The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
DNA analysis of an early modern human from Tianyuan Cave, China
Open accessAbstract
Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (∼30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We evaluated each individual for evidence of authentic ancient DNA by limiting to libraries with a minimum of 3% cytosine-to-thymine errors at the final nucleotide29, by requiring that the ratio of X-to-Y-chromosome sequences was characteristic of either a male or a female, by requiring >95% matching to the consensus sequence of mitochondrial DNA30, and by requiring (for males) a lack of variation”
From Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation (2018) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We assessed the quality of each library at the screening stage using three standard methods for determining ancient DNA authenticity.”
From Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation (2018) · cites this paper as [30]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
MrBayes 3: Bayesian phylogenetic inference under mixed models
Ronquist, F., & Huelsenbeck, J. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg180 · Cited by 29,194
MODELTEST: testing the model of DNA substitution.
Posada, D., & Crandall, K. A. (1998) · Bioinformatics · doi:10.1093/bioinformatics/14.9.817 · Cited by 19,820
Genome sequencing in microfabricated high-density picolitre reactors
Margulies, M., Egholm, M., Altman, W. E., Attiya, S., Bader, J. S., Bemben, L. A., Berka, J., Braverman, M. S., Chen, Y.-J., Chen, Z., et al. (2005) · Nature · doi:10.1038/nature03959 · Cited by 7,693
A draft sequence of the Neandertal genome
Green, R. E., Krause, J., Briggs, A. W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M. H.-Y., et al. (2010) · Science · doi:10.1126/science.1188021 · Cited by 4,318
Self-citationReanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA
Andrews, R. M., Kubacka, I., Chinnery, P. F., Lightowlers, R. N., Turnbull, D. M., & Howell, N. (1999) · Nature Genetics · doi:10.1038/13779 · Cited by 3,337
Ancient Admixture in Human History
Patterson, N., Moorjani, P., Luo, Y., Mallick, S., Rohland, N., Zhan, Y., Genschoreck, T., Webster, T., & Reich, D. (2012) · Genetics · doi:10.1534/genetics.112.145037 · Cited by 2,848
Inference of population splits and mixtures from genome-wide allele frequency data
Pickrell, J. K., & Pritchard, J. K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002967 · Cited by 2,731
Genetic history of an archaic hominin group from Denisova Cave in Siberia
Reich, D., Green, R. E., Kircher, M., Krause, J., Patterson, N., Durand, E. Y., Viola, B., Briggs, A. W., Stenzel, U., Johnson, P. L. F., et al. (2010) · Nature · doi:10.1038/nature09710 · Cited by 1,991
Self-citation
Research works printed but not linked: 1
- H Shang, E Trinkaus The Early Modern Human from Tianyuan Cave (Texas A&M Univ Press, College Station, TX, 2010).
Cited by
Sorted by citations
Items 201–300 of 607
Ancient Cultures and Migrations in Northeastern Siberia
Grebenyuk, P. S., Fedorchenko, A. Y., Dyakonov, V. M., Lebedintsev, A. I., & Malyarchuk, B. А. (2022) · Springer geography · doi:10.1007/978-3-030-90061-8_4 · Cited by 46
Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium
Fu, Q., Cao, P., Dai, Q., Bennett, E. A., Feng, X., Yang, M. A., Ping, W., Pääbo, S., & Ji, Q. (2025) · Cell · doi:10.1016/j.cell.2025.05.040 · Cited by 51
“Two rounds of hybridization capture at 65 ◦ C were conducted using a modified on-bead hybridization protocol 70,71 with a modern human mtDNA probe set.”
