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Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes
Open accessAbstract
To clarify the biological rationale for social regulation of gene expression, this study sought to identify the specific immune cell types that are transcriptionally sensitive to subjective social isolation (loneliness). Using reference distributions for the expression of each human gene in each major leukocyte subtype, we mapped the cellular origin of transcripts found to be differentially expressed in the circulating immune cells from chronically lonely individuals. Loneliness-associated genes derived primarily from plasmacytoid dendritic cells, monocytes, and, to a lesser extent, B lymphocytes. Those dynamics reflected per-cell changes in the expression of inducible genes and related more strongly to the subjective experience of loneliness than to objective social network size. Evolutionarily ancient myeloid antigen-presenting cells appear to have evolved a transcriptional sensitivity to socioenvironmental conditions that may allow them to shift basal gene expression profiles to counter the changing microbial threats associated with hostile vs. affine social conditions.
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“Social isolation has also been related to the up-regulated expression of proinflammatory immune response genes and a reciprocal down-regulation of genes involved in antibody production”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as S. W. Cole, Hawkley, Arevalo, & Cacioppo, 2011
In the citing paper
“Genes up-regulated in socially isolated individuals included a set of transcripts that play a central role in inflammation (e.g., IL1B, IL8, PTGS2), whereas down-regulated transcripts were involved in Type I interferon innate antiviral responses (e.g., ISG, IFI, MX, and OAS family genes) and in antibody production (e.g., IGL, IGH, IGJ, and IGK) [5], [14], [15].”
From Human Social Genomics (2014) · cites this paper as [15]
In the citing paper
“Genome-wide transcriptional profiling of leukocytes from people experiencing chronic social isolation identified >200 genes that showed >50% difference in average expression levels relative to those observed in socially integrated people [14], [15].”
From Human Social Genomics (2014) · cites this paper as [15]
In the citing paper
“Bioinformatic decomposition of transcriptome shifts in the heterogenous leukocyte population initially identified the primary cellular mediators of CTRA transcriptome shifts as myeloid lineage immune cells such as monocytes and dendritic cells [15].”
From Human Social Genomics (2014) · cites this paper as [15]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
The genetical evolution of social behaviour. I
Hamilton, W. D. (1964) · Journal of Theoretical Biology · doi:10.1016/0022-5193(64)90038-4 · Cited by 15,725
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
BERKMAN, L. F., & SYME, S. L. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112674 · Cited by 5,341
The Revised UCLA Loneliness Scale: concurrent and discriminant validity evidence
Russell, D., Peplau, L. A., & Cutrona, C. E. (1980) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.39.3.472 · Cited by 5,173
The genetical evolution of social behaviour. II
Hamilton, W. D. O. (1964) · Journal of Theoretical Biology · doi:10.1016/0022-5193(64)90039-6 · Cited by 4,158
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Uchino, B. N., Cacioppo, J. T., & Kiecolt-Glaser, J. K. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.119.3.488 · Cited by 2,727
Self-citationMartínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,399
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Perceived social isolation and cognition
Cacioppo, J. T., & Hawkley, L. C. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.06.005 · Cited by 2,144
Self-citationChronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Self-citationTrophic macrophages in development and disease
Pollard, J. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2528 · Cited by 1,178
Social ties and health: The benefits of social integration
Seeman, T. E. (1996) · Annals of Epidemiology · doi:10.1016/s1047-2797(96)00095-6 · Cited by 1,137
The sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930
Self-citationMiller, G. E., Chen, E., Fok, A. K., Walker, H., Lim, A., Nicholls, E. F., Cole, S., & Kobor, M. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902971106 · Cited by 822
Self-citationSocial networks, social support, and survival after breast cancer diagnosis
Kroenke, C. H., Kubzansky, L. D., Schernhammer, E. S., Holmes, M. D., & Kawachi, I. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.2846 · Cited by 792
