. S., Cole, S. W., Christodoulou, G., & Figueiredo, J. C. (2018) · Cancer · doi:10.1002/cncr.31356 · Cited by 28
Self-citationBhasin, M., Denninger, J. W., Huffman, J. C., Joseph, M. G., Niles, H. F., Chad‐Friedman, E., Goldman, R. E., Buczynski, B., Mahoney, B. A., Fricchione, G. L., et al. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2017.0053 · Cited by 26
Why may allopregnanolone help alleviate loneliness?
Cacioppo, S., & Cacioppo, J. T. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.09.004 · Cited by 31
Self-citationTelephone-administered versus live group cognitive behavioral stress management for adults with CFS
Hall, D. L., Lattie, E. G., Milrad, S. F., Czaja, S. J., FLETCHER, M. A., Klimas, N. G., Perdomo, D. M., & Antoni, M. H. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.12.004 · Cited by 24
Transcriptomic analyses of black women in neighborhoods with high levels of violence
Lee, M. J., Rittschof, C. C., Greenlee, A. J., Turi, K. N., Rodriguez‐Zas, S. L., Robinson, G. E., Cole, S. W., & Mendenhall, R. M. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105174 · Cited by 27
Self-citationSocial genomics of healthy and disordered internet gaming
Snodgrass, J. G., Dengah, H. J. F., Lacy, M. G., Else, R. J., Polzer, E. R., Arevalo, J. M. G., & Cole, S. W. (2018) · American Journal of Human Biology · doi:10.1002/ajhb.23146 · Cited by 24
Self-citationPsychological Science in the 21st Century
Cacioppo, J. T. (2013) · Teaching of Psychology · doi:10.1177/0098628313501041 · Cited by 23
Self-citationAdverse childhood experiences and transcriptional response in school-age children
Marie-Mitchell, A., & Cole, S. W. (2021) · Development and Psychopathology · doi:10.1017/s095457942000187x · Cited by 28
Self-citationMoisan, M., Foury, A., Dexpert, S., Cole, S. W., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., & Capuron, L. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01323-9 · Cited by 22
Self-citationWest, T. N., Zhou, J., Brantley, M. M., Kim, S. L., Brantley, J. G., Salzberg, S., Cole, S. W., & Fredrickson, B. L. (2022) · Mindfulness · doi:10.1007/s12671-022-01857-z · Cited by 26
Self-citationThe genomic impact of kindness to self vs. others: A randomized controlled trial
Regan, A., Fritz, M. M., Walsh, L. C., Lyubomirsky, S., & Cole, S. W. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.07.159 · Cited by 27
Self-citationThe Type I interferon antiviral gene program is impaired by lockdown and preserved by caregiving
Cole, S. W., Cacioppo, J. T., Cacioppo, S., Bone, K. J., Rosso, L. A. D., Spinner, A., Arevalo, J. M. G., Dizon, T., & Capitanio, J. P. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105803118 · Cited by 23
Self-citationEyre, H. A., Siddarth, P., Cyr, N. S., Yang, H., Cole, S. W., Forbes, M., & Lavretsky, H. (2017) · Pharmacopsychiatry · doi:10.1055/s-0043-107033 · Cited by 24
Self-citationRoss, K. M., Carroll, J., Schetter, C. D., Hobel, C. J., & Cole, S. W. (2019) · American Journal of Reproductive Immunology · doi:10.1111/aji.13190 · Cited by 21
Self-citationLittrell, J. L. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00297 · Cited by 22
Eyre, H. A., Eskin, A., Nelson, S. F., Cyr, N. S., Siddarth, P., Baune, B. T., & Lavretsky, H. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4356 · Cited by 20
Potashkin, J., Santiago, J., & Quinn, J. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065909 · Cited by 22
Robles, T. F., Repetti, R. L., Reynolds, B. M., Chung, P. J., Arevalo, J. M. G., & Cole, S. W. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000591 · Cited by 18
Self-citationHanalis‐Miller, T., Ricon‐Becker, I., Sakis, N., Trachtenberg, E., Ohayon, F., Wadhawker, S., Birnboim-Hazan, Y., Magen, A., Sharon, E., Tarrasch, R., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.009 · Cited by 19
Self-citationIdentification of gene expression predictors of occupational benzene exposure
Schiffman, C., McHale, C. M., Hubbard, A., Zhang, L., Thomas, R., Vermeulen, R. C. H., Li, G., Shen, M., Rappaport, S. M., Yin, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205427 · Cited by 19
