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DNA analysis of an early modern human from Tianyuan Cave, China
Open accessAbstract
Hominins with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 y ago. The genetic relationships between these early modern humans and present-day human populations have not been established. We have extracted DNA from a 40,000-y-old anatomically modern human from Tianyuan Cave outside Beijing, China. Using a highly scalable hybridization enrichment strategy, we determined the DNA sequences of the mitochondrial genome, the entire nonrepetitive portion of chromosome 21 (∼30 Mbp), and over 3,000 polymorphic sites across the nuclear genome of this individual. The nuclear DNA sequences determined from this early modern human reveal that the Tianyuan individual derived from a population that was ancestral to many present-day Asians and Native Americans but postdated the divergence of Asians from Europeans. They also show that this individual carried proportions of DNA variants derived from archaic humans similar to present-day people in mainland Asia.
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“We evaluated each individual for evidence of authentic ancient DNA by limiting to libraries with a minimum of 3% cytosine-to-thymine errors at the final nucleotide29, by requiring that the ratio of X-to-Y-chromosome sequences was characteristic of either a male or a female, by requiring >95% matching to the consensus sequence of mitochondrial DNA30, and by requiring (for males) a lack of variation”
From Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation (2018) · cites this paper as [30]
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“We assessed the quality of each library at the screening stage using three standard methods for determining ancient DNA authenticity.”
From Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation (2018) · cites this paper as [30]
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Self-citationPeopling the Americas: not “out of Japan”
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“A phylogenetic analysis placed the Jomon population divergence between contemporary Southeast and East Asians and the Upper Paleolithic remains from Tiányuán Cave (40,000 cal yr BP) near Beijing (Fu et al. 2013), as well as earlier than the divergence between contemporary and ancient Tibetans, and earlier than the div…”
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InfluentialSelf-citationFregel, R., Cabrera, V. M., Larruga, J. M., Abu‐Amero, K. K., & González, A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129839 · Cited by 22
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“Meanwhile, the ancient DNA analysis of a 40,000-year-old Tianyuan fossil, anatomically classified as an early modern human, resulted in a genetically fully modern human carrying a haplogroup B mtDNA lineage already derived from the Eurasian macrohaplogroup N [30].”
BackgroundAncient genomes revealed the complex human interactions of the ancient western Tibetans
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Maternal Genetic History of Southern East Asians over the Past 12,000 Years
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“…reference genome sequence hs37d5) and the presence of deamination patterns were the main criteria to evaluate whether aDNA preservation was sufficient for employing the targeted enrichment of ca. 1 .2 mio nuclear markers (SNPs) after Haak et al. (99), Mathieson et al. (125), and Fu et al. (126).”
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MethodNeanderthals and Their Contemporaries
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BackgroundAncient genomes reveal insights into ritual life at Chichén Itzá
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MethodA late Neanderthal tooth from northeastern Italy
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Self-citationThe Genomic Formation of Human Populations in East AsiaPreprint
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“Other developments of note include genomic data from other ancient modern humans, such as the 24,000 year old individual from Mal’ta in Siberia [37] and the 40,000 year old individual from Tianyuan Cave in China [38], and what these reveal about migrations and continuity.”
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“…Palaeolithic human DNA results from China and Siberia (Denisova Cave, Ust’-Ishim, and Tianyuan Cave; e.g. Krause et al. 2007; Reich et al. 2010; Fu et al. 2013, 2014; see position of sites in Figure 1), of great significance for understanding human migrations and contacts during the IUP in…”
BackgroundAntCaller: an accurate variant caller incorporating ancient DNA damage
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Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese
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“Numerous evidences from ancient and present-day human genomes suggested an initial settlement in East Asia about 60,000 years ago and multiple waves of population expansion in Paleolithic and Neolithic periods (Fu et al., 2013; Bai et al., 2020; Zhang et al., 2020).”
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African climate and geomorphology drive evolution and ghost introgression in sable antelope
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“We assigned Y-chromosomal haplogroups according to the Yfull 8.09 phylogeny using all trimmed reads mapped to the Y chromosome and report the most downstream diagnostic SNPs (Data S1C).”