Self-citationA combined method for DNA analysis and radiocarbon dating from a single sample
Korlević, P., Talamo, S., & Meyer, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-22472-w · Cited by 46
Self-citationContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium
Nakatsuka, N., Harney, É., Mallick, S., Mah, M., Patterson, N., & Reich, D. (2020) · Genome Biology · doi:10.1186/s13059-020-02111-2 · Cited by 45
Barbosa, S., Paupério, J., Pavlova, S. V., Alves, P. C., & Searle, J. B. (2018) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2018.03.017 · Cited by 45
Zhao, Y., Zhang, Y., Zhang, Q., Li, H., Cui, Y., Xu, Z., Li, J., Zhou, H., & Zhu, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125676 · Cited by 44
New progress in understanding the origins of modern humans in China
Gao, X., Peng, F., Fu, Q., & Feng, L. (2017) · Science China Earth Sciences · doi:10.1007/s11430-017-9144-1 · Cited by 43
Self-citationComparison of Target Enrichment Strategies for Ancient Pathogen DNA
Furtwängler, A., Neukamm, J., Böhme, L., Reiter, E., Vollstedt, M., Arora, N., Singh, P., Cole, S. T., Knauf, S., Calvignac‐Spencer, S., et al. (2020) · BioTechniques · doi:10.2144/btn-2020-0100 · Cited by 44
The age of human remains and associated fauna from Zhiren Cave in Guangxi, southern China
Cai, Y., Qiang, X., Wang, X., Jin, C., Wang, Y., Zhang, Y., Trinkaus, E., & An, Z. (2016) · Quaternary International · doi:10.1016/j.quaint.2015.12.088 · Cited by 44
Quantitative PCR as a Predictor of Aligned Ancient DNA Read Counts Following Targeted Enrichment
Enk, J. M., Rouillard, J. M., & Poinar, H. N. (2013) · BioTechniques · doi:10.2144/000114114 · Cited by 44
Comparative performance of two whole‐genome capture methodologies on ancient DNA Illumina libraries
Ávila‐Arcos, M. C., Sandoval‐Velasco, M., Schroeder, H., Carpenter, M. L., Malaspinas, A., Wales, N., Peñaloza, F., Bustamante, C. D., & Gilbert, M. T. P. (2015) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12353 · Cited by 46
“Until recently, targeted enrichment approaches were limited to small fractions of predefined regions of already characterized genomes (e.g. Maricic, Whitten & Paabo 2010; Schuenemann et al. 2013; Fu et al. 2013a).”
BackgroundMethodInfluentialBongers, J. L., Nakatsuka, N. J., O’Shea, C., Harper, T. K., Tantaleán, H., Stanish, C. S., & Fehren‐Schmitz, L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005965117 · Cited by 49
Genomic and dietary discontinuities during the Mesolithic and Neolithic in Sicily
He, Y. H., van de Loosdrecht, M. S., Mannino, M. A., Talamo, S., Rohrlach, A. B., Childebayeva, A., Villalba‐Mouco, V., Aron, F., Brandt, G., Burri, M., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104244 · Cited by 47
Ancient Plasmodium genomes shed light on the history of human malaria
Michel, M., Skourtanioti, E., Pierini, F., Guevara, E. K., Mötsch, A., Kocher, A., Barquera, R., Bianco, R. A., Carlhoff, S., Bove, L., et al. (2024) · Nature · doi:10.1038/s41586-024-07546-2 · Cited by 53
“Finally, all sample and control libraries were enriched for Plasmodium spp. mitochondrial and/or nuclear DNA using two consecutive rounds of in-solution hybridization capture performed on the Bravo NGS work-station B 72 .”
Influential“Modern behaviors” of ancient populations at Shuidonggou Locality 2 and their implications
Li, F., Chen, F., & Gao, X. (2014) · Quaternary International · doi:10.1016/j.quaint.2014.04.001 · Cited by 43
Self-citationYang, X., Gao, Y., Wangdue, S., Ran, J., Wang, Q., Chen, S., Yang, J., Wang, T., Gu, Z., Zhang, Y., et al. (2024) · Nature Ecology & Evolution · doi:10.1038/s41559-024-02539-w · Cited by 44
“For the nine successful library samples, solution hybridization oligonucleotide probes were used to enrich endogenous DNA for a complete mitochondrial genome 49 and 1.2 million nuclear SNPs (1,240,000 SNPs) 50 .”
InfluentialSelf-citationThe Entwined African and Asian Genetic Roots of the Medieval Peoples of the Swahili CoastPreprint
Brielle, E. S., Fleisher, J., Wynne‐Jones, S., Broomandkhoshbacht, N., Callan, K. A., Curtis, E., Iliev, L., Lawson, A. M., Oppenheimer, J., Qiu, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.10.499442 · Cited by 42
Technical Advances and Challenges in Genome-Scale Analysis of Ancient DNA
Lan, T., & Lindqvist, C. (2018) · Population genomics · doi:10.1007/13836_2018_54 · Cited by 43
Initial Upper Palaeolithic material culture by 45,000 years ago at Shiyu in northern China
Shi-Xia, Y., Zhang, J., Yue, J., Wood, R. E., Guo, Y., Wang, H., Luo, W., Zhang, Y., Raguin, É., Zhao, K., et al. (2024) · Nature Ecology & Evolution · doi:10.1038/s41559-023-02294-4 · Cited by 45
Long genetic and social isolation in Neanderthals before their extinction
Slimak, L., Vimala, T., Seguin‐Orlando, A., Metz, L., Zanolli, C., Joannes‐Boyau, R., Frouin, M., Arnold, L. J., Demuro, M., Devièse, T., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100593 · Cited by 53
“The analysis included 24 Neanderthals, 11,16,33,126 1 Denisovan, 134,135 9 ancient human genomes, 125,126 and 53 contemporary human mitochondrial genomes.”
