The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation
Open accessAbstract
Inappropriate neutrophil activation contributes to the pathogenesis of acute lung injury (ALI). Apoptosis is essential for removal of neutrophils from inflamed tissues and timely resolution of inflammation. Resolvin E1 (RvE1) is an endogenous lipid mediator derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid that displays proresolving actions. Because the balance of prosurvival and proapoptosis signals determines the fate of neutrophils, we investigated the impact of RvE1 on neutrophil apoptosis and the outcome of neutrophil-mediated pulmonary inflammation in mice. Culture of human neutrophils with RvE1 accelerated apoptosis evoked by phagocytosis of opsonized Escherichia coli or yeast. RvE1 through the leukotriene B 4 receptor BLT1 enhanced NADPH oxidase-derived reactive oxygen species generation and subsequent activation of caspase-8 and caspase-3. RvE1 also attenuated ERK and Akt-mediated apoptosis-suppressing signals from myeloperoxidase, serum amyloid A, and bacterial DNA, shifting the balance of pro- and anti-survival signals toward apoptosis via induction of mitochondrial dysfunction. In mice, RvE1 treatment enhanced the resolution of established neutrophil-mediated pulmonary injury evoked by intratracheal instillation or i.p. administration of live E. coli or intratracheal instillation of carrageenan plus myeloperoxidase via facilitating neutrophil apoptosis and their removal by macrophages. The actions of RvE1 were prevented by the pan-caspase inhibitor zVAD-fmk. These results identify a mechanism, promotion of phagocytosis-induced neutrophil apoptosis and mitigation of potent anti-apoptosis signals, by which RvE1 could enhance resolution of acute lung inflammation.
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“The EPA-derived SPM RvE1 limits neutrophil-mediated inflammation by promoting neutrophil apoptosis and efferocytosis113.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [113]
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Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344
Apoptotic cell clearance: basic biology and therapeutic potential
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Targeting inflammation in atherosclerosis — from experimental insights to the clinic
Soehnlein, O., & Libby, P. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00198-1 · Cited by 1,085
Metadata
- Authors
- El Kebir, D., Gjorstrup, P., & Filep, J. G.
- Affiliations
- Research Center, Maisonneuve-Rosemont Hospital, and Department of Pathology and Cell Biology, University of Montréal, Montréal, QC, Canada H1T 2M4; and
- Resolvyx Pharmaceuticals, Cambridge, MA 02142
- Hôpital Maisonneuve-Rosemont (CA)
- ORCID
- Filep, János G.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-08-27
- Volume
- 109
- Issue
- 37
- Pages
- 14983-14988
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3443132
- OpenAlex
- W2050362957
- Cited by
- 289
- References
- 42
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 18 · 2023: 20 · 2022: 25 · 2021: 23 · 2020: 18 · 2019: 15 · 2018: 26 · 2017: 22 · 2016: 16 · 2015: 22 · 2014: 19 · 2013: 31 · 2012: 1
- FWCI
- 21.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP‐97742)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- resolvin E1, neutrophil apoptosis, phagocytosis, inflammation resolution, acute lung injury, reactive oxygen species, caspase-8, caspase-3, myeloperoxidase, serum amyloid A, bacterial DNA, mitochondrial dysfunction, eicosapentaenoic acid
- MeSH terms
- Amino Acid Chloromethyl Ketones, Analysis of Variance, Animals, Cells, Cultured, Escherichia coli, Humans, Mitochondria, Neutrophils, Phagocytosis, Pneumonia, Yeasts, Eicosapentaenoic Acid, Apoptosis, Reactive Oxygen Species, Receptors, Leukotriene B4, Statistics, Nonparametric, Mice, Caspase 3, Caspase 8
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