InfluentialStructural analysis of the femoral diaphyses of an early modern human from Tianyuan Cave, China
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“…diaphyses of an early modern human from Tianyuan Cave, China, Quaternary International (2015), http://dx.doi.org/10.1016/j.quaint.2015.10.099 ancestral to many present-day East Asians and Native Americans, though it was also found to carry a limited number of archaic alleles (Fu et al., 2013).”
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Human Evolution in Asia: Taking Stock and Looking Forward
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MethodGenome sequences of 36,000- to 37,000-year-old modern humans at Buran-Kaya III in Crimea
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“The outgroup-f 3 results, and in particular the higher-than-expected affinity of the East Asian Tianyuan to BuKa3A suggested that similar to Goyet116-1 and several members of the Fournol cluster, BuKa3A may also be admixed with ancestry present in Europe before the CI eruption and Heinrich Stadial 4.”
BackgroundInfluentialLow-cost cross-taxon enrichment of mitochondrial DNA using in-house synthesised RNA probes
Richards, S. M., Hovhannisyan, N., Gilliham, M., Ingram, J., Skadhauge, B., Heiniger, H., Llamas, B., Mitchell, K. J., Meachen, J., Fincher, G. B., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209499 · Cited by 14
Exploring models of human migration to the Japanese archipelago using genome-wide genetic data
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“Studies showed the Tianyuan lineage at the root of all East and Northeast Asian populations (Fu et al., 2013; Yang et al., 2017); however, mixed results have been obtained when trying to determine whether the lineage of the Tianyuan split from ancestors was before or after the split of the early…”
BackgroundResultInfluentialOrigin and dispersal history of Hepatitis B virus in Eastern Eurasia
Sun, B., Valtueña, A. A., Kocher, A., Gao, S., Li, C., Fu, S., Zhang, F., Ma, P., Xuan, Y., Qiu, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47358-6 · Cited by 14
High continuity of forager ancestry in the Neolithic period of the eastern Maghreb
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“A major reconsideration was prompted by the discovery of modern human bones dated to around 40 kya in Tianyuan Cave, near the famous Zhoukoudian Cave (Shang et al. 2007; Shang & Trinkaus 2010), and by the ensuing genetic analysis (Fu et al. 2013).”
BackgroundGenomic and dietary transitions during the Mesolithic and Early Neolithic in SicilyPreprint
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Self-citationAncient Mitogenomes Reveal the Maternal Genetic History of East Asian Dogs
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“Present-day contamination was estimated through a likelihood-based method by comparing sequenced mitochondrial genomes with those found in 626 present-day dogs and wolves worldwide, whose mtDNA haplotypes were treated as the contaminating population (Fu et al. 2013).”
MethodInfluentialSelf-citationEvteev, A., Александровна, С. Т., Grosheva, A. N., Santos, P., Ghirotto, S., Hanihara, T., Hübbe, M., & Menéndez, L. P. (2024) · Journal of Anatomy · doi:10.1111/joa.14115 · Cited by 11
“Second, all these groups share an ancestral origin in Eastern Eurasia (Posth et al., 2018 ; Reich et al., 2012 ), diverging from West Eurasians at about 40,000 years BP (Fu et al., 2013 ).”
BackgroundNeolithic to Bronze Age human maternal genetic history in Yunnan, China
Wei, X., Zhang, M., Min, R., Jiang, Z., Xue, J., Zhu, Z., Yuan, H., Li, X., Zhao, D., Cao, P., et al. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.09.013 · Cited by 13
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“chromosomes [68], exomes [69], or evenwhole genomes [70–72] have already been used with success on aDNA extracts showing minute amounts of endogenous DNA.”
BackgroundKumar, V., Bennett, E. A., Zhao, D., Liang, Y., Tang, Y., Ren, M., Dai, Q., Feng, X., Cao, P., Yang, R., et al. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab216 · Cited by 14
“Mitochondrial sequences were captured using human mitochondrial oligonucleotide probes (Fu et al. 2013) and nuclear DNA was captured using the 1.”