InfluentialDescent, marriage, and residence practices of a 3,800-year-old pastoral community in Central Eurasia
Blöcher, J., Brami, M., Feinauer, I. S., Stolarczyk, E., Diekmann, Y., Vetterdietz, L., Karapetian, M. K., Winkelbach, L., Kokot, V., Vallini, L., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2303574120 · Cited by 45
Llamas, B., Brotherton, P., Mitchell, K. J., Templeton, J. E. L., Thomson, V. A., Metcalf, J. L., Armstrong, K. N., Kasper, M., Richards, S. M., Camens, A. B., et al. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu338 · Cited by 41
“Key words: ancient DNA, phylogenetics, Sthenurinae, Lagostrophinae, Macropodinae.”
Historical biogeography of the leopard (Panthera pardus) and its extinct Eurasian populations
Paijmans, J. L. A., Barlow, A., Förster, D. W., Henneberger, K., Meyer, M., Nickel, B., Nagel, D., Havmøller, R. W., Baryshnikov, G. F., Joger, U., et al. (2018) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1268-0 · Cited by 38
Self-citationOut of Africa and into Asia: Fossil and genetic evidence on modern human origins and dispersals
Reyes‐Centeno, H. (2016) · Quaternary International · doi:10.1016/j.quaint.2015.11.063 · Cited by 40
Detection of chromosomal aneuploidy in ancient genomes
Anastasiadou, K., Silva, M. S. D., Booth, T. J., Speidel, L., Audsley, T., Barrington, C., Buckberry, J., Fernandes, D., Ford, B., Gibson, M., et al. (2024) · Communications Biology · doi:10.1038/s42003-023-05642-z · Cited by 39
“Additionally, we de fi ned an alternative set of assignment thresholds, optimised for use with target enriched libraries on the widely used “ 1240k ” SNP positions 26,27 (see Supplementary Note 4 and Supplementary Figure 3).”
MethodDing, M., Wang, T., Ko, A. M., Chen, H., Wang, H., Dong, G., Lü, H., He, W., Wangdue, S., Yuan, H., et al. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2968 · Cited by 39
Self-citationCsáky, V., Gerber, D., Szeifert, B., Egyed, B., Stégmár, B., Botalov, S. G., Grudochko, I. V., Матвеева, Н. П., Зеленков, А. С., Sleptsova, A. V., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-75910-z · Cited by 43
Ancient Xinjiang mitogenomes reveal intense admixture with high genetic diversity
Wang, W., Ding, M., Gardner, J. D., Wang, Y., Miao, B., Guo, W., Wu, X., Ruan, Q., JianJun, Y., Hu, X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd6690 · Cited by 39
Self-citationRohrlach, A. B., Papac, L., Childebayeva, A., Rivollat, M., Villalba‐Mouco, V., Neumann, G. U., Penske, S., Skourtanioti, E., van de Loosdrecht, M. S., Akar, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94491-z · Cited by 43
Inferring archaic introgression from hominin genetic data
Gopalan, S., Atkinson, E. G., Buck, L. T., Weaver, T. D., & Henn, B. M. (2021) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21895 · Cited by 37
“37,71,72 Initial estimates suggested 40% more Neanderthal ancestry in the Han Chinese and Japanese, compared with Europeans.”