Social regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745 · cited 12×
“Briefly, genome-wide transcriptional profiling was carried out in peripheral blood mononuclear cells (PBMCs) isolated by standard Ficoll density gradient centrifugation of 10 mL of whole blood from 14 participants in the Chicago Health, Aging, and Social Relations Study (CHASRS), 6 of whom had consistently scored in t…”
BackgroundMethodInfluentialSelf-citationMiller, G., Chen, E., & Cole, S. W. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163551 · Cited by 591
Self-citation(1986) · CERN Document Server (European Organization for Nuclear Research) · Cited by 583
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., Ma, R., & Cole, S. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.017 · Cited by 552
Self-citation(Meta)population dynamics of infectious diseases
Grenfell, B. T. (1997) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(97)01174-9 · Cited by 535
Finch, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909606106 · Cited by 417
Eisenberger, N. I., Inagaki, T. K., Mashal, N. M., & Irwin, M. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.12.009 · Cited by 413
Abbas, A. R., Baldwin, D. T., Ma, Y., Ouyang, W., Gurney, A. L., Martin, F., Fong, S. S., Campagne, M. V. L., Godowski, P. J., Williams, P. M., et al. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364173 · Cited by 377
Life history theory and the immune system: Steps toward a human ecological immunology
McDade, T. W. (2003) · American Journal of Physical Anthropology · doi:10.1002/ajpa.10398 · Cited by 371
Chen, E., Miller, G. E., Kobor, M. S., & Cole, S. W. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.53 · Cited by 340
Self-citationAllostasis, Homeostasis, and the Costs of Physiological Adaptation
(2004) · Cambridge University Press eBooks · doi:10.1017/cbo9781316257081 · Cited by 265
Computational identification of gene–social environment interaction at the human IL6 locus
Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256
Self-citationThe environmental contribution to gene expression profiles
Gibson, G. C. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2383 · Cited by 250
Cole, S. W., Korin, Y. D., Fahey, J. L., & Zack, J. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.2.610 · Cited by 228
Self-citationThe Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans
Finch, C. E. (2007) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 194
Capitanio, J. P., Mendoza, S. P., Lerche, N. W., & Mason, W. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4714 · Cited by 187
Social Regulation of Human Gene Expression
Cole, S. W. (2009) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2009.01623.x · Cited by 187
Self-citationNovel Insights on Human NK Cells’ Immunological Modalities Revealed by Gene Expression Profiling1
Hanna, J., Bechtel, P. E., Zhai, Y.-F., Youssef, F., Mclachlan, K., & Mandelboim, O. (2004) · Journal of Immunology · doi:10.4049/jimmunol.173.11.6547 · Cited by 178
Beyond ANOVA, Basics of Applied Statistics
Amster, S. J., & Miller, R. G. (1987) · Technometrics · doi:10.2307/1269361 · Cited by 176
Complex Systems Science in Biomedicine
Deisboeck, T. S., & Kresh, J. Y. (2006) · Springer eBooks · doi:10.1007/978-0-387-33532-2 · Cited by 171
Sloan, E. K., Capitanio, J. P., Tarara, R. P., Mendoza, S. P., Mason, W. A., & Cole, S. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1247-07.2007 · Cited by 170
Self-citationSocial regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity
Cole, S. W. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.02.006 · Cited by 156
Self-citationElevating the perspective on human stress genomics
Cole, S. W. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.06.008 · Cited by 123
Self-citationSympathetic nervous system control of anti-influenza CD8 + T cell responses
Grebe, K. M., Hickman, H. D., Irvine, K. R., Takeda, K., Bennink, J. R., & Yewdell, J. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808851106 · Cited by 118
Genome-wide transcriptional profiling linked to social class in asthma
Chen, E., Miller, G. E., Walker, H. A., Arevalo, J. M., Sung, C. Y., & Cole, S. W. (2008) · Thorax · doi:10.1136/thx.2007.095091 · Cited by 118
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Ledder, G., & Homp, M. (2022) · Foundations for undergraduate research in mathematics · doi:10.1007/978-3-031-08560-4_8 · Cited by 117
Idaghdour, Y., Storey, J. D., Jadallah, S. J., & Gibson, G. C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000052 · Cited by 109
Controlling false-negative errors in microarray differential expression analysis: a PRIM approach
