The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Nfatc1 orchestrates aging in hair follicle stem cells
Open accessAbstract
Significance: Signs of aging often first appear in our skin and hair. As animals age, hair follicles spend more time resting instead of generating hair. Here we show that this decline is rooted in age-related changes in systemic, local, and intrinsic factors, which collaborate to reduce hair follicle stem cell (HFSC) activity. We uncover a unique and hitherto-undescribed age-related role for bone morphogenic protein signaling and a downstream effector, nuclear factor of activated T-cell c1 (NFATc1). In young stem cells, NFATc1 is on when they are quiescent and wanes when they make hair. In aging follicles, NFATc1 and its target genes remain high too long. Importantly, NFATc1 inhibitors restore youthful behavior to aging HFSCs, providing unique insights into age-related changes in skin physiology.
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Defining the Epithelial Stem Cell Niche in Skin
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Self-citationThe ageing systemic milieu negatively regulates neurogenesis and cognitive function
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“Notably, however, we did not find evidence for up-regulation of the Ink4a/4b locus encoding p16 and p19 stress-response proteins, which are often up-regulated in aging (14, 36, 37).”
Background
Cited by
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science · doi:10.1126/science.aad4395 · Cited by 416
Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche
Gonzales, K. A. U., & Fuchs, E. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.10.001 · Cited by 414
Self-citationPioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
Adam, R. C., Yang, H., Rockowitz, S., Larsen, S. B., Nikolova, M., Oristian, D. S., Polak, L., Kadaja, M., Asare, A., Zheng, D., et al. (2015) · Nature · doi:10.1038/nature14289 · Cited by 375
Self-citationWhen stem cells grow old: phenotypes and mechanisms of stem cell aging
Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 331
Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin
Keyes, B. E., Liu, S., Asare, A., Naik, S., Levorse, J., Polak, L., Lu, C. P., Nikolova, M., Pasolli, H. A., & Fuchs, E. (2016) · Cell · doi:10.1016/j.cell.2016.10.052 · Cited by 266
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Metadata
- Authors
- Keyes, B. E., Segal, J. P., Heller, E., Lien, W.-H., Chang, C.-Y., Guo, X., Oristian, D. S., Zheng, D., & Fuchs, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-26
- Volume
- 110
- Issue
- 51
- Pages
- E4950-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1966192759
- Cited by
- 182
- References
- 20
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- green
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