Ancient DNA Evidence from China Reveals the Expansion of Pacific Dogs
Zhang, M., Sun, G., Ren, L., Yuan, H., Dong, G., Zhang, L., Liu, F., Cao, P., Ko, A. M., Yang, M. A., et al. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msz311 · Cited by 40
“In this study, we used aDNA capture techniques (Fu et al. 2013) and successfully obtained 27 high-quality complete mitogenomes of 7,000- to 2,000-year-old specimens identified”
MethodInfluentialSelf-citationNew perspectives on Neanderthal dispersal and turnover from Stajnia Cave (Poland)
Picin, A., Hajdinjak, M., Nowaczewska, W., Benazzi, S., Urbanowski, M., Marciszak, A., Fewlass, H., Bosch, M. D., Socha, P., Stefaniak, K., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71504-x · Cited by 41
Entwined African and Asian genetic roots of medieval peoples of the Swahili coast
Brielle, E. S., Fleisher, J., Wynne‐Jones, S., Sirak, K. A., Broomandkhoshbacht, N., Callan, K. A., Curtis, E., Iliev, L., Lawson, A. M., Oppenheimer, J., et al. (2023) · Nature · doi:10.1038/s41586-023-05754-w · Cited by 83
Diagnosing Homo sapiens in the fossil record
Stringer, C. B., & Buck, L. T. (2014) · Annals of Human Biology · doi:10.3109/03014460.2014.922616 · Cited by 37
Isolation, Library Preparation, and Bioinformatic Analysis of Historical and Ancient Plant DNA
Latorre, S. M., Lang, P. L. M., Burbano, H. A., & Gutaker, R. M. (2020) · Current Protocols in Plant Biology · doi:10.1002/cppb.20121 · Cited by 36
Self-citationDenisovans and Homo sapiens on the Tibetan Plateau: dispersals and adaptations
Zhang, P., Zhang, X., Zhang, X., Gao, X., Huerta‐Sánchez, E., & Zwyns, N. (2021) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2021.11.004 · Cited by 41
Self-citationPaleolithic DNA from the Caucasus reveals core of West Eurasian ancestryPreprint
Lazaridis, I., Belfer‐Cohen, A., Mallick, S., Patterson, N. J., Cheronet, O., Rohland, N., Bar‐Oz, G., Bar‐Yosef, O., Jakeli, N., Kvavadze, E., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/423079 · Cited by 39
The proteome of the late Middle Pleistocene Harbin individual
Fu, Q., Bai, F., Rao, H., Chen, S., Ji, Y., Liu, A., Bennett, E. A., Liu, F., & Ji, Q. (2025) · Science · doi:10.1126/science.adu9677 · Cited by 40
Self-citationMajor transitions in human evolution revisited: A tribute to ancient DNA
Ermini, L., Sarkissian, C. S. I. D., Willerslev, E., & Orlando, L. (2014) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.06.015 · Cited by 37
The efficacy of whole human genome capture on ancient dental calculus and dentin
Ziesemer, K. A., Ramos‐Madrigal, J., Mann, A. E., Brandt, B. W., Sankaranarayanan, K., Ozga, A. T., Hoogland, M. L. P., Hofman, C. A., Salazar‐García, D. C., Frøhlich, B., et al. (2018) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23763 · Cited by 36
“We used contamMix 1.05 (Fu et al., 2013) to estimate the level of modern human DNA contamination.”
InfluentialA demographic history of Late Pleistocene China
Dennell, R., Martinón‐Torres, M., de Castro, J. M. B., & Xing, G. (2020) · Quaternary International · doi:10.1016/j.quaint.2020.03.014 · Cited by 36
“The proportion of Neandertal or Denisovan DNA sequences in its genome was also no larger than in present-day people in the region (Fu Qiaomei et al., 2013).”
BackgroundHuman inbreeding has decreased in time through the Holocene
Ceballos, F. C., Gürün, K., Altınışık, N. E., Gemici, H. C., Karamurat, C., Koptekin, D., Vural, K. B., Mapelli, I., Sağlıcan, E., Sürer, E., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.06.027 · Cited by 41
Jia, W., Anslan, S., Chen, F., Cao, X., Dong, H., Dulias, K., Gu, Z., Heinecke, L., Jiang, H., Kruse, S., et al. (2022) · Quaternary Science Reviews · doi:10.1016/j.quascirev.2022.107703 · Cited by 37
Bronze Age cheese reveals human-Lactobacillus interactions over evolutionary history
Liu, Y., Miao, B., Li, W., Hu, X., Bai, F., Abuduresule, Y., Liu, Y., Zheng, Z., Wang, W., Chen, Z., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.008 · Cited by 37
Self-citationFragmented Landscapes and Economies of Abundance: The Broad-Spectrum Revolution in Arid East Asia
Janz, L. (2016) · Current Anthropology · doi:10.1086/688436 · Cited by 36
Prehistoric genomes from Yunnan reveal ancestry related to Tibetans and Austroasiatic speakers
Wang, T., Yang, M. A., Zhu, Z., Ma, M., Shi, H., Speidel, L., Min, R., Yuan, H., Jiang, Z., Hu, C., et al. (2025) · Science · doi:10.1126/science.adq9792 · Cited by 35
Self-citationSignificance of Neandertal and Denisovan Genomes in Human Evolution
Hawks, J. D. (2013) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-092412-155548 · Cited by 34
Human genetic diversity in the Japanese Archipelago: dual structure and beyond
Jinam, T. A., Kanzawa‐Kiriyama, H., & Saitou, N. (2015) · Genes & Genetic Systems · doi:10.1266/ggs.90.147 · Cited by 34
“Combined analyses with other ancient DNA from the Asian continent (Fu et al., 2013) may also help to answer questions regarding the origins of the Jomon people.”
