Cited by 289Fatty Acid Research and HealthPhagocytosis and Immune RegulationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

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El Kebir, Driss, Gjorstrup, Per, Filep, János G.·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1206641109PMC PMC3443132

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Abstract

Inappropriate neutrophil activation contributes to the pathogenesis of acute lung injury (ALI). Apoptosis is essential for removal of neutrophils from inflamed tissues and timely resolution of inflammation. Resolvin E1 (RvE1) is an endogenous lipid mediator derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid that displays proresolving actions. Because the balance of prosurvival and proapoptosis signals determines the fate of neutrophils, we investigated the impact of RvE1 on neutrophil apoptosis and the outcome of neutrophil-mediated pulmonary inflammation in mice. Culture of human neutrophils with RvE1 accelerated apoptosis evoked by phagocytosis of opsonized Escherichia coli or yeast. RvE1 through the leukotriene B 4 receptor BLT1 enhanced NADPH oxidase-derived reactive oxygen species generation and subsequent activation of caspase-8 and caspase-3. RvE1 also attenuated ERK and Akt-mediated apoptosis-suppressing signals from myeloperoxidase, serum amyloid A, and bacterial DNA, shifting the balance of pro- and anti-survival signals toward apoptosis via induction of mitochondrial dysfunction. In mice, RvE1 treatment enhanced the resolution of established neutrophil-mediated pulmonary injury evoked by intratracheal instillation or i.p. administration of live E. coli or intratracheal instillation of carrageenan plus myeloperoxidase via facilitating neutrophil apoptosis and their removal by macrophages. The actions of RvE1 were prevented by the pan-caspase inhibitor zVAD-fmk. These results identify a mechanism, promotion of phagocytosis-induced neutrophil apoptosis and mitigation of potent anti-apoptosis signals, by which RvE1 could enhance resolution of acute lung inflammation.

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Authors: El Kebir, D., Gjorstrup, P., & Filep, J. G.
Affiliations: Research Center, Maisonneuve-Rosemont Hospital, and Department of Pathology and Cell Biology, University of Montréal, Montréal, QC, Canada H1T 2M4; and
Resolvyx Pharmaceuticals, Cambridge, MA 02142
Hôpital Maisonneuve-Rosemont (CA)
ORCID: Filep, János G.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-08-27
Volume: 109
Issue: 37
Pages: 14983-14988
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1206641109
PMC: PMC3443132
OpenAlex: W2050362957
Cited by: 289
References: 42
Citations by year: 2026: 11 · 2025: 22 · 2024: 18 · 2023: 20 · 2022: 25 · 2021: 23 · 2020: 18 · 2019: 15 · 2018: 26 · 2017: 22 · 2016: 16 · 2015: 22 · 2014: 19 · 2013: 31 · 2012: 1
FWCI: 21.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (MOP‐97742)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: resolvin E1, neutrophil apoptosis, phagocytosis, inflammation resolution, acute lung injury, reactive oxygen species, caspase-8, caspase-3, myeloperoxidase, serum amyloid A, bacterial DNA, mitochondrial dysfunction, eicosapentaenoic acid
MeSH terms: Amino Acid Chloromethyl Ketones, Analysis of Variance, Animals, Cells, Cultured, Escherichia coli, Humans, Mitochondria, Neutrophils, Phagocytosis, Pneumonia, Yeasts, Eicosapentaenoic Acid, Apoptosis, Reactive Oxygen Species, Receptors, Leukotriene B4, Statistics, Nonparametric, Mice, Caspase 3, Caspase 8

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Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

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