MethodInfluentialSelf-citationAnimals for Tools: The Origin and Development of Bone Technologies in China
Ma, S., & Doyon, L. (2021) · Frontiers in Earth Science · doi:10.3389/feart.2021.784313 · Cited by 12
“…events and complex population dynamics (Wu, 2004; Shang et al., 2007; Hou and Zhao, 2010; Keates, 2010; Liu et al., 2010; Kaifu and Fujita, 2012; Fu et al., 2013; Shen et al., 2013; Bae et al., 2014; Liu et al., 2015; Zhu et al., 2015; Bae et al., 2017; Cai et al., 2017; Kaifu, 2017; Li et al.,…”
First Peoples in a New World: Populating Ice Age America
Meltzer, D. J. (2021) · Cited by 12
The genetic structure of the world’s first farmersPreprint
Lazaridis, I., Nadel, D., Rollefson, G. O., Merrett, D. C., Rohland, N., Mallick, S., Fernandes, D., Novak, M., Gamarra, B., Sirak, K. A., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/059311 · Cited by 12
Self-citationThe Stone Age Plague: 1000 years of Persistence in EurasiaPreprint
Valtueña, A. A., Mittnik, A., Key, F. M., Haak, W., Allmäe, R., Belinskij, A., Daubaras, M., Feldman, M., Jankauskas, R., Janković, I., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/094243 · Cited by 13
Parallel ancient genomic transects reveal complex population history of early European farmersPreprint
Lipson, M., Szécsényi‐Nagy, A., Mallick, S., Pósa, A., Stégmár, B., Keerl, V., Rohland, N., Stewardson, K., Ferry, M., Michel, M., et al. (2017) · MPG.PuRe (Max Planck Society) · Cited by 13
Three Reagents for in-Solution Enrichment of Ancient Human DNA at More than a Million SNPsPreprint
Rohland, N., Mallick, S., Mah, M., Maier, R., Patterson, N. J., & Reich, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.13.476259 · Cited by 13
Ancient DNA from Shimao city records kinship practices in Neolithic China
Chen, Z., Gardner, J. D., Sun, Z., Bennett, E. A., Han, Q., Pei, X., Shao, J., Shi, H., Wang, W., Xue, J., et al. (2025) · Nature · doi:10.1038/s41586-025-09799-x · Cited by 12
“For all the individuals, we applied ContamMix 55 to compare mtDNA fragments between the new consensus mitochondrial genomes with the present-day sequences 50 .”
InfluentialSelf-citationAn Ancient DNA Perspective on Horse Evolution
Orlando, L. (2018) · Population genomics · doi:10.1007/13836_2018_23 · Cited by 12
The cultural sequence of the Middle and Upper Palaeolithic in northern China
Kato, S. (2021) · Quaternary International · doi:10.1016/j.quaint.2021.03.042 · Cited by 11
Wei, P., Zhao, Y., Walker, C. S., He, J., Lu, X., Hui, J., Shui, W., Li, J., & Liu, W. (2021) · Quaternary International · doi:10.1016/j.quaint.2021.04.012 · Cited by 11
Neanderthals and Their Contemporaries
Harvati, K. (2014) · Springer eBooks · doi:10.1007/978-3-642-39979-4_56 · Cited by 11
Ancient DNA Analysis of Palaeolithic Ryukyu Islanders
Shinoda, K., & Adachi, N. (2017) · ANU Press eBooks · doi:10.22459/ta45.03.2017.03 · Cited by 11
“Interestingly, haplogroup B was also found in ancient Chinese samples (Fu et al. 2012).”
BackgroundGenomic history of early dogs in Europe
Bergström, A., Furtwängler, A., Johnston, S., Rosengren, E., Breidenstein, A., Booth, T. J., McCabe, J., Peto, J., Williams, M., Kelly, M., et al. (2026) · Nature · doi:10.1038/s41586-026-10112-7 · Cited by 10
“To overcome this, we turned to hybridization capture of single-nucleotide variants (SNVs), an approach that has proven effective in improving DNA recovery in human studies 20 .”
Ancient DNA reveals the origin and history of early dogs in northeastern China
Wang, X., Wei, W., Kang, N., Zhang, N., Tang, Z., Chen, Q., Wang, L., Zhang, W., Tian, H., Liu, W. Y., et al. (2024) · Journal of Archaeological Science · doi:10.1016/j.jas.2024.106010 · Cited by 10
[Juglone inhibits proliferation and induces apoptosis of human cervical squamous cancer SiHa cells].