BackgroundAncient DNA from the skeletons of Roopkund Lake reveals Mediterranean migrants in India
Harney, É., Nayak, A., Patterson, N. J., Joglekar, P. P., Mushrif‐Tripathy, V., Mallick, S., Rohland, N., Sedig, J. W., Adamski, N., Bernardos, R. L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11357-9 · Cited by 34
Braadbaart, F., Reidsma, F. H., Roebroeks, W., Chiotti, L., Slon, V., Meyer, M. J., Théry‐Parisot, I., van Hoesel, A., Nierop, K. G. J., Kaal, J., et al. (2020) · Journal of Archaeological Science Reports · doi:10.1016/j.jasrep.2020.102468 · Cited by 35
“Libraries were amplified and tagged with double indices (Kircher et al., 2012) and enriched by hybridisation capture for both mammalian mtDNA (Slon et al., 2016) as well as specifically for human mtDNA (Maricić et al., 2010; Fu et al., 2013) prior to sequencing on an Illumina MiSeq.”
Self-citationThe Genomic Formation of Human Populations in East AsiaPreprint
Wang, C., Yeh, H., Popov, А. N., Zhang, H., Matsumura, H., Sirak, K. A., Cheronet, O., Kovalev, A., Rohland, N., Kim, A. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.25.004606 · Cited by 35
Ancient humans and the origin of modern humans
Kelso, J. F., & Prüfer, K. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.004 · Cited by 35
“75-fold [36].”
Self-citationKo, A. M., Zhang, Y., Yang, M. A., Hu, Y., Cao, P., Feng, X., Zhang, L., Wei, F., & Fu, Q. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.008 · Cited by 33
Self-citationColl Macià, M., Skov, L., Peter, B. M., & Schierup, M. H. (2021) · Nature Communications · doi:10.1038/s41467-021-25524-4 · Cited by 33
Liu, Y., Xie, J., Wang, M., Liu, C., Zhu, J., Zou, X., Li, W., Wang, L., Leng, C., Xu, Q., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.815160 · Cited by 32
“During the past decade, paleogenomic studies have transformed our knowledge of the population history of East Asians (Fu et al., 2013; Ning et al., 2019; Ning et al., 2020; Yang et al., 2020; Liu et al., 2021a; Wang et al., 2021a; Wang et al., 2021e; Mao et al., 2021).”
BackgroundStiller, M., Sucker, A., Griewank, K., Aust, D. E., Baretton, G. B., Schadendorf, D., & Horn, S. (2016) · Oncotarget · doi:10.18632/oncotarget.10827 · Cited by 33
“For exome capture, 4 ul of libraries prepared from single-stranded DNA were used for hybridization capture as described previously [36].”
MethodHarris, A. M., & DeGiorgio, M. (2017) · Human Biology · doi:10.13110/humanbiology.89.1.02 · Cited by 31
“…samples are from modern whole genomes, but for ancient DNA studies, where coverage may be too low to call genotypes (Skoglund et al. 2012, 2014a; Fu et al. 2013, 2015; Lazaridis et al. 2014; Olalde et al. 2014; Raghavan et al. 2014a, 2014b, 2015; Seguin-Orlando et al. 2014; Rasmussen et al.…”
BackgroundThe Genetic History of Northern EuropePreprint
Mittnik, A., Wang, C., Pfrengle, S., Daubaras, M., Zariņa, G., Hallgren, F., Allmäe, R., Khartanovich, V., Moiseyev, V. G., Furtwängler, A., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/113241 · Cited by 34
Manning, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108784528 · Cited by 35
Maternal genetic structure in ancient Shandong between 9500 and 1800 years ago
Liu, J., Zeng, W., Sun, B., Mao, X., Zhao, Y., Wang, F., Li, Z., Luan, F., Guo, J., Zhu, C., et al. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.01.029 · Cited by 32
Self-citationNasal cavity and maxillary sinuses form variation among modern humans of Asian descent
Evteev, A., & Grosheva, A. N. (2019) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23841 · Cited by 32
Turner‐Walker, G., Gutiérrez, A., Armentano, N., & Hsu, C.-Q. (2022) · Quaternary International · doi:10.1016/j.quaint.2022.12.009 · Cited by 35
A history of multiple Denisovan introgression events in modern humans
Ongaro, L., & Huerta‐Sánchez, E. (2024) · Nature Genetics · doi:10.1038/s41588-024-01960-y · Cited by 34
“For instance, based on sequenced DNA from a ~34 ka female skull cap unearthed from Salkhit valley in Mongolia, introgressed segments in this individual could be inferred 19 , as well as in a ~40 ka individual from Tianyuan Cave in China 21 , and in two North Siberian individuals 22 (31 ka Yana 1, Yana 2).”