Longitudinal evaluation of leukocyte transcripts in killer whales (Orcinus Orca)
Sitt, T., Bowen, L., Lee, C.-S., Blanchard, M. T., McBain, J. F., Dold, C., & Stott, J. L. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.04.011 · Cited by 18
Christian, L. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.010 · Cited by 18
Laudenslager, M. L., Simoneau, T. L., Philips, S., Benitez, P., Natvig, C. L., & Cole, S. W. (2016) · Journal of Behavioral Medicine · doi:10.1007/s10865-015-9709-3 · Cited by 18
Self-citationLoneliness in monkeys: neuroimmune mechanisms
Capitanio, J. P., Cacioppo, S., & Cole, S. W. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.013 · Cited by 19
Self-citationSloan, R. P., & Cole, S. W. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.217 · Cited by 19
Self-citationSawicki, C. M., Kim, J. K., Weber, M. D., Jarrett, B. L., Godbout, J. P., Sheridan, J. F., & Humeidan, M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.11.005 · Cited by 17
Expression of socially sensitive genes: The multi-ethnic study of atherosclerosis
Brown, K., Roux, A. V. D., Smith, J. A., Needham, B. L., Mukherjee, B., Ware, E. B., Liu, Y., Cole, S. W., Seeman, T. E., & Kardia, S. L. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214061 · Cited by 17
Self-citationPuyvelde, M. V., & Maîresse, O. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.08.006 · Cited by 17
Le, C. P., Karnezis, T., Achen, M. G., Stacker, S. A., & Sloan, E. K. (2013) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2013.10.008 · Cited by 15
Elsaid, A. F., Fahmi, R. M., Shaheen, M. A., & Ghoneum, M. H. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02286-7 · Cited by 16
Flowers, E., Flentje, A., Levine, J. D., Olshen, A. B., Hammer, M. J., Paul, S. M., Conley, Y. P., Miaskowski, C. A., & Kober, K. M. (2019) · Biological Research For Nursing · doi:10.1177/1099800418823286 · Cited by 17
Blackwell, A. D., & García, A. R. (2022) · American Journal of Human Biology · doi:10.1002/ajhb.23784 · Cited by 14
Nicoloro‐SantaBarbara, J. M., Carroll, J., Minissian, M., Kilpatrick, S. J., Cole, S. W., Merz, C. N. B., & Accortt, E. E. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13619 · Cited by 15
Self-citationFalkenberg, V. R., Whistler, T., Murray, J., Unger, E. R., & Rajeevan, M. S. (2013) · Genetics & Epigenetics · doi:10.4137/geg.s10944 · Cited by 14
Walton, K. G., Wenuganen, S., & Cole, S. W. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100672 · Cited by 13
Self-citationA study of the role of indoor nature on solidarity and group identity during remote work
Bianchi, E., Bloomfield, L. S. P., Bencharit, L. Z., Altaf, B., Sawe, N. A., Murnane, E. L., Landay, J. A., & Billington, S. L. (2023) · Building and Environment · doi:10.1016/j.buildenv.2023.110909 · Cited by 13
Biltz, R. G., Swanson, S. P., Draime, N., Davis, A. C., Yin, W., Goodman, E. J., Gallagher, N. R., Bhattacharya, A., Sheridan, J. F., & Godbout, J. P. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.011 · Cited by 14
Psychosocial stressors and breast cancer gene expression in the Black Women’s Health Study
Barnard, M. E., Wang, X., Petrick, J. L., Zirpoli, G., Jones, D., Johnson, W. E., & Palmer, J. R. (2023) · Breast Cancer Research and Treatment · doi:10.1007/s10549-023-07182-w · Cited by 13
Beach, S. R. H., Brody, G. H., Barton, A. W., & Philibert, R. A. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000882 · Cited by 14
Frach, L., Tierling, S., Schwaiger, M., Moser, D., Heinrichs, M., Hengstler, J. G., Walter, J., & Kumsta, R. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104653 · Cited by 13
Zang, J. C. S., May, C., Hellwig, B., Moser, D., Hengstler, J. G., Cole, S. W., Heinrichs, M., Rahnenführer, J., Marcus, K., & Kumsta, R. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02320-w · Cited by 13
Self-citationRelationship between depression, anxiety, stress, and SARS-CoV-2 infection: a longitudinal study