Zhang, W., Li, Y., Luo, J., Lu, X., Chen, M., Zhu, W., & Jiang, Y. (2015) · PubMed · Cited by 10
Krettek, K.-L., Casas‐Vargas, A., Mas-Sandoval, À., Alvis, L. A., Reiter, E., Madero, J. M., Urban, M., Vargas, J. C. N., Usaquén, W., Cuenca, J. V. R., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads6284 · Cited by 9
“Both target enrichments were performed in solution using a modified version of Fu et al. ( 56 ).”
Onset of extensive human fire use 50,000 y ago
Jiang, S., Zhao, D., Kaboth‐Bahr, S., Beaufort, L., Tu, H., Lu, Z., Cheng, Z., Zhang, S., Zhong, Y., Hao, X., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2500042122 · Cited by 9
“During the middle Marine isotope stage (MIS) 3, there were more pronounced changes in the diversity of technological behaviors and cultures among humans in northern East Asia (50, 51).”
Can archaeology tell us about the evolution of cognition and language?
Bar‐Yosef, O. (2016) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2016.11.009 · Cited by 9
A Bioarchaeological Investigation of Fraternal Stillborn Twins from Tell el-Hesi
Ullinger, J. M., Gregoricka, L. A., Bernardos, R. L., Reich, D., Langston, A., Ferreri, P., & Ingram, B. (2022) · Near Eastern Archaeology · doi:10.1086/720748 · Cited by 10
“We then enriched the libraries for the mitochondrial genome (Fu et al. 2013), and for about 1.24 million single nucleotide polymorphism (SNP) targets in the nuclear genome (Haak et al. 2015; Fu et al. 2015).”
BackgroundInfluentialWang, Y., Zhang, X., Sun, X., Yi, S., Min, K., Liu, D., Yan, W., Cai, H., Wang, X., Curnoe, D., et al. (2023) · Journal of Human Evolution · doi:10.1016/j.jhevol.2023.103344 · Cited by 9
A massively parallel strategy for STR marker development, capture, and genotyping
Kistler, L., Johnson, S. M., Irwin, M. T., Louis, E. E., Ratan, A., & Perry, G. H. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx574 · Cited by 9
“While a wide variety of strategies for population genomic-scale SNP data collection have been developed, even for ancient DNA (Fu et al. 2013; Haak et al. 2015; Carpenter et al. 2013) and difficult sources such as fecal samples (Perry et al. 2010; Chiou and Bergey 2015; Snyder-Mackler et al. 2016),…”
BackgroundCui, Y., Zhang, F., Ma, P., Fan, L., Ning, C., Zhang, Q., Zhang, W., Wang, L., & Robbeets, M. (2020) · Evolutionary Human Sciences · doi:10.1017/ehs.2020.16 · Cited by 9
“We used SAMtools mpileup with parameters -q 30 and -Q 30 to generate a pileup file containing only sites overlapping with published 1240k panel (Fu et al., 2013; Mathieson et al., 2015) and subsequently we randomly called the genotype for each library by a pseudo-diploid method and implemented it using pileupCaller (h…”
MethodThe Search for Ice Age Americans
Meltzer, D. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108632867.005 · Cited by 9
Jomon genome sheds light on East Asian population historyPreprint
Gakuhari, T., Nakagome, S., Rasmussen, S., Allentoft, M. E., Sato, T. K., Korneliussen, T. S., Chuinneagáin, B. N., Matsumae, H., Koganebuchi, K., Schmidt, R., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/579177 · Cited by 9
“We found that IK002 clusters between present-day Southeast and East Asians and the Upper-Paleolithic human remain (40 kya) from Tiányuán Cave[28,33](Fig.1A).”
BackgroundSocial and genetic diversity among the first farmers of Central EuropePreprint
Gelabert, P., Bickle, P., Hofmann, D., Teschler‐Nicola, M., Anders, A., Huang, X., Olalde, Í., Fournier, R., Ringbauer, H., Akbari, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.07.548126 · Cited by 9
Poseidon – A framework for archaeogenetic human genotype data managementPreprint
Schmid, C., Ghalichi, A., Lamnidis, T. C., Mudiyanselage, D. B. A., Haak, W., & Schiffels, S. (2024) · doi:10.7554/elife.98317.1 · Cited by 9
Ancient Mitochondrial Genomes Provide New Clues to the Origin of Domestic Cattle in China
Zhang, N., Shao, X., Guo, Y., Zhang, X., Zhou, Y., Yuan, J., Tang, Z., Hu, S., Minyaev, S. S., & Cai, D. (2023) · Genes · doi:10.3390/genes14071313 · Cited by 8
“In addition, mitochondrial capture was performed on samples with mitochondrial coverage ranging from approximately 1× to 10× and with endogenous DNA greater than nearly 1% [28].”