InfluentialMohandesan, E., Speller, C., Peters, J., Uerpmann, H., Uerpmann, M., Cupere, B. D., Hofreiter, M., & Burger, P. A. (2016) · Molecular Ecology Resources · doi:10.1111/1755-0998.12551 · Cited by 34
“In this study, we explore two methodological strategies to recover mitochondrial genomes from ancient dromedary specimens: (i) double- or single-stranded DNA library (DSL or SSL) preparation (Meyer & Kircher 2010; Gansauge & Meyer 2013; Fortes & Paijmans 2015) followed by hybridization enrichment (Briggs et al. 2009;…”
MethodGenome of Peştera Muierii skull shows high diversity and low mutational load in pre-glacial Europe
Svensson, E., Günther, T., Hoischen, A., Hervella, M., Munters, A. R., Ioana, M. I., Ridiche, F., Edlund, H., van Deuren, R. C., Soficaru, A., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.04.045 · Cited by 32
Ancient DNA reveals pervasive directional selection across West Eurasia
Akbari, A., Perry, A., Barton, A. R., Kariminejad, M., Gazal, S., Li, Z., Zeng, Y., Mittnik, A., Patterson, N. J., Mah, M., et al. (2026) · Nature · doi:10.1038/s41586-026-10358-1 · Cited by 48
“…UDG-treated double-stranded library preparation 251,252 ; capture was automated using a Perkin Elmer EP3 or Agilent Bravo NGS Workstations 2,188,253 ) to mostly automated processing (DNA extraction 254 , double-stranded and single-stranded library preparation 255 , capture and pooling for…”
Zhoukoudian Upper Cave personal ornaments and ochre: Rediscovery and reevaluation
d’Errico, F., Martí, À. P., Wei, Y. M., Gao, X., Vanhaeren, M., & Doyon, L. (2021) · Journal of Human Evolution · doi:10.1016/j.jhevol.2021.103088 · Cited by 33
Self-citationWang, M., He, G., Zou, X., Chen, P., Wang, Z., Tang, R., Yang, X., Chen, J., Yang, M., Li, Y., et al. (2022) · Journal of Systematics and Evolution · doi:10.1111/jse.12825 · Cited by 30
“6 million years ago and anatomically modern humans expanding into this area around 50 thousand years ago (kya) (Fu et al., 2013; Higham, 2013; Bae et al., 2017).”
BackgroundAllelic bias when performing in‐solution enrichment of ancient human DNA
Davidson, R., Williams, M. P., Roca‐Rada, X., Kassadjikova, K., Tobler, R., Fehren‐Schmitz, L., & Llamas, B. (2023) · Molecular Ecology Resources · doi:10.1111/1755-0998.13869 · Cited by 31
Zilhão, J., d’Errico, F., Banks, W. E., & Teyssandier, N. (2024) · Quaternary Environments and Humans · doi:10.1016/j.qeh.2024.100037 · Cited by 32
Social and genetic diversity in first farmers of central Europe
Gelabert, P., Bickle, P., Hofmann, D., Teschler‐Nicola, M., Anders, A., Huang, X., Hämmerle, M., Olalde, Í., Fournier, R., Ringbauer, H., et al. (2024) · Nature Human Behaviour · doi:10.1038/s41562-024-02034-z · Cited by 36
“Amplified libraries were enriched using two rounds of consecutive hybridisation capture enrichment 1240k strategy 50,51 ).”
Ancient DNA in the Study of Ancient Disease
Stone, A. C., & Ozga, A. T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-809738-0.00008-9 · Cited by 30
Mizuno, F., Gojobori, J., Kumagai, M., Baba, H., Taniguchi, Y., Kondo, O., Matsushita, M., Matsushita, T., Matsuda, F., Higasa, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91357-2 · Cited by 30
Ancient DNA reveals the maternal genetic history of East Asian domestic pigs
Zhang, M., Liu, Y., Li, Z., Lü, P., Gardner, J. D., Ye, M., Wang, J., Yang, M., Shao, J., Wang, W., et al. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.11.014 · Cited by 29
Self-citationExtended longevity of DNA preservation in Levantine Paleolithic sediments, Sefunim Cave, Israel
Slon, V., Clark, J. L., Friesem, D. E., Orbach, M., Porat, N., Meyer, M., Kandel, A. W., & Shimelmitz, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-17399-2 · Cited by 26
Self-citationIn-solution Y-chromosome capture-enrichment on ancient DNA libraries
Dávalos, D. I. C., Nieves-Colón, M. A., Sockell, A., Poznik, G. D., Schroeder, H., Stone, A. C., Bustamante, C. D., Malaspinas, A., & Ávila‐Arcos, M. C. (2018) · BMC Genomics · doi:10.1186/s12864-018-4945-x · Cited by 31
A Late Pleistocene human genome from Southwest China
Zhang, X., Ji, X., Li, C., Yang, T., Huang, J.-H., Zhao, Y., Wu, Y., Ma, S., Pang, Y., Huang, Y., et al. (2022) · Current Biology · doi:10.1016/j.cub.2022.06.016 · Cited by 28
Middle Holocene Siberian genomes reveal highly connected gene pools throughout North Asia
Wang, K., He, Y. H., Radzevičiūtė, R., Kiryushin, Y. F., Tishkin, A. A., Frolov, Y. V., Степанова, Н. Ф., Kiryushin, K. Y., Kungurov, A. L., Shnaider, S. V., et al. (2023) · Current Biology · doi:10.1016/j.cub.2022.11.062 · Cited by 33
Lang, P. L. M., Weiß, C. L., Kersten, S., Latorre, S. M., Nagel, S., Nickel, B., Meyer, M., & Burbano, H. A. (2020) · Molecular Ecology Resources · doi:10.1111/1755-0998.13168 · Cited by 29
“…to Suchan et al. (2016), during bait production, in - stead of employing a commercial biotinylation kit that randomly in - troduces biotinylated nucleotides into the bait sequences, we used a 5′-biotinylated primer in a linear amplification to generate bioti - nylated baits (Fu et al., 2013).”
