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Cited by 349Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP

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Govindarajan, Arvind, Israely, Inbal, Huang, Shu-Ying, Tonegawa, Susumu·2011·Neuron
DOI 10.1016/j.neuron.2010.12.008PMC PMC3032443
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Abstract

The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by itself. Using glutamate uncaging and two-photon imaging, we demonstrate that the efficacy of this facilitation decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines compete for L-LTP expression if stimulated too closely together in time. Furthermore, the facilitation is temporally bidirectional but asymmetric. Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis, which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered within dendritic branches rather than dispersed throughout the dendritic arbor. Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage.

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  • Protein synthesis is proposed to be required for "late" LTP.

    “Protein synthesis is also proposed to be required for “late” LTP (55–57) (see sect. 3.3).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [57]

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Authors
Govindarajan, A., Israely, I., Huang, S.-Y., & Tonegawa, S.
Affiliations
Massachusetts Institute of Technology (US)
Corresponding author
Tonegawa, Susumu
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2011-01
Volume
69
Issue
1
Pages
132-146
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2010.12.008
PMC
PMC3032443
OpenAlex
W2052426068
Cited by
349
References
12
Citations by year
2026: 11 · 2025: 16 · 2024: 27 · 2023: 18 · 2022: 16 · 2021: 27 · 2020: 17 · 2019: 24 · 2018: 22 · 2017: 23 · 2016: 33 · 2015: 20 · 2014: 27 · 2013: 23 · 2012: 33
FWCI
11.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
  • Elsevier eBooks
Funders
  • RIKEN
  • National Institutes of Health
  • Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
long-term potentiation, dendritic branches, synaptic plasticity, synaptic competition, long-term memory storage, dendritic branching, glutamate uncaging, two-photon imaging
MeSH terms
Animals, Dendrites, Electrophysiology, Mice, Inbred Strains, Time Factors, Protein Biosynthesis, Long-Term Potentiation, Glutamic Acid, Tissue Culture Techniques, Dendritic Spines, Mice

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