Ausserhofer, D., Mahlknecht, A., Engl, A., Piccoliori, G., Pfitscher, G., Silbernagl, P., Giacomoni, F., Pycha, R., Lombardo, S., Gärtner, T., et al. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1116566 · Cited by 13
Differences in Gene Expression in Older Compared With Younger Kidney Transplant Recipients
Schaenman, J. M. D., Rossetti, M. M., Lum, E. L., Abdalla, B. A., Bunnapradist, S., Pham, T., Danovitch, G. M., Reed, E. F., & Cole, S. W. (2019) · Transplantation Direct · doi:10.1097/txd.0000000000000870 · Cited by 13
Self-citationThe role of stress in the biological embedding of experience
Kumsta, R. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106364 · Cited by 15
The health consequences of loneliness
Rokach, A., & Patel, K. (2024) · Environment and Social Psychology · doi:10.54517/esp.v9i6.2150 · Cited by 20
Hummel, E. M., Elgizouli, M., Beygo, J., Giuranna, J., Sicorello, M., Leitão, E., Schröder, C., Zeschnigk, M., Müller, S., Öztürk, D., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22177-1 · Cited by 11
Loneliness, Depression, and Genetics in the Elderly: Prognostic Factors of a Worse Health Condition?
Delgado‐Losada, M. L., Bouhaben, J., Arroyo‐Pardo, E., Aparicio, A., & López-Parra, A. M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192315456 · Cited by 13
Chronic psychosocial stressors and salivary biomarkers in emerging adults
Bergen, A. W., Mallick, A., Nishita, D., Wei, X., Michel, M., Wacholder, A. C., David, S. P., Swan, G. E., Reid, M. W., Simons, A. D., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.11.010 · Cited by 11
Social Regulation of Gene Expression in the Immune System
Cole, S. W. (2012) · The Oxford Handbook of Psychoneuroimmunology · doi:10.1093/oxfordhb/9780195394399.013.0014 · Cited by 30
Self-citationAltered immunoemotional regulatory system in COVID-19: From the origins to opportunities
Pourriyahi, H., Saghazadeh, A., & Rezaei, N. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577578 · Cited by 12
Ricon‐Becker, I., Fogel, E., Cole, S. W., Haldar, R., Lev‐Ari, S., & Gidron, Y. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100057 · Cited by 12
Self-citationSocial regulation of the lymph node transcriptome in rhesus macaques (Macaca mulatta)
Chun, K., Capitanio, J. P., Lamkin, D. M., Sloan, E. K., Arevalo, J. M. G., & Cole, S. W. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.029 · Cited by 10
Self-citationZenga, J., Awan, M. J., Frei, A. C., Petrie, E., Sharma, G. P., Shreenivas, A. V., Shukla, M., & Himburg, H. A. (2022) · Head & Neck · doi:10.1002/hed.27028 · Cited by 10
Metadata
- Authors
- Cole, S. W., Hawkley, L. C., Arevalo, J. M. G., & Cacioppo, J. T.
- Affiliations
- Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90095-1678;
- University of Chicago (US)
- University of California, Los Angeles (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-02-07
- Volume
- 108
- Issue
- 7
- Pages
- 3080-3085
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3041107
- OpenAlex
- W2115394480
- Cited by
- 306
- References
- 60
- Citations by year
- 2026: 10 · 2025: 28 · 2024: 11 · 2023: 18 · 2022: 16 · 2021: 26 · 2020: 17 · 2019: 28 · 2018: 19 · 2017: 16 · 2016: 27 · 2015: 21 · 2014: 22 · 2013: 24 · 2012: 17
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG018911, P01 AG19811, R37AG033590, R01AG034052, P30AG028748, R01AG033590)
- National Cancer Institute (R01CA116778)
- National Institute of Allergy and Infectious Diseases (R01 AI52737, R01AI052737)
- National Center for Research Resources (P20RR020645)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Health › Health disparities and outcomes
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- social isolation, loneliness, gene expression, antigen-presenting cells, plasmacytoid dendritic cells, monocytes, B cells, leukocytes, transcriptional regulation, myeloid cells, social network size, microbial threats
- MeSH terms
- Antigen-Presenting Cells, Gene Expression Regulation, Humans, Leukocytes, Loneliness, Social Environment, Computational Biology, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Databases, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