BackgroundKazak mitochondrial genomes provide insights into the human population history of Central Eurasia
Askapuli, A., Vilar, M. G., Garcia‐Ortíz, H., Zhabagin, M. K., Sabitov, Z. M., Akilzhanova, A. R., Ramanculov, E. M., Schamiloglu, U., Martínez-Hernández, A. G., Contreras-Cubas, C., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277771 · Cited by 9
“In support of this view, an mtDNA with the basal sequence motive of haplogroup B was found in a 40-kyr-old ancient human remain excavated from Tianyuan Cave near Beijing, China [55].”
An ancient view on host pathogen interaction across time and space
Barquera, R., & Krause, J. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.05.004 · Cited by 9
Ancient DNA traces a Chinese 5400-year-old cat specimen as leopard cat (Prionailurus bengalensis)
Zhu, S., Chen, Z., Hu, S., Wang, W., Cao, P., Liu, F., Dai, Q., Feng, X., Yang, R., Ping, W., et al. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.07.005 · Cited by 8
Self-citationThe Maglemosian skeleton from Koelbjerg, Denmark revisited: identifying sex and provenance
Hansen, J., Petersen, H. C., Frei, K. M., Courtaud, P., Tillier, A.-M., Fischer, A., & Allentoft, M. E. (2017) · Danish Journal of Archaeology · doi:10.1080/21662282.2017.1381418 · Cited by 7
“The bones of the Koelbjerg individual from Funen, Denmark (Figures 1 and 2), are the oldest human remains presently known from Scandinavia. For this reason, the relatively intact skeleton has received significant scientific and public attention since it was salvaged during peat digging in 1941; see Henriksen and Hanse…”
BackgroundTHE ANCIENT CULTURES OF THE EXTREME NORTHEAST ASIA AND ETHNOGENETIC RECONSTRUCTIONS
Grebenyuk, P. S., Fedorchenko, A. Y., Lebedint︠s︡ev, A. I., & Malyarchuk, B. А. (2019) · Tomsk Journal of Linguistics and Anthropology · doi:10.23951/2307-6119-2019-2-110-136 · Cited by 9
Where Asia meets Europe – recent insights from ancient human genomics
Feldman, M., Gnecchi‐Ruscone, G. A., Lamnidis, T. C., & Posth, C. (2021) · Annals of Human Biology · doi:10.1080/03014460.2021.1949039 · Cited by 9
“Technological advancements in the design and application of DNA enrichment assays (Fu et al. 2013; Haak et al. 2015; Mathieson et al. 2015) as well as a shift in sampling efforts to focus on the petrous portion of the temporal bone, finally enabled the reconstruction of prehistoric Near Eastern…”
BackgroundPopulation Biology and Population Genetics of Pleistocene Hominins
Templeton, A. R. (2014) · Springer eBooks · doi:10.1007/978-3-642-39979-4_60 · Cited by 8
DNA Sequencing in Cultural Heritage
Vai, S., Lari, M., & Caramelli, D. (2016) · Topics in Current Chemistry · doi:10.1007/s41061-015-0009-8 · Cited by 8
“Target could be the whole mitochondrial genome (see [3, 18, 43] for example), pathogenic bacterial genomes [44–46], nuclear SNPs [47], exomes [42, 48], chromosomes [49], or whole nuclear genome [50–52].”
BackgroundColonialism and narratives of human origins in Asia and AfricaPreprint
Athreya, S. G., & Ackermann, R. (2018) · AfricArXiv (OSF Preprints) · doi:10.31730/osf.io/jtkn2 · Cited by 10
“…of our origins has been argued on the basis of fossil morphology to be more complex than this (e.g. Caspari & Wolpo ff 2013; Trinkaus 2005; Wu 2004), and genetic studies have supported these assertions (e.g. Fu et al. 2015; Fu et al. 2013; Templeton 2002), nonetheless these narratives persist.”