InfluentialSelf-citationHodgkins, J., Orr, C. M., Gravel‐Miguel, C., Riel-Salvatore, J. G., Miller, C. E., Bondioli, L., Nava, A., Lugli, F., Talamo, S., Hajdinjak, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-02804-z · Cited by 30
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
Banerjee, N., Polushina, T. V., Bettella, F., Giddaluru, S., Steen, V. M., Andreassen, O. A., & Hellard, S. L. (2018) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1177-2 · Cited by 27
Parallel paleogenomic transects reveal complex genetic history of early European farmersPreprint
Lipson, M., Szécsényi‐Nagy, A., Mallick, S., Pósa, A., Stégmár, B., Keerl, V., Rohland, N., Stewardson, K., Ferry, M., Michel, M., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/114488 · Cited by 28
Re-inventing ancient human DNA
Knapp, M., Lalueza‐Fox, C., & Hofreiter, M. (2015) · Investigative Genetics · doi:10.1186/s13323-015-0020-4 · Cited by 30
“[26,29,40,45,46,56,71,78,83,86-96].”
Whole-Genome Capture of Ancient DNA Using Homemade Baits
Fortes, G. G., & Paijmans, J. L. A. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9176-1_11 · Cited by 29
Maternal genetic structure of a neolithic population of the Yangshao culture
Miao, B., Liu, Y., Gu, W., Wei, Q., Wu, Q., Wang, W., Zhang, M., Ding, M., Wang, T., Liu, J., et al. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.04.005 · Cited by 26
Self-citationAncient human genomics: the methodology behind reconstructing evolutionary pathways
Marciniak, S., Klunk, J., Devault, A. M., Enk, J. M., & Poinar, H. N. (2015) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.11.003 · Cited by 30
Phenotypes from ancient DNA : Approaches, insights and prospects
Fortes, G. G., Speller, C., Hofreiter, M., & King, T. E. (2013) · BioEssays · doi:10.1002/bies.201300036 · Cited by 26
“03% [58].”
Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia
Marrero, P., Abu‐Amero, K. K., Larruga, J. M., & Cabrera, V. M. (2016) · BMC Evolutionary Biology · doi:10.1186/s12862-016-0816-8 · Cited by 27
“Ancient DNA analysis of a morphologically early modern human from Tianyuan cave in northeast China [126] and a modern human from western Siberia of 45 ky old [127] evidenced that both were bearers of B and U mtDNA lineages respectively.”
BackgroundInfluentialXue, J., Wang, W., Shao, J., Dai, X., Sun, Z., Gardner, J. D., Chen, L., Guo, X., Di, N., Pei, X., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.909267 · Cited by 25
“We evaluated the contamination rate using the ContamMix software and compared the mtDNA fragments with the consensus mitochondrial genome for our newly sampled individuals and 311 present-day world-wide sequences (Fu et al., 2013).”
