The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments
Open accessAbstract
Competitive endogenous (ce)RNAs cross-regulate each other through sequestration of shared microRNAs and form complex regulatory networks based on their microRNA signature. However, the molecular requirements for ceRNA cross-regulation and the extent of ceRNA networks remain unknown. Here, we present a mathematical mass-action model to determine the optimal conditions for ceRNA activity in silico . This model was validated using phosphatase and tensin homolog (PTEN) and its ceRNA VAMP (vesicle-associated membrane protein)-associated protein A (VAPA) as paradigmatic examples. A computational assessment of the complexity of ceRNA networks revealed that transcription factor and ceRNA networks are intimately intertwined. Notably, we found that ceRNA networks are responsive to transcription factor up-regulation or their aberrant expression in cancer. Thus, given optimal molecular conditions, alterations of one ceRNA can have striking effects on integrated ceRNA and transcriptional networks.
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MicroRNA expression profiles classify human cancers
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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Self-citationIntegrative Genomic Profiling of Human Prostate Cancer
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A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Poliseno, L., Salmena, L., Zhang, J., Carver, B., Haveman, W. J., & Pandolfi, P. P. (2010) · Nature · doi:10.1038/nature09144 · Cited by 2,323
Self-citationTarget mimicry provides a new mechanism for regulation of microRNA activity
Franco-Zorrilla, J. M., Valli, A., Todesco, M., Mateos, I., Puga, M. I., Rubio-Somoza, I., Leyva, A., Weigel, D., García, J. A., & Paz-Ares, J. (2007) · Nature Genetics · doi:10.1038/ng2079 · Cited by 2,069
A microRNA in a Multiple-Turnover RNAi Enzyme Complex
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Roles for MicroRNAs in Conferring Robustness to Biological Processes
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Impaired microRNA processing enhances cellular transformation and tumorigenesis
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Cited by
The multilayered complexity of ceRNA crosstalk and competition
Tay, Y., Rinn, J., & Pandolfi, P. P. (2014) · Nature · doi:10.1038/nature12986 · Cited by 3,910
Self-citationEndogenous microRNA sponges: evidence and controversy
Thomson, D. W., & Dinger, M. E. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.20 · Cited by 2,185
Circular RNAs function as ceRNAs to regulate and control human cancer progression
Zhong, Y., Du, Y., Yang, X., Mo, Y., Fan, C., Xiong, F., Ren, D., Ye, X., Li, C., Wang, Y., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0827-8 · Cited by 1,007
ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry
Karreth, F. A., & Pandolfi, P. P. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0202 · Cited by 851
Self-citationLong noncoding RNAs in cancer metastasis
Liu, S. J., Dang, H. X., Lim, D. A., Feng, F. Y., & Maher, C. A. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00353-1 · Cited by 648
Metadata
- Authors
- Ala, U., Karreth, F. A., Bosia, C., Pagnani, A., Taulli, R., Léopold, V., Tay, Y., Provero, P., Zecchina, R., & Pandolfi, P. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-03-27
- Volume
- 110
- Issue
- 18
- Pages
- 7154-7159
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965514608
- Cited by
- 332
- References
- 41
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Ala, U., Karreth, F. A., Bosia, C., Pagnani, A., Taulli, R., Léopold, V., Tay, Y., Provero, P., Zecchina, R., & Pandolfi, P. P. (2013). Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1222509110
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