Cole, S. W., Galić, Z., & Zack, J. A. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg242 · Cited by 109
Self-citationImmune System and Atherosclerotic Disease
Shimada, K. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0277 · Cited by 94
Hamrick, N., Cohen, S., & Rodriguez, M. S. (2002) · Health Psychology · doi:10.1037/0278-6133.21.3.294 · Cited by 84
Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2
Maier, S., Staffler, G., Hartmann, A., Höck, J., Henning, K., Grabušić, K., Mailhammer, R., Hoffmann, R. F. G., Wilmanns, M., Lang, R., et al. (2006) · Journal of Virology · doi:10.1128/jvi.00665-06 · Cited by 82
Social Interactions, Stress, and Immunity
Avitsur, R., Powell, N., Padgett, D. A., & Sheridan, J. F. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.006 · Cited by 74
Cole, S. W., Mendoza, S. P., & Capitanio, J. P. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181aa95a9 · Cited by 74
Self-citationCollado-Hidalgo, A., Sung, C., & Cole, S. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.01.005 · Cited by 69
Self-citationFunctional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis
Soehnlein, O., Drechsler, M. D., Hristov, M., & Weber, C. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00965.x · Cited by 37
The evolution of blood cells: facts and enigmas
Millar, D., & Ratcliffe, N. A. (1989) · Endeavour · doi:10.1016/0160-9327(89)90005-7 · Cited by 35
Social Regulation of Gene Expression in the Immune System
Cole, S. W. (2012) · The Oxford Handbook of Psychoneuroimmunology · doi:10.1093/oxfordhb/9780195394399.013.0014 · Cited by 30
Self-citationThe Oxford handbook of psychoneuroimmunology
(2012) · Choice Reviews Online · doi:10.5860/choice.50-2057 · Cited by 28
The Complexity of Dynamic Host Networks
Cole, S. W. (2007) · Springer eBooks · doi:10.1007/978-0-387-33532-2_26 · Cited by 27
Self-citation
Research works printed but not linked: 3
- CA Janeway, P Travers, M Walport, MJ Shlomchik Immunobiology (Garland Science, 5th Ed, New York, 2001).
- DM Knipe, et al. Fields Virology (Lippincott Williams & Wilkins, Philadelphia, 2007).
- S Wrzesinski J Uhlenhake J Fisher M Ernstoff Gene Expression Omnibus GSE11943: Human dendritic cell subtype gene arrays. Available at http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE11943. Accessed December 1 2010. (2008).
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Self-citationLoneliness: clinical import and interventions
Cacioppo, S., Grippo, A. J., London, S., Goossens, L., & Cacioppo, J. T. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615570616 · Cited by 1,206
Self-citationSocial relationships and health: The toxic effects of perceived social isolation
Cacioppo, J. T., & Cacioppo, S. (2014) · Social and Personality Psychology Compass · doi:10.1111/spc3.12087 · Cited by 1,057
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Cacioppo, J. T., Cacioppo, S., Capitanio, J. P., & Cole, S. W. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015240 · Cited by 977
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Metadata
- Authors
- Cole, S. W., Hawkley, L. C., Arevalo, J. M. G., & Cacioppo, J. T.
- Affiliations
- Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90095-1678;
- University of Chicago (US)
- University of California, Los Angeles (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-02-07
- Volume
- 108
- Issue
- 7
- Pages
- 3080-3085
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3041107
- OpenAlex
- W2115394480
- Cited by
- 306
- References
- 60
- Citations by year
- 2026: 10 · 2025: 28 · 2024: 11 · 2023: 18 · 2022: 16 · 2021: 26 · 2020: 17 · 2019: 28 · 2018: 19 · 2017: 16 · 2016: 27 · 2015: 21 · 2014: 22 · 2013: 24 · 2012: 17
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG018911, P01 AG19811, R37AG033590, R01AG034052, P30AG028748, R01AG033590)
- National Cancer Institute (R01CA116778)
- National Institute of Allergy and Infectious Diseases (R01 AI52737, R01AI052737)
- National Center for Research Resources (P20RR020645)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Health › Health disparities and outcomes
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- social isolation, loneliness, gene expression, antigen-presenting cells, plasmacytoid dendritic cells, monocytes, B cells, leukocytes, transcriptional regulation, myeloid cells, social network size, microbial threats
- MeSH terms
- Antigen-Presenting Cells, Gene Expression Regulation, Humans, Leukocytes, Loneliness, Social Environment, Computational Biology, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Databases, Genetic
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