MethodSelf-citationAncient Yersinia pestis and Salmonella enterica genomes from Bronze Age Crete
Neumann, G. U., Skourtanioti, E., Burri, M., Nelson, E. A., Michel, M., Hiss, A. N., McGeorge, P. J. P., Betancourt, P. P., Spyrou, M. A., Krause, J., et al. (2022) · Current Biology · doi:10.1016/j.cub.2022.06.094 · Cited by 30
Fine-scale sampling uncovers the complexity of migrations in 5th–6th century Pannonia
Vyas, D. N., Koncz, I., Modi, A., Mende, B. G., Tian, Y., Francalacci, P., Lari, M., Vai, S., Straub, P., Gallina, Z., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.07.063 · Cited by 27
Nikitin, A. G., Potekhina, I. D., Rohland, N., Mallick, S., Reich, D., & Lillie, M. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172952 · Cited by 24
Evteev, A., Movsesian, А. A., & Grosheva, A. N. (2017) · Journal of Human Evolution · doi:10.1016/j.jhevol.2017.02.008 · Cited by 26
Dong, Y., Li, Luan, Li, Li, Cui, Y., Zhou, & Malhi, R. S. (2007) · Human Biology · doi:10.13110/humanbiology.87.1.0071 · Cited by 78
“…number of prehistoric populations in China (Ancient DNA Laboratory 2001; Gao et al. 2007; Li et al. 2007; Zhang et al. 2010; Cui et al. 2013a; Fu et al. 2013), how or whether ancient communities changed in kinship organization and postmarital residence in diffferent regions within China…”
BackgroundAncient genomes reveal a deep history of Treponema pallidum in the Americas
Barquera, R., Sitter, T. L., Kirkpatrick, C. L., Ramírez, D. A., Kocher, A., Spyrou, M. A., Couoh, L. R., Talavera-González, J. A., Castro, M., von Hunnius, T. E., et al. (2024) · Nature · doi:10.1038/s41586-024-08515-5 · Cited by 33
Holliday, T. W., Gautney, J. R., & Friedl, L. (2014) · Current Anthropology · doi:10.1086/679068 · Cited by 24
“Galeta et al. (2011) used three demographic models to test the idea of nearly complete replacement of indigenous Central European foragers by “invading” Neolithic farmers and found that such a result required unreasonably high levels of fertility, female survivorship, and population growth among…”
MethodPopulation distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)
Knappskog, S., Gansmo, L. B., Dibirova, K., Metspalu, A., Cybulski, C., Peterlongo, P., Aaltonen, L. A., VATTEN, L. J., Romundstad, P., Hveem, K., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1910 · Cited by 24
“Calculations based on nuclear DNA divergence has estimated the separation between the European and Asian population to have occurred around 23,000 (CI: 17,000 - 40,000) years ago, [17], while calculations based on mitochondrial DNA divergence have estimated this event to take place approximately 40,000 years ago [29].”
BackgroundBailey, S., Mao, X., Struebig, M., Tsagkogeorga, G., Csorba, G., Heaney, L. R., Sedlock, J. L., Stanley, W. T., Rouillard, J. M., & Rossiter, S. J. (2015) · Biological Journal of the Linnean Society · doi:10.1111/bij.12620 · Cited by 25
Di, D., Sanchez‐Mazas, A., & Currat, M. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0512-0 · Cited by 24
“…originating from the two migration routes would be, to some extent, reflected by the recent analyses of ancient human DNA from Tianyuan Cave (~40 kya) in northern China [67], on one side, and from Mal ’ ta (~24 kya) and Afontova Gora-2 (~17 kya) in Southern Siberia [68], on the other side (Fig.”
BackgroundDirect radiocarbon dating and DNA analysis of the Darra-i-Kur (Afghanistan) human temporal bone
Douka, K., Slon, V., Stringer, C. B., Potts, R., Hübner, A., Meyer, M., Spoor, F., Pääbo, S., & Higham, T. (2017) · Journal of Human Evolution · doi:10.1016/j.jhevol.2017.03.003 · Cited by 23
Self-citation
Metadata
- Authors
- Fu, Q., Meyer, M., Gao, X., Stenzel, U., Burbano, H. A., Kelso, J., & Pääbo, S.
- Affiliations
- Max Planck Society (DE)
- Max Planck Institute for Evolutionary Anthropology (DE)
- Max Planck Institute for Developmental Biology (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-01-22
- Volume
- 110
- Issue
- 6
- Pages
- 2223-2227
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3568306
- OpenAlex
- W2149683346
- Cited by
- 608
- References
- 47
- Citations by year
- 2026: 27 · 2025: 52 · 2024: 45 · 2023: 45 · 2022: 45 · 2021: 78 · 2020: 64 · 2019: 35 · 2018: 49 · 2017: 43 · 2016: 38 · 2015: 35 · 2014: 34 · 2013: 17
- FWCI
- 27.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- early modern humans, ancient DNA, mitochondrial genome, nuclear genome, chromosome 21, archaic admixture, Asian ancestry, Native American ancestry
- MeSH terms
- Animals, Base Sequence, China, Chromosomes, Human, Pair 21, DNA, Mitochondrial, Fossils, Genetics, Population, Humans, Molecular Sequence Data, Phylogeny, Sequence Homology, Nucleic Acid, Hominidae, Gene Library, Sequence Analysis, DNA, Asian People, History, Ancient, Phylogeography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
