The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety
Open accessAbstract
Significance: The clinical outcomes of anticancer drugs are compromised by their poor physicochemical properties, low tumor targeting, insufficient bioavailability, and side effects. Matrix metalloproteinase 2 (MMP2) has been found overexpressed in most cancers and responsible for tumor cell proliferation and metastasis. In this study, a self-assembling MMP2-sensitive paclitaxel-containing micellar nanopreparation was developed. Several major drug delivery strategies, including self-assembly, PEGylation, the enhanced permeability and retention effect, stimulus sensitivity, a cell-penetrating moiety, and the concept of prodrug, were used in a collaborative fashion to design this nanoparticle. The nanopreparation showed superior tumor targeting, cell internalization, and antitumor efficacy over its nonsensitive counterpart, free paclitaxel and conventional micelles. This uniquely engineered nanoparticle has potential for effective intracellular delivery of drug into cancer cells.
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Cites
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Cited by
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Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Liu, H.-W., Chen, L., Xu, C., Li, Z., Zhang, H., Zhang, X.-B., & Tan, W. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00862g · Cited by 948
Polymer–drug conjugate therapeutics: advances, insights and prospects
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Insight into nanoparticle cellular uptake and intracellular targeting
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Polymeric Nanostructures for Imaging and Therapy
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Metadata
- Authors
- Zhu, L., Wang, T., Perche, F., Taigind, A., & Torchilin, V. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-23
- Volume
- 110
- Issue
- 42
- Pages
- 17047-17052
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2132732108
- Cited by
- 358
- References
- 32
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhu, L., Wang, T., Perche, F., Taigind, A., & Torchilin, V. P. (2013). Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1304987110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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