Yang, T., He, J., Li, C., Ning, C., Zhang, T., Wang, J., Hai, Z., Wang, G., Jia, X., Zhang, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63743-1 · Cited by 9
He, G., Sun, Y., Duan, S., Luo, L., Sun, Q., Li, B., Yun, L., Liu, C., & Wang, M. (2025) · Genome biology · doi:10.1186/s13059-025-03859-1 · Cited by 11
“…genetic similarity was observed between the Paleolithic AR33K and Tianyuan individuals, the AR33K sample did not share the same genetic affinity with ancient western Eurasians (e.g., GoyrtQ116-1 from Belgium) or present-day Native Americans (e.g., Surui from the Amazon) as Tianyuan did [38, 39].”
Evaluation of ancient DNA imputation: a simulation study
Escobar‐Rodríguez, M., & Veeramah, K. R. (2024) · Human Population Genetics and Genomics · doi:10.47248/hpgg2404010002 · Cited by 7
Human history and behavioral adaptations in North China during marine isotope stage 3
Yang, S., Petraglia, M. D., & Deng, C. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-0079 · Cited by 7
A History of Humanity: The Evolution of the Human System
Manning, P. M. (2020) · Cited by 7
An early Holocene human skull from Zhaoguo cave, Southwestern China
Zhang, Y., Lü, H., Zhang, X., Zhu, M., He, K., Yuan, H., & Xing, S. (2021) · American Journal of Physical Anthropology · doi:10.1002/ajpa.24294 · Cited by 7
After the blades: The late MIS3 flake-based technology at Shuidonggou Locality 2, North China
Zhang, P., Zwyns, N., Peng, F., Lin, S. C. H., Johnson, C. L., Guo, J., Wang, H., & Gao, X. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274777 · Cited by 9
“Both Bacho-Kiro and Tianyuan lineages contributed to ancestry of present-day East Asians, yet they are not directly related [41, 47].”
BackgroundSelf-citationCauret, C. M. S., Jordan, D. C., Kukoly, L. M., Burton, S., Anele, E. U., Kwiecień, J. M., Gansauge, M.-T., Senthillmohan, S., Greenbaum, E., Meyer, M., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010990 · Cited by 9
Self-citationLan, T., & Lindqvist, C. (2018) · Population genomics · doi:10.1007/13836_2017_7 · Cited by 7
Variation analysis of anti-Müllerian hormone gene in Chinese women with polycystic ovary syndrome
Qin, L., Zhao, S., Yang, P., Cao, Y., Zhang, J., Chen, Z., Dunaif, A. E., & Zhao, H. (2020) · Endocrine · doi:10.1007/s12020-020-02538-4 · Cited by 7
“This observation suggests that AMH regulates key pathways in PCOS pathogenesis in different ethnic groups and these deleterious AMH variants likely arose less than ~40,000 years ago after the separation of the ancestral Eurasian population [28].”
Background
Metadata
- Authors
- Fu, Q., Meyer, M., Gao, X., Stenzel, U., Burbano, H. A., Kelso, J., & Pääbo, S.
- Affiliations
- Max Planck Society (DE)
- Max Planck Institute for Evolutionary Anthropology (DE)
- Max Planck Institute for Developmental Biology (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-01-22
- Volume
- 110
- Issue
- 6
- Pages
- 2223-2227
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3568306
- OpenAlex
- W2149683346
- Cited by
- 608
- References
- 47
- Citations by year
- 2026: 27 · 2025: 52 · 2024: 45 · 2023: 45 · 2022: 45 · 2021: 78 · 2020: 64 · 2019: 35 · 2018: 49 · 2017: 43 · 2016: 38 · 2015: 35 · 2014: 34 · 2013: 17
- FWCI
- 27.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- early modern humans, ancient DNA, mitochondrial genome, nuclear genome, chromosome 21, archaic admixture, Asian ancestry, Native American ancestry
- MeSH terms
- Animals, Base Sequence, China, Chromosomes, Human, Pair 21, DNA, Mitochondrial, Fossils, Genetics, Population, Humans, Molecular Sequence Data, Phylogeny, Sequence Homology, Nucleic Acid, Hominidae, Gene Library, Sequence Analysis, DNA, Asian People, History, Ancient, Phylogeography
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